NECTIN2

Functionⁱ

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).2 Publications

(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acrosome assembly Source: Ensembl
adherens junction organization Source: Reactome
adhesion of symbiont to host
Source: BHF-UCL
Inferred from direct assayⁱ
- 12915581
cell part morphogenesis Source: Ensembl
cilium organization Source: Ensembl
coreceptor-mediated virion attachment to host cell
Source: BHF-UCL
Inferred from direct assayⁱ
- 12915581
cytoskeleton organization Source: Ensembl
establishment of mitochondrion localization Source: Ensembl
fertilization Source: Ensembl
fusion of virus membrane with host plasma membrane
Source: BHF-UCL
Inferred from direct assayⁱ
- 12915581
homophilic cell adhesion via plasma membrane adhesion molecules
Source: BHF-UCL
Inferred from direct assayⁱ
- 9845526
positive regulation of immunoglobulin mediated immune response
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16831868
positive regulation of mast cell activation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16831868
positive regulation of natural killer cell mediated cytotoxicity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16304049
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12913096
positive regulation of T cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 26755705
regulation of immune response Source: Reactome
regulation of viral entry into host cell
Source: CACAO
Inferred from direct assayⁱ
- 11602758
spermatid development Source: BHF-UCL
spermatid nucleus differentiation Source: Ensembl
sperm mitochondrion organization Source: Ensembl
susceptibility to natural killer cell mediated cytotoxicity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12913096
susceptibility to T cell mediated cytotoxicity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15039383

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Cell adhesion, Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-418990 Adherens junctions interactions R-HSA-420597 Nectin/Necl trans heterodimerization

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-418990 Adherens junctions interactions
R-HSA-420597 Nectin/Necl trans heterodimerization

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nectin-2 Alternative name(s): Herpes virus entry mediator B Short name: Herpesvirus entry mediator B Short name: HveB Nectin cell adhesion molecule 2Imported Poliovirus receptor-related protein 2 CD_antigen: CD112
Gene namesⁱ	Name:NECTIN2Imported Synonyms:HVEB, PRR2, PVRL2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130202.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9707 NECTIN2
MIMⁱ	600798 gene
neXtProtⁱ	NX_Q92692

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	32 – 360	ExtracellularSequence analysisAdd BLAST	329
Transmembraneⁱ	361 – 381	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	382 – 538	CytoplasmicSequence analysisAdd BLAST	157

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	81	N → A: Abolishes homodimerization. 1 Publication	1
Mutagenesisⁱ	89	M → F: Loss of entry of HHV-1/Rid1 and HSV-2. No effect on PRV entry. 1 Publication	1
Mutagenesisⁱ	89	M → I: Increased entry of HHV-1/Rid1 and HSV-2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5819
Open Targets More...OpenTargetsⁱ	ENSG00000130202
PharmGKBⁱ	PA34052

Polymorphism and mutation databases

BioMutaⁱ	PVRL2
DMDMⁱ	12643789

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	Sequence analysisAdd BLAST		31
ChainⁱPRO_0000015136	32 – 538	Nectin-2Add BLAST		507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	54 ↔ 140	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	183 ↔ 238	PROSITE-ProRule annotation
Disulfide bondⁱ	283 ↔ 329	PROSITE-ProRule annotation
Glycosylationⁱ	324	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	410	PhosphothreonineCombined sources	1
Modified residueⁱ	433	PhosphoserineCombined sources	1
Isoform Alpha (identifier: Q92692-2)
Modified residueⁱ	465	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	470	PhosphoserineCombined sourcesCurated	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q92692
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92692
PaxDbⁱ	Q92692
PeptideAtlas More...PeptideAtlasⁱ	Q92692
PRIDEⁱ	Q92692
ProteomicsDBⁱ	75411 75412 [Q92692-2]

PTM databases

GlyConnectⁱ	1537
iPTMnetⁱ	Q92692
PhosphoSitePlusⁱ	Q92692
SwissPalmⁱ	Q92692

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000130202 Expressed in 214 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_PVRL2
ExpressionAtlasⁱ	Q92692 baseline and differential
Genevisibleⁱ	Q92692 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026138 HPA012759 HPA073459

HPAⁱ

CAB026138
HPA012759
HPA073459

Interactionⁱ

Subunit structureⁱ

Can form trans-heterodimers with NECTIN3 (By similarity). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT.By similarity3 Publications

(Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D (PubMed:11602758, PubMed:9657005).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		8	EBI-718419,EBI-718419
AFDN	P55196	2	EBI-718419,EBI-365875
CD226	Q15762	2	EBI-718419,EBI-4314442
KRTAP10-5	P60370	3	EBI-718419,EBI-10172150
KRTAP10-7	P60409	3	EBI-718419,EBI-10172290
KRTAP5-9	P26371	3	EBI-718419,EBI-3958099
MDFI	Q99750	4	EBI-718419,EBI-724076
NECTIN3	Q9NQS3	3	EBI-718419,EBI-2826725
NECTIN3	Q9NQS3-1	2	EBI-718419,EBI-16007706
NOTCH2NL	Q7Z3S9	3	EBI-718419,EBI-945833
SIAH1	Q8IUQ4	3	EBI-718419,EBI-747107
TIGIT	Q495A1	6	EBI-718419,EBI-4314807

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111777, 43 interactors
Database of interacting proteins More...DIPⁱ	DIP-41043N
IntActⁱ	Q92692, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q92692
STRINGⁱ	9606.ENSP00000252483

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	35 – 37	Combined sources	3
Beta strandⁱ	40 – 43	Combined sources	4
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	55 – 58	Combined sources	4
Beta strandⁱ	64 – 71	Combined sources	8
Beta strandⁱ	73 – 75	Combined sources	3
Helixⁱ	77 – 79	Combined sources	3
Beta strandⁱ	81 – 86	Combined sources	6
Turnⁱ	87 – 89	Combined sources	3
Beta strandⁱ	90 – 92	Combined sources	3
Beta strandⁱ	95 – 98	Combined sources	4
Helixⁱ	100 – 102	Combined sources	3
Beta strandⁱ	103 – 107	Combined sources	5
Turnⁱ	113 – 115	Combined sources	3
Beta strandⁱ	125 – 127	Combined sources	3
Helixⁱ	132 – 134	Combined sources	3
Beta strandⁱ	136 – 145	Combined sources	10
Beta strandⁱ	148 – 157	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92692
SMRⁱ	Q92692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92692

EvolutionaryTraceⁱ

Q92692

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	32 – 156	Ig-like V-typeAdd BLAST	125
Domainⁱ	162 – 256	Ig-like C2-type 1Add BLAST	95
Domainⁱ	261 – 345	Ig-like C2-type 2Add BLAST	85

Sequence similaritiesⁱ

Belongs to the nectin family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIB8 Eukaryota ENOG4111FZM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140811
HOGENOMⁱ	HOG000237277
HOVERGENⁱ	HBG019169
InParanoidⁱ	Q92692
KEGG Orthology (KO) More...KOⁱ	K06531
OMAⁱ	KDDMESH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CPW
PhylomeDBⁱ	Q92692
TreeFamⁱ	TF331051

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR033318 Nectin-2
PANTHERⁱ	PTHR23277:SF63 PTHR23277:SF63, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Delta (identifier: Q92692-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV 
        60         70         80         90        100
ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS 
       110        120        130        140        150
ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV 
       160        170        180        190        200
RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL 
       210        220        230        240        250
DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL 
       260        270        280        290        300
IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS 
       310        320        330        340        350
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP 
       360        370        380        390        400
NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL 
       410        420        430        440        450
EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE 
       460        470        480        490        500
MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE 
       510        520        530 
EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV

Length:538

Mass (Da):57,742

Last modified:February 1, 1997 - v1

Checksum:ⁱ3AE4F83E92F6F624

GO

Isoform Alpha (identifier: Q92692-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
351-479: NTAGAGATGG...GATSLGSPIP → RASPRDVGPL...SLISRRAVYV
480-538: Missing.

« Hide

        10         20         30         40         50
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV 
        60         70         80         90        100
ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS 
       110        120        130        140        150
ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV 
       160        170        180        190        200
RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL 
       210        220        230        240        250
DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL 
       260        270        280        290        300
IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS 
       310        320        330        340        350
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP 
       360        370        380        390        400
RASPRDVGPL VWGAVGGTLL VLLLLAGGSL AFILLRVRRR RKSPGGAGGG 
       410        420        430        440        450
ASGDGGFYDP KAQVLGNGDP VFWTPVVPGP MEPDGKDEEE EEEEEKAEKG 
       460        470 
LMLPPPPALE DDMESQLDGS LISRRAVYV

Show »

Length:479

Mass (Da):51,359

Checksum:ⁱ870F08D7B9D896F2

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EKE8	K7EKE8_HUMAN	Nectin-2 Nectin-2	NECTIN2	210	Annotation score:
K7EK87	K7EK87_HUMAN	Nectin-2 Nectin-2	NECTIN2	56	Annotation score:
K7ERL3	K7ERL3_HUMAN	Nectin-2 Nectin-2	NECTIN2	54	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform Alpha (identifier: Q92692-2)
Sequence conflictⁱ	410	P → L in BAF84019 (PubMed:14702039).Combined sourcesCurated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002628	351 – 479	NTAGA…GSPIP → RASPRDVGPLVWGAVGGTLL VLLLLAGGSLAFILLRVRRR RKSPGGAGGGASGDGGFYDP KAQVLGNGDPVFWTPVVPGP MEPDGKDEEEEEEEEKAEKG LMLPPPPALEDDMESQLDGS LISRRAVYV in isoform Alpha. 4 PublicationsAdd BLAST		129
Alternative sequenceⁱVSP_002629	480 – 538	Missing in isoform Alpha. 4 PublicationsAdd BLAST		59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80038 mRNA Translation: CAA56342.1 AF058448 mRNA Translation: AAC23797.1 AK291330 mRNA Translation: BAF84019.1 CR456818 mRNA Translation: CAG33099.1 CH471126 Genomic DNA Translation: EAW57298.1 BC003091 mRNA Translation: AAH03091.1 AF044968 AF044967 Genomic DNA Translation: AAC82348.1 AF050154 Genomic DNA Translation: AAD02503.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12645.1 [Q92692-2] CCDS42576.1 [Q92692-1]
PIRⁱ	I68093
NCBI Reference Sequences More...RefSeqⁱ	NP_001036189.1, NM_001042724.1 [Q92692-1] NP_002847.1, NM_002856.2 [Q92692-2]
UniGeneⁱ	Hs.655455

Genome annotation databases

Ensemblⁱ	ENST00000252483; ENSP00000252483; ENSG00000130202 [Q92692-1] ENST00000252485; ENSP00000252485; ENSG00000130202 [Q92692-2]
GeneIDⁱ	5819
KEGGⁱ	hsa:5819
UCSC genome browser More...UCSCⁱ	uc002ozv.4 human [Q92692-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92692	Poliovirus receptor related 2 (Fragment)		HUMAN		159	UniRef100_Q92692
Q92692-2	Polio virus related protein 2, alpha isoform (Fragment)		HUMAN		449	UniRef100_Q92692-2

Protein	Similar proteins		Species	Score	Length	Source
Q92692	Poliovirus receptor related 2 (Fragment)		HUMAN		159	UniRef90_Q92692
Uncharacterized protein		RHIBE		573
Poliovirus receptor-related protein 2 isoform delta (Fragment)		MACMU		40
Uncharacterized protein		COLAP		549
Uncharacterized protein		MANLE		546
+31
Q92692-2	Polio virus related protein 2, alpha isoform (Fragment)		HUMAN		449	UniRef90_Q92692-2
Nectin cell adhesion molecule 2		CALJA		485
Uncharacterized protein		Cebus capucinus imitator		485
Nectin cell adhesion molecule 2		GORGO		481
Poliovirus receptor-related protein 2 isoform alpha (Fragment)		MACMU		44
+11

Protein	Similar proteins		Species	Score	Length	Source
Q92692	Poliovirus receptor related 2 (Fragment)		HUMAN		159	UniRef50_Q92692
Uncharacterized protein		RHIBE		573
Poliovirus receptor-related protein 2 isoform delta (Fragment)		MACMU		40
Uncharacterized protein		COLAP		549
Uncharacterized protein		MANLE		546
+87
Q92692-2	Nectin-2	)	MOUSE		530	UniRef50_Q92692-2
Polio virus related protein 2, alpha isoform (Fragment)		HUMAN		449
Uncharacterized protein		Cebus capucinus imitator		485
Nectin cell adhesion molecule 2		CALJA		485
Nectin cell adhesion molecule 2		GORGO		481
+171

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X80038 mRNA Translation: CAA56342.1 AF058448 mRNA Translation: AAC23797.1 AK291330 mRNA Translation: BAF84019.1 CR456818 mRNA Translation: CAG33099.1 CH471126 Genomic DNA Translation: EAW57298.1 BC003091 mRNA Translation: AAH03091.1 AF044968 AF044967 Genomic DNA Translation: AAC82348.1 AF050154 Genomic DNA Translation: AAD02503.1
CCDSⁱ	CCDS12645.1 [Q92692-2] CCDS42576.1 [Q92692-1]
PIRⁱ	I68093
RefSeqⁱ	NP_001036189.1, NM_001042724.1 [Q92692-1] NP_002847.1, NM_002856.2 [Q92692-2]
UniGeneⁱ	Hs.655455

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3R0N	X-ray	1.30	A	32-158	[»]
	4DFH	X-ray	1.85	A/B	32-158	[»]
	4DFI	X-ray	1.80	A	32-158	[»]
	4HZA	X-ray	1.70	A/B	32-158	[»]
	5V52	X-ray	3.10	C/D	32-158	[»]
ProteinModelPortalⁱ	Q92692
SMRⁱ	Q92692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111777, 43 interactors
DIPⁱ	DIP-41043N
IntActⁱ	Q92692, 37 interactors
MINTⁱ	Q92692
STRINGⁱ	9606.ENSP00000252483

PTM databases

GlyConnectⁱ	1537
iPTMnetⁱ	Q92692
PhosphoSitePlusⁱ	Q92692
SwissPalmⁱ	Q92692

Polymorphism and mutation databases

BioMutaⁱ	PVRL2
DMDMⁱ	12643789

Proteomic databases

EPDⁱ	Q92692
MaxQBⁱ	Q92692
PaxDbⁱ	Q92692
PeptideAtlasⁱ	Q92692
PRIDEⁱ	Q92692
ProteomicsDBⁱ	75411 75412 [Q92692-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5819
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000252483; ENSP00000252483; ENSG00000130202 [Q92692-1] ENST00000252485; ENSP00000252485; ENSG00000130202 [Q92692-2]
GeneIDⁱ	5819
KEGGⁱ	hsa:5819
UCSCⁱ	uc002ozv.4 human [Q92692-1]

Organism-specific databases

CTDⁱ	5819
DisGeNETⁱ	5819
EuPathDBⁱ	HostDB:ENSG00000130202.9
GeneCardsⁱ	NECTIN2
HGNCⁱ	HGNC:9707 NECTIN2
HPAⁱ	CAB026138 HPA012759 HPA073459
MIMⁱ	600798 gene
neXtProtⁱ	NX_Q92692
OpenTargetsⁱ	ENSG00000130202
PharmGKBⁱ	PA34052
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIB8 Eukaryota ENOG4111FZM LUCA
GeneTreeⁱ	ENSGT00900000140811
HOGENOMⁱ	HOG000237277
HOVERGENⁱ	HBG019169
InParanoidⁱ	Q92692
KOⁱ	K06531
OMAⁱ	KDDMESH
OrthoDBⁱ	EOG091G0CPW
PhylomeDBⁱ	Q92692
TreeFamⁱ	TF331051

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-418990 Adherens junctions interactions R-HSA-420597 Nectin/Necl trans heterodimerization

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-418990 Adherens junctions interactions
R-HSA-420597 Nectin/Necl trans heterodimerization

Miscellaneous databases

ChiTaRSⁱ	NECTIN2 human
EvolutionaryTraceⁱ	Q92692
GeneWikiⁱ	PVRL2
GenomeRNAiⁱ	5819
Protein Ontology More...PROⁱ	PR:Q92692
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130202 Expressed in 214 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_PVRL2
ExpressionAtlasⁱ	Q92692 baseline and differential
Genevisibleⁱ	Q92692 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR033318 Nectin-2
PANTHERⁱ	PTHR23277:SF63 PTHR23277:SF63, 1 hit
Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NECT2_HUMAN
Accessionⁱ	Q92692Primary (citable) accession number: Q92692 Secondary accession number(s): A8K5L5 , O75455, Q6IBI6, Q96J29
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - Q92692 (NECT2_HUMAN)

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Nectin-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

PTM databases

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Gene expression databases

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GO - Molecular functioni

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

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Enzyme and pathway databases

Miscellaneous databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ