UniProtKB - Q92696 (PGTA_HUMAN)
Geranylgeranyl transferase type-2 subunit alpha
RABGGTA
Functioni
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
1 PublicationCatalytic activityi
- geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]1 PublicationEC:2.5.1.601 Publication
Activity regulationi
GO - Molecular functioni
- Rab geranylgeranyltransferase activity Source: UniProtKB
- small GTPase binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular protein modification process Source: ProtInc
- protein geranylgeranylation Source: UniProtKB
- visual perception Source: ProtInc
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q92696 |
Reactomei | R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | Q92696 |
SIGNORi | Q92696 |
Names & Taxonomyi
Protein namesi | Recommended name: Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)Alternative name(s): Geranylgeranyl transferase type II subunit alpha Rab geranyl-geranyltransferase subunit alpha Short name: Rab GG transferase alpha Short name: Rab GGTase alpha Rab geranylgeranyltransferase subunit alpha |
Gene namesi | Name:RABGGTA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9795, RABGGTA |
MIMi | 601905, gene |
neXtProti | NX_Q92696 |
VEuPathDBi | HostDB:ENSG00000100949 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5875 |
OpenTargetsi | ENSG00000100949 |
PharmGKBi | PA34156 |
Miscellaneous databases
Pharosi | Q92696, Tdark |
Chemistry databases
ChEMBLi | CHEMBL5249 |
DrugBanki | DB07780, Farnesyl diphosphate DB07841, Geranylgeranyl diphosphate DB04464, N-Formylmethionine |
Genetic variation databases
BioMutai | RABGGTA |
DMDMi | 6093707 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119757 | 1 – 567 | Geranylgeranyl transferase type-2 subunit alphaAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 98 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q92696 |
jPOSTi | Q92696 |
MassIVEi | Q92696 |
MaxQBi | Q92696 |
PaxDbi | Q92696 |
PeptideAtlasi | Q92696 |
PRIDEi | Q92696 |
ProteomicsDBi | 75413 |
PTM databases
GlyGeni | Q92696, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92696 |
PhosphoSitePlusi | Q92696 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100949, Expressed in lower esophagus mucosa and 212 other tissues |
ExpressionAtlasi | Q92696, baseline and differential |
Genevisiblei | Q92696, HS |
Organism-specific databases
HPAi | ENSG00000100949, Tissue enhanced (esophagus) |
Interactioni
Subunit structurei
Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding (PubMed:7991565). The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (PubMed:18532927).
Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction (PubMed:26824392).
3 PublicationsBinary interactionsi
GO - Molecular functioni
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111813, 75 interactors |
ComplexPortali | CPX-2919, Protein geranylgeranyltransferase type II complex |
CORUMi | Q92696 |
IntActi | Q92696, 23 interactors |
MINTi | Q92696 |
STRINGi | 9606.ENSP00000382341 |
Miscellaneous databases
RNActi | Q92696, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 44 – 78 | PFTA 1Add BLAST | 35 | |
Repeati | 88 – 122 | PFTA 2Add BLAST | 35 | |
Repeati | 124 – 158 | PFTA 3Add BLAST | 35 | |
Repeati | 159 – 193 | PFTA 4Add BLAST | 35 | |
Repeati | 207 – 241 | PFTA 5Add BLAST | 35 | |
Repeati | 363 – 397 | PFTA 6Add BLAST | 35 | |
Repeati | 442 – 463 | LRR 1Add BLAST | 22 | |
Repeati | 464 – 486 | LRR 2Add BLAST | 23 | |
Repeati | 487 – 508 | LRR 3Add BLAST | 22 | |
Repeati | 509 – 530 | LRR 4Add BLAST | 22 | |
Repeati | 534 – 555 | LRR 5Add BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0529, Eukaryota |
GeneTreei | ENSGT00550000075121 |
InParanoidi | Q92696 |
OMAi | YNAWHHR |
OrthoDBi | 1527547at2759 |
PhylomeDBi | Q92696 |
TreeFami | TF315057 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR002088, Prenyl_trans_a IPR036254, RabGGT_asu_insert-dom_sf IPR009087, RabGGT_asu_insert-domain IPR032955, RabGGTase_alpha |
PANTHERi | PTHR11129:SF2, PTHR11129:SF2, 1 hit |
Pfami | View protein in Pfam PF01239, PPTA, 5 hits PF07711, RabGGT_insert, 1 hit |
SUPFAMi | SSF49594, SSF49594, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 5 hits PS51147, PFTA, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE
60 70 80 90 100
LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL
110 120 130 140 150
RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR
160 170 180 190 200
FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ
210 220 230 240 250
GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV
260 270 280 290 300
SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW
310 320 330 340 350
LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ
360 370 380 390 400
LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY
410 420 430 440 450
EKETLQYFQT LKAVDPMRAT YLDDLRSKFL LENSVLKMEY AEVRVLHLAH
460 470 480 490 500
KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES
510 520 530 540 550
LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL QGNPLCQAVG
560
ILEQLAELLP SVSSVLT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YLH3 | H0YLH3_HUMAN | Geranylgeranyl transferase type-2 s... | RABGGTA | 424 | Annotation score: | ||
H0YKP6 | H0YKP6_HUMAN | Geranylgeranyl transferase type-2 s... | RABGGTA | 73 | Annotation score: | ||
H0YLG7 | H0YLG7_HUMAN | Geranylgeranyl transferase type-2 s... | RABGGTA | 176 | Annotation score: | ||
H0YKZ8 | H0YKZ8_HUMAN | Geranylgeranyl transferase type-2 s... | RABGGTA | 136 | Annotation score: | ||
H0YMG5 | H0YMG5_HUMAN | Geranylgeranyl transferase type-2 s... | RABGGTA | 175 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020406 | 420 | T → A1 PublicationCorresponds to variant dbSNP:rs729421Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08200 mRNA Translation: CAA69382.1 AK291347 mRNA Translation: BAF84036.1 AK292613 mRNA Translation: BAF85302.1 CH471078 Genomic DNA Translation: EAW66044.1 CH471078 Genomic DNA Translation: EAW66045.1 BC003093 mRNA Translation: AAH03093.1 |
CCDSi | CCDS45088.1 |
PIRi | JC5538 |
RefSeqi | NP_004572.3, NM_004581.5 NP_878256.1, NM_182836.2 |
Genome annotation databases
Ensembli | ENST00000216840.11; ENSP00000216840.6; ENSG00000100949.15 ENST00000399409.7; ENSP00000382341.3; ENSG00000100949.15 ENST00000644383.1; ENSP00000494636.1; ENSG00000285193.1 ENST00000646658.1; ENSP00000496595.1; ENSG00000285193.1 |
GeneIDi | 5875 |
KEGGi | hsa:5875 |
MANE-Selecti | ENST00000216840.11; ENSP00000216840.6; NM_182836.3; NP_878256.1 |
UCSCi | uc001wof.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08200 mRNA Translation: CAA69382.1 AK291347 mRNA Translation: BAF84036.1 AK292613 mRNA Translation: BAF85302.1 CH471078 Genomic DNA Translation: EAW66044.1 CH471078 Genomic DNA Translation: EAW66045.1 BC003093 mRNA Translation: AAH03093.1 |
CCDSi | CCDS45088.1 |
PIRi | JC5538 |
RefSeqi | NP_004572.3, NM_004581.5 NP_878256.1, NM_182836.2 |
3D structure databases
AlphaFoldDBi | Q92696 |
SMRi | Q92696 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111813, 75 interactors |
ComplexPortali | CPX-2919, Protein geranylgeranyltransferase type II complex |
CORUMi | Q92696 |
IntActi | Q92696, 23 interactors |
MINTi | Q92696 |
STRINGi | 9606.ENSP00000382341 |
Chemistry databases
ChEMBLi | CHEMBL5249 |
DrugBanki | DB07780, Farnesyl diphosphate DB07841, Geranylgeranyl diphosphate DB04464, N-Formylmethionine |
PTM databases
GlyGeni | Q92696, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92696 |
PhosphoSitePlusi | Q92696 |
Genetic variation databases
BioMutai | RABGGTA |
DMDMi | 6093707 |
Proteomic databases
EPDi | Q92696 |
jPOSTi | Q92696 |
MassIVEi | Q92696 |
MaxQBi | Q92696 |
PaxDbi | Q92696 |
PeptideAtlasi | Q92696 |
PRIDEi | Q92696 |
ProteomicsDBi | 75413 |
Protocols and materials databases
Antibodypediai | 22812, 89 antibodies from 22 providers |
DNASUi | 5875 |
Genome annotation databases
Ensembli | ENST00000216840.11; ENSP00000216840.6; ENSG00000100949.15 ENST00000399409.7; ENSP00000382341.3; ENSG00000100949.15 ENST00000644383.1; ENSP00000494636.1; ENSG00000285193.1 ENST00000646658.1; ENSP00000496595.1; ENSG00000285193.1 |
GeneIDi | 5875 |
KEGGi | hsa:5875 |
MANE-Selecti | ENST00000216840.11; ENSP00000216840.6; NM_182836.3; NP_878256.1 |
UCSCi | uc001wof.5, human |
Organism-specific databases
CTDi | 5875 |
DisGeNETi | 5875 |
GeneCardsi | RABGGTA |
HGNCi | HGNC:9795, RABGGTA |
HPAi | ENSG00000100949, Tissue enhanced (esophagus) |
MIMi | 601905, gene |
neXtProti | NX_Q92696 |
OpenTargetsi | ENSG00000100949 |
PharmGKBi | PA34156 |
VEuPathDBi | HostDB:ENSG00000100949 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0529, Eukaryota |
GeneTreei | ENSGT00550000075121 |
InParanoidi | Q92696 |
OMAi | YNAWHHR |
OrthoDBi | 1527547at2759 |
PhylomeDBi | Q92696 |
TreeFami | TF315057 |
Enzyme and pathway databases
PathwayCommonsi | Q92696 |
Reactomei | R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | Q92696 |
SIGNORi | Q92696 |
Miscellaneous databases
BioGRID-ORCSi | 5875, 668 hits in 1085 CRISPR screens |
ChiTaRSi | RABGGTA, human |
GenomeRNAii | 5875 |
Pharosi | Q92696, Tdark |
PROi | PR:Q92696 |
RNActi | Q92696, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100949, Expressed in lower esophagus mucosa and 212 other tissues |
ExpressionAtlasi | Q92696, baseline and differential |
Genevisiblei | Q92696, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR002088, Prenyl_trans_a IPR036254, RabGGT_asu_insert-dom_sf IPR009087, RabGGT_asu_insert-domain IPR032955, RabGGTase_alpha |
PANTHERi | PTHR11129:SF2, PTHR11129:SF2, 1 hit |
Pfami | View protein in Pfam PF01239, PPTA, 5 hits PF07711, RabGGT_insert, 1 hit |
SUPFAMi | SSF49594, SSF49594, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 5 hits PS51147, PFTA, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PGTA_HUMAN | |
Accessioni | Q92696Primary (citable) accession number: Q92696 Secondary accession number(s): A8K5N2, D3DS69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 15, 1999 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families