UniProtKB - Q92692 (NECT2_HUMAN)
Nectin-2
NECTIN2
Functioni
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- coreceptor activity Source: ProtInc
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- acrosome assembly Source: GO_Central
- adherens junction organization Source: Reactome
- adhesion of symbiont to host Source: BHF-UCL
- cell part morphogenesis Source: Ensembl
- cilium organization Source: Ensembl
- coreceptor-mediated virion attachment to host cell Source: BHF-UCL
- cytoskeleton organization Source: GO_Central
- establishment of mitochondrion localization Source: GO_Central
- fertilization Source: Ensembl
- fusion of virus membrane with host plasma membrane Source: BHF-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
- positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
- positive regulation of mast cell activation Source: BHF-UCL
- positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
- positive regulation of T cell receptor signaling pathway Source: UniProtKB
- regulation of immune response Source: Reactome
- regulation of viral entry into host cell Source: CACAO
- spermatid development Source: BHF-UCL
- spermatid nucleus differentiation Source: Ensembl
- sperm mitochondrion organization Source: Ensembl
- susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
- susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Cell adhesion, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q92692 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-418990, Adherens junctions interactions R-HSA-420597, Nectin/Necl trans heterodimerization |
SIGNORi | Q92692 |
Names & Taxonomyi
Protein namesi | Recommended name: Nectin-2Alternative name(s): Herpes virus entry mediator B Short name: Herpesvirus entry mediator B Short name: HveB Nectin cell adhesion molecule 2Imported Poliovirus receptor-related protein 2 CD_antigen: CD112 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9707, NECTIN2 |
MIMi | 600798, gene |
neXtProti | NX_Q92692 |
VEuPathDBi | HostDB:ENSG00000130202.9 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- apical junction complex Source: GO_Central
- cell surface Source: BHF-UCL
- cell-cell contact zone Source: Ensembl
- cell-cell junction Source: BHF-UCL
- focal adhesion Source: UniProtKB
- integral component of membrane Source: BHF-UCL
- zonula adherens Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 360 | ExtracellularSequence analysisAdd BLAST | 329 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 382 – 538 | CytoplasmicSequence analysisAdd BLAST | 157 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 81 | N → A: Abolishes homodimerization. 1 Publication | 1 | |
Mutagenesisi | 89 | M → F: Loss of entry of HHV-1/Rid1 and HSV-2. No effect on PRV entry. 1 Publication | 1 | |
Mutagenesisi | 89 | M → I: Increased entry of HHV-1/Rid1 and HSV-2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5819 |
OpenTargetsi | ENSG00000130202 |
PharmGKBi | PA34052 |
Miscellaneous databases
Pharosi | Q92692, Tbio |
Genetic variation databases
BioMutai | NECTIN2 |
DMDMi | 12643789 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000015136 | 32 – 538 | Nectin-2Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 54 ↔ 140 | PROSITE-ProRule annotation1 Publication | |||
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 183 ↔ 238 | PROSITE-ProRule annotation | |||
Disulfide bondi | 283 ↔ 329 | PROSITE-ProRule annotation | |||
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Modified residuei | 410 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 433 | PhosphoserineCombined sources | 1 | ||
Isoform Alpha (identifier: Q92692-2) | |||||
Modified residuei | 465 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 470 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q92692 |
jPOSTi | Q92692 |
MassIVEi | Q92692 |
MaxQBi | Q92692 |
PaxDbi | Q92692 |
PeptideAtlasi | Q92692 |
PRIDEi | Q92692 |
ProteomicsDBi | 75411 [Q92692-1] 75412 [Q92692-2] |
PTM databases
GlyConnecti | 1537, 2 N-Linked glycans (1 site) |
GlyGeni | Q92692, 2 sites |
iPTMneti | Q92692 |
PhosphoSitePlusi | Q92692 |
SwissPalmi | Q92692 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130202, Expressed in lower esophagus mucosa and 227 other tissues |
ExpressionAtlasi | Q92692, baseline and differential |
Genevisiblei | Q92692, HS |
Organism-specific databases
HPAi | ENSG00000130202, Low tissue specificity |
Interactioni
Subunit structurei
Can form trans-heterodimers with NECTIN3 (By similarity).
Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT.
By similarity3 PublicationsBinary interactionsi
Hide detailsQ92692
Isoform Alpha [Q92692-2]
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111777, 75 interactors |
DIPi | DIP-41043N |
IntActi | Q92692, 55 interactors |
MINTi | Q92692 |
STRINGi | 9606.ENSP00000252483 |
Miscellaneous databases
RNActi | Q92692, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92692 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92692 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 156 | Ig-like V-typeAdd BLAST | 125 | |
Domaini | 162 – 256 | Ig-like C2-type 1Add BLAST | 95 | |
Domaini | 261 – 345 | Ig-like C2-type 2Add BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000161167 |
HOGENOMi | CLU_029618_0_1_1 |
InParanoidi | Q92692 |
OMAi | KDDMESH |
OrthoDBi | 1087343at2759 |
PhylomeDBi | Q92692 |
TreeFami | TF331051 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR033318, Nectin-2 |
PANTHERi | PTHR47387:SF1, PTHR47387:SF1, 1 hit |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV
60 70 80 90 100
ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS
110 120 130 140 150
ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV
160 170 180 190 200
RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL
210 220 230 240 250
DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL
260 270 280 290 300
IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS
310 320 330 340 350
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP
360 370 380 390 400
NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL
410 420 430 440 450
EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE
460 470 480 490 500
MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE
510 520 530
EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV
The sequence of this isoform differs from the canonical sequence as follows:
351-479: NTAGAGATGG...GATSLGSPIP → RASPRDVGPL...SLISRRAVYV
480-538: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKE8 | K7EKE8_HUMAN | Nectin-2 | NECTIN2 | 210 | Annotation score: | ||
K7EK87 | K7EK87_HUMAN | Nectin-2 | NECTIN2 | 56 | Annotation score: | ||
K7ERL3 | K7ERL3_HUMAN | Nectin-2 | NECTIN2 | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform Alpha (identifier: Q92692-2) | |||||
Sequence conflicti | 410 | P → L in BAF84019 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002628 | 351 – 479 | NTAGA…GSPIP → RASPRDVGPLVWGAVGGTLL VLLLLAGGSLAFILLRVRRR RKSPGGAGGGASGDGGFYDP KAQVLGNGDPVFWTPVVPGP MEPDGKDEEEEEEEEKAEKG LMLPPPPALEDDMESQLDGS LISRRAVYV in isoform Alpha. 4 PublicationsAdd BLAST | 129 | |
Alternative sequenceiVSP_002629 | 480 – 538 | Missing in isoform Alpha. 4 PublicationsAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80038 mRNA Translation: CAA56342.1 AF058448 mRNA Translation: AAC23797.1 AK291330 mRNA Translation: BAF84019.1 CR456818 mRNA Translation: CAG33099.1 CH471126 Genomic DNA Translation: EAW57298.1 BC003091 mRNA Translation: AAH03091.1 AF044968 , AF044962, AF044963, AF044964, AF044966, AF044967 Genomic DNA Translation: AAC82348.1 AF050154 Genomic DNA Translation: AAD02503.1 |
CCDSi | CCDS12645.1 [Q92692-2] CCDS42576.1 [Q92692-1] |
PIRi | I68093 |
RefSeqi | NP_001036189.1, NM_001042724.1 [Q92692-1] NP_002847.1, NM_002856.2 [Q92692-2] |
Genome annotation databases
Ensembli | ENST00000252483; ENSP00000252483; ENSG00000130202 [Q92692-1] ENST00000252485; ENSP00000252485; ENSG00000130202 [Q92692-2] |
GeneIDi | 5819 |
KEGGi | hsa:5819 |
UCSCi | uc002ozv.4, human [Q92692-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80038 mRNA Translation: CAA56342.1 AF058448 mRNA Translation: AAC23797.1 AK291330 mRNA Translation: BAF84019.1 CR456818 mRNA Translation: CAG33099.1 CH471126 Genomic DNA Translation: EAW57298.1 BC003091 mRNA Translation: AAH03091.1 AF044968 , AF044962, AF044963, AF044964, AF044966, AF044967 Genomic DNA Translation: AAC82348.1 AF050154 Genomic DNA Translation: AAD02503.1 |
CCDSi | CCDS12645.1 [Q92692-2] CCDS42576.1 [Q92692-1] |
PIRi | I68093 |
RefSeqi | NP_001036189.1, NM_001042724.1 [Q92692-1] NP_002847.1, NM_002856.2 [Q92692-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3R0N | X-ray | 1.30 | A | 32-158 | [»] | |
4DFH | X-ray | 1.85 | A/B | 32-158 | [»] | |
4DFI | X-ray | 1.80 | A | 32-158 | [»] | |
4HZA | X-ray | 1.70 | A/B | 32-158 | [»] | |
5V52 | X-ray | 3.10 | C/D | 32-158 | [»] | |
SMRi | Q92692 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111777, 75 interactors |
DIPi | DIP-41043N |
IntActi | Q92692, 55 interactors |
MINTi | Q92692 |
STRINGi | 9606.ENSP00000252483 |
PTM databases
GlyConnecti | 1537, 2 N-Linked glycans (1 site) |
GlyGeni | Q92692, 2 sites |
iPTMneti | Q92692 |
PhosphoSitePlusi | Q92692 |
SwissPalmi | Q92692 |
Genetic variation databases
BioMutai | NECTIN2 |
DMDMi | 12643789 |
Proteomic databases
EPDi | Q92692 |
jPOSTi | Q92692 |
MassIVEi | Q92692 |
MaxQBi | Q92692 |
PaxDbi | Q92692 |
PeptideAtlasi | Q92692 |
PRIDEi | Q92692 |
ProteomicsDBi | 75411 [Q92692-1] 75412 [Q92692-2] |
Protocols and materials databases
Antibodypediai | 2425, 548 antibodies |
DNASUi | 5819 |
Genome annotation databases
Ensembli | ENST00000252483; ENSP00000252483; ENSG00000130202 [Q92692-1] ENST00000252485; ENSP00000252485; ENSG00000130202 [Q92692-2] |
GeneIDi | 5819 |
KEGGi | hsa:5819 |
UCSCi | uc002ozv.4, human [Q92692-1] |
Organism-specific databases
CTDi | 5819 |
DisGeNETi | 5819 |
GeneCardsi | NECTIN2 |
HGNCi | HGNC:9707, NECTIN2 |
HPAi | ENSG00000130202, Low tissue specificity |
MIMi | 600798, gene |
neXtProti | NX_Q92692 |
OpenTargetsi | ENSG00000130202 |
PharmGKBi | PA34052 |
VEuPathDBi | HostDB:ENSG00000130202.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000161167 |
HOGENOMi | CLU_029618_0_1_1 |
InParanoidi | Q92692 |
OMAi | KDDMESH |
OrthoDBi | 1087343at2759 |
PhylomeDBi | Q92692 |
TreeFami | TF331051 |
Enzyme and pathway databases
PathwayCommonsi | Q92692 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-418990, Adherens junctions interactions R-HSA-420597, Nectin/Necl trans heterodimerization |
SIGNORi | Q92692 |
Miscellaneous databases
BioGRID-ORCSi | 5819, 10 hits in 872 CRISPR screens |
ChiTaRSi | NECTIN2, human |
EvolutionaryTracei | Q92692 |
GeneWikii | PVRL2 |
GenomeRNAii | 5819 |
Pharosi | Q92692, Tbio |
PROi | PR:Q92692 |
RNActi | Q92692, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130202, Expressed in lower esophagus mucosa and 227 other tissues |
ExpressionAtlasi | Q92692, baseline and differential |
Genevisiblei | Q92692, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR033318, Nectin-2 |
PANTHERi | PTHR47387:SF1, PTHR47387:SF1, 1 hit |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NECT2_HUMAN | |
Accessioni | Q92692Primary (citable) accession number: Q92692 Secondary accession number(s): A8K5L5 Q96J29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries