UniProtKB - Q92674 (CENPI_HUMAN)
Centromere protein I
CENPI
Functioni
GO - Biological processi
- CENP-A containing nucleosome assembly Source: Reactome
- sex differentiation Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q92674 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: Centromere protein IShort name: CENP-I Alternative name(s): FSH primary response protein 1 Follicle-stimulating hormone primary response protein Interphase centromere complex protein 19 Leucine-rich primary response protein 1 |
Gene namesi | Name:CENPI Synonyms:FSHPRH1, ICEN19, LRPR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3968, CENPI |
MIMi | 300065, gene |
neXtProti | NX_Q92674 |
VEuPathDBi | HostDB:ENSG00000102384.13 |
Subcellular locationi
Nucleus
Other locations
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: Reactome
Other locations
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2491 |
OpenTargetsi | ENSG00000102384 |
PharmGKBi | PA28385 |
Miscellaneous databases
Pharosi | Q92674, Tbio |
Genetic variation databases
BioMutai | CENPI |
DMDMi | 77416860 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087354 | 1 – 756 | Centromere protein IAdd BLAST | 756 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q92674 |
jPOSTi | Q92674 |
MassIVEi | Q92674 |
MaxQBi | Q92674 |
PaxDbi | Q92674 |
PeptideAtlasi | Q92674 |
PRIDEi | Q92674 |
ProteomicsDBi | 75403 [Q92674-1] 75404 [Q92674-2] |
PTM databases
iPTMneti | Q92674 |
PhosphoSitePlusi | Q92674 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000102384, Expressed in lung and 164 other tissues |
ExpressionAtlasi | Q92674, baseline and differential |
Genevisiblei | Q92674, HS |
Organism-specific databases
HPAi | ENSG00000102384, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
Interacts with SENP6.
3 PublicationsBinary interactionsi
Q92674
With | #Exp. | IntAct |
---|---|---|
CEP76 [Q8TAP6] | 3 | EBI-11085153,EBI-742887 |
Protein-protein interaction databases
BioGRIDi | 108769, 21 interactors |
ComplexPortali | CPX-5646, Kinetochore CCAN complex |
CORUMi | Q92674 |
IntActi | Q92674, 15 interactors |
STRINGi | 9606.ENSP00000362018 |
Miscellaneous databases
RNActi | Q92674, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QU9H, Eukaryota |
GeneTreei | ENSGT00390000013235 |
HOGENOMi | CLU_022189_0_0_1 |
InParanoidi | Q92674 |
OMAi | LMRSTMK |
PhylomeDBi | Q92674 |
TreeFami | TF101137 |
Family and domain databases
InterProi | View protein in InterPro IPR012485, CENP-I |
Pfami | View protein in Pfam PF07778, CENP-I, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP
60 70 80 90 100
VGDYEHADDQ AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW
110 120 130 140 150
KNGLASEEID ILLNIALSGK FGNAVNTRIL KCMIPATVIS EDSVVKAVSW
160 170 180 190 200
LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ INLLYGFFFA SLQDDALCPY
210 220 230 240 250
VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS LYKFFAPALI
260 270 280 290 300
SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL
310 320 330 340 350
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL
360 370 380 390 400
LQNIHCLELP SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC
410 420 430 440 450
IWYKVNNYEH GKEFTNFLDT IIRAECFLQE GFYSCEAFLY KSLPLWDGLC
460 470 480 490 500
CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ LFFTSTIYFK CSVLQSLKEL
510 520 530 540 550
LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV GWLSTTAMRL
560 570 580 590 600
ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL
610 620 630 640 650
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC
660 670 680 690 700
LWTSKPFGKG IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES
710 720 730 740 750
PEERTVNVSS IRGKKWSWYL DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI
NCNNQY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JX01 | Q5JX01_HUMAN | Centromere protein I | CENPI | 75 | Annotation score: | ||
Q5JX02 | Q5JX02_HUMAN | Centromere protein I | CENPI | 45 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 262 – 263 | FK → LQ in CAA65884 (PubMed:8921378).Curated | 2 | |
Sequence conflicti | 389 | Y → H in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 432 | F → Y in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 450 | C → S in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 532 | S → C in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 576 | N → D in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 642 | H → Y in CAA65884 (PubMed:8921378).Curated | 1 | |
Sequence conflicti | 658 | G → A in CAA65884 (PubMed:8921378).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015797 | 523 – 756 | Missing in isoform 2. 1 PublicationAdd BLAST | 234 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97249 mRNA Translation: CAA65884.1 AL109963 Genomic DNA No translation available. BC012462 mRNA Translation: AAH12462.1 |
CCDSi | CCDS14479.1 [Q92674-1] CCDS83482.1 [Q92674-2] |
RefSeqi | NP_001305452.1, NM_001318523.1 [Q92674-2] NP_006724.2, NM_006733.3 [Q92674-1] XP_005262168.1, XM_005262111.2 [Q92674-1] XP_011529196.1, XM_011530894.2 [Q92674-1] XP_011529197.1, XM_011530895.2 [Q92674-1] XP_011529199.1, XM_011530897.2 [Q92674-1] XP_011529201.1, XM_011530899.2 [Q92674-1] |
Genome annotation databases
Ensembli | ENST00000372926; ENSP00000362017; ENSG00000102384 [Q92674-2] ENST00000372927; ENSP00000362018; ENSG00000102384 [Q92674-1] ENST00000423383; ENSP00000399274; ENSG00000102384 [Q92674-1] |
GeneIDi | 2491 |
KEGGi | hsa:2491 |
UCSCi | uc004egy.4, human [Q92674-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97249 mRNA Translation: CAA65884.1 AL109963 Genomic DNA No translation available. BC012462 mRNA Translation: AAH12462.1 |
CCDSi | CCDS14479.1 [Q92674-1] CCDS83482.1 [Q92674-2] |
RefSeqi | NP_001305452.1, NM_001318523.1 [Q92674-2] NP_006724.2, NM_006733.3 [Q92674-1] XP_005262168.1, XM_005262111.2 [Q92674-1] XP_011529196.1, XM_011530894.2 [Q92674-1] XP_011529197.1, XM_011530895.2 [Q92674-1] XP_011529199.1, XM_011530897.2 [Q92674-1] XP_011529201.1, XM_011530899.2 [Q92674-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108769, 21 interactors |
ComplexPortali | CPX-5646, Kinetochore CCAN complex |
CORUMi | Q92674 |
IntActi | Q92674, 15 interactors |
STRINGi | 9606.ENSP00000362018 |
PTM databases
iPTMneti | Q92674 |
PhosphoSitePlusi | Q92674 |
Genetic variation databases
BioMutai | CENPI |
DMDMi | 77416860 |
Proteomic databases
EPDi | Q92674 |
jPOSTi | Q92674 |
MassIVEi | Q92674 |
MaxQBi | Q92674 |
PaxDbi | Q92674 |
PeptideAtlasi | Q92674 |
PRIDEi | Q92674 |
ProteomicsDBi | 75403 [Q92674-1] 75404 [Q92674-2] |
Protocols and materials databases
Antibodypediai | 28595, 151 antibodies |
Genome annotation databases
Ensembli | ENST00000372926; ENSP00000362017; ENSG00000102384 [Q92674-2] ENST00000372927; ENSP00000362018; ENSG00000102384 [Q92674-1] ENST00000423383; ENSP00000399274; ENSG00000102384 [Q92674-1] |
GeneIDi | 2491 |
KEGGi | hsa:2491 |
UCSCi | uc004egy.4, human [Q92674-1] |
Organism-specific databases
CTDi | 2491 |
DisGeNETi | 2491 |
GeneCardsi | CENPI |
HGNCi | HGNC:3968, CENPI |
HPAi | ENSG00000102384, Tissue enhanced (lymphoid) |
MIMi | 300065, gene |
neXtProti | NX_Q92674 |
OpenTargetsi | ENSG00000102384 |
PharmGKBi | PA28385 |
VEuPathDBi | HostDB:ENSG00000102384.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU9H, Eukaryota |
GeneTreei | ENSGT00390000013235 |
HOGENOMi | CLU_022189_0_0_1 |
InParanoidi | Q92674 |
OMAi | LMRSTMK |
PhylomeDBi | Q92674 |
TreeFami | TF101137 |
Enzyme and pathway databases
PathwayCommonsi | Q92674 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 2491, 275 hits in 512 CRISPR screens |
ChiTaRSi | CENPI, human |
GeneWikii | CENPI |
GenomeRNAii | 2491 |
Pharosi | Q92674, Tbio |
PROi | PR:Q92674 |
RNActi | Q92674, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102384, Expressed in lung and 164 other tissues |
ExpressionAtlasi | Q92674, baseline and differential |
Genevisiblei | Q92674, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012485, CENP-I |
Pfami | View protein in Pfam PF07778, CENP-I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CENPI_HUMAN | |
Accessioni | Q92674Primary (citable) accession number: Q92674 Secondary accession number(s): Q5JWZ9, Q96ED0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families