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Protein

Ryanodine receptor 2

Gene

RYR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.3 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92736

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.3.1.1 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 2
Short name:
RYR-2
Short name:
RyR2
Short name:
hRYR-2
Alternative name(s):
Cardiac muscle ryanodine receptor
Cardiac muscle ryanodine receptor-calcium release channel
Type 2 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198626.15

Human Gene Nomenclature Database

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HGNCi
HGNC:10484 RYR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
180902 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92736

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4281CytoplasmicSequence analysisAdd BLAST4281
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4282 – 4302HelicalSequence analysisAdd BLAST21
Transmembranei4504 – 4524HelicalSequence analysisAdd BLAST21
Transmembranei4580 – 4600HelicalSequence analysisAdd BLAST21
Transmembranei4730 – 4750HelicalSequence analysisAdd BLAST21
Transmembranei4769 – 4789HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4820 – 4829Pore-formingBy similarity10
Transmembranei4850 – 4870HelicalSequence analysisAdd BLAST21
Topological domaini4871 – 4967CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arrhythmogenic right ventricular dysplasia, familial, 2 (ARVD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
See also OMIM:600996
Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy (CPVT1)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT1 inheritance is autosomal dominant.
See also OMIM:604772
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044086164P → S in CPVT1. 1 Publication1
Natural variantiVAR_044088414R → L in CPVT1. 2 Publications1
Natural variantiVAR_044089419I → F in CPVT1; decreases protein stability. 3 Publications1
Natural variantiVAR_044090420R → W in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs190140598EnsemblClinVar.1
Natural variantiVAR_079513466P → A in CPVT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs376612295EnsemblClinVar.1
Natural variantiVAR_0113962246S → L in CPVT1. 3 PublicationsCorresponds to variant dbSNP:rs121918597EnsemblClinVar.1
Natural variantiVAR_0236942306V → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728746EnsemblClinVar.1
Natural variantiVAR_0440922311E → D in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728747Ensembl.1
Natural variantiVAR_0113972328P → S in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918603EnsemblClinVar.1
Natural variantiVAR_0440932387A → P in CPVT1. 1 Publication1
Natural variantiVAR_0440942392Y → C in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs772220753Ensembl.1
Natural variantiVAR_0440952403A → T in CPVT1. 2 Publications1
Natural variantiVAR_0113992474R → S in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918598EnsemblClinVar.1
Natural variantiVAR_0440973778L → F in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1472508624Ensembl.1
Natural variantiVAR_0795143800C → F in CPVT1. 1 Publication1
Natural variantiVAR_0440983946G → S in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 PublicationsCorresponds to variant dbSNP:rs794728777EnsemblClinVar.1
Natural variantiVAR_0440994097N → S in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728784EnsemblClinVar.1
Natural variantiVAR_0114004104N → K in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918599EnsemblClinVar.1
Natural variantiVAR_0795154124S → T in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0441004146E → K in CPVT1. 1 Publication1
Natural variantiVAR_0441014158T → P in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0795164159Q → P in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0114014201Q → R in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918605EnsemblClinVar.1
Natural variantiVAR_0114024497R → C in CPVT1. 3 PublicationsCorresponds to variant dbSNP:rs121918600EnsemblClinVar.1
Natural variantiVAR_0441024499F → C in CPVT1. 2 Publications1
Natural variantiVAR_0441034504M → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1323621379Ensembl.1
Natural variantiVAR_0441044510A → T in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs397516510EnsemblClinVar.1
Natural variantiVAR_0795174556A → T in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs189345192EnsemblClinVar.1
Natural variantiVAR_0441054607A → P in CPVT1. 1 Publication1
Natural variantiVAR_0114034653V → F in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918604EnsemblClinVar.1
Natural variantiVAR_0441064671G → R in CPVT1. 1 Publication1
Natural variantiVAR_0441074771V → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728804EnsemblClinVar.1
Natural variantiVAR_0441084848I → V in CPVT1. 2 Publications1
Natural variantiVAR_0441094860A → G in CPVT1; diminishes the response to activation by luminal Ca(2+) but has little effect on the sensitivity of the channel to activation by cytosolic Ca(2+); shows caffeine-induced Ca(2+) release but exhibits no store-overload-induced Ca(2+) release (SOICR); HL1 cardiac cells transfected with the G-4860 mutant displayed attenuated SOICR activity compared to cells transfected with wild-type RYR2. 2 PublicationsCorresponds to variant dbSNP:rs121918606EnsemblClinVar.1
Natural variantiVAR_0441104867I → M in CPVT1. 1 Publication1
Natural variantiVAR_0441114880V → A in CPVT1. 1 Publication1
Natural variantiVAR_0441124895N → D in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1185619003Ensembl.1
Natural variantiVAR_0236954902P → L in CPVT1. 1 Publication1
Natural variantiVAR_0441134950E → K in CPVT1. 1 Publication1
Natural variantiVAR_0236964959R → Q in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs794728811EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2808S → A: Abolishes phosphorylation by PKA. 1 Publication1
Mutagenesisi3946G → A: Changed ryanodine-sensitive calcium-release channel activity characterized by increased sensitivity to cytosolic calcium activation. 1 Publication1
Mutagenesisi3978M → I: Changed ryanodine-sensitive calcium-release channel activity characterized by increased sensitivity to cytosolic calcium activation. 1 Publication1
Mutagenesisi4108H → N: Changed ryanodine-sensitive calcium-release channel activity characterized by increased sensitivity to cytosolic calcium activation. 1 Publication1
Mutagenesisi4108H → Q: Changed ryanodine-sensitive calcium-release channel activity characterized by increased sensitivity to cytosolic calcium activation. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6262

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
RYR2

MalaCards human disease database

More...
MalaCardsi
RYR2
MIMi600996 phenotype
604772 phenotype

Open Targets

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OpenTargetsi
ENSG00000198626

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3286 Catecholaminergic polymorphic ventricular tachycardia
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4403

Drug and drug target database

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DrugBanki
DB09085 Tetracaine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
748

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RYR2

Domain mapping of disease mutations (DMDM)

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DMDMi
308153558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193611 – 4967Ryanodine receptor 2Add BLAST4967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1341PhosphoserineBy similarity1
Modified residuei1869PhosphoserineBy similarity1
Modified residuei2031Phosphoserine; by PKABy similarity1
Modified residuei2369PhosphoserineBy similarity1
Modified residuei2697PhosphoserineBy similarity1
Modified residuei2797PhosphoserineBy similarity1
Modified residuei2808Phosphoserine; by CaMK2D and PKA2 Publications1
Modified residuei2811PhosphoserineBy similarity1
Modified residuei2814Phosphoserine; by CaMK2D1 Publication1
Modified residuei2947PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca2+ levels.2 Publications
Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92736

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92736

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92736

PeptideAtlas

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PeptideAtlasi
Q92736

PRoteomics IDEntifications database

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PRIDEi
Q92736

ProteomicsDB human proteome resource

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ProteomicsDBi
75431
75432 [Q92736-2]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q92736

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92736

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92736

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in myometrium during pregnancy.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TGFB1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198626 Expressed in 151 organ(s), highest expression level in heart right ventricle

CleanEx database of gene expression profiles

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CleanExi
HS_RYR2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92736 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92736 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020028

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca2+ leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SELENON (By similarity). In cardiac muscles, identified in a complex, composed of FSD2, CMYA5 and RYR2 (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112174, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3156 Ryanodine 2 complex

Database of interacting proteins

More...
DIPi
DIP-38325N

Protein interaction database and analysis system

More...
IntActi
Q92736, 12 interactors

Molecular INTeraction database

More...
MINTi
Q92736

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355533

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14967
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92736

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92736

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 165MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini172 – 217MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini225 – 280MIR 3PROSITE-ProRule annotationAdd BLAST56
Domaini286 – 343MIR 4PROSITE-ProRule annotationAdd BLAST58
Domaini351 – 408MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini599 – 809B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST211
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati853 – 9661Add BLAST114
Repeati967 – 10802Add BLAST114
Domaini1025 – 1222B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST198
Domaini1337 – 1562B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST226
Repeati2692 – 28103Add BLAST119
Repeati2812 – 29254Add BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni853 – 29254 X approximate repeatsAdd BLAST2073
Regioni3581 – 3610Interaction with CALM1 PublicationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4412 – 4445Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4414 – 4455Glu-rich (acidic)Add BLAST42

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231428

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006699

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92736

KEGG Orthology (KO)

More...
KOi
K04962

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFSMKDT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00T0

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92736

TreeFam database of animal gene trees

More...
TreeFami
TF315244

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13715 PTHR13715, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADGGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE
60 70 80 90 100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF
110 120 130 140 150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ
160 170 180 190 200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNGS
210 220 230 240 250
LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
260 270 280 290 300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV
310 320 330 340 350
TTGKYLSLME DKNLLLMDKE KADVKSTAFT FRSSKEKLDV GVRKEVDGMG
360 370 380 390 400
TSEIKYGDSV CYIQHVDTGL WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD
410 420 430 440 450
DGISLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKA KASTVDLPIE
460 470 480 490 500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE
510 520 530 540 550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ
560 570 580 590 600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL
610 620 630 640 650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN
660 670 680 690 700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST
710 720 730 740 750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR
760 770 780 790 800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV
810 820 830 840 850
RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL
860 870 880 890 900
LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL
910 920 930 940 950
GWQYGPVRDD NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV
960 970 980 990 1000
GISDEHAEDK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA
1010 1020 1030 1040 1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL
1060 1070 1080 1090 1100
REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA EKTYAVKAGR
1110 1120 1130 1140 1150
WYFEFETVTA GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE
1160 1170 1180 1190 1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG
1210 1220 1230 1240 1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW
1260 1270 1280 1290 1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNSNTDIM
1310 1320 1330 1340 1350
FYRLSMPIEC AEVFSKTVAG GLPGAGLFGP KNDLEDYDAD SDFEVLMKTA
1360 1370 1380 1390 1400
HGHLVPDRVD KDKEATKPEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTS
1410 1420 1430 1440 1450
HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF
1460 1470 1480 1490 1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR
1510 1520 1530 1540 1550
NNNGLEIGCV VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP
1560 1570 1580 1590 1600
NVFQFELGRI KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP
1610 1620 1630 1640 1650
NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD ILELTEQEEL
1660 1670 1680 1690 1700
LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRA
1710 1720 1730 1740 1750
GYYDLLIDIH LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG
1760 1770 1780 1790 1800
IGLSTSLRPR MQFSSPSFVS ISNECYQYSP EFPLDILKSK TIQMLTEAVK
1810 1820 1830 1840 1850
EGSLHARDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK HILQLIEPSV
1860 1870 1880 1890 1900
FKEAATPEEE SDTLEKELSV DDAKLQGAGE EEAKGGKRPK EGLLQMKLPE
1910 1920 1930 1940 1950
PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA
1960 1970 1980 1990 2000
LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH
2010 2020 2030 2040 2050
EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES
2060 2070 2080 2090 2100
DSKKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR
2110 2120 2130 2140 2150
ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM
2160 2170 2180 2190 2200
NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL
2210 2220 2230 2240 2250
CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN
2260 2270 2280 2290 2300
NELALALREP DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPVEGERYLD
2310 2320 2330 2340 2350
FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA
2360 2370 2380 2390 2400
IKIAEDPSRD GPSPNSGSSK TLDTEEEEDD TIHMGNAIMT FYSALIDLLG
2410 2420 2430 2440 2450
RCAPEMHLIH AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGN
2460 2470 2480 2490 2500
VVEPDMSAGF CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA
2510 2520 2530 2540 2550
SLDTAALSAT DMALALNRYL CTAVLPLLTR CAPLFAGTEH HASLIDSLLH
2560 2570 2580 2590 2600
TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN
2610 2620 2630 2640 2650
EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD
2660 2670 2680 2690 2700
ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN
2710 2720 2730 2740 2750
FNPQPVDTSN ITIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS
2760 2770 2780 2790 2800
SKVQPLMKPY KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL
2810 2820 2830 2840 2850
YNRTRRISQT SQVSVDAAHG YSPRAIDMSN VTLSRDLHAM AEMMAENYHN
2860 2870 2880 2890 2900
IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING
2910 2920 2930 2940 2950
YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK
2960 2970 2980 2990 3000
GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE
3010 3020 3030 3040 3050
KEMVTSLFCK LGVLVRHRIS LFGNDATSIV NCLHILGQTL DARTVMKTGL
3060 3070 3080 3090 3100
ESVKSALRAF LDNAAEDLEK TMENLKQGQF THTRNQPKGV TQIINYTTVA
3110 3120 3130 3140 3150
LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER
3160 3170 3180 3190 3200
QRSALGECLA AFAGAFPVAF LETHLDKHNI YSIYNTKSSR ERAALSLPTN
3210 3220 3230 3240 3250
VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW
3260 3270 3280 3290 3300
EHGPENNPER AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA
3310 3320 3330 3340 3350
VFSQPIINKV KPQLLKTHFL PLMEKLKKKA ATVVSEEDHL KAEARGDMSE
3360 3370 3380 3390 3400
AELLILDEFT TLARDLYAFY PLLIRFVDYN RAKWLKEPNP EAEELFRMVA
3410 3420 3430 3440 3450
EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS KAAVSDQERK
3460 3470 3480 3490 3500
KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD
3510 3520 3530 3540 3550
TEDEVRDIIR SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD TSDPEKTVER
3560 3570 3580 3590 3600
VLDIANVLFH LEQKSKRVGR RHYCLVEHPQ RSKKAVWHKL LSKQRKRAVV
3610 3620 3630 3640 3650
ACFRMAPLYN LPRHRAVNLF LQGYEKSWIE TEEHYFEDKL IEDLAKPGAE
3660 3670 3680 3690 3700
PPEEDEGTKR VDPLHQLILL FSRTALTEKC KLEEDFLYMA YADIMAKSCH
3710 3720 3730 3740 3750
DEEDDDGEEE VKSFEEKEME KQKLLYQQAR LHDRGAAEMV LQTISASKGE
3760 3770 3780 3790 3800
TGPMVAATLK LGIAILNGGN STVQQKMLDY LKEKKDVGFF QSLAGLMQSC
3810 3820 3830 3840 3850
SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF RFLQLLCEGH
3860 3870 3880 3890 3900
NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE
3910 3920 3930 3940 3950
QGQRNFSKAI QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV
3960 3970 3980 3990 4000
FAHMQMKLSQ DSSQIELLKE LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV
4010 4020 4030 4040 4050
DMLVESSNNV EMILKFFDMF LKLKDLTSSD TFKEYDPDGK GVISKRDFHK
4060 4070 4080 4090 4100
AMESHKHYTQ SETEFLLSCA ETDENETLDY EEFVKRFHEP AKDIGFNVAV
4110 4120 4130 4140 4150
LLTNLSEHMP NDTRLQTFLE LAESVLNYFQ PFLGRIEIMG SAKRIERVYF
4160 4170 4180 4190 4200
EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM
4210 4220 4230 4240 4250
QLAAQISESD LNERSANKEE SEKERPEEQG PRMAFFSILT VRSALFALRY
4260 4270 4280 4290 4300
NILTLMRMLS LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI FMTLLHFVAS
4310 4320 4330 4340 4350
VFRGFFRIIC SLLLGGSLVE GAKKIKVAEL LANMPDPTQD EVRGDGEEGE
4360 4370 4380 4390 4400
RKPLEAALPS EDLTDLKELT EESDLLSDIF GLDLKREGGQ YKLIPHNPNA
4410 4420 4430 4440 4450
GLSDLMSNPV PMPEVQEKFQ EQKAKEEEKE EKEETKSEPE KAEGEDGEKE
4460 4470 4480 4490 4500
EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY
4510 4520 4530 4540 4550
NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPTRSSSE NAKVTSLDSS
4560 4570 4580 4590 4600
SHRIIAVHYV LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF
4610 4620 4630 4640 4650
KREKEVARKL EFDGLYITEQ PSEDDIKGQW DRLVINTQSF PNNYWDKFVK
4660 4670 4680 4690 4700
RKVMDKYGEF YGRDRISELL GMDKAALDFS DAREKKKPKK DSSLSAVLNS
4710 4720 4730 4740 4750
IDVKYQMWKL GVVFTDNSFL YLAWYMTMSV LGHYNNFFFA AHLLDIAMGF
4760 4770 4780 4790 4800
KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDGD
4810 4820 4830 4840 4850
TPDMKCDDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE IYRIIFDITF
4860 4870 4880 4890 4900
FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT
4910 4920 4930 4940 4950
VPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE
4960
FFPAGDCFRK QYEDQLN
Length:4,967
Mass (Da):564,567
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44984485F8677B42
GO
Isoform 2 (identifier: Q92736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3715-3715: E → EVTGSQRSK

Show »
Length:4,975
Mass (Da):565,411
Checksum:iC24909FF9BC665B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY35H7BY35_HUMAN
Ryanodine receptor 2
RYR2
4,950Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH71369 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAH71393 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAH73918 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAI14440 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAI15350 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAI15936 differs from that shown. Erroneous gene model prediction.Curated
The sequence CAI22065 differs from that shown. Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1037L → P in CAA66975 (PubMed:8809036).Curated1
Sequence conflicti1037L → P in CAC18855 (PubMed:11159936).Curated1
Sequence conflicti2785 – 2789WGWRI → RTMRT in CAA66975 (PubMed:8809036).Curated5
Sequence conflicti2785 – 2789WGWRI → RTMRT in CAC18855 (PubMed:11159936).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07528329H → D Found in a patient with short-coupled polymorphic ventricular tachycardia at rest; unknown pathological significance; no effect on cytosolic Ca(2+) activation. 2 Publications1
Natural variantiVAR_044086164P → S in CPVT1. 1 Publication1
Natural variantiVAR_044087176R → Q in ARVD2 and CPVT1. 3 PublicationsCorresponds to variant dbSNP:rs794728708EnsemblClinVar.1
Natural variantiVAR_044088414R → L in CPVT1. 2 Publications1
Natural variantiVAR_044089419I → F in CPVT1; decreases protein stability. 3 Publications1
Natural variantiVAR_044090420R → W in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs190140598EnsemblClinVar.1
Natural variantiVAR_011395433L → P in ARVD2 and CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918602EnsemblClinVar.1
Natural variantiVAR_079513466P → A in CPVT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs376612295EnsemblClinVar.1
Natural variantiVAR_044091507V → I. Corresponds to variant dbSNP:rs16835270EnsemblClinVar.1
Natural variantiVAR_0220781886G → S. Corresponds to variant dbSNP:rs3766871EnsemblClinVar.1
Natural variantiVAR_0113962246S → L in CPVT1. 3 PublicationsCorresponds to variant dbSNP:rs121918597EnsemblClinVar.1
Natural variantiVAR_0236942306V → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728746EnsemblClinVar.1
Natural variantiVAR_0440922311E → D in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728747Ensembl.1
Natural variantiVAR_0113972328P → S in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918603EnsemblClinVar.1
Natural variantiVAR_0113982386N → I in ARVD2 and CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918601EnsemblClinVar.1
Natural variantiVAR_0440932387A → P in CPVT1. 1 Publication1
Natural variantiVAR_0440942392Y → C in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs772220753Ensembl.1
Natural variantiVAR_0440952403A → T in CPVT1. 2 Publications1
Natural variantiVAR_0113992474R → S in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918598EnsemblClinVar.1
Natural variantiVAR_0440962504T → M in ARVD2 and CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs769219555EnsemblClinVar.1
Natural variantiVAR_0115902958Q → R1 PublicationCorresponds to variant dbSNP:rs34967813EnsemblClinVar.1
Natural variantiVAR_0440973778L → F in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1472508624Ensembl.1
Natural variantiVAR_0795143800C → F in CPVT1. 1 Publication1
Natural variantiVAR_0440983946G → S in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 PublicationsCorresponds to variant dbSNP:rs794728777EnsemblClinVar.1
Natural variantiVAR_0440994097N → S in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728784EnsemblClinVar.1
Natural variantiVAR_0114004104N → K in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs121918599EnsemblClinVar.1
Natural variantiVAR_0795154124S → T in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0441004146E → K in CPVT1. 1 Publication1
Natural variantiVAR_0441014158T → P in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0795164159Q → P in CPVT1; changed ryanodine-sensitive calcium-release channel activity; increased sensitivity to cytosolic calcium activation. 2 Publications1
Natural variantiVAR_0114014201Q → R in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918605EnsemblClinVar.1
Natural variantiVAR_0114024497R → C in CPVT1. 3 PublicationsCorresponds to variant dbSNP:rs121918600EnsemblClinVar.1
Natural variantiVAR_0441024499F → C in CPVT1. 2 Publications1
Natural variantiVAR_0441034504M → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1323621379Ensembl.1
Natural variantiVAR_0441044510A → T in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs397516510EnsemblClinVar.1
Natural variantiVAR_0795174556A → T in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs189345192EnsemblClinVar.1
Natural variantiVAR_0441054607A → P in CPVT1. 1 Publication1
Natural variantiVAR_0114034653V → F in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs121918604EnsemblClinVar.1
Natural variantiVAR_0441064671G → R in CPVT1. 1 Publication1
Natural variantiVAR_0441074771V → I in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs794728804EnsemblClinVar.1
Natural variantiVAR_0441084848I → V in CPVT1. 2 Publications1
Natural variantiVAR_0441094860A → G in CPVT1; diminishes the response to activation by luminal Ca(2+) but has little effect on the sensitivity of the channel to activation by cytosolic Ca(2+); shows caffeine-induced Ca(2+) release but exhibits no store-overload-induced Ca(2+) release (SOICR); HL1 cardiac cells transfected with the G-4860 mutant displayed attenuated SOICR activity compared to cells transfected with wild-type RYR2. 2 PublicationsCorresponds to variant dbSNP:rs121918606EnsemblClinVar.1
Natural variantiVAR_0441104867I → M in CPVT1. 1 Publication1
Natural variantiVAR_0441114880V → A in CPVT1. 1 Publication1
Natural variantiVAR_0441124895N → D in CPVT1. 1 PublicationCorresponds to variant dbSNP:rs1185619003Ensembl.1
Natural variantiVAR_0236954902P → L in CPVT1. 1 Publication1
Natural variantiVAR_0441134950E → K in CPVT1. 1 Publication1
Natural variantiVAR_0786484955G → E Probable disease-associated mutation found in a patient with intellectual disability, seizures, short stature and severe atrial arrhythmias. 1 Publication1
Natural variantiVAR_0236964959R → Q in CPVT1. 2 PublicationsCorresponds to variant dbSNP:rs794728811EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0059533715E → EVTGSQRSK in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X98330 mRNA Translation: CAA66975.1
AJ300340
, AJ300341, AJ300342, AJ300343, AJ300347, AJ300349, AJ300351, AJ300353, AJ300355, AJ300364, AJ300363, AJ300362, AJ300361, AJ300360, AJ300359, AJ300358, AJ300357, AJ300356, AJ300373, AJ300372, AJ300371, AJ300370, AJ300369, AJ300368, AJ300367, AJ300366, AJ300365, AJ300382, AJ300381, AJ300380, AJ300379, AJ300378, AJ300377, AJ300376, AJ300375, AJ300374, AJ300399, AJ300398, AJ300397, AJ300396, AJ300395, AJ300394, AJ300393, AJ300392, AJ300391, AJ300416, AJ300415, AJ300414, AJ300413, AJ300412, AJ300411, AJ300410, AJ300409, AJ300408, AJ300433, AJ300432, AJ300431, AJ300430, AJ300429, AJ300428, AJ300427, AJ300426, AJ300425, AJ300444, AJ300443, AJ300442, AJ300441, AJ300440, AJ300439, AJ300438, AJ300437, AJ300436, AJ300435, AJ300434, AJ300424, AJ300423, AJ300422, AJ300421, AJ300420, AJ300419, AJ300418, AJ300417, AJ300407, AJ300406, AJ300405, AJ300404, AJ300403, AJ300402, AJ300401, AJ300400, AJ300390, AJ300389, AJ300388, AJ300387, AJ300386, AJ300385, AJ300384, AJ300383, AJ300354, AJ300352, AJ300350, AJ300348, AJ300346, AJ300345, AJ300344 Genomic DNA Translation: CAC18855.1
AL365332
, AL356773, AL359924, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAH71369.1 Sequence problems.
AL445473
, AL356773, AL359924, AL365332, AL391809, AL442065, AL513130 Genomic DNA Translation: CAH71393.1 Sequence problems.
AL356773
, AL359924, AL365332, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAH73918.1 Sequence problems.
AL391809
, AL356773, AL359924, AL365332, AL442065, AL445473, AL513130 Genomic DNA Translation: CAI14440.1 Sequence problems.
AL442065
, AL356773, AL359924, AL365332, AL391809, AL445473, AL513130 Genomic DNA Translation: CAI15350.1 Sequence problems.
AL513130
, AL356773, AL359924, AL365332, AL391809, AL442065, AL445473 Genomic DNA Translation: CAI15936.1 Sequence problems.
AL359924
, AL356773, AL365332, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAI22065.1 Sequence problems.
Y08218 mRNA Translation: CAA69395.1
X91869 mRNA Translation: CAA62975.1
AJ002511 mRNA Translation: CAA05502.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55691.1 [Q92736-1]

Protein sequence database of the Protein Information Resource

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PIRi
S72269

NCBI Reference Sequences

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RefSeqi
NP_001026.2, NM_001035.2 [Q92736-1]
XP_006711868.1, XM_006711805.3 [Q92736-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.109514
Hs.738571

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366574; ENSP00000355533; ENSG00000198626 [Q92736-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6262

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6262

UCSC genome browser

More...
UCSCi
uc001hyl.2 human [Q92736-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ryanodine receptor entry

Wikipedia

RYR2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98330 mRNA Translation: CAA66975.1
AJ300340
, AJ300341, AJ300342, AJ300343, AJ300347, AJ300349, AJ300351, AJ300353, AJ300355, AJ300364, AJ300363, AJ300362, AJ300361, AJ300360, AJ300359, AJ300358, AJ300357, AJ300356, AJ300373, AJ300372, AJ300371, AJ300370, AJ300369, AJ300368, AJ300367, AJ300366, AJ300365, AJ300382, AJ300381, AJ300380, AJ300379, AJ300378, AJ300377, AJ300376, AJ300375, AJ300374, AJ300399, AJ300398, AJ300397, AJ300396, AJ300395, AJ300394, AJ300393, AJ300392, AJ300391, AJ300416, AJ300415, AJ300414, AJ300413, AJ300412, AJ300411, AJ300410, AJ300409, AJ300408, AJ300433, AJ300432, AJ300431, AJ300430, AJ300429, AJ300428, AJ300427, AJ300426, AJ300425, AJ300444, AJ300443, AJ300442, AJ300441, AJ300440, AJ300439, AJ300438, AJ300437, AJ300436, AJ300435, AJ300434, AJ300424, AJ300423, AJ300422, AJ300421, AJ300420, AJ300419, AJ300418, AJ300417, AJ300407, AJ300406, AJ300405, AJ300404, AJ300403, AJ300402, AJ300401, AJ300400, AJ300390, AJ300389, AJ300388, AJ300387, AJ300386, AJ300385, AJ300384, AJ300383, AJ300354, AJ300352, AJ300350, AJ300348, AJ300346, AJ300345, AJ300344 Genomic DNA Translation: CAC18855.1
AL365332
, AL356773, AL359924, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAH71369.1 Sequence problems.
AL445473
, AL356773, AL359924, AL365332, AL391809, AL442065, AL513130 Genomic DNA Translation: CAH71393.1 Sequence problems.
AL356773
, AL359924, AL365332, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAH73918.1 Sequence problems.
AL391809
, AL356773, AL359924, AL365332, AL442065, AL445473, AL513130 Genomic DNA Translation: CAI14440.1 Sequence problems.
AL442065
, AL356773, AL359924, AL365332, AL391809, AL445473, AL513130 Genomic DNA Translation: CAI15350.1 Sequence problems.
AL513130
, AL356773, AL359924, AL365332, AL391809, AL442065, AL445473 Genomic DNA Translation: CAI15936.1 Sequence problems.
AL359924
, AL356773, AL365332, AL391809, AL442065, AL445473, AL513130 Genomic DNA Translation: CAI22065.1 Sequence problems.
Y08218 mRNA Translation: CAA69395.1
X91869 mRNA Translation: CAA62975.1
AJ002511 mRNA Translation: CAA05502.1
CCDSiCCDS55691.1 [Q92736-1]
PIRiS72269
RefSeqiNP_001026.2, NM_001035.2 [Q92736-1]
XP_006711868.1, XM_006711805.3 [Q92736-2]
UniGeneiHs.109514
Hs.738571

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JKQX-ray2.39A1-606[»]
ProteinModelPortaliQ92736
SMRiQ92736
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112174, 27 interactors
ComplexPortaliCPX-3156 Ryanodine 2 complex
DIPiDIP-38325N
IntActiQ92736, 12 interactors
MINTiQ92736
STRINGi9606.ENSP00000355533

Chemistry databases

ChEMBLiCHEMBL4403
DrugBankiDB09085 Tetracaine
GuidetoPHARMACOLOGYi748

Protein family/group databases

TCDBi1.A.3.1.1 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

CarbonylDBiQ92736
iPTMnetiQ92736
PhosphoSitePlusiQ92736

Polymorphism and mutation databases

BioMutaiRYR2
DMDMi308153558

Proteomic databases

EPDiQ92736
MaxQBiQ92736
PaxDbiQ92736
PeptideAtlasiQ92736
PRIDEiQ92736
ProteomicsDBi75431
75432 [Q92736-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366574; ENSP00000355533; ENSG00000198626 [Q92736-1]
GeneIDi6262
KEGGihsa:6262
UCSCiuc001hyl.2 human [Q92736-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6262
DisGeNETi6262
EuPathDBiHostDB:ENSG00000198626.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RYR2
GeneReviewsiRYR2
HGNCiHGNC:10484 RYR2
HPAiHPA020028
MalaCardsiRYR2
MIMi180902 gene
600996 phenotype
604772 phenotype
neXtProtiNX_Q92736
OpenTargetsiENSG00000198626
Orphaneti3286 Catecholaminergic polymorphic ventricular tachycardia
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000154906
HOGENOMiHOG000231428
HOVERGENiHBG006699
InParanoidiQ92736
KOiK04962
OMAiRFSMKDT
OrthoDBiEOG091G00T0
PhylomeDBiQ92736
TreeFamiTF315244

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis
SIGNORiQ92736

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RYR2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Ryanodine_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6262

Protein Ontology

More...
PROi
PR:Q92736

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198626 Expressed in 151 organ(s), highest expression level in heart right ventricle
CleanExiHS_RYR2
ExpressionAtlasiQ92736 baseline and differential
GenevisibleiQ92736 HS

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92736
Secondary accession number(s): Q15411, Q546N8, Q5T3P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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