UniProtKB - Q92696 (PGTA_HUMAN)

BLAST

>sp|Q92696|PGTA_HUMAN Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANP
DFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRL
PEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSS
WHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAD
PQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVW
LCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEK
STVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRAT
YLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP
ALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNL
QGNPLCQAVGILEQLAELLPSVSSVLT

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History
Entry version 167 (07 Nov 2018)
Sequence version 2 (15 Jul 1999)
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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.1 Publication

Catalytic activityⁱ

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

Activity regulationⁱ

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
Rab geranylgeranyltransferase activity Source: UniProtKB
Rab GTPase binding Source: UniProtKB
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 2018975
- 8380507
post-translational protein modification Source: Reactome
protein-containing complex assembly Source: Ensembl
protein geranylgeranylation Source: UniProtKB
regulation of apoptotic process Source: Reactome
visual perception
Source: ProtInc
Traceable author statementⁱ
- 8380507

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Prenyltransferase, Transferase

Molecular function

Prenyltransferase, Transferase

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60) Alternative name(s): Geranylgeranyl transferase type II subunit alpha Rab geranyl-geranyltransferase subunit alpha Short name: Rab GG transferase alpha Short name: Rab GGTase alpha Rab geranylgeranyltransferase subunit alpha
Gene namesⁱ	Name:RABGGTA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100949.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9795 RABGGTA
MIMⁱ	601905 gene
neXtProtⁱ	NX_Q92696

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5875
Open Targets More...OpenTargetsⁱ	ENSG00000100949
PharmGKBⁱ	PA34156

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB07780 FARNESYL DIPHOSPHATE DB07841 GERANYLGERANYL DIPHOSPHATE DB04464 N-Formylmethionine

DrugBankⁱ

DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaⁱ	RABGGTA
DMDMⁱ	6093707

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119757	1 – 567	Geranylgeranyl transferase type-2 subunit alphaAdd BLAST		567

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	98	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q92696
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92696
PaxDbⁱ	Q92696
PeptideAtlas More...PeptideAtlasⁱ	Q92696
PRIDEⁱ	Q92696
ProteomicsDBⁱ	75413

PTM databases

iPTMnetⁱ	Q92696
PhosphoSitePlusⁱ	Q92696

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100949 Expressed in 198 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RABGGTA
ExpressionAtlasⁱ	Q92696 baseline and differential
Genevisibleⁱ	Q92696 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043488

HPAⁱ

HPA043488

Interactionⁱ

Subunit structureⁱ

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp.2 Publications

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
Rab GTPase binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111813, 36 interactors
ComplexPortalⁱ	CPX-2919 Protein geranylgeranyltransferase type II complex
IntActⁱ	Q92696, 6 interactors
STRINGⁱ	9606.ENSP00000216840

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92696
SMRⁱ	Q92696
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	44 – 78	PFTA 1Add BLAST	35
Repeatⁱ	88 – 122	PFTA 2Add BLAST	35
Repeatⁱ	124 – 158	PFTA 3Add BLAST	35
Repeatⁱ	159 – 193	PFTA 4Add BLAST	35
Repeatⁱ	207 – 241	PFTA 5Add BLAST	35
Repeatⁱ	363 – 397	PFTA 6Add BLAST	35
Repeatⁱ	442 – 463	LRR 1Add BLAST	22
Repeatⁱ	464 – 486	LRR 2Add BLAST	23
Repeatⁱ	487 – 508	LRR 3Add BLAST	22
Repeatⁱ	509 – 530	LRR 4Add BLAST	22
Repeatⁱ	534 – 555	LRR 5Add BLAST	22

Sequence similaritiesⁱ

Belongs to the protein prenyltransferase subunit alpha family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0529 Eukaryota COG5536 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075121
HOGENOMⁱ	HOG000007845
HOVERGENⁱ	HBG002171
InParanoidⁱ	Q92696
KEGG Orthology (KO) More...KOⁱ	K14050
OMAⁱ	NDSSAWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L9H
PhylomeDBⁱ	Q92696
TreeFamⁱ	TF315057

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR002088 Prenyl_trans_a IPR036254 RabGGT_asu_insert-dom_sf IPR009087 RabGGT_asu_insert-domain IPR032955 RabGGTase_alpha
PANTHERⁱ	PTHR11129:SF2 PTHR11129:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01239 PPTA, 4 hits PF07711 RabGGT_insert, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD331837 RabGG_trans_A, 1 hit
SUPFAMⁱ	SSF49594 SSF49594, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 5 hits PS51147 PFTA, 6 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q92696-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE 
        60         70         80         90        100
LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL 
       110        120        130        140        150
RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR 
       160        170        180        190        200
FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ 
       210        220        230        240        250
GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV 
       260        270        280        290        300
SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW 
       310        320        330        340        350
LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ 
       360        370        380        390        400
LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY 
       410        420        430        440        450
EKETLQYFQT LKAVDPMRAT YLDDLRSKFL LENSVLKMEY AEVRVLHLAH 
       460        470        480        490        500
KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES 
       510        520        530        540        550
LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL QGNPLCQAVG 
       560 
ILEQLAELLP SVSSVLT

Length:567

Mass (Da):65,072

Last modified:July 15, 1999 - v2

Checksum:ⁱABA1AFFC8A496C5F

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YLH3	H0YLH3_HUMAN	Geranylgeranyl transferase type-2 s... Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	424	Annotation score:
H0YKP6	H0YKP6_HUMAN	Geranylgeranyl transferase type-2 s... Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	73	Annotation score:
H0YKZ8	H0YKZ8_HUMAN	Geranylgeranyl transferase type-2 s... Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	136	Annotation score:
H0YLG7	H0YLG7_HUMAN	Geranylgeranyl transferase type-2 s... Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	176	Annotation score:
H0YMG5	H0YMG5_HUMAN	Geranylgeranyl transferase type-2 s... Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	175	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020406	420	T → A1 PublicationCorresponds to variant dbSNP:rs729421Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08200 mRNA Translation: CAA69382.1 AK291347 mRNA Translation: BAF84036.1 AK292613 mRNA Translation: BAF85302.1 CH471078 Genomic DNA Translation: EAW66044.1 CH471078 Genomic DNA Translation: EAW66045.1 BC003093 mRNA Translation: AAH03093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45088.1
PIRⁱ	JC5538
NCBI Reference Sequences More...RefSeqⁱ	NP_004572.3, NM_004581.5 NP_878256.1, NM_182836.2
UniGeneⁱ	Hs.377992

Genome annotation databases

Ensemblⁱ	ENST00000216840; ENSP00000216840; ENSG00000100949 ENST00000399409; ENSP00000382341; ENSG00000100949 ENST00000644383; ENSP00000494636; ENSG00000285193 ENST00000646658; ENSP00000496595; ENSG00000285193
GeneIDⁱ	5875
KEGGⁱ	hsa:5875
UCSC genome browser More...UCSCⁱ	uc001wof.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q92696	Rab geranylgeranyltransferase, alpha subunit, isoform CRA_a		HUMAN		297	UniRef100_Q92696
Geranylgeranyl transferase type-2 subunit alpha		HUMAN		176

Protein	Similar proteins		Species	Score	Length	Source
Q92696	Geranylgeranyl transferase type-2 subunit alpha		BOVIN		567	UniRef90_Q92696
Geranylgeranyl transferase type-2 subunit alpha		PONAB		567
Rab geranylgeranyltransferase, alpha subunit, isoform CRA_a		HUMAN		297
Uncharacterized protein		PROCO		570
Uncharacterized protein		COLAP		569
+109

Protein	Similar proteins		Species	Score	Length	Source
Q92696	Geranylgeranyl transferase type-2 subunit alpha		BOVIN		567	UniRef50_Q92696
Geranylgeranyl transferase type-2 subunit alpha		PONAB		567
Geranylgeranyl transferase type-2 subunit alpha		MOUSE		567
Geranylgeranyl transferase type-2 subunit alpha		PIG		567
Geranylgeranyl transferase type-2 subunit alpha	)	RAT		567
+265

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08200 mRNA Translation: CAA69382.1 AK291347 mRNA Translation: BAF84036.1 AK292613 mRNA Translation: BAF85302.1 CH471078 Genomic DNA Translation: EAW66044.1 CH471078 Genomic DNA Translation: EAW66045.1 BC003093 mRNA Translation: AAH03093.1
CCDSⁱ	CCDS45088.1
PIRⁱ	JC5538
RefSeqⁱ	NP_004572.3, NM_004581.5 NP_878256.1, NM_182836.2
UniGeneⁱ	Hs.377992

3D structure databases

ProteinModelPortalⁱ	Q92696
SMRⁱ	Q92696
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111813, 36 interactors
ComplexPortalⁱ	CPX-2919 Protein geranylgeranyltransferase type II complex
IntActⁱ	Q92696, 6 interactors
STRINGⁱ	9606.ENSP00000216840

Chemistry databases

DrugBankⁱ	DB07780 FARNESYL DIPHOSPHATE DB07841 GERANYLGERANYL DIPHOSPHATE DB04464 N-Formylmethionine

DrugBankⁱ

DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB04464 N-Formylmethionine

PTM databases

iPTMnetⁱ	Q92696
PhosphoSitePlusⁱ	Q92696

Polymorphism and mutation databases

BioMutaⁱ	RABGGTA
DMDMⁱ	6093707

Proteomic databases

EPDⁱ	Q92696
MaxQBⁱ	Q92696
PaxDbⁱ	Q92696
PeptideAtlasⁱ	Q92696
PRIDEⁱ	Q92696
ProteomicsDBⁱ	75413

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000216840; ENSP00000216840; ENSG00000100949 ENST00000399409; ENSP00000382341; ENSG00000100949 ENST00000644383; ENSP00000494636; ENSG00000285193 ENST00000646658; ENSP00000496595; ENSG00000285193
GeneIDⁱ	5875
KEGGⁱ	hsa:5875
UCSCⁱ	uc001wof.5 human

Organism-specific databases

CTDⁱ	5875
DisGeNETⁱ	5875
EuPathDBⁱ	HostDB:ENSG00000100949.14
GeneCardsⁱ	RABGGTA
HGNCⁱ	HGNC:9795 RABGGTA
HPAⁱ	HPA043488
MIMⁱ	601905 gene
neXtProtⁱ	NX_Q92696
OpenTargetsⁱ	ENSG00000100949
PharmGKBⁱ	PA34156
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0529 Eukaryota COG5536 LUCA
GeneTreeⁱ	ENSGT00550000075121
HOGENOMⁱ	HOG000007845
HOVERGENⁱ	HBG002171
InParanoidⁱ	Q92696
KOⁱ	K14050
OMAⁱ	NDSSAWF
OrthoDBⁱ	EOG091G0L9H
PhylomeDBⁱ	Q92696
TreeFamⁱ	TF315057

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

GenomeRNAiⁱ	5875
Protein Ontology More...PROⁱ	PR:Q92696
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100949 Expressed in 198 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_RABGGTA
ExpressionAtlasⁱ	Q92696 baseline and differential
Genevisibleⁱ	Q92696 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR002088 Prenyl_trans_a IPR036254 RabGGT_asu_insert-dom_sf IPR009087 RabGGT_asu_insert-domain IPR032955 RabGGTase_alpha
PANTHERⁱ	PTHR11129:SF2 PTHR11129:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF01239 PPTA, 4 hits PF07711 RabGGT_insert, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD331837 RabGG_trans_A, 1 hit
SUPFAMⁱ	SSF49594 SSF49594, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 5 hits PS51147 PFTA, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGTA_HUMAN
Accessionⁱ	Q92696Primary (citable) accession number: Q92696 Secondary accession number(s): A8K5N2, D3DS69
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 15, 1999
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q92696 (PGTA_HUMAN)

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Geranylgeranyl transferase type-2 subunit alpha

RABGGTA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ