UniProtKB - Q92630 (DYRK2_HUMAN)
Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2
Functioni
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
14 PublicationsCatalytic activityi
Cofactori
Protein has several cofactor binding sites:Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 251 | ATPCurated | 1 | |
Active sitei | 348 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 228 – 236 | ATPCurated | 9 | |
Nucleotide bindingi | 301 – 304 | ATPCurated | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
- positive regulation of glycogen biosynthetic process Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- smoothened signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Biological process | Apoptosis, Ubl conjugation pathway |
Ligand | ATP-binding, Magnesium, Manganese, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q92630 |
Reactomei | R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation |
SignaLinki | Q92630 |
SIGNORi | Q92630 |
Names & Taxonomyi
Protein namesi | Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC:2.7.12.11 Publication) |
Gene namesi | Name:DYRK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3093, DYRK2 |
MIMi | 603496, gene |
neXtProti | NX_Q92630 |
VEuPathDBi | HostDB:ENSG00000127334 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ribonucleoprotein complex Source: Ensembl
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 106 | T → A: Impaired ATM-mediated phosphorylation, reduced affinity with MDM2 and altered MDM2-triggered ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 189 – 191 | KKR → NNN: Impaired nuclear translocation. 1 Publication | 3 | |
Mutagenesisi | 251 | K → R: Abolishes protein serine/threonine kinase activity. 1 Publication | 1 | |
Mutagenesisi | 442 | S → A: Impaired ATM-mediated phosphorylation, reduced affinity with MDM2 and altered MDM2-triggered ubiquitination. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8445 |
OpenTargetsi | ENSG00000127334 |
PharmGKBi | PA27550 |
Miscellaneous databases
Pharosi | Q92630, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4376 |
DrugCentrali | Q92630 |
GuidetoPHARMACOLOGYi | 2011 |
Genetic variation databases
BioMutai | DYRK2 |
DMDMi | 148887370 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085936 | 1 – 601 | Dual specificity tyrosine-phosphorylation-regulated kinase 2Add BLAST | 601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | PhosphoserineCombined sources | 1 | |
Modified residuei | 106 | Phosphothreonine; by ATM1 Publication | 1 | |
Modified residuei | 381 | Phosphothreonine; by MAP3K101 Publication | 1 | |
Modified residuei | 382 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 442 | Phosphoserine; by ATM1 Publication | 1 | |
Modified residuei | 449 | Phosphoserine; by MAP3K101 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q92630 |
jPOSTi | Q92630 |
MassIVEi | Q92630 |
MaxQBi | Q92630 |
PaxDbi | Q92630 |
PeptideAtlasi | Q92630 |
PRIDEi | Q92630 |
ProteomicsDBi | 75387 [Q92630-1] 75388 [Q92630-2] |
PTM databases
GlyGeni | Q92630, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92630 |
PhosphoSitePlusi | Q92630 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000127334, Expressed in neocortex and 249 other tissues |
ExpressionAtlasi | Q92630, baseline and differential |
Genevisiblei | Q92630, HS |
Organism-specific databases
HPAi | ENSG00000127334, Low tissue specificity |
Interactioni
Subunit structurei
Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 (EDVP complex).
Interacts directly with EDD/UBR5, DDB1 and DCAF1.
Interacts with SIAH2 and MDM2.
Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
6 PublicationsBinary interactionsi
Q92630
Protein-protein interaction databases
BioGRIDi | 114023, 73 interactors |
CORUMi | Q92630 |
IntActi | Q92630, 236 interactors |
STRINGi | 9606.ENSP00000342105 |
Chemistry databases
BindingDBi | Q92630 |
Miscellaneous databases
RNActi | Q92630, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q92630 |
SMRi | Q92630 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92630 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 222 – 535 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 314 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 189 – 191 | Nuclear localization signal1 Publication | 3 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000158113 |
HOGENOMi | CLU_000288_5_13_1 |
InParanoidi | Q92630 |
OMAi | YPRYCSI |
OrthoDBi | 870358at2759 |
PhylomeDBi | Q92630 |
TreeFami | TF314624 |
Family and domain databases
Gene3Di | 3.30.10.30, 1 hit |
InterProi | View protein in InterPro IPR042521, DYRK IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI
60 70 80 90 100
ALPPLRASNA AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK
110 120 130 140 150
RTVLTTQPNG LTTVGKTGLP VVPERQLDSI HRRQGSSTSL KSMEGMGKVK
160 170 180 190 200
ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE IYFLGLNAKK RQGMTGGPNN
210 220 230 240 250
GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY DHKVHQHVAL
260 270 280 290 300
KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT
310 320 330 340 350
FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK
360 370 380 390 400
PENILLKQQG RSGIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG
410 420 430 440 450
MPIDMWSLGC ILAELLTGYP LLPGEDEGDQ LACMIELLGM PSQKLLDASK
460 470 480 490 500
RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG RSRRGKLRGP PESREWGNAL
510 520 530 540 550
KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP KPPTGEKTSV
560 570 580 590 600
KRITESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV
S
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H5L5 | F5H5L5_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK2 | 167 | Annotation score: | ||
F5GXG1 | F5GXG1_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK2 | 156 | Annotation score: | ||
A0A0A0MR56 | A0A0A0MR56_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK2 | 93 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | A → P in CAA73885 (PubMed:9748265).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040458 | 98 | S → G1 PublicationCorresponds to variant dbSNP:rs35139851Ensembl. | 1 | |
Natural variantiVAR_040459 | 198 | P → L in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1384093596Ensembl. | 1 | |
Natural variantiVAR_040460 | 245 | H → N1 PublicationCorresponds to variant dbSNP:rs34166200Ensembl. | 1 | |
Natural variantiVAR_040461 | 295 | N → S1 PublicationCorresponds to variant dbSNP:rs56293072Ensembl. | 1 | |
Natural variantiVAR_040462 | 451 | R → Q1 PublicationCorresponds to variant dbSNP:rs35688869Ensembl. | 1 | |
Natural variantiVAR_040463 | 455 | F → Y1 PublicationCorresponds to variant dbSNP:rs55774594Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026115 | 1 – 73 | Missing in isoform 2. 1 PublicationAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13493 mRNA Translation: CAA73885.1 Different initiation. AK313937 mRNA Translation: BAG36656.1 CH471054 Genomic DNA Translation: EAW97176.1 BC005809 mRNA Translation: AAH05809.1 BC006375 mRNA Translation: AAH06375.1 Y09216 mRNA Translation: CAA70418.1 |
CCDSi | CCDS8978.1 [Q92630-1] CCDS8979.1 [Q92630-2] |
RefSeqi | NP_003574.1, NM_003583.3 [Q92630-2] NP_006473.2, NM_006482.2 [Q92630-1] XP_016875521.1, XM_017020032.1 [Q92630-2] |
Genome annotation databases
Ensembli | ENST00000344096.4; ENSP00000342105.4; ENSG00000127334.11 ENST00000393555.3; ENSP00000377186.3; ENSG00000127334.11 [Q92630-2] |
GeneIDi | 8445 |
KEGGi | hsa:8445 |
MANE-Selecti | ENST00000344096.4; ENSP00000342105.4; NM_006482.3; NP_006473.2 |
UCSCi | uc001str.5, human [Q92630-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13493 mRNA Translation: CAA73885.1 Different initiation. AK313937 mRNA Translation: BAG36656.1 CH471054 Genomic DNA Translation: EAW97176.1 BC005809 mRNA Translation: AAH05809.1 BC006375 mRNA Translation: AAH06375.1 Y09216 mRNA Translation: CAA70418.1 |
CCDSi | CCDS8978.1 [Q92630-1] CCDS8979.1 [Q92630-2] |
RefSeqi | NP_003574.1, NM_003583.3 [Q92630-2] NP_006473.2, NM_006482.2 [Q92630-1] XP_016875521.1, XM_017020032.1 [Q92630-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3K2L | X-ray | 2.36 | A | 146-552 | [»] | |
3KVW | X-ray | 2.28 | A | 146-552 | [»] | |
4AZF | X-ray | 2.55 | A | 146-540 | [»] | |
5LXC | X-ray | 2.15 | A/B | 146-552 | [»] | |
5LXD | X-ray | 2.58 | A/B | 146-552 | [»] | |
5ZTN | X-ray | 2.50 | A/B | 146-552 | [»] | |
6HDP | X-ray | 2.30 | A | 146-552 | [»] | |
6HDR | X-ray | 2.20 | A | 146-552 | [»] | |
6K0J | X-ray | 2.35 | A | 212-536 | [»] | |
7AKF | X-ray | 2.60 | A | 146-552 | [»] | |
7AKH | X-ray | 2.85 | A | 146-552 | [»] | |
7DG4 | X-ray | 2.58 | A | 215-538 | [»] | |
7DH3 | X-ray | 2.33 | A | 213-538 | [»] | |
7DH9 | X-ray | 2.19 | A | 215-538 | [»] | |
7DHC | X-ray | 2.59 | A | 215-538 | [»] | |
7DHH | X-ray | 2.49 | A | 215-538 | [»] | |
7DHK | X-ray | 2.34 | A | 215-538 | [»] | |
7DHN | X-ray | 2.38 | A | 215-538 | [»] | |
7DHO | X-ray | 3.29 | A | 215-538 | [»] | |
7DHV | X-ray | 2.68 | A | 212-538 | [»] | |
7DJO | X-ray | 2.50 | A | 215-538 | [»] | |
7DL6 | X-ray | 2.65 | A | 215-538 | [»] | |
AlphaFoldDBi | Q92630 | |||||
SMRi | Q92630 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114023, 73 interactors |
CORUMi | Q92630 |
IntActi | Q92630, 236 interactors |
STRINGi | 9606.ENSP00000342105 |
Chemistry databases
BindingDBi | Q92630 |
ChEMBLi | CHEMBL4376 |
DrugCentrali | Q92630 |
GuidetoPHARMACOLOGYi | 2011 |
PTM databases
GlyGeni | Q92630, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92630 |
PhosphoSitePlusi | Q92630 |
Genetic variation databases
BioMutai | DYRK2 |
DMDMi | 148887370 |
Proteomic databases
EPDi | Q92630 |
jPOSTi | Q92630 |
MassIVEi | Q92630 |
MaxQBi | Q92630 |
PaxDbi | Q92630 |
PeptideAtlasi | Q92630 |
PRIDEi | Q92630 |
ProteomicsDBi | 75387 [Q92630-1] 75388 [Q92630-2] |
Protocols and materials databases
Antibodypediai | 16684, 333 antibodies from 37 providers |
DNASUi | 8445 |
Genome annotation databases
Ensembli | ENST00000344096.4; ENSP00000342105.4; ENSG00000127334.11 ENST00000393555.3; ENSP00000377186.3; ENSG00000127334.11 [Q92630-2] |
GeneIDi | 8445 |
KEGGi | hsa:8445 |
MANE-Selecti | ENST00000344096.4; ENSP00000342105.4; NM_006482.3; NP_006473.2 |
UCSCi | uc001str.5, human [Q92630-1] |
Organism-specific databases
CTDi | 8445 |
DisGeNETi | 8445 |
GeneCardsi | DYRK2 |
HGNCi | HGNC:3093, DYRK2 |
HPAi | ENSG00000127334, Low tissue specificity |
MIMi | 603496, gene |
neXtProti | NX_Q92630 |
OpenTargetsi | ENSG00000127334 |
PharmGKBi | PA27550 |
VEuPathDBi | HostDB:ENSG00000127334 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000158113 |
HOGENOMi | CLU_000288_5_13_1 |
InParanoidi | Q92630 |
OMAi | YPRYCSI |
OrthoDBi | 870358at2759 |
PhylomeDBi | Q92630 |
TreeFami | TF314624 |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q92630 |
Reactomei | R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation |
SignaLinki | Q92630 |
SIGNORi | Q92630 |
Miscellaneous databases
BioGRID-ORCSi | 8445, 14 hits in 1111 CRISPR screens |
ChiTaRSi | DYRK2, human |
EvolutionaryTracei | Q92630 |
GeneWikii | DYRK2 |
GenomeRNAii | 8445 |
Pharosi | Q92630, Tchem |
PROi | PR:Q92630 |
RNActi | Q92630, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127334, Expressed in neocortex and 249 other tissues |
ExpressionAtlasi | Q92630, baseline and differential |
Genevisiblei | Q92630, HS |
Family and domain databases
Gene3Di | 3.30.10.30, 1 hit |
InterProi | View protein in InterPro IPR042521, DYRK IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYRK2_HUMAN | |
Accessioni | Q92630Primary (citable) accession number: Q92630 Secondary accession number(s): B2R9V9, Q9BRB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | June 12, 2007 | |
Last modified: | May 25, 2022 | |
This is version 211 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families