Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

USP6 N-terminal-like protein

Gene

USP6NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.3 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SignaLinkiQ92738

Names & Taxonomyi

Protein namesi
Recommended name:
USP6 N-terminal-like protein
Alternative name(s):
Related to the N-terminus of tre
Short name:
RN-tre
Gene namesi
Name:USP6NL
Synonyms:KIAA0019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148429.14
HGNCiHGNC:16858 USP6NL
MIMi605405 gene
neXtProtiNX_Q92738

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi106R → A: Loss of GAP activity on RAB5A. 1 Publication1
Mutagenesisi147D → A: Loss of GAP activity on RAB5A. 1 Publication1
Mutagenesisi150R → A: Loss of GAP activity on RAB5A. 2 Publications1

Organism-specific databases

DisGeNETi9712
OpenTargetsiENSG00000148429
PharmGKBiPA134955568

Polymorphism and mutation databases

BioMutaiUSP6NL
DMDMi50897492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080561 – 828USP6 N-terminal-like proteinAdd BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei546PhosphoserineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Modified residuei582PhosphotyrosineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei676PhosphoserineBy similarity1
Modified residuei680PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei729PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92738
MaxQBiQ92738
PaxDbiQ92738
PeptideAtlasiQ92738
PRIDEiQ92738
ProteomicsDBi75435
75436 [Q92738-2]

PTM databases

iPTMnetiQ92738
PhosphoSitePlusiQ92738

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000148429 Expressed in 216 organ(s), highest expression level in amniotic fluid
CleanExiHS_USP6NL
ExpressionAtlasiQ92738 baseline and differential
GenevisibleiQ92738 HS

Organism-specific databases

HPAiHPA039196

Interactioni

Subunit structurei

Interacts with EPS8.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115063, 28 interactors
ELMiQ92738
IntActiQ92738, 10 interactors
MINTiQ92738
STRINGi9606.ENSP00000277575

Structurei

3D structure databases

ProteinModelPortaliQ92738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 292Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST193

Phylogenomic databases

eggNOGiKOG1102 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00920000148983
HOGENOMiHOG000139916
HOVERGENiHBG059159
InParanoidiQ92738
KOiK20133
PhylomeDBiQ92738
TreeFamiTF318099

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92738-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSDQDVALK LAQERAEIVA KYDRGREGAE IEPWEDADYL VYKVTDRFGF
60 70 80 90 100
LHEEELPDHN VAVERQKHLE IERTTKWLKM LKGWEKYKNT EKFHRRIYKG
110 120 130 140 150
IPLQLRGEVW ALLLEIPKMK EETRDLYSKL KHRARGCSPD IRQIDLDVNR
160 170 180 190 200
TFRDHIMFRD RYGVKQQSLF HVLAAYSIYN TEVGYCQGMS QITALLLMYM
210 220 230 240 250
NEEDAFWALV KLFSGPKHAM HGFFVQGFPK LLRFQEHHEK ILNKFLSKLK
260 270 280 290 300
QHLDSQEIYT SFYTMKWFFQ CFLDRTPFTL NLRIWDIYIF EGERVLTAMS
310 320 330 340 350
YTILKLHKKH LMKLSMEELV EFFQETLAKD FFFEDDFVIE QLQISMTELK
360 370 380 390 400
RAKLDLPEPG KEDEYPKKPL GQLPPELQSW GVHHLSNGQR SVGRPSPLAS
410 420 430 440 450
GRRESGAPHR RHEHSPHPQS RTGTPERAQP PRRKSVEEES KKLKDEADFQ
460 470 480 490 500
RKLPSGPQDS SRQYNHAAAN QNSNATSNIR KEFVPKWNKP SDVSATERTA
510 520 530 540 550
KYTMEGKGRA AHPALAVTVP GPAEVRVSNV RPKMKALDAE DGKRGSTASQ
560 570 580 590 600
YDNVPGPELD SGASVEEALE RAYSQSPRHA LYPPSPRKHA EPSSSPSKVS
610 620 630 640 650
NKFTFKVQPP SHARYPSQLD GEARGLAHPP SYSNPPVYHG NSPKHFPTAN
660 670 680 690 700
SSFASPQFSP GTQLNPSRRP HGSTLSVSAS PEKSYSRPSP LVLPSSRIEV
710 720 730 740 750
LPVDTGAGGY SGNSGSPKNG KLIIPPVDYL PDNRTWSEVS YTYRPETQGQ
760 770 780 790 800
SWTRDASRGN LPKYSAFQLA PFQDHGLPAV SVDSPVRYKA SPAAEDASPS
810 820
GYPYSGPPPP AYHYRNRDGL SIQESVLL
Length:828
Mass (Da):94,104
Last modified:July 30, 2004 - v3
Checksum:iA5E3DBF0FEE04E78
GO
Isoform 2 (identifier: Q92738-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MN → MRTEAVVNSQGQTDYLTKD

Show »
Length:845
Mass (Da):95,997
Checksum:i3C174D986C902346
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RAB3X6RAB3_HUMAN
USP6 N-terminal-like protein
USP6NL
851Annotation score:
V9GYH2V9GYH2_HUMAN
USP6 N-terminal-like protein
USP6NL
48Annotation score:

Sequence cautioni

The sequence BAA02807 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti622E → D in BAF85633 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0408501 – 2MN → MRTEAVVNSQGQTDYLTKD in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449916 mRNA Translation: BAH16659.1
D13644 mRNA Translation: BAA02807.2 Different initiation.
AK292944 mRNA Translation: BAF85633.1
AL512631 Genomic DNA No translation available.
AL590416 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86344.1
BC042943 mRNA Translation: AAH42943.1
CF121539 mRNA No translation available.
CCDSiCCDS44357.1 [Q92738-2]
CCDS53492.1 [Q92738-1]
RefSeqiNP_001073960.1, NM_001080491.3 [Q92738-2]
NP_055503.1, NM_014688.3 [Q92738-1]
UniGeneiHs.498661
Hs.688100

Genome annotation databases

EnsembliENST00000277575; ENSP00000277575; ENSG00000148429 [Q92738-2]
ENST00000609104; ENSP00000476462; ENSG00000148429 [Q92738-1]
GeneIDi9712
KEGGihsa:9712
UCSCiuc001iks.1 human [Q92738-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449916 mRNA Translation: BAH16659.1
D13644 mRNA Translation: BAA02807.2 Different initiation.
AK292944 mRNA Translation: BAF85633.1
AL512631 Genomic DNA No translation available.
AL590416 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86344.1
BC042943 mRNA Translation: AAH42943.1
CF121539 mRNA No translation available.
CCDSiCCDS44357.1 [Q92738-2]
CCDS53492.1 [Q92738-1]
RefSeqiNP_001073960.1, NM_001080491.3 [Q92738-2]
NP_055503.1, NM_014688.3 [Q92738-1]
UniGeneiHs.498661
Hs.688100

3D structure databases

ProteinModelPortaliQ92738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115063, 28 interactors
ELMiQ92738
IntActiQ92738, 10 interactors
MINTiQ92738
STRINGi9606.ENSP00000277575

PTM databases

iPTMnetiQ92738
PhosphoSitePlusiQ92738

Polymorphism and mutation databases

BioMutaiUSP6NL
DMDMi50897492

Proteomic databases

EPDiQ92738
MaxQBiQ92738
PaxDbiQ92738
PeptideAtlasiQ92738
PRIDEiQ92738
ProteomicsDBi75435
75436 [Q92738-2]

Protocols and materials databases

DNASUi9712
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277575; ENSP00000277575; ENSG00000148429 [Q92738-2]
ENST00000609104; ENSP00000476462; ENSG00000148429 [Q92738-1]
GeneIDi9712
KEGGihsa:9712
UCSCiuc001iks.1 human [Q92738-1]

Organism-specific databases

CTDi9712
DisGeNETi9712
EuPathDBiHostDB:ENSG00000148429.14
GeneCardsiUSP6NL
HGNCiHGNC:16858 USP6NL
HPAiHPA039196
MIMi605405 gene
neXtProtiNX_Q92738
OpenTargetsiENSG00000148429
PharmGKBiPA134955568
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1102 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00920000148983
HOGENOMiHOG000139916
HOVERGENiHBG059159
InParanoidiQ92738
KOiK20133
PhylomeDBiQ92738
TreeFamiTF318099

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SignaLinkiQ92738

Miscellaneous databases

ChiTaRSiUSP6NL human
GeneWikiiUSP6NL
GenomeRNAii9712
PROiPR:Q92738
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148429 Expressed in 216 organ(s), highest expression level in amniotic fluid
CleanExiHS_USP6NL
ExpressionAtlasiQ92738 baseline and differential
GenevisibleiQ92738 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUS6NL_HUMAN
AccessioniPrimary (citable) accession number: Q92738
Secondary accession number(s): A8KA79
, Q15400, Q5VV10, Q7L0K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 30, 2004
Last sequence update: July 30, 2004
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again