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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene

ANP32B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • RNA polymerase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

SIGNORiQ92688

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Alternative name(s):
Acidic protein rich in leucines
Putative HLA-DR-associated protein I-2
Short name:
PHAPI2
Silver-stainable protein SSP29
Gene namesi
Name:ANP32B
Synonyms:APRIL, PHAPI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136938.8
HGNCiHGNC:16677 ANP32B
neXtProtiNX_Q92688

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10541
OpenTargetsiENSG00000136938
PharmGKBiPA24812

Polymorphism and mutation databases

BioMutaiANP32B
DMDMi26390818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375951 – 251Acidic leucine-rich nuclear phosphoprotein 32 family member BAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86N6-acetyllysineCombined sources1
Modified residuei158PhosphoserineBy similarity1
Modified residuei244PhosphothreonineCombined sources1

Post-translational modificationi

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92688
MaxQBiQ92688
PaxDbiQ92688
PeptideAtlasiQ92688
PRIDEiQ92688
ProteomicsDBi75409
75410 [Q92688-2]
TopDownProteomicsiQ92688-1 [Q92688-1]
Q92688-2 [Q92688-2]

PTM databases

CarbonylDBiQ92688
iPTMnetiQ92688
PhosphoSitePlusiQ92688
SwissPalmiQ92688

Miscellaneous databases

PMAP-CutDBiQ92688

Expressioni

Tissue specificityi

Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.1 Publication

Gene expression databases

BgeeiENSG00000136938 Expressed in 240 organ(s), highest expression level in amniotic fluid
CleanExiHS_ANP32B
GenevisibleiQ92688 HS

Organism-specific databases

HPAiHPA063133
HPA067561

Interactioni

Subunit structurei

Monomer. Interacts with histones H3 and H4.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115795, 57 interactors
IntActiQ92688, 42 interactors
MINTiQ92688
STRINGi9606.ENSP00000345848

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92688
SMRiQ92688
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92688

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 40LRR 11 PublicationAdd BLAST25
Repeati43 – 64LRR 21 PublicationAdd BLAST22
Repeati65 – 84LRR 31 PublicationAdd BLAST20
Repeati89 – 110LRR 41 PublicationAdd BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 251Asp/Glu-rich (highly acidic)Add BLAST106

Domaini

Histone binding is mediated by the concave surface of the LRR region.

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiQ92688
KOiK18647
OMAiEEDFGQD
OrthoDBiEOG091G0R8Z
PhylomeDBiQ92688
TreeFamiTF317206

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q92688-1) [UniParc]FASTAAdd to basket
Also known as: Anp32b1, PHAPI2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMKRRIHLE LRNRTPAAVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI
60 70 80 90 100
NVGLISVSNL PKLPKLKKLE LSENRIFGGL DMLAEKLPNL THLNLSGNKL
110 120 130 140 150
KDISTLEPLK KLECLKSLDL FNCEVTNLND YRESVFKLLP QLTYLDGYDR
160 170 180 190 200
EDQEAPDSDA EVDGVDEEEE DEEGEDEEDE DDEDGEEEEF DEEDDEDEDV
210 220 230 240 250
EGDEDDDEVS EEEEEFGLDE EDEDEDEDEE EEEGGKGEKR KRETDDEGED

D
Length:251
Mass (Da):28,788
Last modified:February 1, 1997 - v1
Checksum:i93A1AADF8EDE7D53
GO
Isoform 2 (identifier: Q92688-2) [UniParc]FASTAAdd to basket
Also known as: Anp32b2, PHAPI2b

The sequence of this isoform differs from the canonical sequence as follows:
     196-251: Missing.

Note: No canonical donor splice site.
Show »
Length:195
Mass (Da):22,277
Checksum:iC504A0E604F16F73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 2Missing in CAA69265 (PubMed:9473664).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019304196 – 251Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07569 mRNA Translation: CAA68855.1
U70439 mRNA Translation: AAB37579.1
Y07969 mRNA Translation: CAA69265.1
Y07570 mRNA Translation: CAA68856.1
AK313733 mRNA Translation: BAG36474.1
AL354726 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58865.1
BC013003 mRNA Translation: AAH13003.1
BC019658 mRNA Translation: AAH19658.1
CCDSiCCDS6732.1 [Q92688-1]
RefSeqiNP_006392.1, NM_006401.2 [Q92688-1]
UniGeneiHs.730654

Genome annotation databases

EnsembliENST00000339399; ENSP00000345848; ENSG00000136938 [Q92688-1]
GeneIDi10541
KEGGihsa:10541
UCSCiuc004aya.4 human [Q92688-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07569 mRNA Translation: CAA68855.1
U70439 mRNA Translation: AAB37579.1
Y07969 mRNA Translation: CAA69265.1
Y07570 mRNA Translation: CAA68856.1
AK313733 mRNA Translation: BAG36474.1
AL354726 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58865.1
BC013003 mRNA Translation: AAH13003.1
BC019658 mRNA Translation: AAH19658.1
CCDSiCCDS6732.1 [Q92688-1]
RefSeqiNP_006392.1, NM_006401.2 [Q92688-1]
UniGeneiHs.730654

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ELLNMR-A1-161[»]
2RR6NMR-A1-161[»]
ProteinModelPortaliQ92688
SMRiQ92688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115795, 57 interactors
IntActiQ92688, 42 interactors
MINTiQ92688
STRINGi9606.ENSP00000345848

PTM databases

CarbonylDBiQ92688
iPTMnetiQ92688
PhosphoSitePlusiQ92688
SwissPalmiQ92688

Polymorphism and mutation databases

BioMutaiANP32B
DMDMi26390818

Proteomic databases

EPDiQ92688
MaxQBiQ92688
PaxDbiQ92688
PeptideAtlasiQ92688
PRIDEiQ92688
ProteomicsDBi75409
75410 [Q92688-2]
TopDownProteomicsiQ92688-1 [Q92688-1]
Q92688-2 [Q92688-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339399; ENSP00000345848; ENSG00000136938 [Q92688-1]
GeneIDi10541
KEGGihsa:10541
UCSCiuc004aya.4 human [Q92688-1]

Organism-specific databases

CTDi10541
DisGeNETi10541
EuPathDBiHostDB:ENSG00000136938.8
GeneCardsiANP32B
HGNCiHGNC:16677 ANP32B
HPAiHPA063133
HPA067561
neXtProtiNX_Q92688
OpenTargetsiENSG00000136938
PharmGKBiPA24812
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiQ92688
KOiK18647
OMAiEEDFGQD
OrthoDBiEOG091G0R8Z
PhylomeDBiQ92688
TreeFamiTF317206

Enzyme and pathway databases

SIGNORiQ92688

Miscellaneous databases

ChiTaRSiANP32B human
EvolutionaryTraceiQ92688
GeneWikiiANP32B
GenomeRNAii10541
PMAP-CutDBiQ92688
PROiPR:Q92688

Gene expression databases

BgeeiENSG00000136938 Expressed in 240 organ(s), highest expression level in amniotic fluid
CleanExiHS_ANP32B
GenevisibleiQ92688 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAN32B_HUMAN
AccessioniPrimary (citable) accession number: Q92688
Secondary accession number(s): B2R9C7
, O00655, P78458, P78459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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