UniProtKB - Q92729 (PTPRU_HUMAN)
Receptor-type tyrosine-protein phosphatase U
PTPRU
Functioni
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
3 PublicationsCatalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphatePROSITE-ProRule annotation1 PublicationEC:3.1.3.48PROSITE-ProRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1053 | SubstrateSequence analysis | 1 | |
Active sitei | 1085 | Phosphocysteine intermediateBy similarity | 1 | |
Binding sitei | 1129 | SubstrateBy similarity | 1 | |
Active sitei | 1380 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- protein tyrosine phosphatase activity Source: UniProtKB
- transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB
GO - Biological processi
- animal organ regeneration Source: Ensembl
- cell adhesion Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- homotypic cell-cell adhesion Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
- protein dephosphorylation Source: UniProtKB
- protein localization to cell surface Source: UniProtKB
- response to glucocorticoid Source: Ensembl
- transmembrane receptor protein tyrosine phosphatase signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase, Receptor |
Biological process | Cell adhesion, Differentiation |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q92729 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT |
SignaLinki | Q92729 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)Short name: R-PTP-U Alternative name(s): Pancreatic carcinoma phosphatase 2 Short name: PCP-2 Protein-tyrosine phosphatase J Short name: PTP-J Short name: hPTP-J Protein-tyrosine phosphatase pi Short name: PTP pi Protein-tyrosine phosphatase receptor omicron Short name: PTP-RO Receptor-type protein-tyrosine phosphatase psi Short name: R-PTP-psi |
Gene namesi | Name:PTPRU Synonyms:FMI, PCP2, PTPRO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9683, PTPRU |
MIMi | 602454, gene |
neXtProti | NX_Q92729 |
VEuPathDBi | HostDB:ENSG00000060656 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- Cell junction 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell-cell junction Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 749 | ExtracellularSequence analysisAdd BLAST | 731 | |
Transmembranei | 750 – 770 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 771 – 1446 | CytoplasmicSequence analysisAdd BLAST | 676 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1085 | C → S: Loss of phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1; when associated with S-1380. 2 Publications | 1 | |
Mutagenesisi | 1380 | C → S: No effect on phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1; when associated with S-1085. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 10076 |
OpenTargetsi | ENSG00000060656 |
PharmGKBi | PA34028 |
Miscellaneous databases
Pharosi | Q92729, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1961785 |
Genetic variation databases
BioMutai | PTPRU |
DMDMi | 229462800 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000371658 | 19 – 1446 | Receptor-type tyrosine-protein phosphatase UAdd BLAST | 1428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 210 ↔ 264 | Sequence analysis | ||
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 848 | PhosphoserineCombined sources | 1 | |
Modified residuei | 853 | PhosphoserineCombined sources | 1 | |
Modified residuei | 863 | PhosphoserineBy similarity | 1 | |
Modified residuei | 865 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q92729 |
jPOSTi | Q92729 |
MassIVEi | Q92729 |
MaxQBi | Q92729 |
PaxDbi | Q92729 |
PeptideAtlasi | Q92729 |
PRIDEi | Q92729 |
ProteomicsDBi | 75416 [Q92729-1] 75417 [Q92729-2] 75418 [Q92729-3] 75419 [Q92729-4] |
PTM databases
DEPODi | PTPRU |
GlyGeni | Q92729, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q92729 |
PhosphoSitePlusi | Q92729 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000060656, Expressed in epithelium of bronchus and 211 other tissues |
Genevisiblei | Q92729, HS |
Organism-specific databases
HPAi | ENSG00000060656, Low tissue specificity |
Interactioni
Subunit structurei
Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable).
Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex.
Interacts with KIT. May interact with AP3B1.
Curated4 PublicationsBinary interactionsi
Q92729
With | #Exp. | IntAct |
---|---|---|
KIT [P10721] | 2 | EBI-7052301,EBI-1379503 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115386, 154 interactors |
IntActi | Q92729, 22 interactors |
MINTi | Q92729 |
STRINGi | 9606.ENSP00000334941 |
Miscellaneous databases
RNActi | Q92729, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q92729 |
SMRi | Q92729 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 188 | MAMPROSITE-ProRule annotationAdd BLAST | 164 | |
Domaini | 190 – 275 | Ig-like C2-typeAdd BLAST | 86 | |
Domaini | 288 – 383 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 386 – 484 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 485 – 591 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 592 – 674 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 888 – 1144 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 257 | |
Domaini | 1176 – 1439 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 264 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 771 – 887 | Mediates interaction with CTNNB1By similarityAdd BLAST | 117 | |
Regioni | 833 – 861 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1085 – 1091 | Substrate bindingBy similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 833 – 847 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000157151 |
HOGENOMi | CLU_001645_0_2_1 |
InParanoidi | Q92729 |
OMAi | WEQVRSH |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q92729 |
TreeFami | TF312900 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARAQALVLA LTFQLCAPET ETPAAGCTFE EASDPAVPCE YSQAQYDDFQ
60 70 80 90 100
WEQVRIHPGT RAPADLPHGS YLMVNTSQHA PGQRAHVIFQ SLSENDTHCV
110 120 130 140 150
QFSYFLYSRD GHSPGTLGVY VRVNGGPLGS AVWNMTGSHG RQWHQAELAV
160 170 180 190 200
STFWPNEYQV LFEALISPDR RGYMGLDDIL LLSYPCAKAP HFSRLGDVEV
210 220 230 240 250
NAGQNASFQC MAAGRAAEAE RFLLQRQSGA LVPAAGVRHI SHRRFLATFP
260 270 280 290 300
LAAVSRAEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT
310 320 330 340 350
YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVSLQ TYKLWHLDPD
360 370 380 390 400
TEYEISVLLT RPGDGGTGRP GPPLISRTKC AEPMRAPKGL AFAEIQARQL
410 420 430 440 450
TLQWEPLGYN VTRCHTYTVS LCYHYTLGSS HNQTIRECVK TEQGVSRYTI
460 470 480 490 500
KNLLPYRNVH VRLVLTNPEG RKEGKEVTFQ TDEDVPSGIA AESLTFTPLE
510 520 530 540 550
DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR RTISKLRNET
560 570 580 590 600
YHVFSNLHPG TTYLFSVRAR TGKGFGQAAL TEITTNISAP SFDYADMPSP
610 620 630 640 650
LGESENTITV LLRPAQGRGA PISVYQVIVE EERARRLRRE PGGQDCFPVP
660 670 680 690 700
LTFEAALARG LVHYFGAELA ASSLPEAMPF TVGDNQTYRG FWNPPLEPRK
710 720 730 740 750
AYLIYFQAAS HLKGETRLNC IRIARKAACK ESKRPLEVSQ RSEEMGLILG
760 770 780 790 800
ICAGGLAVLI LLLGAIIVII RKGRDHYAYS YYPKPVNMTK ATVNYRQEKT
810 820 830 840 850
HMMSAVDRSF TDQSTLQEDE RLGLSFMDTH GYSTRGDQRS GGVTEASSLL
860 870 880 890 900
GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES
910 920 930 940 950
FFEGWDATKK KDKVKGSRQE PMPAYDRHRV KLHPMLGDPN ADYINANYID
960 970 980 990 1000
GYHRSNHFIA TQGPKPEMVY DFWRMVWQEH CSSIVMITKL VEVGRVKCSR
1010 1020 1030 1040 1050
YWPEDSDTYG DIKIMLVKTE TLAEYVVRTF ALERRGYSAR HEVRQFHFTA
1060 1070 1080 1090 1100
WPEHGVPYHA TGLLAFIRRV KASTPPDAGP IVIHCSAGTG RTGCYIVLDV
1110 1120 1130 1140 1150
MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA ILEACLCGET
1160 1170 1180 1190 1200
TIPVSEFKAT YKEMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL
1210 1220 1230 1240 1250
PRNRDKNRSM DVLPPDRCLP FLISTDGDSN NYINAALTDS YTRSAAFIVT
1260 1270 1280 1290 1300
LHPLQSTTPD FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY
1310 1320 1330 1340 1350
GLMEVEFMSG TADEDLVARV FRVQNISRLQ EGHLLVRHFQ FLRWSAYRDT
1360 1370 1380 1390 1400
PDSKKAFLHL LAEVDKWQAE SGDGRTIVHC LNGGGRSGTF CACATVLEMI
1410 1420 1430 1440
RCHNLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EGLESR
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 359 – 360 | LT → S in AAC51938 (PubMed:9434160).Curated | 2 | |
Sequence conflicti | 401 | T → A in AAC51938 (PubMed:9434160).Curated | 1 | |
Sequence conflicti | 715 | E → D in AAB51343 (PubMed:9070223).Curated | 1 | |
Sequence conflicti | 840 – 841 | SG → GW in AAC51938 (PubMed:9434160).Curated | 2 | |
Sequence conflicti | 1215 | P → A in AAB07074 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1245 | A → R in AAC51938 (PubMed:9434160).Curated | 1 | |
Sequence conflicti | 1399 | M → I in AAC51938 (PubMed:9434160).Curated | 1 | |
Sequence conflicti | 1436 | A → V in AAB07074 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055075 | 60 | T → N. Corresponds to variant dbSNP:rs35332573Ensembl. | 1 | |
Natural variantiVAR_055076 | 471 | R → L. Corresponds to variant dbSNP:rs35745442Ensembl. | 1 | |
Natural variantiVAR_035650 | 830 | H → Y in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035651 | 835 | R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs558954146Ensembl. | 1 | |
Natural variantiVAR_035652 | 856 | R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs763868325Ensembl. | 1 | |
Natural variantiVAR_055077 | 940 | N → S. Corresponds to variant dbSNP:rs2235937Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037082 | 774 – 783 | Missing in isoform 2, isoform 3 and isoform 4. 5 Publications | 10 | |
Alternative sequenceiVSP_037083 | 950 | D → DIRINRE in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_037084 | 993 – 995 | Missing in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_037085 | 1329 – 1330 | Missing in isoform 4. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95712 mRNA Translation: CAA65016.1 Sequence problems. X97198 mRNA Translation: CAA65832.1 Sequence problems. U73727 mRNA Translation: AAB51343.1 U71075 mRNA Translation: AAC51938.1 U60289 Genomic DNA Translation: AAB07074.1 AL645859 Genomic DNA No translation available. AL590729 Genomic DNA No translation available. AL049570 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07651.1 CH471059 Genomic DNA Translation: EAX07652.1 BC146655 mRNA Translation: AAI46656.1 AB208855 mRNA Translation: BAD92092.1 |
CCDSi | CCDS334.1 [Q92729-1] CCDS335.1 [Q92729-2] CCDS44098.2 [Q92729-4] CCDS53290.1 [Q92729-3] |
PIRi | JC5290 S72441 |
RefSeqi | NP_001181930.1, NM_001195001.1 [Q92729-3] NP_005695.3, NM_005704.4 [Q92729-1] NP_573438.3, NM_133177.3 [Q92729-4] NP_573439.2, NM_133178.3 [Q92729-2] |
Genome annotation databases
Ensembli | ENST00000345512.7; ENSP00000334941.5; ENSG00000060656.20 ENST00000373779.8; ENSP00000362884.3; ENSG00000060656.20 [Q92729-2] ENST00000428026.6; ENSP00000392332.2; ENSG00000060656.20 [Q92729-3] ENST00000460170.2; ENSP00000432906.1; ENSG00000060656.20 [Q92729-4] |
GeneIDi | 10076 |
KEGGi | hsa:10076 |
MANE-Selecti | ENST00000373779.8; ENSP00000362884.3; NM_133178.4; NP_573439.2 [Q92729-2] |
UCSCi | uc001bru.4, human [Q92729-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95712 mRNA Translation: CAA65016.1 Sequence problems. X97198 mRNA Translation: CAA65832.1 Sequence problems. U73727 mRNA Translation: AAB51343.1 U71075 mRNA Translation: AAC51938.1 U60289 Genomic DNA Translation: AAB07074.1 AL645859 Genomic DNA No translation available. AL590729 Genomic DNA No translation available. AL049570 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07651.1 CH471059 Genomic DNA Translation: EAX07652.1 BC146655 mRNA Translation: AAI46656.1 AB208855 mRNA Translation: BAD92092.1 |
CCDSi | CCDS334.1 [Q92729-1] CCDS335.1 [Q92729-2] CCDS44098.2 [Q92729-4] CCDS53290.1 [Q92729-3] |
PIRi | JC5290 S72441 |
RefSeqi | NP_001181930.1, NM_001195001.1 [Q92729-3] NP_005695.3, NM_005704.4 [Q92729-1] NP_573438.3, NM_133177.3 [Q92729-4] NP_573439.2, NM_133178.3 [Q92729-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SUB | X-ray | 1.72 | A | 871-1153 | [»] | |
6SUC | X-ray | 1.97 | A | 871-1153 | [»] | |
AlphaFoldDBi | Q92729 | |||||
SMRi | Q92729 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115386, 154 interactors |
IntActi | Q92729, 22 interactors |
MINTi | Q92729 |
STRINGi | 9606.ENSP00000334941 |
Chemistry databases
ChEMBLi | CHEMBL1961785 |
PTM databases
DEPODi | PTPRU |
GlyGeni | Q92729, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q92729 |
PhosphoSitePlusi | Q92729 |
Genetic variation databases
BioMutai | PTPRU |
DMDMi | 229462800 |
Proteomic databases
EPDi | Q92729 |
jPOSTi | Q92729 |
MassIVEi | Q92729 |
MaxQBi | Q92729 |
PaxDbi | Q92729 |
PeptideAtlasi | Q92729 |
PRIDEi | Q92729 |
ProteomicsDBi | 75416 [Q92729-1] 75417 [Q92729-2] 75418 [Q92729-3] 75419 [Q92729-4] |
Protocols and materials databases
Antibodypediai | 31032, 42 antibodies from 17 providers |
DNASUi | 10076 |
Genome annotation databases
Ensembli | ENST00000345512.7; ENSP00000334941.5; ENSG00000060656.20 ENST00000373779.8; ENSP00000362884.3; ENSG00000060656.20 [Q92729-2] ENST00000428026.6; ENSP00000392332.2; ENSG00000060656.20 [Q92729-3] ENST00000460170.2; ENSP00000432906.1; ENSG00000060656.20 [Q92729-4] |
GeneIDi | 10076 |
KEGGi | hsa:10076 |
MANE-Selecti | ENST00000373779.8; ENSP00000362884.3; NM_133178.4; NP_573439.2 [Q92729-2] |
UCSCi | uc001bru.4, human [Q92729-1] |
Organism-specific databases
CTDi | 10076 |
DisGeNETi | 10076 |
GeneCardsi | PTPRU |
HGNCi | HGNC:9683, PTPRU |
HPAi | ENSG00000060656, Low tissue specificity |
MIMi | 602454, gene |
neXtProti | NX_Q92729 |
OpenTargetsi | ENSG00000060656 |
PharmGKBi | PA34028 |
VEuPathDBi | HostDB:ENSG00000060656 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000157151 |
HOGENOMi | CLU_001645_0_2_1 |
InParanoidi | Q92729 |
OMAi | WEQVRSH |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q92729 |
TreeFami | TF312900 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q92729 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT |
SignaLinki | Q92729 |
Miscellaneous databases
BioGRID-ORCSi | 10076, 14 hits in 1067 CRISPR screens |
ChiTaRSi | PTPRU, human |
GeneWikii | PTPRU |
GenomeRNAii | 10076 |
Pharosi | Q92729, Tbio |
PROi | PR:Q92729 |
RNActi | Q92729, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000060656, Expressed in epithelium of bronchus and 211 other tissues |
Genevisiblei | Q92729, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPRU_HUMAN | |
Accessioni | Q92729Primary (citable) accession number: Q92729 Secondary accession number(s): A6H8L1 Q92850 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 5, 2009 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families