UniProtKB - Q92674 (CENPI_HUMAN)

BLAST

>sp|Q92674|CENPI_HUMAN Centromere protein I OS=Homo sapiens OX=9606 GN=CENPI PE=1 SV=2
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQ
AEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGK
FGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQ
INLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLS
LYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPL
KRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELP
SQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDT
IIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQ
LFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYV
GWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSIL
NQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKG
IYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYL
DYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY

Align

Format
Add to basket Added to basket
History
Entry version 151 (07 Nov 2018)
Sequence version 2 (11 Oct 2005)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Centromere protein I

Gene

CENPI

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.2 Publications

GO - Biological processⁱ

CENP-A containing nucleosome assembly Source: Reactome
sex differentiation
Source: ProtInc
Traceable author statementⁱ
- 8921378

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Centromere protein I Short name: CENP-I Alternative name(s): FSH primary response protein 1 Follicle-stimulating hormone primary response protein Interphase centromere complex protein 19 Leucine-rich primary response protein 1
Gene namesⁱ	Name:CENPI Synonyms:FSHPRH1, ICEN19, LRPR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102384.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3968 CENPI
MIMⁱ	300065 gene
neXtProtⁱ	NX_Q92674

Keywords - Cellular componentⁱ

Centromere, Chromosome, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2491
Open Targets More...OpenTargetsⁱ	ENSG00000102384
PharmGKBⁱ	PA28385

Polymorphism and mutation databases

BioMutaⁱ	CENPI
DMDMⁱ	77416860

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087354	1 – 756	Centromere protein IAdd BLAST		756

Post-translational modificationⁱ

Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	Q92674
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92674
PaxDbⁱ	Q92674
PeptideAtlas More...PeptideAtlasⁱ	Q92674
PRIDEⁱ	Q92674
ProteomicsDBⁱ	75403 75404 [Q92674-2]

PTM databases

iPTMnetⁱ	Q92674
PhosphoSitePlusⁱ	Q92674

Expressionⁱ

Inductionⁱ

By follicle-stimulating hormone (FSH).

Gene expression databases

Bgeeⁱ	ENSG00000102384 Expressed in 147 organ(s), highest expression level in lung
CleanExⁱ	HS_CENPI
ExpressionAtlasⁱ	Q92674 baseline and differential
Genevisibleⁱ	Q92674 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061297

HPAⁱ

HPA061297

Interactionⁱ

Subunit structureⁱ

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.3 Publications

Protein-protein interaction databases

BioGridⁱ	108769, 16 interactors
CORUMⁱ	Q92674
IntActⁱ	Q92674, 8 interactors
STRINGⁱ	9606.ENSP00000362018

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92674
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CENP-I/CTF3 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEZD Eukaryota ENOG410ZT13 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013235
HOGENOMⁱ	HOG000049199
HOVERGENⁱ	HBG080256
InParanoidⁱ	Q92674
KEGG Orthology (KO) More...KOⁱ	K11501
OMAⁱ	PQKRVKN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03AH
PhylomeDBⁱ	Q92674
TreeFamⁱ	TF101137

Family and domain databases

InterProⁱ	View protein in InterPro IPR012485 CENP-I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07778 CENP-I, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92674-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP 
        60         70         80         90        100
VGDYEHADDQ AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW 
       110        120        130        140        150
KNGLASEEID ILLNIALSGK FGNAVNTRIL KCMIPATVIS EDSVVKAVSW 
       160        170        180        190        200
LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ INLLYGFFFA SLQDDALCPY 
       210        220        230        240        250
VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS LYKFFAPALI 
       260        270        280        290        300
SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL 
       310        320        330        340        350
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL 
       360        370        380        390        400
LQNIHCLELP SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC 
       410        420        430        440        450
IWYKVNNYEH GKEFTNFLDT IIRAECFLQE GFYSCEAFLY KSLPLWDGLC 
       460        470        480        490        500
CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ LFFTSTIYFK CSVLQSLKEL 
       510        520        530        540        550
LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV GWLSTTAMRL 
       560        570        580        590        600
ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL 
       610        620        630        640        650
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC 
       660        670        680        690        700
LWTSKPFGKG IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES 
       710        720        730        740        750
PEERTVNVSS IRGKKWSWYL DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI 

NCNNQY

Length:756

Mass (Da):86,720

Last modified:October 11, 2005 - v2

Checksum:ⁱA3439CF1729D7A66

Isoform 2 (identifier: Q92674-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
523-756: Missing.

« Hide

        10         20         30         40         50
MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP 
        60         70         80         90        100
VGDYEHADDQ AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW 
       110        120        130        140        150
KNGLASEEID ILLNIALSGK FGNAVNTRIL KCMIPATVIS EDSVVKAVSW 
       160        170        180        190        200
LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ INLLYGFFFA SLQDDALCPY 
       210        220        230        240        250
VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS LYKFFAPALI 
       260        270        280        290        300
SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL 
       310        320        330        340        350
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL 
       360        370        380        390        400
LQNIHCLELP SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC 
       410        420        430        440        450
IWYKVNNYEH GKEFTNFLDT IIRAECFLQE GFYSCEAFLY KSLPLWDGLC 
       460        470        480        490        500
CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ LFFTSTIYFK CSVLQSLKEL 
       510        520 
LQNWLLWLSM DIHMKPVTNS PL

Note: No experimental confirmation available.

Show »

Length:522

Mass (Da):59,813

Checksum:ⁱBAB3AA874485BD51

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JX01	Q5JX01_HUMAN	Centromere protein I Centromere protein I	CENPI	75	Annotation score:
Q5JX02	Q5JX02_HUMAN	Centromere protein I Centromere protein I	CENPI	45	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	262 – 263	FK → LQ in CAA65884 (PubMed:8921378).Curated	2
Sequence conflictⁱ	389	Y → H in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	432	F → Y in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	450	C → S in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	532	S → C in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	576	N → D in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	642	H → Y in CAA65884 (PubMed:8921378).Curated	1
Sequence conflictⁱ	658	G → A in CAA65884 (PubMed:8921378).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015797	523 – 756	Missing in isoform 2. 1 PublicationAdd BLAST		234

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97249 mRNA Translation: CAA65884.1 AL109963 Genomic DNA No translation available. BC012462 mRNA Translation: AAH12462.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14479.1 [Q92674-1] CCDS83482.1 [Q92674-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001305452.1, NM_001318523.1 [Q92674-2] NP_006724.2, NM_006733.3 [Q92674-1] XP_005262168.1, XM_005262111.2 [Q92674-1] XP_011529196.1, XM_011530894.2 [Q92674-1] XP_011529197.1, XM_011530895.2 [Q92674-1] XP_011529199.1, XM_011530897.2 [Q92674-1] XP_011529201.1, XM_011530899.2 [Q92674-1]
UniGeneⁱ	Hs.348920 Hs.737663

Genome annotation databases

Ensemblⁱ	ENST00000372926; ENSP00000362017; ENSG00000102384 [Q92674-2] ENST00000372927; ENSP00000362018; ENSG00000102384 [Q92674-1] ENST00000423383; ENSP00000399274; ENSG00000102384 [Q92674-1]
GeneIDⁱ	2491
KEGGⁱ	hsa:2491
UCSC genome browser More...UCSCⁱ	uc004egy.4 human [Q92674-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92674	FSH primary response (LRPR1 homolog, rat) 1, isoform CRA_b		HUMAN		756	UniRef100_Q92674
Centromere protein I (Fragment)		HUMAN		45
Isoform 2 of Centromere protein I		HUMAN		522
Centromere protein I (Fragment)		HUMAN		75

Protein	Similar proteins		Species	Score	Length	Source
Q92674	FSH primary response (LRPR1 homolog, rat) 1, isoform CRA_b		HUMAN		756	UniRef90_Q92674
Uncharacterized protein		PANTR		776
Centromere protein I		SAIBB		756
CENPI isoform 1		PONAB		756
Centromere protein I		MACMU		755
+45

Protein	Similar proteins		Species	Score	Length	Source
Q92674	FSH primary response (LRPR1 homolog, rat) 1, isoform CRA_b		HUMAN		756	UniRef50_Q92674
Uncharacterized protein		PANTR		776
Centromere protein I		SAIBB		756
CENPI isoform 1		PONAB		756
Centromere protein I		MACMU		755
+85

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97249 mRNA Translation: CAA65884.1 AL109963 Genomic DNA No translation available. BC012462 mRNA Translation: AAH12462.1
CCDSⁱ	CCDS14479.1 [Q92674-1] CCDS83482.1 [Q92674-2]
RefSeqⁱ	NP_001305452.1, NM_001318523.1 [Q92674-2] NP_006724.2, NM_006733.3 [Q92674-1] XP_005262168.1, XM_005262111.2 [Q92674-1] XP_011529196.1, XM_011530894.2 [Q92674-1] XP_011529197.1, XM_011530895.2 [Q92674-1] XP_011529199.1, XM_011530897.2 [Q92674-1] XP_011529201.1, XM_011530899.2 [Q92674-1]
UniGeneⁱ	Hs.348920 Hs.737663

3D structure databases

ProteinModelPortalⁱ	Q92674
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108769, 16 interactors
CORUMⁱ	Q92674
IntActⁱ	Q92674, 8 interactors
STRINGⁱ	9606.ENSP00000362018

PTM databases

iPTMnetⁱ	Q92674
PhosphoSitePlusⁱ	Q92674

Polymorphism and mutation databases

BioMutaⁱ	CENPI
DMDMⁱ	77416860

Proteomic databases

EPDⁱ	Q92674
MaxQBⁱ	Q92674
PaxDbⁱ	Q92674
PeptideAtlasⁱ	Q92674
PRIDEⁱ	Q92674
ProteomicsDBⁱ	75403 75404 [Q92674-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000372926; ENSP00000362017; ENSG00000102384 [Q92674-2] ENST00000372927; ENSP00000362018; ENSG00000102384 [Q92674-1] ENST00000423383; ENSP00000399274; ENSG00000102384 [Q92674-1]
GeneIDⁱ	2491
KEGGⁱ	hsa:2491
UCSCⁱ	uc004egy.4 human [Q92674-1]

Organism-specific databases

CTDⁱ	2491
DisGeNETⁱ	2491
EuPathDBⁱ	HostDB:ENSG00000102384.13
GeneCardsⁱ	CENPI
H-InvDBⁱ	HIX0016922
HGNCⁱ	HGNC:3968 CENPI
HPAⁱ	HPA061297
MIMⁱ	300065 gene
neXtProtⁱ	NX_Q92674
OpenTargetsⁱ	ENSG00000102384
PharmGKBⁱ	PA28385
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEZD Eukaryota ENOG410ZT13 LUCA
GeneTreeⁱ	ENSGT00390000013235
HOGENOMⁱ	HOG000049199
HOVERGENⁱ	HBG080256
InParanoidⁱ	Q92674
KOⁱ	K11501
OMAⁱ	PQKRVKN
OrthoDBⁱ	EOG091G03AH
PhylomeDBⁱ	Q92674
TreeFamⁱ	TF101137

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68877 Mitotic Prometaphase

Reactomeⁱ

Miscellaneous databases

GeneWikiⁱ	CENPI
GenomeRNAiⁱ	2491
Protein Ontology More...PROⁱ	PR:Q92674
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102384 Expressed in 147 organ(s), highest expression level in lung
CleanExⁱ	HS_CENPI
ExpressionAtlasⁱ	Q92674 baseline and differential
Genevisibleⁱ	Q92674 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012485 CENP-I
Pfamⁱ	View protein in Pfam PF07778 CENP-I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CENPI_HUMAN
Accessionⁱ	Q92674Primary (citable) accession number: Q92674 Secondary accession number(s): Q5JWZ9, Q96ED0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q92674 (CENPI_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Centromere protein I

CENPI

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ