Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - Q92629 (SGCD_HUMAN)

Entry version 189 (25 May 2022)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Delta-sarcoglycan

Gene

SGCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92629

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92629

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92629

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-sarcoglycan
Short name:
Delta-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name:
35DAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGCD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10807, SGCD

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601411, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92629

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170624

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 289ExtracellularSequence analysisAdd BLAST233

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy, limb-girdle, autosomal recessive 6 (LGMDR6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive degenerative myopathy initially affecting the proximal limb girdle musculature. Muscle from patients shows a complete loss of delta-sarcoglycan as well as of the others components of the sarcoglycan complex.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010396261E → K in LGMDR6. 1 PublicationCorresponds to variant dbSNP:rs121909297Ensembl.1
Cardiomyopathy, dilated 1L (CMD1L)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013181150S → A in CMD1L. 1 PublicationCorresponds to variant dbSNP:rs121909298Ensembl.1

Keywords - Diseasei

Cardiomyopathy, Disease variant, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...DisGeNETi		6444

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SGCD

MalaCards human disease database

More...MalaCardsi		SGCD
MIMi601287, phenotype
606685, phenotype

Open Targets

More...OpenTargetsi		ENSG00000170624

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		219, Delta-sarcoglycan-related limb-girdle muscular dystrophy R6
154, Familial isolated dilated cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35718

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92629, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SGCD

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276471

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001752451 – 289Delta-sarcoglycanAdd BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi263 ↔ 288Sequence analysis
Disulfide bondi265 ↔ 281Sequence analysis
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.
Disulfide bonds are present.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92629

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92629

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92629

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92629

PeptideAtlas

More...PeptideAtlasi		Q92629

PRoteomics IDEntifications database

More...PRIDEi		Q92629

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75384 [Q92629-1]
75385 [Q92629-2]
75386 [Q92629-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92629, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92629

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92629

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170624, Expressed in heart left ventricle and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92629, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92629, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170624, Tissue enhanced (heart muscle, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FLNC and DAG1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112342, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92629

Protein interaction database and analysis system

More...IntActi		Q92629, 13 interactors

Molecular INTeraction database

More...MINTi		Q92629

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338343

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92629, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q92629

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sarcoglycan beta/delta/gamma/zeta family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3950, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158509

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043450_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92629

Identification of Orthologs from Complete Genome Data

More...OMAi		XPKAVEA

Database of Orthologous Groups

More...OrthoDBi		1407024at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92629

TreeFam database of animal gene trees

More...TreeFami		TF313538

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006875, Sarcoglycan
IPR039972, Sarcoglycan_gamma/delta/zeta
IPR027661, SGCD

The PANTHER Classification System

More...PANTHERi		PTHR12939, PTHR12939, 1 hit
PTHR12939:SF6, PTHR12939:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04790, Sarcoglycan_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQEQYTHHR STMPGSVGPQ VYKVGIYGWR KRCLYFFVLL LMILILVNLA 
        60         70         80         90        100
MTIWILKVMN FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIQSRPGNA 
       110        120        130        140        150
LYFKSARNVT VNILNDQTKV LTQLITGPKA VEAYGKKFEV KTVSGKLLFS 
       160        170        180        190        200
ADNNEVVVGA ERLRVLGAEG TVFPKSIETP NVRADPFKEL RLESPTRSLV 
       210        220        230        240        250
MEAPKGVEIN AEAGNMEATC RTELRLESKD GEIKLDAAKI RLPRLPHGSY 
       260        270        280 
TPTGTRQKVF EICVCANGRL FLSQAGAGST CQINTSVCL
Length:289
Mass (Da):32,071
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB775E2427D260B7
GO
Isoform 2 (identifier: Q92629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MM

Show »
Length:290
Mass (Da):32,203
Checksum:i905E9A9B75D83682
GO
Isoform 3 (identifier: Q92629-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MM
     233-255: IKLDAAKIRLPRLPHGSYTPTGT → VRDEKDRSSKSYSFNRPTLPITG
     256-289: Missing.

Show »
Length:256
Mass (Da):28,750
Checksum:i0C8B9E567462F713
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RI34E5RI34_HUMAN
Delta-sarcoglycan
SGCD
82Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01042996R → Q1 PublicationCorresponds to variant dbSNP:rs45559835Ensembl.1
Natural variantiVAR_013181150S → A in CMD1L. 1 PublicationCorresponds to variant dbSNP:rs121909298Ensembl.1
Natural variantiVAR_010396261E → K in LGMDR6. 1 PublicationCorresponds to variant dbSNP:rs121909297Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0392451M → MM in isoform 2 and isoform 3. 4 Publications1
Alternative sequenceiVSP_039246233 – 255IKLDA…TPTGT → VRDEKDRSSKSYSFNRPTLP ITG in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_039247256 – 289Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X95191 mRNA Translation: CAA64490.1
U58331 mRNA Translation: AAC50921.1
AK292794 mRNA Translation: BAF85483.1
BX537948 mRNA Translation: CAD97916.1
BC020740 mRNA Translation: AAH20740.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47325.1 [Q92629-2]
CCDS47326.1 [Q92629-3]
CCDS47327.1 [Q92629-1]

NCBI Reference Sequences

More...RefSeqi		NP_000328.2, NM_000337.5 [Q92629-2]
NP_001121681.1, NM_001128209.1 [Q92629-1]
NP_758447.1, NM_172244.2 [Q92629-3]
XP_005266023.1, XM_005265966.4 [Q92629-2]
XP_011532923.1, XM_011534621.2 [Q92629-1]
XP_016865212.1, XM_017009723.1 [Q92629-2]
XP_016865213.1, XM_017009724.1 [Q92629-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337851.9; ENSP00000338343.4; ENSG00000170624.14 [Q92629-2]
ENST00000435422.7; ENSP00000403003.2; ENSG00000170624.14
ENST00000517913.5; ENSP00000429378.1; ENSG00000170624.14 [Q92629-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6444

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000337851.9; ENSP00000338343.4; NM_000337.6; NP_000328.2 [Q92629-2]

UCSC genome browser

More...UCSCi		uc003lwc.5, human [Q92629-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Leiden Muscular Dystrophy pages

SGCD mutations in LGMD2F/CMD1L

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95191 mRNA Translation: CAA64490.1
U58331 mRNA Translation: AAC50921.1
AK292794 mRNA Translation: BAF85483.1
BX537948 mRNA Translation: CAD97916.1
BC020740 mRNA Translation: AAH20740.1
CCDSiCCDS47325.1 [Q92629-2]
CCDS47326.1 [Q92629-3]
CCDS47327.1 [Q92629-1]
RefSeqiNP_000328.2, NM_000337.5 [Q92629-2]
NP_001121681.1, NM_001128209.1 [Q92629-1]
NP_758447.1, NM_172244.2 [Q92629-3]
XP_005266023.1, XM_005265966.4 [Q92629-2]
XP_011532923.1, XM_011534621.2 [Q92629-1]
XP_016865212.1, XM_017009723.1 [Q92629-2]
XP_016865213.1, XM_017009724.1 [Q92629-2]

3D structure databases

AlphaFoldDBiQ92629
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi112342, 65 interactors
CORUMiQ92629
IntActiQ92629, 13 interactors
MINTiQ92629
STRINGi9606.ENSP00000338343

PTM databases

GlyGeniQ92629, 3 sites
iPTMnetiQ92629
PhosphoSitePlusiQ92629

Genetic variation databases

BioMutaiSGCD
DMDMi212276471

Proteomic databases

jPOSTiQ92629
MassIVEiQ92629
MaxQBiQ92629
PaxDbiQ92629
PeptideAtlasiQ92629
PRIDEiQ92629
ProteomicsDBi75384 [Q92629-1]
75385 [Q92629-2]
75386 [Q92629-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8150, 288 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		6444

Genome annotation databases

EnsembliENST00000337851.9; ENSP00000338343.4; ENSG00000170624.14 [Q92629-2]
ENST00000435422.7; ENSP00000403003.2; ENSG00000170624.14
ENST00000517913.5; ENSP00000429378.1; ENSG00000170624.14 [Q92629-3]
GeneIDi6444
KEGGihsa:6444
MANE-SelectiENST00000337851.9; ENSP00000338343.4; NM_000337.6; NP_000328.2 [Q92629-2]
UCSCiuc003lwc.5, human [Q92629-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6444
DisGeNETi6444

GeneCards: human genes, protein and diseases

More...GeneCardsi		SGCD
GeneReviewsiSGCD
HGNCiHGNC:10807, SGCD
HPAiENSG00000170624, Tissue enhanced (heart muscle, skeletal muscle, tongue)
MalaCardsiSGCD
MIMi601287, phenotype
601411, gene
606685, phenotype
neXtProtiNX_Q92629
OpenTargetsiENSG00000170624
Orphaneti219, Delta-sarcoglycan-related limb-girdle muscular dystrophy R6
154, Familial isolated dilated cardiomyopathy
PharmGKBiPA35718
VEuPathDBiHostDB:ENSG00000170624

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3950, Eukaryota
GeneTreeiENSGT00940000158509
HOGENOMiCLU_043450_0_0_1
InParanoidiQ92629
OMAiXPKAVEA
OrthoDBi1407024at2759
PhylomeDBiQ92629
TreeFamiTF313538

Enzyme and pathway databases

PathwayCommonsiQ92629
SignaLinkiQ92629
SIGNORiQ92629

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6444, 17 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SGCD, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Delta-sarcoglycan
SGCD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6444
PharosiQ92629, Tbio

Protein Ontology

More...PROi		PR:Q92629
RNActiQ92629, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170624, Expressed in heart left ventricle and 223 other tissues
ExpressionAtlasiQ92629, baseline and differential
GenevisibleiQ92629, HS

Family and domain databases

InterProiView protein in InterPro
IPR006875, Sarcoglycan
IPR039972, Sarcoglycan_gamma/delta/zeta
IPR027661, SGCD
PANTHERiPTHR12939, PTHR12939, 1 hit
PTHR12939:SF6, PTHR12939:SF6, 1 hit
PfamiView protein in Pfam
PF04790, Sarcoglycan_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGCD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92629
Secondary accession number(s): A8K9S9, Q53XA5, Q99644
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 4, 2008
Last modified: May 25, 2022
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again