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Entry version 163 (07 Oct 2020)
Sequence version 5 (18 May 2010)
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Protein

Keratin, type I cuticular Ha5

Gene

KRT35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei346Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q92764

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cuticular Ha5
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name:
K35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT35
Synonyms:HHA5, HKA5, KRTHA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197079.8

Human Gene Nomenclature Database

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HGNCi
HGNC:6453, KRT35

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602764, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92764

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3886

Open Targets

More...
OpenTargetsi
ENSG00000197079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30242

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92764, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT35

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636921 – 455Keratin, type I cuticular Ha5Add BLAST455

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92764

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92764

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92764

PeptideAtlas

More...
PeptideAtlasi
Q92764

PRoteomics IDEntifications database

More...
PRIDEi
Q92764

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12649
75448

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92764

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q92764

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197079, Expressed in hair follicle and 44 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92764, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92764, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197079, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92764
With#Exp.IntAct
ABI3 [Q9P2A4]3EBI-1058674,EBI-742038
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-1058674,EBI-12006308
BCAS2 [O75934]3EBI-1058674,EBI-1050106
C1orf109 [Q9NX04]3EBI-1058674,EBI-8643161
C21orf58 [Q0VAL7]3EBI-1058674,EBI-10226774
CCDC120 [Q96HB5]3EBI-1058674,EBI-744556
CCDC185 [Q8N715]3EBI-1058674,EBI-740814
CCDC196 [A0A1B0GWI1]3EBI-1058674,EBI-10181422
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-1058674,EBI-10175300
CD33 [P20138]3EBI-1058674,EBI-3906571
CTSZ [Q9UBR2]3EBI-1058674,EBI-8636823
DMRT3 [Q9NQL9]3EBI-1058674,EBI-9679045
DTNB - isoform 5 [O60941-5]3EBI-1058674,EBI-11984733
EFCAB3 - isoform 2 [Q8N7B9-2]3EBI-1058674,EBI-11958551
ENKD1 [Q9H0I2]3EBI-1058674,EBI-744099
EXOSC5 [Q9NQT4]3EBI-1058674,EBI-371876
FAM221B [A6H8Z2]3EBI-1058674,EBI-12006844
FRS3 [O43559]3EBI-1058674,EBI-725515
HAPLN2 [Q9GZV7]3EBI-1058674,EBI-11956675
hCG_1987119 [A0A024R8L2]3EBI-1058674,EBI-14103818
HCK - isoform 2 [P08631-2]3EBI-1058674,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-1058674,EBI-11953488
HGS [O14964]3EBI-1058674,EBI-740220
HOXA1 [P49639]3EBI-1058674,EBI-740785
HOXC8 [P31273]3EBI-1058674,EBI-1752118
KCTD9 [Q7L273]3EBI-1058674,EBI-4397613
KDM1A [O60341]3EBI-1058674,EBI-710124
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-1058674,EBI-14069005
KLHL38 [Q2WGJ6]3EBI-1058674,EBI-6426443
KRT1 [P04264]3EBI-1058674,EBI-298429
KRT2 [P35908]3EBI-1058674,EBI-1247312
KRT3 [P12035]3EBI-1058674,EBI-2430095
KRT4 [P19013]3EBI-1058674,EBI-2371606
KRT5 [P13647]3EBI-1058674,EBI-702187
KRT6A [P02538]3EBI-1058674,EBI-702198
KRT6B [P04259]3EBI-1058674,EBI-740907
KRT6C [P48668]3EBI-1058674,EBI-2564105
KRT71 [Q3SY84]3EBI-1058674,EBI-2952676
KRT72 [Q14CN4]3EBI-1058674,EBI-1221280
KRT74 [Q7RTS7]3EBI-1058674,EBI-968660
KRT75 [O95678]3EBI-1058674,EBI-2949715
KRT77 [Q7Z794]3EBI-1058674,EBI-3045529
KRT78 [Q8N1N4]5EBI-1058674,EBI-1056564
KRT79 [Q5XKE5]3EBI-1058674,EBI-2514135
KRT8 [P05787]3EBI-1058674,EBI-297852
KRT80 - isoform 2 [Q6KB66-2]3EBI-1058674,EBI-11999246
KRT81 [Q14533]3EBI-1058674,EBI-739648
KRT82 [Q9NSB4]3EBI-1058674,EBI-1045341
KRT83 [P78385]3EBI-1058674,EBI-10221390
KRT85 [P78386]3EBI-1058674,EBI-1049371
KRT86 [O43790]3EBI-1058674,EBI-9996498
LENG1 [Q96BZ8]3EBI-1058674,EBI-726510
LGALS14 [Q8TCE9]3EBI-1058674,EBI-10274069
LONRF1 [Q17RB8]3EBI-1058674,EBI-2341787
MAPKBP1 [O60336]3EBI-1058674,EBI-947402
MCRS1 [Q96EZ8]3EBI-1058674,EBI-348259
OIP5 [O43482]3EBI-1058674,EBI-536879
OTX1 [P32242]3EBI-1058674,EBI-740446
PKN1 [Q16512]3EBI-1058674,EBI-602382
POU4F2 [Q12837]3EBI-1058674,EBI-17236143
PRPF18 [Q99633]3EBI-1058674,EBI-2798416
PRPF31 [Q8WWY3]3EBI-1058674,EBI-1567797
PRR35 [P0CG20]3EBI-1058674,EBI-11986293
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-1058674,EBI-11984663
SCNM1 [Q9BWG6]3EBI-1058674,EBI-748391
SHC3 [Q92529]3EBI-1058674,EBI-79084
SLC43A2 [Q8N370]3EBI-1058674,EBI-10265149
SMARCE1 [Q969G3]3EBI-1058674,EBI-455078
SMYD1 [Q8NB12]3EBI-1058674,EBI-8463848
TAPBPL [Q9BX59]3EBI-1058674,EBI-12017416
TBC1D21 [Q8IYX1]3EBI-1058674,EBI-12018146
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-1058674,EBI-17455779
TBC1D7 [Q9P0N9]3EBI-1058674,EBI-3258000
TCEANC - isoform 2 [Q8N8B7-2]3EBI-1058674,EBI-11955057
TCHP [Q9BT92]3EBI-1058674,EBI-740781
TEKT4 [Q8WW24]3EBI-1058674,EBI-750487
TEPSIN [Q96N21]3EBI-1058674,EBI-11139477
TLE5 - isoform 2 [Q08117-2]3EBI-1058674,EBI-11741437
TRIM29 [Q14134]3EBI-1058674,EBI-702370
TSG101 [Q99816]3EBI-1058674,EBI-346882
TXLNA [P40222]3EBI-1058674,EBI-359793
TXLNB [Q8N3L3]3EBI-1058674,EBI-6116822
UBASH3A - isoform 2 [P57075-2]3EBI-1058674,EBI-7353612
USP2 [O75604]3EBI-1058674,EBI-743272
VPS9D1 [Q9Y2B5]3EBI-1058674,EBI-9031083
ZNF417 [Q8TAU3]3EBI-1058674,EBI-740727
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-1058674,EBI-740232

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110084, 93 interactors

Protein interaction database and analysis system

More...
IntActi
Q92764, 91 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377558

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92764, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92764

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 408IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 97HeadAdd BLAST97
Regioni98 – 132Coil 1AAdd BLAST35
Regioni133 – 143Linker 1Add BLAST11
Regioni144 – 244Coil 1BAdd BLAST101
Regioni245 – 260Linker 12Add BLAST16
Regioni261 – 404Coil 2Add BLAST144
Regioni405 – 455TailAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 36Poly-Ser4
Compositional biasi83 – 86Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQY9, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161787

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92764

KEGG Orthology (KO)

More...
KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
EWFNTQT

Database of Orthologous Groups

More...
OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92764

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS
60 70 80 90 100
ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI
210 220 230 240 250
NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
310 320 330 340 350
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS
360 370 380 390 400
QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC

PGGRF
Length:455
Mass (Da):50,361
Last modified:May 18, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E72080469C8E80B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C4AM86C4AM86_HUMAN
Keratin, type I cuticular Ha5
KRT35
425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA62286 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA76387 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117 – 118QL → HV in CAA62286 (PubMed:8823373).Curated2
Sequence conflicti117 – 118QL → HV in CAA76387 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05601936S → P1 PublicationCorresponds to variant dbSNP:rs743686Ensembl.1
Natural variantiVAR_056020441C → Y. Corresponds to variant dbSNP:rs12451652Ensembl.1
Natural variantiVAR_056021443P → A1 PublicationCorresponds to variant dbSNP:rs2071601Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X90762 Genomic DNA Translation: CAA62285.1
X90763 mRNA Translation: CAA62286.1 Different initiation.
Y16791 Genomic DNA Translation: CAA76387.1 Different initiation.
AC019349 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11394.2

NCBI Reference Sequences

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RefSeqi
NP_002271.3, NM_002280.4
XP_011523096.1, XM_011524794.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000393989; ENSP00000377558; ENSG00000197079

Database of genes from NCBI RefSeq genomes

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GeneIDi
3886

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3886

UCSC genome browser

More...
UCSCi
uc002hws.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90762 Genomic DNA Translation: CAA62285.1
X90763 mRNA Translation: CAA62286.1 Different initiation.
Y16791 Genomic DNA Translation: CAA76387.1 Different initiation.
AC019349 Genomic DNA No translation available.
CCDSiCCDS11394.2
RefSeqiNP_002271.3, NM_002280.4
XP_011523096.1, XM_011524794.1

3D structure databases

SMRiQ92764
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110084, 93 interactors
IntActiQ92764, 91 interactors
STRINGi9606.ENSP00000377558

PTM databases

iPTMnetiQ92764
MetOSiteiQ92764
PhosphoSitePlusiQ92764

Polymorphism and mutation databases

BioMutaiKRT35
DMDMi296439499

Proteomic databases

jPOSTiQ92764
MassIVEiQ92764
PaxDbiQ92764
PeptideAtlasiQ92764
PRIDEiQ92764
ProteomicsDBi12649
75448

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28853, 140 antibodies

The DNASU plasmid repository

More...
DNASUi
3886

Genome annotation databases

EnsembliENST00000393989; ENSP00000377558; ENSG00000197079
GeneIDi3886
KEGGihsa:3886
UCSCiuc002hws.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3886
DisGeNETi3886
EuPathDBiHostDB:ENSG00000197079.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT35
HGNCiHGNC:6453, KRT35
HPAiENSG00000197079, Tissue enriched (skin)
MIMi602764, gene
neXtProtiNX_Q92764
OpenTargetsiENSG00000197079
PharmGKBiPA30242

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQY9, Eukaryota
GeneTreeiENSGT00940000161787
InParanoidiQ92764
KOiK07604
OMAiEWFNTQT
OrthoDBi798081at2759
PhylomeDBiQ92764
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiQ92764
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3886, 3 hits in 862 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3886
PharosiQ92764, Tbio

Protein Ontology

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PROi
PR:Q92764
RNActiQ92764, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197079, Expressed in hair follicle and 44 other tissues
ExpressionAtlasiQ92764, baseline and differential
GenevisibleiQ92764, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRT35_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 163 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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