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Protein

Regulatory solute carrier protein family 1 member 1

Gene

RSC1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.3 Publications

GO - Molecular functioni

  • sodium channel inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport
R-HSA-8981373 Intestinal hexose absorption

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory solute carrier protein family 1 member 1
Alternative name(s):
Transporter regulator RS1
Short name:
hRS1
Gene namesi
Name:RSC1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000215695.1
HGNCiHGNC:10458 RSC1A1
MIMi601966 gene
neXtProtiNX_Q92681

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6248
OpenTargetsiENSG00000215695
PharmGKBiPA34872

Polymorphism and mutation databases

BioMutaiRSC1A1
DMDMi74751656

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241501 – 617Regulatory solute carrier protein family 1 member 1Add BLAST617

Proteomic databases

PaxDbiQ92681
PeptideAtlasiQ92681
PRIDEiQ92681
ProteomicsDBi75405

PTM databases

iPTMnetiQ92681
PhosphoSitePlusiQ92681

Expressioni

Tissue specificityi

Expressed in small intestine, kidney and brain.1 Publication

Gene expression databases

BgeeiENSG00000215695 Expressed in 71 organ(s), highest expression level in intestine
CleanExiHS_RSC1A1
GenevisibleiQ92681 HS

Organism-specific databases

HPAiHPA027813
HPA028676

Interactioni

Subunit structurei

Interacts with YRDC.By similarity

Protein-protein interaction databases

BioGridi112162, 10 interactors
IntActiQ92681, 2 interactors
STRINGi9606.ENSP00000341963

Structurei

3D structure databases

ProteinModelPortaliQ92681
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini571 – 611UBAPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni410 – 412Involved in post-transcriptional down-regulation of SLC5A13

Domaini

The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1.1 Publication

Phylogenomic databases

eggNOGiENOG410IJPT Eukaryota
ENOG4111B03 LUCA
GeneTreeiENSGT00390000005744
HOGENOMiHOG000049187
HOVERGENiHBG101192
InParanoidiQ92681
OMAiETREDVC
OrthoDBiEOG091G0CIP
PhylomeDBiQ92681
TreeFamiTF335675

Family and domain databases

InterProiView protein in InterPro
IPR039222 RSC1A1
IPR015940 UBA
PANTHERiPTHR15397 PTHR15397, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q92681-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLPTSDGF NHPARSSGQS PDVGNPMSLA RSVSASVCPI KPSDSDRIEP
60 70 80 90 100
KAVKALKASA EFQLNSEKKE HLSLQDLSDH ASSADHAPTD QSPAMPMQNS
110 120 130 140 150
SEEITVAGNL EKSAERSTQG LKFHLHTRQE ASLSVTSTRM HEPQMFLGEK
160 170 180 190 200
DWHPENQNLS QVSDPQQHEE PGNEQYEVAQ QKASHDQEYL CNIGDLELPE
210 220 230 240 250
ERQQNQHKIV DLEATMKGNG LPQNVDPPSA KKSIPSSECS GCSNSETFME
260 270 280 290 300
IDTAQQSLVT LLNSTGRQNA NVKNIGALDL TLDNPLMEVE TSKCNPSSEI
310 320 330 340 350
LNDSISTQDL QPPETNVEIP GTNKEYGHYS SPSLCGSCQP SVESAEESCP
360 370 380 390 400
SITAALKELH ELLVVSSKPA SENTSEEVIC QSETIAEGQT SIKDLSERWT
410 420 430 440 450
QNEHLTQNEQ CPQVSFHQAI SVSVETEKLT GTSSDTGREA VENVNFRSLG
460 470 480 490 500
DGLSTDKEGV PKSRESINKN RSVTVTSAKT SNQLHCTLGV EISPKLLAGE
510 520 530 540 550
EDALNQTSEQ TKSLSSNFIL VKDLGQGIQN SVTDRPETRE NVCPDASRPL
560 570 580 590 600
LEYEPPTSHP SSSPAILPPL IFPATDIDRI LRAGFTLQEA LGALHRVGGN
610
ADLALLVLLA KNIVVPT
Length:617
Mass (Da):66,790
Last modified:February 1, 1997 - v1
Checksum:iAAF1D6B5F3F5F27D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03967962F → L1 PublicationCorresponds to variant dbSNP:rs3766163Ensembl.1
Natural variantiVAR_039680191C → W. Corresponds to variant dbSNP:rs34091519Ensembl.1
Natural variantiVAR_039681271N → S. Corresponds to variant dbSNP:rs3738648Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82877 Genomic DNA Translation: CAA58058.1
AK314753 mRNA Translation: BAG37292.1
AL121992 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51744.1
CCDSiCCDS161.1
RefSeqiNP_006502.1, NM_006511.2
UniGeneiHs.239459
Hs.709169
Hs.718857

Genome annotation databases

EnsembliENST00000345034; ENSP00000341963; ENSG00000215695
GeneIDi6248
KEGGihsa:6248
UCSCiuc010obn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82877 Genomic DNA Translation: CAA58058.1
AK314753 mRNA Translation: BAG37292.1
AL121992 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51744.1
CCDSiCCDS161.1
RefSeqiNP_006502.1, NM_006511.2
UniGeneiHs.239459
Hs.709169
Hs.718857

3D structure databases

ProteinModelPortaliQ92681
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112162, 10 interactors
IntActiQ92681, 2 interactors
STRINGi9606.ENSP00000341963

PTM databases

iPTMnetiQ92681
PhosphoSitePlusiQ92681

Polymorphism and mutation databases

BioMutaiRSC1A1
DMDMi74751656

Proteomic databases

PaxDbiQ92681
PeptideAtlasiQ92681
PRIDEiQ92681
ProteomicsDBi75405

Protocols and materials databases

DNASUi6248
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345034; ENSP00000341963; ENSG00000215695
GeneIDi6248
KEGGihsa:6248
UCSCiuc010obn.2 human

Organism-specific databases

CTDi6248
DisGeNETi6248
EuPathDBiHostDB:ENSG00000215695.1
GeneCardsiRSC1A1
HGNCiHGNC:10458 RSC1A1
HPAiHPA027813
HPA028676
MIMi601966 gene
neXtProtiNX_Q92681
OpenTargetsiENSG00000215695
PharmGKBiPA34872
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJPT Eukaryota
ENOG4111B03 LUCA
GeneTreeiENSGT00390000005744
HOGENOMiHOG000049187
HOVERGENiHBG101192
InParanoidiQ92681
OMAiETREDVC
OrthoDBiEOG091G0CIP
PhylomeDBiQ92681
TreeFamiTF335675

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport
R-HSA-8981373 Intestinal hexose absorption

Miscellaneous databases

GenomeRNAii6248
PROiPR:Q92681
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215695 Expressed in 71 organ(s), highest expression level in intestine
CleanExiHS_RSC1A1
GenevisibleiQ92681 HS

Family and domain databases

InterProiView protein in InterPro
IPR039222 RSC1A1
IPR015940 UBA
PANTHERiPTHR15397 PTHR15397, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSCA1_HUMAN
AccessioniPrimary (citable) accession number: Q92681
Secondary accession number(s): B2RBP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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