RORB

Functionⁱ

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).By similarity

Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	18 – 93	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	21 – 41	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	57 – 81	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
melatonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7935491
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
steroid hormone receptor activity Source: InterPro
transcription factor binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amacrine cell differentiation Source: UniProtKB
cellular response to retinoic acid Source: UniProtKB
eye photoreceptor cell development Source: UniProtKB
negative regulation of osteoblast differentiation Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of circadian rhythm Source: UniProtKB
regulation of transcription, DNA-templated
Source: ProtInc
Traceable author statementⁱ
- 7935491
retina development in camera-type eye Source: UniProtKB
retinal cone cell development Source: UniProtKB
retinal rod cell development Source: UniProtKB
rhythmic process Source: UniProtKB-KW
transcription initiation from RNA polymerase II promoter Source: Reactome
visual perception Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Receptor
Biological process	Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-HSA-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor ROR-beta Alternative name(s): Nuclear receptor RZR-beta Nuclear receptor subfamily 1 group F member 2 Retinoid-related orphan receptor-beta
Gene namesⁱ	Name:RORB Synonyms:NR1F2, RZRB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198963.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10259 RORB
MIMⁱ	601972 gene
neXtProtⁱ	NX_Q92753

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6096
Open Targets More...OpenTargetsⁱ	ENSG00000198963
PharmGKBⁱ	PA34631

Chemistry databases

ChEMBLⁱ	CHEMBL3091268
Drug and drug target database More...DrugBankⁱ	DB01065 Melatonin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	599

Polymorphism and mutation databases

DMDMⁱ	124028630

DMDMⁱ

124028630

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053514	1 – 470	Nuclear receptor ROR-betaAdd BLAST		470

Proteomic databases

PaxDbⁱ	Q92753
PeptideAtlas More...PeptideAtlasⁱ	Q92753
PRIDEⁱ	Q92753
ProteomicsDBⁱ	75444 75445 [Q92753-1]

PTM databases

iPTMnetⁱ	Q92753
PhosphoSitePlusⁱ	Q92753

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198963 Expressed in 149 organ(s), highest expression level in primary visual cortex
CleanExⁱ	HS_RORB
ExpressionAtlasⁱ	Q92753 baseline and differential
Genevisibleⁱ	Q92753 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008393

HPAⁱ

HPA008393

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with CRX (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Clock	O08785	2	EBI-6144615,EBI-79859	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Clock

O08785

2

EBI-6144615,EBI-79859

From Mus musculus.

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q92753, 16 interactors
STRINGⁱ	9606.ENSP00000366093

Chemistry databases

BindingDBⁱ

Q92753

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92753
SMRⁱ	Q92753
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	222 – 460	NR LBDPROSITE-ProRule annotationAdd BLAST		239

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	94 – 221	HingeSequence analysisAdd BLAST		128

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	456 – 461	AF-2		6

Domainⁱ

AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity.By similarity

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	21 – 41	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	57 – 81	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000010200
HOVERGENⁱ	HBG106848
InParanoidⁱ	Q92753
OMAⁱ	CTLHTEE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0649
PhylomeDBⁱ	Q92753
TreeFamⁱ	TF319910

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative promoter usage. Align Add to basket

Isoform 2 (identifier: Q92753-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ 
        60         70         80         90        100
NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ 
       110        120        130        140        150
RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG 
       160        170        180        190        200
TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV 
       210        220        230        240        250
PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW 
       260        270        280        290        300
QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN 
       310        320        330        340        350
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV 
       360        370        380        390        400
NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY 
       410        420        430        440        450
FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN 
       460        470
TLFPPLYKEL FNPDCATGCK

Length:470

Mass (Da):53,220

Last modified:January 23, 2007 - v3

Checksum:ⁱF41FAF95FA5E7100

GO

Isoform 1 (identifier: Q92753-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-13: MCENQLKTKADAT → MR

« Hide

        10         20         30         40         50
MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR 
        60         70         80         90        100
NCLIDRTNRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH 
       110        120        130        140        150
QQRLQEQRQQ QSGEAEALAR VYSSSISNGL SNLNNETSGT YANGHVIDLP 
       160        170        180        190        200
KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ EPIYDLTSVP NLFTYSSFNN 
       210        220        230        240        250
GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELHQLAWQ THTYEEIKAY 
       260        270        280        290        300
QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL 
       310        320        330        340        350
EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC 
       360        370        380        390        400
SLQLTEEEIA LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH 
       410        420        430        440        450
LDDETLAKLI AKIPTITAVC NLHGEKLQVF KQSHPEIVNT LFPPLYKELF 

NPDCATGCK

Show »

Length:459

Mass (Da):52,073

Checksum:ⁱE15FD91422CCD67C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	121	Q → E in CAA69929 (Ref. 1) Curated	1
Sequence conflictⁱ	128	A → R in CAA69929 (Ref. 1) Curated	1
Sequence conflictⁱ	156	H → S in CAA69929 (Ref. 1) Curated	1
Sequence conflictⁱ	170	D → V in CAA69929 (Ref. 1) Curated	1
Sequence conflictⁱ	468	G → A in CAA69929 (Ref. 1) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_022575	1 – 13	MCENQ…KADAT → MR in isoform 1. 1 PublicationAdd BLAST		13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08639 mRNA Translation: CAA69929.1 BX647070 mRNA No translation available. AL137018 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6646.1 [Q92753-1]
UniGeneⁱ	Hs.494178

Genome annotation databases

Ensemblⁱ	ENST00000376896; ENSP00000366093; ENSG00000198963 [Q92753-1] ENST00000396204; ENSP00000379507; ENSG00000198963 [Q92753-2]
UCSC genome browser More...UCSCⁱ	uc004ajh.4 human [Q92753-2]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92753	RAR related orphan receptor B isoform 2		HUMAN		470	UniRef100_Q92753
RAR related orphan receptor B		MACMU		470
RAR related orphan receptor B		MACFA		470
RAR related orphan receptor B		SAIBB		470
Uncharacterized protein		COLAP		470
+6
Q92753-1	RAR related orphan receptor B isoform 1		HUMAN		459	UniRef100_Q58EY0
Nuclear receptor ROR-beta		MACMU		459
Uncharacterized protein		COLAP		459
Uncharacterized protein		AOTNA		459
Uncharacterized protein		PAPAN		459
+6

Protein	Similar proteins		Species	Score	Length	Source
Q92753	Nuclear receptor ROR-beta		MOUSE		470	UniRef90_Q8R1B8
Nuclear receptor ROR-beta	)	RAT		470
RAR related orphan receptor B		RABIT		490
Uncharacterized protein		MACMU		484
Uncharacterized protein		PANPA		482
+140
Q92753-1	Isoform 1 of Nuclear receptor ROR-beta		MOUSE		459	UniRef90_Q8R1B8-1
nuclear receptor ROR-beta		Enhydra lutris kenyoni		557
RAR related orphan receptor B		SAIBB		463
Nuclear receptor ROR-beta (Fragment)		Struthio camelus australis		462
Nuclear receptor ROR-beta (Fragment)		CORBR		462
+134

Protein	Similar proteins		Species	Score	Length	Source
Q92753	Nuclear receptor ROR-alpha	)	HUMAN		523	UniRef50_P35398
Nuclear receptor ROR-alpha		MOUSE		523
Nuclear receptor ROR-beta	)	RAT		470
RAR related orphan receptor A		PANTR		523
RORA isoform 1		PONAB		523
+915

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08639 mRNA Translation: CAA69929.1 BX647070 mRNA No translation available. AL137018 Genomic DNA No translation available.
CCDSⁱ	CCDS6646.1 [Q92753-1]
UniGeneⁱ	Hs.494178

3D structure databases

ProteinModelPortalⁱ	Q92753
SMRⁱ	Q92753
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q92753, 16 interactors
STRINGⁱ	9606.ENSP00000366093

Chemistry databases

BindingDBⁱ	Q92753
ChEMBLⁱ	CHEMBL3091268
DrugBankⁱ	DB01065 Melatonin
GuidetoPHARMACOLOGYⁱ	599

PTM databases

iPTMnetⁱ	Q92753
PhosphoSitePlusⁱ	Q92753

Polymorphism and mutation databases

DMDMⁱ	124028630

DMDMⁱ

124028630

Proteomic databases

PaxDbⁱ	Q92753
PeptideAtlasⁱ	Q92753
PRIDEⁱ	Q92753
ProteomicsDBⁱ	75444 75445 [Q92753-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6096
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376896; ENSP00000366093; ENSG00000198963 [Q92753-1] ENST00000396204; ENSP00000379507; ENSG00000198963 [Q92753-2]
UCSCⁱ	uc004ajh.4 human [Q92753-2]

Organism-specific databases

DisGeNETⁱ	6096
EuPathDBⁱ	HostDB:ENSG00000198963.10
GeneCardsⁱ	RORB
HGNCⁱ	HGNC:10259 RORB
HPAⁱ	HPA008393
MIMⁱ	601972 gene
neXtProtⁱ	NX_Q92753
OpenTargetsⁱ	ENSG00000198963
PharmGKBⁱ	PA34631
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000010200
HOVERGENⁱ	HBG106848
InParanoidⁱ	Q92753
OMAⁱ	CTLHTEE
OrthoDBⁱ	EOG091G0649
PhylomeDBⁱ	Q92753
TreeFamⁱ	TF319910

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-HSA-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	RORB human
Protein Ontology More...PROⁱ	PR:Q92753
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198963 Expressed in 149 organ(s), highest expression level in primary visual cortex
CleanExⁱ	HS_RORB
ExpressionAtlasⁱ	Q92753 baseline and differential
Genevisibleⁱ	Q92753 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RORB_HUMAN
Accessionⁱ	Q92753Primary (citable) accession number: Q92753 Secondary accession number(s): Q8WX73
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q92753 (RORB_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Nuclear receptor ROR-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ