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Protein

A-kinase anchor protein 1, mitochondrial

Gene

AKAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.

GO - Molecular functioni

  • protein kinase A regulatory subunit binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-8949215 Mitochondrial calcium ion transport
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 1, mitochondrial
Alternative name(s):
A-kinase anchor protein 149 kDa
Short name:
AKAP 1491 Publication
Dual specificity A-kinase-anchoring protein 1
Short name:
D-AKAP-1
Protein kinase A-anchoring protein 1
Short name:
PRKA1
Spermatid A-kinase anchor protein 84
Short name:
S-AKAP841 Publication
Gene namesi
Name:AKAP1
Synonyms:AKAP149, PRKA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000121057.12
HGNCiHGNC:367 AKAP1
MIMi602449 gene
neXtProtiNX_Q92667

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8165
OpenTargetsiENSG00000121057
PharmGKBiPA24661

Polymorphism and mutation databases

BioMutaiAKAP1
DMDMi8134304

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000001665930 – 903A-kinase anchor protein 1, mitochondrialAdd BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphothreonineCombined sources1
Modified residuei105PhosphoserineBy similarity1
Modified residuei107PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei533PhosphothreonineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei590PhosphothreonineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92667
MaxQBiQ92667
PaxDbiQ92667
PeptideAtlasiQ92667
PRIDEiQ92667
ProteomicsDBi75399
75400 [Q92667-2]

PTM databases

iPTMnetiQ92667
PhosphoSitePlusiQ92667
SwissPalmiQ92667

Miscellaneous databases

PMAP-CutDBiQ92667

Expressioni

Tissue specificityi

Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).2 Publications

Gene expression databases

BgeeiENSG00000121057
CleanExiHS_AKAP1
ExpressionAtlasiQ92667 baseline and differential
GenevisibleiQ92667 HS

Organism-specific databases

HPAiCAB019286
HPA008620
HPA008691

Interactioni

Subunit structurei

Interacts with SLC8A3.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase A regulatory subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113818, 37 interactors
CORUMiQ92667
ELMiQ92667
IntActiQ92667, 32 interactors
MINTiQ92667
STRINGi9606.ENSP00000337736

Structurei

3D structure databases

ProteinModelPortaliQ92667
SMRiQ92667
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini607 – 671KHPROSITE-ProRule annotationAdd BLAST65
Domaini758 – 817TudorPROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 357PKA-RII subunit binding domainAdd BLAST14

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Transit peptide, Transmembrane

Phylogenomic databases

eggNOGiKOG2279 Eukaryota
ENOG410Z0DP LUCA
GeneTreeiENSGT00390000001360
HOGENOMiHOG000013170
HOVERGENiHBG057436
InParanoidiQ92667
KOiK16518
OMAiWWFFSRK
OrthoDBiEOG091G0SWL
PhylomeDBiQ92667
TreeFamiTF105401

Family and domain databases

Gene3Di2.40.50.90, 2 hits
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR033104 Akap1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PANTHERiPTHR22948:SF18 PTHR22948:SF18, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50304 TUDOR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92667-1) [UniParc]FASTAAdd to basket
Also known as: AKAP149

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIQFRSLFP LALPGMLALL GWWWFFSRKK GHVSSHDEQQ VEAGAVQLRA
60 70 80 90 100
DPAIKEPLPV EDVCPKVVST PPSVTEPPEK ELSTVSKLPA EPPALLQTHP
110 120 130 140 150
PCRRSESSGI LPNTTDMRLR PGTRRDDSTK LELALTGGEA KSIPLECPLS
160 170 180 190 200
SPKGVLFSSK SAEVCKQDSP FSRVPRKVQP GYPVVPAEKR SSGERARETG
210 220 230 240 250
GAEGTGDAVL GEKVLEEALL SREHVLELEN SKGPSLASLE GEEDKGKSSS
260 270 280 290 300
SQVVGPVQEE EYVAEKLPSR FIESAHTELA KDDAAPAPPV ADAKAQDRGV
310 320 330 340 350
EGELGNEESL DRNEEGLDRN EEGLDRNEES LDRNEEGLDR NEEIKRAAFQ
360 370 380 390 400
IISQVISEAT EQVLATTVGK VAGRVCQASQ LQGQKEESCV PVHQKTVLGP
410 420 430 440 450
DTAEPATAEA AVAPPDAGLP LPGLPAEGSP PPKTYVSCLK SLLSSPTKDS
460 470 480 490 500
KPNISAHHIS LASCLALTTP SEELPDRAGI LVEDATCVTC MSDSSQSVPL
510 520 530 540 550
VASPGHCSDS FSTSGLEDSC TETSSSPRDK AITPPLPEST VPFSNGVLKG
560 570 580 590 600
ELSDLGAEDG WTMDAEADHS GGSDRNSMDS VDSCCSLKKT ESFQNAQAGS
610 620 630 640 650
NPKKVDLIIW EIEVPKHLVG RLIGKQGRYV SFLKQTSGAK IYISTLPYTQ
660 670 680 690 700
SVQICHIEGS QHHVDKALNL IGKKFKELNL TNIYAPPLPS LALPSLPMTS
710 720 730 740 750
WLMLPDGITV EVIVVNQVNA GHLFVQQHTH PTFHALRSLD QQMYLCYSQP
760 770 780 790 800
GIPTLPTPVE ITVICAAPGA DGAWWRAQVV ASYEETNEVE IRYVDYGGYK
810 820 830 840 850
RVKVDVLRQI RSDFVTLPFQ GAEVLLDSVM PLSDDDQFSP EADAAMSEMT
860 870 880 890 900
GNTALLAQVT SYSPTGLPLI QLWSVVGDEV VLINRSLVER GLAQWVDSYY

TSL
Length:903
Mass (Da):97,342
Last modified:February 1, 1997 - v1
Checksum:i0C906FAFFB0DBAF7
GO
Isoform 2 (identifier: Q92667-2) [UniParc]FASTAAdd to basket
Also known as: S-AKAP84

The sequence of this isoform differs from the canonical sequence as follows:
     572-593: GSDRNSMDSVDSCCSLKKTESF → VAAPPPGKRGTLITRCPGFFEC
     594-903: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:593
Mass (Da):62,921
Checksum:i3F2FC6A1381EFEC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti795D → H in AAH00729 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04967618A → V. Corresponds to variant dbSNP:rs17761023Ensembl.1
Natural variantiVAR_02451260V → M. Corresponds to variant dbSNP:rs2230770Ensembl.1
Natural variantiVAR_049677102C → Y. Corresponds to variant dbSNP:rs2230771Ensembl.1
Natural variantiVAR_049678124R → C. Corresponds to variant dbSNP:rs17833723Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002845572 – 593GSDRN…KTESF → VAAPPPGKRGTLITRCPGFF EC in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_002846594 – 903Missing in isoform 2. 1 PublicationAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97335 mRNA Translation: CAA66000.1
U34074 mRNA Translation: AAC50279.1
AK292416 mRNA Translation: BAF85105.1
CH471109 Genomic DNA Translation: EAW94515.1
CH471109 Genomic DNA Translation: EAW94516.1
CH471109 Genomic DNA Translation: EAW94518.1
BC000729 mRNA Translation: AAH00729.1
CCDSiCCDS11594.1 [Q92667-1]
PIRiI39173
RefSeqiNP_001229831.1, NM_001242902.1 [Q92667-1]
NP_001229832.1, NM_001242903.1 [Q92667-1]
NP_003479.1, NM_003488.3 [Q92667-1]
XP_005257764.1, XM_005257707.2 [Q92667-1]
XP_005257766.1, XM_005257709.2 [Q92667-1]
XP_016880678.1, XM_017025189.1 [Q92667-1]
XP_016880679.1, XM_017025190.1 [Q92667-1]
XP_016880680.1, XM_017025191.1 [Q92667-1]
UniGeneiHs.463506

Genome annotation databases

EnsembliENST00000314126; ENSP00000314075; ENSG00000121057 [Q92667-2]
ENST00000337714; ENSP00000337736; ENSG00000121057 [Q92667-1]
ENST00000481416; ENSP00000433212; ENSG00000121057 [Q92667-2]
ENST00000539273; ENSP00000443139; ENSG00000121057 [Q92667-1]
ENST00000571629; ENSP00000459968; ENSG00000121057 [Q92667-1]
ENST00000572557; ENSP00000459895; ENSG00000121057 [Q92667-1]
ENST00000621116; ENSP00000478212; ENSG00000121057 [Q92667-1]
GeneIDi8165
KEGGihsa:8165
UCSCiuc002iux.4 human [Q92667-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKAP1_HUMAN
AccessioniPrimary (citable) accession number: Q92667
Secondary accession number(s): A8K8Q1
, D3DTZ0, Q13320, Q9BW14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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