UniProtKB - Q92665 (RT31_HUMAN)
Protein
28S ribosomal protein S31, mitochondrial
Gene
MRPS31
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q92665 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q92665 |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S31, mitochondrialShort name: MRP-S31 Short name: S31mt Alternative name(s): Imogen 38 Mitochondrial small ribosomal subunit protein mS311 Publication |
Gene namesi | Name:MRPS31 Synonyms:IMOGN38 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16632, MRPS31 |
MIMi | 611992, gene |
neXtProti | NX_Q92665 |
VEuPathDBi | HostDB:ENSG00000102738.7 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial small ribosomal subunit Source: InterPro
- mitochondrion Source: HPA
Nucleus
- nucleolus Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 10240 |
OpenTargetsi | ENSG00000102738 |
PharmGKBi | PA31019 |
Miscellaneous databases
Pharosi | Q92665, Tdark |
Genetic variation databases
BioMutai | MRPS31 |
DMDMi | 93186129 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 65 | MitochondrionSequence analysisAdd BLAST | 65 | |
ChainiPRO_0000030594 | 66 – 395 | 28S ribosomal protein S31, mitochondrialAdd BLAST | 330 |
Proteomic databases
EPDi | Q92665 |
jPOSTi | Q92665 |
MassIVEi | Q92665 |
MaxQBi | Q92665 |
PaxDbi | Q92665 |
PeptideAtlasi | Q92665 |
PRIDEi | Q92665 |
ProteomicsDBi | 75398 |
PTM databases
iPTMneti | Q92665 |
MetOSitei | Q92665 |
PhosphoSitePlusi | Q92665 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102738, Expressed in bronchial epithelial cell and 248 other tissues |
Genevisiblei | Q92665, HS |
Organism-specific databases
HPAi | ENSG00000102738, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
1 PublicationBinary interactionsi
Q92665
With | #Exp. | IntAct |
---|---|---|
STAT3 [P40763] | 2 | EBI-720602,EBI-518675 |
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115534, 111 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q92665 |
IntActi | Q92665, 93 interactors |
MINTi | Q92665 |
STRINGi | 9606.ENSP00000315397 |
Miscellaneous databases
RNActi | Q92665, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mitochondrion-specific ribosomal protein mS31 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QSX9, Eukaryota |
GeneTreei | ENSGT00390000010017 |
HOGENOMi | CLU_052666_0_0_1 |
InParanoidi | Q92665 |
OMAi | EYAPKKR |
OrthoDBi | 1584591at2759 |
PhylomeDBi | Q92665 |
TreeFami | TF324305 |
Family and domain databases
InterProi | View protein in InterPro IPR026299, MRP-S31 |
PANTHERi | PTHR13231, PTHR13231, 1 hit |
Pfami | View protein in Pfam PF15433, MRP-S31, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q92665-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA
60 70 80 90 100
RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL
110 120 130 140 150
GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP
160 170 180 190 200
LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS
210 220 230 240 250
FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI
260 270 280 290 300
FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE
310 320 330 340 350
LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF
360 370 380 390
MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | T → I in AAH22045 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 132 | T → A in AAH22045 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052049 | 241 | T → M. Corresponds to variant dbSNP:rs1854421Ensembl. | 1 | |
Natural variantiVAR_061812 | 279 | D → N1 PublicationCorresponds to variant dbSNP:rs13508Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z68747 mRNA Translation: CAA92951.1 AK315248 mRNA Translation: BAG37670.1 AL355132 Genomic DNA No translation available. AL161614 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08629.1 BC022045 mRNA Translation: AAH22045.1 |
CCDSi | CCDS9372.1 |
RefSeqi | NP_005821.2, NM_005830.3 |
Genome annotation databases
Ensembli | ENST00000323563; ENSP00000315397; ENSG00000102738 |
GeneIDi | 10240 |
KEGGi | hsa:10240 |
UCSCi | uc001uxm.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z68747 mRNA Translation: CAA92951.1 AK315248 mRNA Translation: BAG37670.1 AL355132 Genomic DNA No translation available. AL161614 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08629.1 BC022045 mRNA Translation: AAH22045.1 |
CCDSi | CCDS9372.1 |
RefSeqi | NP_005821.2, NM_005830.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J9M | electron microscopy | 3.50 | AY | 1-395 | [»] | |
6NU2 | electron microscopy | 3.90 | AY | 276-383 | [»] | |
6NU3 | electron microscopy | 4.40 | AY | 1-395 | [»] | |
6RW4 | electron microscopy | 2.97 | Y | 1-395 | [»] | |
6RW5 | electron microscopy | 3.14 | Y | 1-395 | [»] | |
6VLZ | electron microscopy | 2.97 | AY | 1-395 | [»] | |
6VMI | electron microscopy | 2.96 | AY | 1-395 | [»] | |
6ZS9 | electron microscopy | 4.00 | AY | 1-395 | [»] | |
6ZSA | electron microscopy | 4.00 | AY | 1-395 | [»] | |
6ZSB | electron microscopy | 4.50 | AY | 1-395 | [»] | |
6ZSC | electron microscopy | 3.50 | AY | 1-395 | [»] | |
6ZSD | electron microscopy | 3.70 | AY | 1-395 | [»] | |
6ZSE | electron microscopy | 5.00 | AY | 1-395 | [»] | |
6ZSG | electron microscopy | 4.00 | AY | 1-395 | [»] | |
SMRi | Q92665 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115534, 111 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q92665 |
IntActi | Q92665, 93 interactors |
MINTi | Q92665 |
STRINGi | 9606.ENSP00000315397 |
PTM databases
iPTMneti | Q92665 |
MetOSitei | Q92665 |
PhosphoSitePlusi | Q92665 |
Genetic variation databases
BioMutai | MRPS31 |
DMDMi | 93186129 |
Proteomic databases
EPDi | Q92665 |
jPOSTi | Q92665 |
MassIVEi | Q92665 |
MaxQBi | Q92665 |
PaxDbi | Q92665 |
PeptideAtlasi | Q92665 |
PRIDEi | Q92665 |
ProteomicsDBi | 75398 |
Protocols and materials databases
Antibodypediai | 23335, 153 antibodies |
DNASUi | 10240 |
Genome annotation databases
Ensembli | ENST00000323563; ENSP00000315397; ENSG00000102738 |
GeneIDi | 10240 |
KEGGi | hsa:10240 |
UCSCi | uc001uxm.5, human |
Organism-specific databases
CTDi | 10240 |
DisGeNETi | 10240 |
GeneCardsi | MRPS31 |
HGNCi | HGNC:16632, MRPS31 |
HPAi | ENSG00000102738, Low tissue specificity |
MIMi | 611992, gene |
neXtProti | NX_Q92665 |
OpenTargetsi | ENSG00000102738 |
PharmGKBi | PA31019 |
VEuPathDBi | HostDB:ENSG00000102738.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSX9, Eukaryota |
GeneTreei | ENSGT00390000010017 |
HOGENOMi | CLU_052666_0_0_1 |
InParanoidi | Q92665 |
OMAi | EYAPKKR |
OrthoDBi | 1584591at2759 |
PhylomeDBi | Q92665 |
TreeFami | TF324305 |
Enzyme and pathway databases
PathwayCommonsi | Q92665 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q92665 |
Miscellaneous databases
BioGRID-ORCSi | 10240, 277 hits in 875 CRISPR screens |
ChiTaRSi | MRPS31, human |
GenomeRNAii | 10240 |
Pharosi | Q92665, Tdark |
PROi | PR:Q92665 |
RNActi | Q92665, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102738, Expressed in bronchial epithelial cell and 248 other tissues |
Genevisiblei | Q92665, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026299, MRP-S31 |
PANTHERi | PTHR13231, PTHR13231, 1 hit |
Pfami | View protein in Pfam PF15433, MRP-S31, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT31_HUMAN | |
Accessioni | Q92665Primary (citable) accession number: Q92665 Secondary accession number(s): B2RCS3, Q5VYC8, Q8WTV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | February 7, 2006 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families