UniProtKB - Q92731 (ESR2_HUMAN)
Estrogen receptor beta
ESR2
Functioni
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).
4 PublicationsLacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
1 PublicationCaution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 149 – 214 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 149 – 169 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 185 – 209 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- enzyme binding Source: UniProtKB
- estrogen receptor activity Source: CAFA
- estrogen response element binding Source: CAFA
- nuclear receptor activity Source: ParkinsonsUK-UCL
- receptor antagonist activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- steroid binding Source: UniProtKB
- steroid hormone receptor activity Source: ProtInc
- zinc ion binding Source: InterPro
GO - Biological processi
- cell-cell signaling Source: ProtInc
- cellular response to estradiol stimulus Source: CAFA
- intracellular estrogen receptor signaling pathway Source: CAFA
- intracellular steroid hormone receptor signaling pathway Source: GO_Central
- negative regulation of cell growth Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: CAFA
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q92731 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8939211, ESR-mediated signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | Q92731 |
SIGNORi | Q92731 |
Protein family/group databases
MoonDBi | Q92731, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptor betaShort name: ER-beta Alternative name(s): Nuclear receptor subfamily 3 group A member 2 |
Gene namesi | Name:ESR2 Synonyms:ESTRB, NR3A2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3468, ESR2 |
MIMi | 601663, gene |
neXtProti | NX_Q92731 |
VEuPathDBi | HostDB:ENSG00000140009 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Ovarian dysgenesis 8 (ODG8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081788 | 314 | K → R in ODG8; completely inactive in positive regulation of DNA-binding transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs1567753148EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 87 | S → A: Enhances repression by activated ErbB2/ErbB3; when associated with A-105. 1 Publication | 1 | |
Mutagenesisi | 87 | S → D: Abolishes repression by activated ErbB2/ErbB3; when associated with D-105. 1 Publication | 1 | |
Mutagenesisi | 105 | S → A: Enhances repression by activated ErbB2/ErbB3; when associated with A-87. 1 Publication | 1 | |
Mutagenesisi | 105 | S → D: Abolishes repression by activated ErbB2/ErbB3; when associated with D-87. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2100 |
MalaCardsi | ESR2 |
MIMi | 618187, phenotype |
OpenTargetsi | ENSG00000140009 |
Orphaneti | 99361, Familial medullary thyroid carcinoma |
PharmGKBi | PA27886 |
Miscellaneous databases
Pharosi | Q92731, Tclin |
Chemistry databases
ChEMBLi | CHEMBL242 |
DrugBanki | DB07638, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07036, (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol DB08020, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07757, (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DB07702, 17alpha-Estriol DB07032, 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL DB13869, 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE DB04020, 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME DB06937, 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL DB03882, 5-Alpha-Androstane-3-Beta,17beta-Diol DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB04468, Afimoxifene DB06249, Arzoxifene DB06401, Bazedoxifene DB01878, Benzophenone DB05882, CHF 4227 DB00286, Conjugated estrogens DB00255, Diethylstilbestrol DB11219, Enzacamene DB11674, Equol DB06875, ERB-196 DB07933, Erteberel DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB04574, Estrone sulfate DB09086, Eugenol DB15690, Fluoroestradiol F-18 DB01645, Genistein DB03860, ICI-164384 DB06202, Lasofoxifene DB05052, MF101 DB03467, Naringenin DB09535, Octocrylene DB01428, Oxybenzone DB02983, Para-Mercury-Benzenesulfonic Acid DB02746, Phthalic Acid DB01708, Prasterone DB06832, Prinaberel DB00396, Progesterone DB02757, Pyrazole DB04216, Quercetin DB00481, Raloxifene DB00675, Tamoxifen DB05966, TAS-108 DB01108, Trilostane |
DrugCentrali | Q92731 |
GuidetoPHARMACOLOGYi | 621 |
Genetic variation databases
BioMutai | ESR2 |
DMDMi | 6166154 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053642 | 1 – 530 | Estrogen receptor betaAdd BLAST | 530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | Phosphoserine1 Publication | 1 | |
Modified residuei | 105 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q92731 |
PeptideAtlasi | Q92731 |
PRIDEi | Q92731 |
ProteomicsDBi | 33568 75421 [Q92731-1] 75422 [Q92731-2] 75423 [Q92731-3] 75424 [Q92731-4] 75425 [Q92731-5] 75426 [Q92731-6] 75427 [Q92731-7] 75428 [Q92731-8] |
PTM databases
iPTMneti | Q92731 |
PhosphoSitePlusi | Q92731 |
SwissPalmi | Q92731 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000140009, Expressed in right adrenal gland and 138 other tissues |
ExpressionAtlasi | Q92731, baseline and differential |
Genevisiblei | Q92731, HS |
Organism-specific databases
HPAi | ENSG00000140009, Tissue enhanced (adrenal) |
Interactioni
Subunit structurei
Binds DNA as a homodimer. Can form a heterodimer with ESR1.
Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.
Interacts with UBE1C.
Interacts with AKAP13.
Interacts with DNTTIP2.
Interacts with isoform 4 of TXNRD1.
Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes, including cyclin-D1/CCND1 AP-1 promoter.
Interacts with DNAAF4 (By similarity).
Interacts with PRMT2.
Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.
Interacts with RBM39, in the presence of estradiol (E2) (By similarity).
By similarity9 PublicationsPreferentially forms a heterodimer with ESR1 rather than ESR2 isoform 1 and inhibits DNA-binding by ESR1.
1 PublicationBinary interactionsi
Q92731
Isoform 1 [Q92731-1]
With | #Exp. | IntAct |
---|---|---|
CCDC62 [Q6P9F0] | 6 | EBI-11176604,EBI-11176612 |
Isoform 3 [Q92731-3]
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- receptor antagonist activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108404, 2281 interactors |
CORUMi | Q92731 |
DIPi | DIP-5966N |
ELMi | Q92731 |
IntActi | Q92731, 461 interactors |
MINTi | Q92731 |
STRINGi | 9606.ENSP00000343925 |
Chemistry databases
BindingDBi | Q92731 |
Miscellaneous databases
RNActi | Q92731, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92731 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92731 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 264 – 498 | NR LBDPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 148 | ModulatingAdd BLAST | 148 | |
Regioni | 507 – 530 | DisorderedSequence analysisAdd BLAST | 24 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 149 – 169 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 185 – 209 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156116 |
HOGENOMi | CLU_862048_0_0_1 |
InParanoidi | Q92731 |
OMAi | SHKEFSQ |
PhylomeDBi | Q92731 |
TreeFami | TF323751 |
Family and domain databases
DisProti | DP00079 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00091 |
InterProi | View protein in InterPro IPR028355, ER-beta/gamma IPR024178, Est_rcpt/est-rel_rcp IPR021064, Estrogen_rcpt_beta_N IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12497, ERbeta_N, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500102, ER-b, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS
60 70 80 90 100
PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA
110 120 130 140 150
EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA
160 170 180 190 200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS
210 220 230 240 250
CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG
260 270 280 290 300
HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK
310 320 330 340 350
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH
360 370 380 390 400
PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV
410 420 430 440 450
KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ
460 470 480 490 500
QSMRLANLLM LLSHVRHASN KGMEHLLNMK CKNVVPVYDL LLEMLNAHVL
510 520 530
RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ
The sequence of this isoform differs from the canonical sequence as follows:
319-323: FVELS → MRGNA
324-530: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V5S2 | G3V5S2_HUMAN | Estrogen receptor beta | ESR2 | 513 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081786 | 84 | G → V Found in a patient with a 46,XY disorder of sex development; unknown pathological significance; no change in positive regulation of DNA-binding transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs1460814363Ensembl. | 1 | |
Natural variantiVAR_081787 | 181 | Missing Found in a patient with a 46,XY disorder of sex development; unknown pathological significance; shows increased positive regulation of DNA-binding transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs750091675Ensembl. | 1 | |
Natural variantiVAR_081788 | 314 | K → R in ODG8; completely inactive in positive regulation of DNA-binding transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs1567753148EnsemblClinVar. | 1 | |
Natural variantiVAR_081789 | 426 | L → R Found in a patient with a 46,XY disorder of sex development; unknown pathological significance; shows a higher positive regulation of DNA-binding transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs1217623435EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003685 | 319 – 409 | Missing in isoform 7. 1 PublicationAdd BLAST | 91 | |
Alternative sequenceiVSP_003684 | 319 – 323 | FVELS → MRGNA in isoform 3. 2 Publications | 5 | |
Alternative sequenceiVSP_003686 | 324 – 530 | Missing in isoform 3. 2 PublicationsAdd BLAST | 207 | |
Alternative sequenceiVSP_003687 | 365 – 375 | DEGKCVEGILE → YVPSGHSDPGC in isoform 8. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_003688 | 376 – 530 | Missing in isoform 8. 1 PublicationAdd BLAST | 155 | |
Alternative sequenceiVSP_003689 | 469 – 530 | SNKGM…NPQSQ → RAEKASQTLTSFGMKMETLL PEATMEQ in isoform 2. 3 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_003690 | 469 – 530 | SNKGM…NPQSQ → SSLSLSWRLFMLREASCHGV RQTPGGAHMSVSRSRSFEAC QQPRE in isoform 4. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_003691 | 469 – 530 | SNKGM…NPQSQ → RWGEKQFIHLKLS in isoform 5. 2 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_003692 | 469 – 530 | SNKGM…NPQSQ → RYAP in isoform 6. 2 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_055746 | 469 – 474 | SNKGME → RSCVYK in isoform 9. Curated | 6 | |
Alternative sequenceiVSP_055747 | 475 – 530 | Missing in isoform 9. CuratedAdd BLAST | 56 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000267525; ENSP00000267525; ENSG00000140009 [Q92731-7] ENST00000341099; ENSP00000343925; ENSG00000140009 ENST00000344288; ENSP00000345616; ENSG00000140009 [Q92731-3] ENST00000353772; ENSP00000335551; ENSG00000140009 [Q92731-2] ENST00000358599; ENSP00000351412; ENSG00000140009 [Q92731-2] ENST00000553796; ENSP00000452426; ENSG00000140009 [Q92731-9] ENST00000554572; ENSP00000450699; ENSG00000140009 [Q92731-2] ENST00000555278; ENSP00000450488; ENSG00000140009 [Q92731-5] ENST00000557772; ENSP00000451582; ENSG00000140009 [Q92731-6] |
GeneIDi | 2100 |
KEGGi | hsa:2100 |
MANE-Selecti | ENST00000341099.6; ENSP00000343925.4; NM_001437.3; NP_001428.1 |
UCSCi | uc001xgu.4, human [Q92731-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Estrogen receptor entry |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1L2J | X-ray | 2.95 | A/B | 256-505 | [»] | |
1NDE | X-ray | 3.00 | A | 256-501 | [»] | |
1QKM | X-ray | 1.80 | A | 255-509 | [»] | |
1U3Q | X-ray | 2.40 | A/B/C/D | 261-500 | [»] | |
1U3R | X-ray | 2.21 | A/B | 261-501 | [»] | |
1U3S | X-ray | 2.50 | A/B | 261-500 | [»] | |
1U9E | X-ray | 2.40 | A/B | 261-501 | [»] | |
1X76 | X-ray | 2.20 | A/B | 261-500 | [»] | |
1X78 | X-ray | 2.30 | A/B | 261-500 | [»] | |
1X7B | X-ray | 2.30 | A/B | 261-500 | [»] | |
1X7J | X-ray | 2.30 | A/B | 261-500 | [»] | |
1YY4 | X-ray | 2.70 | A/B | 263-530 | [»] | |
1YYE | X-ray | 2.03 | A/B | 263-530 | [»] | |
1ZAF | X-ray | 2.20 | A/B | 263-500 | [»] | |
2FSZ | X-ray | 2.20 | A/B | 257-502 | [»] | |
2GIU | X-ray | 2.20 | A | 260-500 | [»] | |
2I0G | X-ray | 2.50 | A/B | 256-505 | [»] | |
2JJ3 | X-ray | 2.28 | A/B | 256-505 | [»] | |
2NV7 | X-ray | 2.10 | A/B | 263-500 | [»] | |
2QTU | X-ray | 2.53 | A/B | 256-505 | [»] | |
2YJD | X-ray | 1.93 | A/B | 261-500 | [»] | |
2YLY | X-ray | 3.20 | A/B | 260-500 | [»] | |
2Z4B | X-ray | 2.34 | A/B | 256-505 | [»] | |
3OLL | X-ray | 1.50 | A/B | 261-500 | [»] | |
3OLS | X-ray | 2.20 | A/B | 261-500 | [»] | |
3OMO | X-ray | 2.21 | A/B | 261-500 | [»] | |
3OMP | X-ray | 2.05 | A/B | 261-500 | [»] | |
3OMQ | X-ray | 1.97 | A/B | 261-500 | [»] | |
4J24 | X-ray | 2.10 | A/B/C/D | 261-500 | [»] | |
4J26 | X-ray | 2.30 | A/B | 261-500 | [»] | |
4ZI1 | X-ray | 2.10 | A | 262-509 | [»] | |
5TOA | X-ray | 2.50 | A/B | 262-509 | [»] | |
SMRi | Q92731 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108404, 2281 interactors |
CORUMi | Q92731 |
DIPi | DIP-5966N |
ELMi | Q92731 |
IntActi | Q92731, 461 interactors |
MINTi | Q92731 |
STRINGi | 9606.ENSP00000343925 |
Chemistry databases
BindingDBi | Q92731 |
ChEMBLi | CHEMBL242 |
DrugBanki | DB07638, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07036, (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol DB08020, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL DB07757, (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one DB07119, 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DB07702, 17alpha-Estriol DB07032, 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL DB07009, 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL DB13869, 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol DB07236, 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL DB07230, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE DB04020, 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol DB07150, 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME DB06937, 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL DB03882, 5-Alpha-Androstane-3-Beta,17beta-Diol DB07198, 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE DB06927, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE DB04468, Afimoxifene DB06249, Arzoxifene DB06401, Bazedoxifene DB01878, Benzophenone DB05882, CHF 4227 DB00286, Conjugated estrogens DB00255, Diethylstilbestrol DB11219, Enzacamene DB11674, Equol DB06875, ERB-196 DB07933, Erteberel DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB04574, Estrone sulfate DB09086, Eugenol DB15690, Fluoroestradiol F-18 DB01645, Genistein DB03860, ICI-164384 DB06202, Lasofoxifene DB05052, MF101 DB03467, Naringenin DB09535, Octocrylene DB01428, Oxybenzone DB02983, Para-Mercury-Benzenesulfonic Acid DB02746, Phthalic Acid DB01708, Prasterone DB06832, Prinaberel DB00396, Progesterone DB02757, Pyrazole DB04216, Quercetin DB00481, Raloxifene DB00675, Tamoxifen DB05966, TAS-108 DB01108, Trilostane |
DrugCentrali | Q92731 |
GuidetoPHARMACOLOGYi | 621 |
Protein family/group databases
MoonDBi | Q92731, Predicted |
PTM databases
iPTMneti | Q92731 |
PhosphoSitePlusi | Q92731 |
SwissPalmi | Q92731 |
Genetic variation databases
BioMutai | ESR2 |
DMDMi | 6166154 |
Proteomic databases
PaxDbi | Q92731 |
PeptideAtlasi | Q92731 |
PRIDEi | Q92731 |
ProteomicsDBi | 33568 75421 [Q92731-1] 75422 [Q92731-2] 75423 [Q92731-3] 75424 [Q92731-4] 75425 [Q92731-5] 75426 [Q92731-6] 75427 [Q92731-7] 75428 [Q92731-8] |
Protocols and materials databases
Antibodypediai | 11874, 1745 antibodies from 44 providers |
DNASUi | 2100 |
Genome annotation databases
Organism-specific databases
CTDi | 2100 |
DisGeNETi | 2100 |
GeneCardsi | ESR2 |
HGNCi | HGNC:3468, ESR2 |
HPAi | ENSG00000140009, Tissue enhanced (adrenal) |
MalaCardsi | ESR2 |
MIMi | 601663, gene 618187, phenotype |
neXtProti | NX_Q92731 |
OpenTargetsi | ENSG00000140009 |
Orphaneti | 99361, Familial medullary thyroid carcinoma |
PharmGKBi | PA27886 |
VEuPathDBi | HostDB:ENSG00000140009 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156116 |
HOGENOMi | CLU_862048_0_0_1 |
InParanoidi | Q92731 |
OMAi | SHKEFSQ |
PhylomeDBi | Q92731 |
TreeFami | TF323751 |
Enzyme and pathway databases
PathwayCommonsi | Q92731 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8939211, ESR-mediated signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | Q92731 |
SIGNORi | Q92731 |
Miscellaneous databases
BioGRID-ORCSi | 2100, 8 hits in 1060 CRISPR screens |
ChiTaRSi | ESR2, human |
EvolutionaryTracei | Q92731 |
GeneWikii | Estrogen_receptor_beta |
GenomeRNAii | 2100 |
Pharosi | Q92731, Tclin |
PROi | PR:Q92731 |
RNActi | Q92731, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140009, Expressed in right adrenal gland and 138 other tissues |
ExpressionAtlasi | Q92731, baseline and differential |
Genevisiblei | Q92731, HS |
Family and domain databases
DisProti | DP00079 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00091 |
InterProi | View protein in InterPro IPR028355, ER-beta/gamma IPR024178, Est_rcpt/est-rel_rcp IPR021064, Estrogen_rcpt_beta_N IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12497, ERbeta_N, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500102, ER-b, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ESR2_HUMAN | |
Accessioni | Q92731Primary (citable) accession number: Q92731 Secondary accession number(s): A8K8K5 Q9UQK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 236 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families