UniProtKB - Q92754 (AP2C_HUMAN)
Transcription factor AP-2 gamma
TFAP2C
Functioni
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
2 PublicationsGO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell-cell signaling Source: ProtInc
- male gonad development Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of cell population proliferation Source: GO_Central
- regulation of gene expression, epigenetic Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q92754 |
Reactomei | R-HSA-3232118, SUMOylation of transcription factors R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906, TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors |
SignaLinki | Q92754 |
SIGNORi | Q92754 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-2 gammaShort name: AP2-gamma Alternative name(s): Activating enhancer-binding protein 2 gamma Transcription factor ERF-1 |
Gene namesi | Name:TFAP2C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11744, TFAP2C |
MIMi | 601602, gene |
neXtProti | NX_Q92754 |
VEuPathDBi | HostDB:ENSG00000087510 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 59 | Y → A: Loss of interaction with WWOX; when associated with A-64. 1 Publication | 1 | |
Mutagenesisi | 64 | Y → A: Loss of interaction with WWOX; when associated with A-59. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7022 |
OpenTargetsi | ENSG00000087510 |
PharmGKBi | PA36461 |
Miscellaneous databases
Pharosi | Q92754, Tbio |
Genetic variation databases
BioMutai | TFAP2C |
DMDMi | 12643310 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184803 | 1 – 450 | Transcription factor AP-2 gammaAdd BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 10 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 252 | Phosphoserine; by PKABy similarity | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q92754 |
jPOSTi | Q92754 |
MassIVEi | Q92754 |
MaxQBi | Q92754 |
PaxDbi | Q92754 |
PeptideAtlasi | Q92754 |
PRIDEi | Q92754 |
ProteomicsDBi | 5349 75446 [Q92754-1] |
PTM databases
iPTMneti | Q92754 |
PhosphoSitePlusi | Q92754 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000087510, Expressed in thoracic mammary gland and 152 other tissues |
ExpressionAtlasi | Q92754, baseline and differential |
Genevisiblei | Q92754, HS |
Organism-specific databases
HPAi | ENSG00000087510, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
Interacts with WWOX.
Interacts with CITED4.
Interacts with UBE2I.
Interacts with KCTD1; this interaction represses transcription activation.
Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity.
Interacts with MTA1.
By similarity7 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 112880, 28 interactors |
CORUMi | Q92754 |
ELMi | Q92754 |
IntActi | Q92754, 78 interactors |
STRINGi | 9606.ENSP00000201031 |
Miscellaneous databases
RNActi | Q92754, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 63 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 90 – 126 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 293 – 424 | H-S-H (helix-span-helix), dimerizationAdd BLAST | 132 | |
Regioni | 431 – 450 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 59 – 64 | PPxY motif | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 92 – 107 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | Q92754 |
OMAi | KTYMNTG |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q92754 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C IPR008123, TF_AP2_gamma |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01751, AP2CTNSCPFCT PR01748, AP2TNSCPFCT |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ
110 120 130 140 150
QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL
160 170 180 190 200
PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM
210 220 230 240 250
TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR
260 270 280 290 300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT
310 320 330 340 350
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN
360 370 380 390 400
MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF
410 420 430 440 450
GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2A2R7 | A2A2R7_HUMAN | Transcription factor AP-2 gamma | TFAP2C | 118 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056501 | 1 – 169 | Missing in isoform 2. 1 PublicationAdd BLAST | 169 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95693 mRNA Translation: CAA64989.1 U85658 mRNA Translation: AAC51305.1 AJ315934 Genomic DNA Translation: CAC86997.1 AK301572 mRNA Translation: BAG63065.1 AL121920 Genomic DNA No translation available. BC035664 mRNA Translation: AAH35664.2 BC051829 mRNA Translation: AAH51829.2 AB041717 Genomic DNA Translation: BAC11805.1 |
CCDSi | CCDS13454.1 [Q92754-1] |
RefSeqi | NP_003213.1, NM_003222.3 [Q92754-1] |
Genome annotation databases
Ensembli | ENST00000201031; ENSP00000201031; ENSG00000087510 |
GeneIDi | 7022 |
KEGGi | hsa:7022 |
MANE-Selecti | ENST00000201031.3; ENSP00000201031.2; NM_003222.4; NP_003213.1 |
UCSCi | uc002xya.4, human [Q92754-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Activating protein 2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95693 mRNA Translation: CAA64989.1 U85658 mRNA Translation: AAC51305.1 AJ315934 Genomic DNA Translation: CAC86997.1 AK301572 mRNA Translation: BAG63065.1 AL121920 Genomic DNA No translation available. BC035664 mRNA Translation: AAH35664.2 BC051829 mRNA Translation: AAH51829.2 AB041717 Genomic DNA Translation: BAC11805.1 |
CCDSi | CCDS13454.1 [Q92754-1] |
RefSeqi | NP_003213.1, NM_003222.3 [Q92754-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112880, 28 interactors |
CORUMi | Q92754 |
ELMi | Q92754 |
IntActi | Q92754, 78 interactors |
STRINGi | 9606.ENSP00000201031 |
PTM databases
iPTMneti | Q92754 |
PhosphoSitePlusi | Q92754 |
Genetic variation databases
BioMutai | TFAP2C |
DMDMi | 12643310 |
Proteomic databases
EPDi | Q92754 |
jPOSTi | Q92754 |
MassIVEi | Q92754 |
MaxQBi | Q92754 |
PaxDbi | Q92754 |
PeptideAtlasi | Q92754 |
PRIDEi | Q92754 |
ProteomicsDBi | 5349 75446 [Q92754-1] |
Protocols and materials databases
Antibodypediai | 4230, 427 antibodies from 42 providers |
DNASUi | 7022 |
Genome annotation databases
Ensembli | ENST00000201031; ENSP00000201031; ENSG00000087510 |
GeneIDi | 7022 |
KEGGi | hsa:7022 |
MANE-Selecti | ENST00000201031.3; ENSP00000201031.2; NM_003222.4; NP_003213.1 |
UCSCi | uc002xya.4, human [Q92754-1] |
Organism-specific databases
CTDi | 7022 |
DisGeNETi | 7022 |
GeneCardsi | TFAP2C |
HGNCi | HGNC:11744, TFAP2C |
HPAi | ENSG00000087510, Tissue enhanced (esophagus, skin) |
MIMi | 601602, gene |
neXtProti | NX_Q92754 |
OpenTargetsi | ENSG00000087510 |
PharmGKBi | PA36461 |
VEuPathDBi | HostDB:ENSG00000087510 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | Q92754 |
OMAi | KTYMNTG |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q92754 |
TreeFami | TF313718 |
Enzyme and pathway databases
PathwayCommonsi | Q92754 |
Reactomei | R-HSA-3232118, SUMOylation of transcription factors R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906, TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors |
SignaLinki | Q92754 |
SIGNORi | Q92754 |
Miscellaneous databases
BioGRID-ORCSi | 7022, 58 hits in 1067 CRISPR screens |
ChiTaRSi | TFAP2C, human |
GeneWikii | TFAP2C |
GenomeRNAii | 7022 |
Pharosi | Q92754, Tbio |
PROi | PR:Q92754 |
RNActi | Q92754, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087510, Expressed in thoracic mammary gland and 152 other tissues |
ExpressionAtlasi | Q92754, baseline and differential |
Genevisiblei | Q92754, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C IPR008123, TF_AP2_gamma |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01751, AP2CTNSCPFCT PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | AP2C_HUMAN | |
Accessioni | Q92754Primary (citable) accession number: Q92754 Secondary accession number(s): B4DWK3 Q9P1X2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 193 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families