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Protein

Lysophosphatidic acid receptor 1

Gene

LPAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca2+ levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).By similarity2 Publications7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Lysophosphatidic acid1 Publication1
Binding sitei210Lysophosphatidic acid1 Publication1

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc
  • lysophosphatidic acid binding Source: UniProtKB
  • lysophosphatidic acid receptor activity Source: UniProtKB
  • PDZ domain binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ92633

Chemistry databases

SwissLipidsiSLP:000001567

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1
Short name:
LPA receptor 1
Short name:
LPA-1
Alternative name(s):
Lysophosphatidic acid receptor Edg-21 Publication
Gene namesi
Name:LPAR1
Synonyms:EDG2, LPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198121.13
HGNCiHGNC:3166 LPAR1
MIMi602282 gene
neXtProtiNX_Q92633

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularAdd BLAST50
Transmembranei51 – 75Helical; Name=1Add BLAST25
Topological domaini76 – 83Cytoplasmic8
Transmembranei84 – 107Helical; Name=2Add BLAST24
Topological domaini108 – 121ExtracellularAdd BLAST14
Transmembranei122 – 144Helical; Name=3Add BLAST23
Topological domaini145 – 163CytoplasmicAdd BLAST19
Transmembranei164 – 184Helical; Name=4Add BLAST21
Topological domaini185 – 204ExtracellularAdd BLAST20
Transmembranei205 – 225Helical; Name=5Add BLAST21
Topological domaini226 – 255CytoplasmicAdd BLAST30
Transmembranei256 – 280Helical; Name=6Add BLAST25
Topological domaini281 – 294ExtracellularAdd BLAST14
Transmembranei295 – 315Helical; Name=7Add BLAST21
Topological domaini316 – 364CytoplasmicAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85Y → A: Impairs localization at the cell membrane. 1 Publication1
Mutagenesisi87L → A: Impairs localization at the cell membrane. 1 Publication1
Mutagenesisi325 – 326IL → AA: Impairs localization at the cell membrane. 1 Publication2

Organism-specific databases

DisGeNETi1902
OpenTargetsiENSG00000198121
PharmGKBiPA162394187

Chemistry databases

ChEMBLiCHEMBL3819
GuidetoPHARMACOLOGYi272

Polymorphism and mutation databases

BioMutaiLPAR1
DMDMi26454626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694171 – 364Lysophosphatidic acid receptor 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 190Combined sources
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 195Combined sources
Disulfide bondi284 ↔ 287Combined sources
Modified residuei341PhosphoserineCombined sources1
Modified residuei351PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92633
PaxDbiQ92633
PeptideAtlasiQ92633
PRIDEiQ92633
ProteomicsDBi75389

PTM databases

iPTMnetiQ92633
PhosphoSitePlusiQ92633
SwissPalmiQ92633

Expressioni

Tissue specificityi

Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).3 Publications

Gene expression databases

BgeeiENSG00000198121 Expressed in 236 organ(s), highest expression level in medial globus pallidus
CleanExiHS_LPAR1
ExpressionAtlasiQ92633 baseline and differential
GenevisibleiQ92633 HS

Organism-specific databases

HPAiHPA050667

Interactioni

Subunit structurei

Interacts with RALA and GRK2 (PubMed:19306925). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108226, 154 interactors
IntActiQ92633, 2 interactors
MINTiQ92633
STRINGi9606.ENSP00000351755

Chemistry databases

BindingDBiQ92633

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92633
SMRiQ92633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 129Lysophosphatidic acid binding1 Publication6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ92633
KOiK04289
OMAiCCQRQEN
OrthoDBiEOG091G0DD4
PhylomeDBiQ92633
TreeFamiTF330052

Family and domain databases

CDDicd15344 7tmA_LPAR1_Edg2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK
60 70 80 90 100
LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
160 170 180 190 200
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Length:364
Mass (Da):41,109
Last modified:December 6, 2002 - v3
Checksum:i4CA6262FD00DFE74
GO
Isoform 2 (identifier: Q92633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAISTSIPVISQPQ → MLLLLIPAHSSVLENE

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,346
Checksum:i91E76F133A9EB55B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AP63B1AP63_HUMAN
Lysophosphatidic acid receptor 1
LPAR1
182Annotation score:
Q6GPG7Q6GPG7_HUMAN
LPAR1 protein
LPAR1
346Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340G → S in AAC51139 (PubMed:9070858).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04941477N → S. Corresponds to variant dbSNP:rs11542862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570461 – 15MAAIS…ISQPQ → MLLLLIPAHSSVLENE in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80811 mRNA Translation: AAC51139.1
Y09479 mRNA Translation: CAA70686.1
Y09479 mRNA Translation: CAA70687.1
U78192 mRNA Translation: AAC00530.1
AY322546 mRNA Translation: AAP84359.1
AK296374 mRNA Translation: BAG59048.1
AC007157 Genomic DNA No translation available.
AL157881 Genomic DNA No translation available.
AL442064 Genomic DNA No translation available.
BC030615 mRNA Translation: AAH30615.1
BC036034 mRNA Translation: AAH36034.1
CCDSiCCDS6777.1 [Q92633-1]
PIRiJC5293
RefSeqiNP_001392.2, NM_001401.3 [Q92633-1]
NP_476500.1, NM_057159.2 [Q92633-1]
XP_005251838.1, XM_005251781.3
XP_005251839.1, XM_005251782.3 [Q92633-1]
XP_016869872.1, XM_017014383.1
XP_016869873.1, XM_017014384.1
XP_016869874.1, XM_017014385.1
XP_016869875.1, XM_017014386.1
XP_016869876.1, XM_017014387.1
XP_016869877.1, XM_017014388.1
XP_016869878.1, XM_017014389.1
XP_016869879.1, XM_017014390.1
XP_016869880.1, XM_017014391.1
XP_016869881.1, XM_017014392.1
XP_016869882.1, XM_017014393.1
XP_016869883.1, XM_017014394.1
XP_016869884.1, XM_017014395.1
XP_016869885.1, XM_017014396.1
XP_016869886.1, XM_017014397.1
XP_016869887.1, XM_017014398.1
XP_016869888.1, XM_017014399.1
XP_016869889.1, XM_017014400.1
XP_016869890.1, XM_017014401.1
XP_016869891.1, XM_017014402.1
XP_016869892.1, XM_017014403.1
XP_016869893.1, XM_017014404.1 [Q92633-1]
XP_016869894.1, XM_017014405.1
XP_016869895.1, XM_017014406.1
XP_016869896.1, XM_017014407.1
UniGeneiHs.126667
Hs.738834

Genome annotation databases

EnsembliENST00000358883; ENSP00000351755; ENSG00000198121 [Q92633-1]
ENST00000374430; ENSP00000363552; ENSG00000198121 [Q92633-1]
ENST00000374431; ENSP00000363553; ENSG00000198121 [Q92633-1]
GeneIDi1902
KEGGihsa:1902
UCSCiuc004bfa.4 human [Q92633-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80811 mRNA Translation: AAC51139.1
Y09479 mRNA Translation: CAA70686.1
Y09479 mRNA Translation: CAA70687.1
U78192 mRNA Translation: AAC00530.1
AY322546 mRNA Translation: AAP84359.1
AK296374 mRNA Translation: BAG59048.1
AC007157 Genomic DNA No translation available.
AL157881 Genomic DNA No translation available.
AL442064 Genomic DNA No translation available.
BC030615 mRNA Translation: AAH30615.1
BC036034 mRNA Translation: AAH36034.1
CCDSiCCDS6777.1 [Q92633-1]
PIRiJC5293
RefSeqiNP_001392.2, NM_001401.3 [Q92633-1]
NP_476500.1, NM_057159.2 [Q92633-1]
XP_005251838.1, XM_005251781.3
XP_005251839.1, XM_005251782.3 [Q92633-1]
XP_016869872.1, XM_017014383.1
XP_016869873.1, XM_017014384.1
XP_016869874.1, XM_017014385.1
XP_016869875.1, XM_017014386.1
XP_016869876.1, XM_017014387.1
XP_016869877.1, XM_017014388.1
XP_016869878.1, XM_017014389.1
XP_016869879.1, XM_017014390.1
XP_016869880.1, XM_017014391.1
XP_016869881.1, XM_017014392.1
XP_016869882.1, XM_017014393.1
XP_016869883.1, XM_017014394.1
XP_016869884.1, XM_017014395.1
XP_016869885.1, XM_017014396.1
XP_016869886.1, XM_017014397.1
XP_016869887.1, XM_017014398.1
XP_016869888.1, XM_017014399.1
XP_016869889.1, XM_017014400.1
XP_016869890.1, XM_017014401.1
XP_016869891.1, XM_017014402.1
XP_016869892.1, XM_017014403.1
XP_016869893.1, XM_017014404.1 [Q92633-1]
XP_016869894.1, XM_017014405.1
XP_016869895.1, XM_017014406.1
XP_016869896.1, XM_017014407.1
UniGeneiHs.126667
Hs.738834

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z34X-ray3.00A2-232[»]
A248-326[»]
4Z35X-ray2.90A2-232[»]
A248-326[»]
4Z36X-ray2.90A2-232[»]
A249-327[»]
ProteinModelPortaliQ92633
SMRiQ92633
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108226, 154 interactors
IntActiQ92633, 2 interactors
MINTiQ92633
STRINGi9606.ENSP00000351755

Chemistry databases

BindingDBiQ92633
ChEMBLiCHEMBL3819
GuidetoPHARMACOLOGYi272
SwissLipidsiSLP:000001567

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ92633
PhosphoSitePlusiQ92633
SwissPalmiQ92633

Polymorphism and mutation databases

BioMutaiLPAR1
DMDMi26454626

Proteomic databases

MaxQBiQ92633
PaxDbiQ92633
PeptideAtlasiQ92633
PRIDEiQ92633
ProteomicsDBi75389

Protocols and materials databases

DNASUi1902
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358883; ENSP00000351755; ENSG00000198121 [Q92633-1]
ENST00000374430; ENSP00000363552; ENSG00000198121 [Q92633-1]
ENST00000374431; ENSP00000363553; ENSG00000198121 [Q92633-1]
GeneIDi1902
KEGGihsa:1902
UCSCiuc004bfa.4 human [Q92633-1]

Organism-specific databases

CTDi1902
DisGeNETi1902
EuPathDBiHostDB:ENSG00000198121.13
GeneCardsiLPAR1
HGNCiHGNC:3166 LPAR1
HPAiHPA050667
MIMi602282 gene
neXtProtiNX_Q92633
OpenTargetsiENSG00000198121
PharmGKBiPA162394187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ92633
KOiK04289
OMAiCCQRQEN
OrthoDBiEOG091G0DD4
PhylomeDBiQ92633
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ92633

Miscellaneous databases

ChiTaRSiLPAR1 human
GeneWikiiLPAR1
GenomeRNAii1902
PROiPR:Q92633
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198121 Expressed in 236 organ(s), highest expression level in medial globus pallidus
CleanExiHS_LPAR1
ExpressionAtlasiQ92633 baseline and differential
GenevisibleiQ92633 HS

Family and domain databases

CDDicd15344 7tmA_LPAR1_Edg2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR1_HUMAN
AccessioniPrimary (citable) accession number: Q92633
Secondary accession number(s): B4DK36
, O00656, O00722, P78351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2002
Last modified: October 10, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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