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Protein

Keratin, type I cuticular Ha5

Gene

KRT35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei346Stutter1

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • cornification Source: Reactome
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name:
K35
Gene namesi
Name:KRT35
Synonyms:HHA5, HKA5, KRTHA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000197079.8
HGNCiHGNC:6453 KRT35
MIMi602764 gene
neXtProtiNX_Q92764

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3886
OpenTargetsiENSG00000197079
PharmGKBiPA30242

Polymorphism and mutation databases

BioMutaiKRT35
DMDMi296439499

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636921 – 455Keratin, type I cuticular Ha5Add BLAST455

Proteomic databases

EPDiQ92764
PaxDbiQ92764
PeptideAtlasiQ92764
PRIDEiQ92764
ProteomicsDBi12649
75448

PTM databases

iPTMnetiQ92764
PhosphoSitePlusiQ92764

Expressioni

Tissue specificityi

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.1 Publication

Gene expression databases

BgeeiENSG00000197079
CleanExiHS_KRT35
ExpressionAtlasiQ92764 baseline and differential
GenevisibleiQ92764 HS

Interactioni

Protein-protein interaction databases

BioGridi110084, 5 interactors
IntActiQ92764, 94 interactors
STRINGi9606.ENSP00000377558

Structurei

3D structure databases

ProteinModelPortaliQ92764
SMRiQ92764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 408IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97HeadAdd BLAST97
Regioni98 – 132Coil 1AAdd BLAST35
Regioni133 – 143Linker 1Add BLAST11
Regioni144 – 244Coil 1BAdd BLAST101
Regioni245 – 260Linker 12Add BLAST16
Regioni261 – 404Coil 2Add BLAST144
Regioni405 – 455TailAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 36Poly-Ser4
Compositional biasi83 – 86Poly-Gly4

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHJD Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ92764
KOiK07604
OMAiYRATSCL
OrthoDBiEOG091G087I
PhylomeDBiQ92764
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS
60 70 80 90 100
ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI
210 220 230 240 250
NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
310 320 330 340 350
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS
360 370 380 390 400
QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC

PGGRF
Length:455
Mass (Da):50,361
Last modified:May 18, 2010 - v5
Checksum:i3E72080469C8E80B
GO

Sequence cautioni

The sequence CAA62286 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA76387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117 – 118QL → HV in CAA62286 (PubMed:8823373).Curated2
Sequence conflicti117 – 118QL → HV in CAA76387 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05601936S → P1 PublicationCorresponds to variant dbSNP:rs743686Ensembl.1
Natural variantiVAR_056020441C → Y. Corresponds to variant dbSNP:rs12451652Ensembl.1
Natural variantiVAR_056021443P → A1 PublicationCorresponds to variant dbSNP:rs2071601Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90762 Genomic DNA Translation: CAA62285.1
X90763 mRNA Translation: CAA62286.1 Different initiation.
Y16791 Genomic DNA Translation: CAA76387.1 Different initiation.
AC019349 Genomic DNA No translation available.
CCDSiCCDS11394.2
RefSeqiNP_002271.3, NM_002280.4
XP_011523096.1, XM_011524794.1
UniGeneiHs.73082

Genome annotation databases

EnsembliENST00000393989; ENSP00000377558; ENSG00000197079
GeneIDi3886
KEGGihsa:3886
UCSCiuc002hws.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRT35_HUMAN
AccessioniPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 146 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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