UniProtKB - Q92754 (AP2C_HUMAN)

BLAST

>sp|Q92754|AP2C_HUMAN Transcription factor AP-2 gamma OS=Homo sapiens OX=9606 GN=TFAP2C PE=1 SV=1
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYF
PPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGR
PAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNV
DDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKY
KVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVT
LLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCK
EFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEAL
IVIDKSYMNPGDQSPADSNKTLEKMEKHRK

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History
Entry version 173 (07 Nov 2018)
Sequence version 1 (01 Feb 1997)
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Protein

Transcription factor AP-2 gamma

Gene

TFAP2C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.2 Publications

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12072434
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9113991
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12072434
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: UniProtKB
Inferred from direct assayⁱ
- 11278550
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: UniProtKB
Inferred from direct assayⁱ
- 11278550
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24413532
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 9113991
male gonad development
Source: UniProtKB
Inferred from expression patternⁱ
- 17848411
negative regulation of transcription by RNA polymerase II Source: Reactome
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 22735262
regulation of gene expression, epigenetic
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24413532
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3232118 SUMOylation of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
SignaLinkⁱ	Q92754
SIGNORⁱ	Q92754

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor AP-2 gamma Short name: AP2-gamma Alternative name(s): Activating enhancer-binding protein 2 gamma Transcription factor ERF-1
Gene namesⁱ	Name:TFAP2C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000087510.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11744 TFAP2C
MIMⁱ	601602 gene
neXtProtⁱ	NX_Q92754

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	59	Y → A: Loss of interaction with WWOX; when associated with A-64. 1 Publication		1
Mutagenesisⁱ	64	Y → A: Loss of interaction with WWOX; when associated with A-59. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7022
Open Targets More...OpenTargetsⁱ	ENSG00000087510
PharmGKBⁱ	PA36461

Polymorphism and mutation databases

BioMutaⁱ	TFAP2C
DMDMⁱ	12643310

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184803	1 – 450	Transcription factor AP-2 gammaAdd BLAST		450

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	10	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residueⁱ	252	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	434	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Sumoylated on Lys-10; which inhibits transcriptional activity.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q92754
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92754
PaxDbⁱ	Q92754
PeptideAtlas More...PeptideAtlasⁱ	Q92754
PRIDEⁱ	Q92754
ProteomicsDBⁱ	75446

PTM databases

iPTMnetⁱ	Q92754
PhosphoSitePlusⁱ	Q92754

Expressionⁱ

Inductionⁱ

During retinoic acid-mediated differentiation.

Gene expression databases

Bgeeⁱ	ENSG00000087510 Expressed in 131 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_TFAP2C
ExpressionAtlasⁱ	Q92754 baseline and differential
Genevisibleⁱ	Q92754 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016061 CAB016079 HPA055179 HPA057076

HPAⁱ

CAB016061
CAB016079
HPA055179
HPA057076

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CITED2	Q99967	2	EBI-937309,EBI-937732
UBE2I	P63279	5	EBI-937309,EBI-80168

GO - Molecular functionⁱ

protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12072434

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112880, 17 interactors
CORUMⁱ	Q92754
ELMⁱ	Q92754
IntActⁱ	Q92754, 78 interactors
STRINGⁱ	9606.ENSP00000201031

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	293 – 424	H-S-H (helix-span-helix), dimerizationAdd BLAST		132

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	59 – 64	PPxY motif		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	30 – 119	Gln/Pro-rich (transactivation domain)Add BLAST		90

Domainⁱ

The PPxY motif mediates interaction with WWOX.1 Publication

Sequence similaritiesⁱ

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q92754
KEGG Orthology (KO) More...KOⁱ	K09177
OMAⁱ	RPHVERN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q92754
TreeFamⁱ	TF313718

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C IPR008123 TF_AP2_gamma
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01751 AP2CTNSCPFCT PR01748 AP2TNSCPFCT

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q92754-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG 
        60         70         80         90        100
VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ 
       110        120        130        140        150
QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL 
       160        170        180        190        200
PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM 
       210        220        230        240        250
TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR 
       260        270        280        290        300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
       310        320        330        340        350
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN 
       360        370        380        390        400
MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF 
       410        420        430        440        450
GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK

Length:450

Mass (Da):49,177

Last modified:February 1, 1997 - v1

Checksum:ⁱ2D4F5FBC269A34A8

Isoform 2 (identifier: Q92754-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-169: Missing.

« Hide

        10         20         30         40         50
MPHQMDEVQN VDDQHLLLHD QTVIRKGPIS MTKNPLNLPC QKELVGAVMN 
        60         70         80         90        100
PTEVFCSVPG RLSLLSSTSK YKVTVAEVQR RLSPPECLNA SLLGGVLRRA 
       110        120        130        140        150
KSKNGGRSLR EKLDKIGLNL PAGRRKAAHV TLLTSLVEGE AVHLARDFAY 
       160        170        180        190        200
VCEAEFPSKP VAEYLTRPHL GGRNEMAARK NMLLAAQQLC KEFTELLSQD 
       210        220        230        240        250
RTPHGTSRLA PVLETNIQNC LSHFSLITHG FGSQAICAAV SALQNYIKEA 
       260        270        280 
LIVIDKSYMN PGDQSPADSN KTLEKMEKHR K

Note: No experimental confirmation available.

Show »

Length:281

Mass (Da):31,010

Checksum:ⁱA5A874EDB6D7B2BC

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2A2R7	A2A2R7_HUMAN		Transcription factor AP-2 gamma Transcription factor AP-2 gamma	TFAP2C	118	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056501	1 – 169	Missing in isoform 2. 1 PublicationAdd BLAST		169

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95693 mRNA Translation: CAA64989.1 U85658 mRNA Translation: AAC51305.1 AJ315934 Genomic DNA Translation: CAC86997.1 AK301572 mRNA Translation: BAG63065.1 AL121920 Genomic DNA No translation available. BC035664 mRNA Translation: AAH35664.2 BC051829 mRNA Translation: AAH51829.2 AB041717 Genomic DNA Translation: BAC11805.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13454.1 [Q92754-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003213.1, NM_003222.3 [Q92754-1]
UniGeneⁱ	Hs.473152

Genome annotation databases

Ensemblⁱ	ENST00000201031; ENSP00000201031; ENSG00000087510 [Q92754-1]
GeneIDⁱ	7022
KEGGⁱ	hsa:7022
UCSC genome browser More...UCSCⁱ	uc002xya.4 human [Q92754-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q92754	Transcription factor AP-2 gamma		PANTR		450	UniRef100_Q92754
Uncharacterized protein		PANPA		450
Transcription factor AP-2 gamma		GORGO		450
Isoform 2 of Transcription factor AP-2 gamma		HUMAN		281

Protein	Similar proteins		Species	Score	Length	Source
Q92754	Transcription factor AP-2 gamma		PANTR		450	UniRef90_Q92754
Uncharacterized protein		PANPA		450
Transcription factor AP-2 gamma		GORGO		450
Isoform 2 of Transcription factor AP-2 gamma		HUMAN		281
Transcription factor AP-2 gamma		CALJA		548
+103

Protein	Similar proteins		Species	Score	Length	Source
Q92754	Transcription factor AP-2 gamma		PANTR		450	UniRef50_Q92754
Uncharacterized protein		PANPA		450
Transcription factor AP-2 gamma		GORGO		450
Isoform 2 of Transcription factor AP-2 gamma		HUMAN		281
Transcription factor AP-2 gamma		CALJA		548
+112

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Activating protein 2 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X95693 mRNA Translation: CAA64989.1 U85658 mRNA Translation: AAC51305.1 AJ315934 Genomic DNA Translation: CAC86997.1 AK301572 mRNA Translation: BAG63065.1 AL121920 Genomic DNA No translation available. BC035664 mRNA Translation: AAH35664.2 BC051829 mRNA Translation: AAH51829.2 AB041717 Genomic DNA Translation: BAC11805.1
CCDSⁱ	CCDS13454.1 [Q92754-1]
RefSeqⁱ	NP_003213.1, NM_003222.3 [Q92754-1]
UniGeneⁱ	Hs.473152

3D structure databases

ProteinModelPortalⁱ	Q92754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112880, 17 interactors
CORUMⁱ	Q92754
ELMⁱ	Q92754
IntActⁱ	Q92754, 78 interactors
STRINGⁱ	9606.ENSP00000201031

PTM databases

iPTMnetⁱ	Q92754
PhosphoSitePlusⁱ	Q92754

Polymorphism and mutation databases

BioMutaⁱ	TFAP2C
DMDMⁱ	12643310

Proteomic databases

EPDⁱ	Q92754
MaxQBⁱ	Q92754
PaxDbⁱ	Q92754
PeptideAtlasⁱ	Q92754
PRIDEⁱ	Q92754
ProteomicsDBⁱ	75446

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7022
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000201031; ENSP00000201031; ENSG00000087510 [Q92754-1]
GeneIDⁱ	7022
KEGGⁱ	hsa:7022
UCSCⁱ	uc002xya.4 human [Q92754-1]

Organism-specific databases

CTDⁱ	7022
DisGeNETⁱ	7022
EuPathDBⁱ	HostDB:ENSG00000087510.6
GeneCardsⁱ	TFAP2C
HGNCⁱ	HGNC:11744 TFAP2C
HPAⁱ	CAB016061 CAB016079 HPA055179 HPA057076
MIMⁱ	601602 gene
neXtProtⁱ	NX_Q92754
OpenTargetsⁱ	ENSG00000087510
PharmGKBⁱ	PA36461
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q92754
KOⁱ	K09177
OMAⁱ	RPHVERN
OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q92754
TreeFamⁱ	TF313718

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3232118 SUMOylation of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
SignaLinkⁱ	Q92754
SIGNORⁱ	Q92754

Miscellaneous databases

GeneWikiⁱ	TFAP2C
GenomeRNAiⁱ	7022
Protein Ontology More...PROⁱ	PR:Q92754
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000087510 Expressed in 131 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_TFAP2C
ExpressionAtlasⁱ	Q92754 baseline and differential
Genevisibleⁱ	Q92754 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C IPR008123 TF_AP2_gamma
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01751 AP2CTNSCPFCT PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP2C_HUMAN
Accessionⁱ	Q92754Primary (citable) accession number: Q92754 Secondary accession number(s): B4DWK3 , O00685, O00730, Q86V30, Q8IVB6, Q9P1X2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q92754 (AP2C_HUMAN)

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Transcription factor AP-2 gamma

TFAP2C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ