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Protein

Thyroid hormone-inducible hepatic protein

Gene

THRSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone-inducible hepatic protein
Alternative name(s):
Spot 14 protein
Short name:
S14
Short name:
SPOT14
Gene namesi
Name:THRSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151365.2
HGNCiHGNC:11800 THRSP
MIMi601926 gene
neXtProtiNX_Q92748

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7069
OpenTargetsiENSG00000151365
PharmGKBiPA36509

Polymorphism and mutation databases

BioMutaiTHRSP
DMDMi2842710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237731 – 146Thyroid hormone-inducible hepatic proteinAdd BLAST146

Proteomic databases

PaxDbiQ92748
PeptideAtlasiQ92748
PRIDEiQ92748
ProteomicsDBi75439

PTM databases

PhosphoSitePlusiQ92748

Expressioni

Tissue specificityi

Mainly expressed in tissues that synthesize triglycerides.

Gene expression databases

BgeeiENSG00000151365
CleanExiHS_THRSP
GenevisibleiQ92748 HS

Organism-specific databases

HPAiHPA040642

Interactioni

Subunit structurei

Homodimer. Heterodimer with MID1IP1 (By similarity). Interacts with THRB and PLAGL1.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi112925, 62 interactors
DIPiDIP-40451N
IntActiQ92748, 29 interactors
MINTiQ92748
STRINGi9606.ENSP00000281030

Structurei

3D structure databases

ProteinModelPortaliQ92748
SMRiQ92748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPOT14 family.Curated

Phylogenomic databases

eggNOGiENOG410J34G Eukaryota
ENOG410YT7Q LUCA
GeneTreeiENSGT00500000044890
HOGENOMiHOG000001157
HOVERGENiHBG002528
InParanoidiQ92748
OMAiTVMDRYS
OrthoDBiEOG091G0Z4G
PhylomeDBiQ92748
TreeFamiTF326826

Family and domain databases

InterProiView protein in InterPro
IPR009786 Spot_14
PANTHERiPTHR14315 PTHR14315, 1 hit
PfamiView protein in Pfam
PF07084 Spot_14, 1 hit

Sequencei

Sequence statusi: Complete.

Q92748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ
60 70 80 90 100
AEAPDLYTYF TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED
110 120 130 140
ESASGELDLE AQFHLHFSSL HHILMHLTEK AQEVTRKYQE MTGQVW
Length:146
Mass (Da):16,561
Last modified:February 1, 1997 - v1
Checksum:i5135FB8EE380DF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08409 Genomic DNA Translation: CAA69685.1
AK311975 mRNA Translation: BAG34914.1
CH471076 Genomic DNA Translation: EAW75045.1
BC031989 mRNA Translation: AAH31989.1
CCDSiCCDS8256.1
RefSeqiNP_003242.1, NM_003251.3
UniGeneiHs.591969

Genome annotation databases

EnsembliENST00000281030; ENSP00000281030; ENSG00000151365
GeneIDi7069
KEGGihsa:7069
UCSCiuc001oyx.4 human

Similar proteinsi

Entry informationi

Entry nameiTHRSP_HUMAN
AccessioniPrimary (citable) accession number: Q92748
Secondary accession number(s): B2R4W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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