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Entry version 178 (18 Sep 2019)
Sequence version 3 (06 Dec 2002)
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Protein

Lysophosphatidic acid receptor 1

Gene

LPAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca2+ levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).By similarity2 Publications7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39Lysophosphatidic acid1 Publication1
Binding sitei210Lysophosphatidic acid1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92633

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001567

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1
Short name:
LPA receptor 1
Short name:
LPA-1
Alternative name(s):
Lysophosphatidic acid receptor Edg-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPAR1
Synonyms:EDG2, LPA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3166 LPAR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602282 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92633

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 50ExtracellularAdd BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 75Helical; Name=1Add BLAST25
Topological domaini76 – 83Cytoplasmic8
Transmembranei84 – 107Helical; Name=2Add BLAST24
Topological domaini108 – 121ExtracellularAdd BLAST14
Transmembranei122 – 144Helical; Name=3Add BLAST23
Topological domaini145 – 163CytoplasmicAdd BLAST19
Transmembranei164 – 184Helical; Name=4Add BLAST21
Topological domaini185 – 204ExtracellularAdd BLAST20
Transmembranei205 – 225Helical; Name=5Add BLAST21
Topological domaini226 – 255CytoplasmicAdd BLAST30
Transmembranei256 – 280Helical; Name=6Add BLAST25
Topological domaini281 – 294ExtracellularAdd BLAST14
Transmembranei295 – 315Helical; Name=7Add BLAST21
Topological domaini316 – 364CytoplasmicAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi85Y → A: Impairs localization at the cell membrane. 1 Publication1
Mutagenesisi87L → A: Impairs localization at the cell membrane. 1 Publication1
Mutagenesisi325 – 326IL → AA: Impairs localization at the cell membrane. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
1902

Open Targets

More...
OpenTargetsi
ENSG00000198121

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394187

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3819

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
272

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPAR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
26454626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694171 – 364Lysophosphatidic acid receptor 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 190Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 195Combined sources
Disulfide bondi284 ↔ 287Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphoserineCombined sources1
Modified residuei351PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92633

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92633

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92633

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92633

PeptideAtlas

More...
PeptideAtlasi
Q92633

PRoteomics IDEntifications database

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PRIDEi
Q92633

ProteomicsDB human proteome resource

More...
ProteomicsDBi
4425
75389 [Q92633-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92633

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92633

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92633

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198121 Expressed in 236 organ(s), highest expression level in medial globus pallidus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92633 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92633 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050667

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RALA and GRK2 (PubMed:19306925).

Interacts with GNAQ and GNA13.

Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108226, 156 interactors

Protein interaction database and analysis system

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IntActi
Q92633, 103 interactors

Molecular INTeraction database

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MINTi
Q92633

STRING: functional protein association networks

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STRINGi
9606.ENSP00000363553

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92633

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 129Lysophosphatidic acid binding1 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000193419

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233501

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92633

KEGG Orthology (KO)

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KOi
K04289

Identification of Orthologs from Complete Genome Data

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OMAi
EQCYYNE

Database of Orthologous Groups

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OrthoDBi
989859at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92633

TreeFam database of animal gene trees

More...
TreeFami
TF330052

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15344 7tmA_LPAR1_Edg2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK
60 70 80 90 100
LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
110 120 130 140 150
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
160 170 180 190 200
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP
210 220 230 240 250
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
260 270 280 290 300
DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
310 320 330 340 350
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH
360
TILAGVHSND HSVV
Length:364
Mass (Da):41,109
Last modified:December 6, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CA6262FD00DFE74
GO
Isoform 2 (identifier: Q92633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAISTSIPVISQPQ → MLLLLIPAHSSVLENE

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,346
Checksum:i91E76F133A9EB55B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AP63B1AP63_HUMAN
Lysophosphatidic acid receptor 1
LPAR1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6GPG7Q6GPG7_HUMAN
LPAR1 protein
LPAR1
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti340G → S in AAC51139 (PubMed:9070858).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04941477N → S. Corresponds to variant dbSNP:rs11542862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570461 – 15MAAIS…ISQPQ → MLLLLIPAHSSVLENE in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U80811 mRNA Translation: AAC51139.1
Y09479 mRNA Translation: CAA70686.1
Y09479 mRNA Translation: CAA70687.1
U78192 mRNA Translation: AAC00530.1
AY322546 mRNA Translation: AAP84359.1
AK296374 mRNA Translation: BAG59048.1
AC007157 Genomic DNA No translation available.
AL157881 Genomic DNA No translation available.
AL442064 Genomic DNA No translation available.
BC030615 mRNA Translation: AAH30615.1
BC036034 mRNA Translation: AAH36034.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6777.1 [Q92633-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5293

NCBI Reference Sequences

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RefSeqi
NP_001392.2, NM_001401.3 [Q92633-1]
NP_476500.1, NM_057159.2 [Q92633-1]
XP_005251838.1, XM_005251781.3
XP_005251839.1, XM_005251782.3 [Q92633-1]
XP_016869872.1, XM_017014383.1
XP_016869873.1, XM_017014384.1
XP_016869874.1, XM_017014385.1
XP_016869875.1, XM_017014386.1
XP_016869876.1, XM_017014387.1
XP_016869877.1, XM_017014388.1
XP_016869878.1, XM_017014389.1
XP_016869879.1, XM_017014390.1
XP_016869880.1, XM_017014391.1
XP_016869881.1, XM_017014392.1
XP_016869882.1, XM_017014393.1
XP_016869883.1, XM_017014394.1
XP_016869884.1, XM_017014395.1
XP_016869885.1, XM_017014396.1
XP_016869886.1, XM_017014397.1
XP_016869887.1, XM_017014398.1
XP_016869888.1, XM_017014399.1
XP_016869889.1, XM_017014400.1
XP_016869890.1, XM_017014401.1
XP_016869891.1, XM_017014402.1
XP_016869892.1, XM_017014403.1
XP_016869893.1, XM_017014404.1 [Q92633-1]
XP_016869894.1, XM_017014405.1
XP_016869895.1, XM_017014406.1
XP_016869896.1, XM_017014407.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358883; ENSP00000351755; ENSG00000198121 [Q92633-1]
ENST00000374430; ENSP00000363552; ENSG00000198121 [Q92633-1]
ENST00000374431; ENSP00000363553; ENSG00000198121 [Q92633-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1902

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1902

UCSC genome browser

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UCSCi
uc004bfa.4 human [Q92633-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80811 mRNA Translation: AAC51139.1
Y09479 mRNA Translation: CAA70686.1
Y09479 mRNA Translation: CAA70687.1
U78192 mRNA Translation: AAC00530.1
AY322546 mRNA Translation: AAP84359.1
AK296374 mRNA Translation: BAG59048.1
AC007157 Genomic DNA No translation available.
AL157881 Genomic DNA No translation available.
AL442064 Genomic DNA No translation available.
BC030615 mRNA Translation: AAH30615.1
BC036034 mRNA Translation: AAH36034.1
CCDSiCCDS6777.1 [Q92633-1]
PIRiJC5293
RefSeqiNP_001392.2, NM_001401.3 [Q92633-1]
NP_476500.1, NM_057159.2 [Q92633-1]
XP_005251838.1, XM_005251781.3
XP_005251839.1, XM_005251782.3 [Q92633-1]
XP_016869872.1, XM_017014383.1
XP_016869873.1, XM_017014384.1
XP_016869874.1, XM_017014385.1
XP_016869875.1, XM_017014386.1
XP_016869876.1, XM_017014387.1
XP_016869877.1, XM_017014388.1
XP_016869878.1, XM_017014389.1
XP_016869879.1, XM_017014390.1
XP_016869880.1, XM_017014391.1
XP_016869881.1, XM_017014392.1
XP_016869882.1, XM_017014393.1
XP_016869883.1, XM_017014394.1
XP_016869884.1, XM_017014395.1
XP_016869885.1, XM_017014396.1
XP_016869886.1, XM_017014397.1
XP_016869887.1, XM_017014398.1
XP_016869888.1, XM_017014399.1
XP_016869889.1, XM_017014400.1
XP_016869890.1, XM_017014401.1
XP_016869891.1, XM_017014402.1
XP_016869892.1, XM_017014403.1
XP_016869893.1, XM_017014404.1 [Q92633-1]
XP_016869894.1, XM_017014405.1
XP_016869895.1, XM_017014406.1
XP_016869896.1, XM_017014407.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z34X-ray3.00A2-232[»]
A248-326[»]
4Z35X-ray2.90A2-232[»]
A248-326[»]
4Z36X-ray2.90A2-232[»]
A249-327[»]
SMRiQ92633
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108226, 156 interactors
IntActiQ92633, 103 interactors
MINTiQ92633
STRINGi9606.ENSP00000363553

Chemistry databases

BindingDBiQ92633
ChEMBLiCHEMBL3819
GuidetoPHARMACOLOGYi272
SwissLipidsiSLP:000001567

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ92633
PhosphoSitePlusiQ92633
SwissPalmiQ92633

Polymorphism and mutation databases

BioMutaiLPAR1
DMDMi26454626

Proteomic databases

jPOSTiQ92633
MassIVEiQ92633
MaxQBiQ92633
PaxDbiQ92633
PeptideAtlasiQ92633
PRIDEiQ92633
ProteomicsDBi4425
75389 [Q92633-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1902
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358883; ENSP00000351755; ENSG00000198121 [Q92633-1]
ENST00000374430; ENSP00000363552; ENSG00000198121 [Q92633-1]
ENST00000374431; ENSP00000363553; ENSG00000198121 [Q92633-1]
GeneIDi1902
KEGGihsa:1902
UCSCiuc004bfa.4 human [Q92633-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1902
DisGeNETi1902

GeneCards: human genes, protein and diseases

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GeneCardsi
LPAR1
HGNCiHGNC:3166 LPAR1
HPAiHPA050667
MIMi602282 gene
neXtProtiNX_Q92633
OpenTargetsiENSG00000198121
PharmGKBiPA162394187

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00970000193419
HOGENOMiHOG000233501
InParanoidiQ92633
KOiK04289
OMAiEQCYYNE
OrthoDBi989859at2759
PhylomeDBiQ92633
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ92633

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPAR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LPAR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1902

Pharos

More...
Pharosi
Q92633

Protein Ontology

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PROi
PR:Q92633

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198121 Expressed in 236 organ(s), highest expression level in medial globus pallidus
ExpressionAtlasiQ92633 baseline and differential
GenevisibleiQ92633 HS

Family and domain databases

CDDicd15344 7tmA_LPAR1_Edg2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPAR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92633
Secondary accession number(s): B4DK36
, O00656, O00722, P78351
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2002
Last modified: September 18, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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