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Protein

Neurogranin

Gene

NRGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38Crucial for interaction with calmodulinBy similarity1

GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • phosphatidic acid binding Source: Ensembl
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl

GO - Biological processi

  • associative learning Source: Ensembl
  • nervous system development Source: ProtInc
  • positive regulation of long-term synaptic potentiation Source: Ensembl
  • signal transduction Source: ProtInc
  • telencephalon development Source: Ensembl

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

SignaLinkiQ92686
SIGNORiQ92686

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogranin
Short name:
Ng
Alternative name(s):
RC3
Cleaved into the following chain:
Gene namesi
Name:NRGN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000154146.12
HGNCiHGNC:8000 NRGN
MIMi602350 gene
neXtProtiNX_Q92686

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4900
OpenTargetsiENSG00000154146
Orphaneti3140 Schizophrenia
PharmGKBiPA31779

Polymorphism and mutation databases

BioMutaiNRGN
DMDMi2498625

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595911 – 78NeurograninAdd BLAST78
PeptideiPRO_000037770355 – 78NEUG(55-78)By similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei36Phosphoserine; by PHK and PKCBy similarity1
Modified residuei68Citrulline; partial1 Publication1
Modified residuei68Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.By similarity

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ92686
PaxDbiQ92686
PeptideAtlasiQ92686
PRIDEiQ92686
ProteomicsDBi75408
TopDownProteomicsiQ92686

PTM databases

iPTMnetiQ92686
PhosphoSitePlusiQ92686

Expressioni

Tissue specificityi

In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.1 Publication

Gene expression databases

BgeeiENSG00000154146
CleanExiHS_NRGN
ExpressionAtlasiQ92686 baseline and differential
GenevisibleiQ92686 HS

Organism-specific databases

HPAiCAB006908
HPA038171

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: ProtInc

Protein-protein interaction databases

BioGridi110956, 12 interactors
IntActiQ92686, 1 interactor
STRINGi9606.ENSP00000284292

Structurei

3D structure databases

ProteinModelPortaliQ92686
SMRiQ92686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 47IQPROSITE-ProRule annotationAdd BLAST22
Domaini48 – 78Collagen-likeAdd BLAST31

Domaini

Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.By similarity

Sequence similaritiesi

Belongs to the neurogranin family.Curated

Phylogenomic databases

eggNOGiENOG410JNUP Eukaryota
ENOG41118RJ LUCA
GeneTreeiENSGT00440000039324
HOVERGENiHBG000470
InParanoidiQ92686
OMAiPQESACS
PhylomeDBiQ92686
TreeFamiTF342962

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE
60 70
RGRKGPGPGG PGGAGVARGG AGGGPSGD
Length:78
Mass (Da):7,618
Last modified:February 1, 1997 - v1
Checksum:i0D6ED790A31D5785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09689 mRNA Translation: CAA70867.1
Y15058, Y15059 Genomic DNA Translation: CAA75343.1
X99076, X99075 Genomic DNA Translation: CAA67533.1
U89165 mRNA Translation: AAB49458.1
AJ317956 Genomic DNA Translation: CAC37631.1
BT007325 mRNA Translation: AAP35989.1
BC002835 mRNA Translation: AAH02835.1
CCDSiCCDS8451.1
RefSeqiNP_001119653.1, NM_001126181.1
NP_006167.1, NM_006176.2
UniGeneiHs.524116

Genome annotation databases

EnsembliENST00000284292; ENSP00000284292; ENSG00000154146
ENST00000412681; ENSP00000399591; ENSG00000154146
GeneIDi4900
KEGGihsa:4900
UCSCiuc001qaq.3 human

Similar proteinsi

Entry informationi

Entry nameiNEUG_HUMAN
AccessioniPrimary (citable) accession number: Q92686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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