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Entry version 179 (16 Oct 2019)
Sequence version 2 (26 Feb 2008)
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Protein

Peroxidasin homolog

Gene

PXDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays low peroxidase activity and is likely to participate in H2O2 metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.15 mM for H2O21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei826Heme (covalent; via 2 links)By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei827Proton acceptorPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi828CalciumPROSITE-ProRule annotation1
    Metal bindingi907CalciumPROSITE-ProRule annotation1
    Metal bindingi909Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
    Metal bindingi911CalciumPROSITE-ProRule annotation1
    Metal bindingi913CalciumPROSITE-ProRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei977Transition state stabilizerPROSITE-ProRule annotation1
    Binding sitei980Heme (covalent; via 2 links)By similarity1
    Metal bindingi1074Iron (heme axial ligand)PROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase, Peroxidase
    Biological processHydrogen peroxide
    LigandCalcium, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.11.1.7 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2243919 Crosslinking of collagen fibrils

    Protein family/group databases

    PeroxiBase, a peroxidase database

    More...
    PeroxiBasei
    3355 HsPxd01

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Peroxidasin homolog (EC:1.11.1.7)
    Alternative name(s):
    Melanoma-associated antigen MG50
    Vascular peroxidase 1
    p53-responsive gene 2 protein
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PXDN
    Synonyms:KIAA0230, MG50, PRG2, VPO, VPO1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:14966 PXDN

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605158 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q92626

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Anterior segment dysgenesis 7 (ASGD7)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of anterior segment dysgenesis, a group of defects affecting anterior structures of the eye including cornea, iris, lens, trabecular meshwork, and Schlemm canal. Anterior segment dysgeneses result from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to components of the anterior chamber during eye development. Different anterior segment anomalies may exist alone or in combination, including iris hypoplasia, enlarged or reduced corneal diameter, corneal vascularization and opacity, posterior embryotoxon, corectopia, polycoria, abnormal iridocorneal angle, ectopia lentis, and anterior synechiae between the iris and posterior corneal surface. Clinical conditions falling within the phenotypic spectrum of anterior segment dysgeneses include aniridia, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. ASGD7 is an autosomal recessive disease.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071389880R → C in ASGD7. 1 PublicationCorresponds to variant dbSNP:rs587777572EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    7837

    MalaCards human disease database

    More...
    MalaCardsi
    PXDN
    MIMi269400 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000130508

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    289499 Congenital cataract microcornea with corneal opacity

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA128394535

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q92626

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PXDN

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    172045828

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031961927 – 1479Peroxidasin homologAdd BLAST1453

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi267 ↔ 317By similarity
    Disulfide bondi363 ↔ 412By similarity
    Disulfide bondi454 ↔ 502By similarity
    Disulfide bondi546 ↔ 594By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi732 ↔ 748By similarity
    Disulfide bondi847 ↔ 857By similarity
    Disulfide bondi851 ↔ 875By similarity
    Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi959 ↔ 970By similarity
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1176PhosphotyrosineCombined sources1
    Disulfide bondi1177 ↔ 1234By similarity
    Glycosylationi1178N-linked (GlcNAc...) asparagine1 Publication1
    Modified residuei1180PhosphoserineCombined sources1
    Disulfide bondi1275 ↔ 1301By similarity
    Glycosylationi1280N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi1368N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi1425N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q92626

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q92626

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q92626

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q92626

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q92626

    PeptideAtlas

    More...
    PeptideAtlasi
    Q92626

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q92626

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    75381 [Q92626-1]
    75382 [Q92626-2]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1600

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q92626

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q92626

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q92626

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis.4 Publications

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed in fetal liver and spleen.1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By TGFB1 in fibroblasts and up-regulated in apoptotic cells.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000130508 Expressed in 218 organ(s), highest expression level in lung

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q92626 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q92626 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA012375

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    113596, 35 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q92626, 20 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000252804

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q92626

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 63LRRNTAdd BLAST37
    <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 108LRR 1Add BLAST22
    Repeati111 – 132LRR 2Add BLAST22
    Repeati135 – 156LRR 3Add BLAST22
    Repeati159 – 180LRR 4Add BLAST22
    Domaini192 – 245LRRCTAdd BLAST54
    Domaini246 – 332Ig-like C2-type 1Add BLAST87
    Domaini342 – 428Ig-like C2-type 2Add BLAST87
    Domaini433 – 520Ig-like C2-type 3Add BLAST88
    Domaini521 – 610Ig-like C2-type 4Add BLAST90
    Domaini1413 – 1471VWFCPROSITE-ProRule annotationAdd BLAST59

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2408 Eukaryota
    ENOG410XPZ3 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157666

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000016084

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q92626

    KEGG Orthology (KO)

    More...
    KOi
    K19511

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QPIAQGH

    Database of Orthologous Groups

    More...
    OrthoDBi
    276568at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q92626

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314316

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09826 peroxidasin_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.640.10, 1 hit
    2.60.40.10, 4 hits
    3.80.10.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000483 Cys-rich_flank_reg_C
    IPR019791 Haem_peroxidase_animal
    IPR010255 Haem_peroxidase_sf
    IPR037120 Haem_peroxidase_sf_animal
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR034828 Peroxidasin
    IPR034824 Peroxidasin_peroxidase
    IPR001007 VWF_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11475:SF75 PTHR11475:SF75, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03098 An_peroxidase, 1 hit
    PF07679 I-set, 4 hits
    PF13855 LRR_8, 1 hit
    PF00093 VWC, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00457 ANPEROXIDASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00409 IG, 4 hits
    SM00408 IGc2, 4 hits
    SM00369 LRR_TYP, 5 hits
    SM00082 LRRCT, 1 hit
    SM00214 VWC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48113 SSF48113, 1 hit
    SSF48726 SSF48726, 4 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50835 IG_LIKE, 4 hits
    PS51450 LRR, 5 hits
    PS50292 PEROXIDASE_3, 1 hit
    PS01208 VWFC_1, 1 hit
    PS50184 VWFC_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: Additional isoforms seem to exist.

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q92626-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MAKRSRGPGR RCLLALVLFC AWGTLAVVAQ KPGAGCPSRC LCFRTTVRCM
    60 70 80 90 100
    HLLLEAVPAV APQTSILDLR FNRIREIQPG AFRRLRNLNT LLLNNNQIKR
    110 120 130 140 150
    IPSGAFEDLE NLKYLYLYKN EIQSIDRQAF KGLASLEQLY LHFNQIETLD
    160 170 180 190 200
    PDSFQHLPKL ERLFLHNNRI THLVPGTFNH LESMKRLRLD SNTLHCDCEI
    210 220 230 240 250
    LWLADLLKTY AESGNAQAAA ICEYPRRIQG RSVATITPEE LNCERPRITS
    260 270 280 290 300
    EPQDADVTSG NTVYFTCRAE GNPKPEIIWL RNNNELSMKT DSRLNLLDDG
    310 320 330 340 350
    TLMIQNTQET DQGIYQCMAK NVAGEVKTQE VTLRYFGSPA RPTFVIQPQN
    360 370 380 390 400
    TEVLVGESVT LECSATGHPP PRISWTRGDR TPLPVDPRVN ITPSGGLYIQ
    410 420 430 440 450
    NVVQGDSGEY ACSATNNIDS VHATAFIIVQ ALPQFTVTPQ DRVVIEGQTV
    460 470 480 490 500
    DFQCEAKGNP PPVIAWTKGG SQLSVDRRHL VLSSGTLRIS GVALHDQGQY
    510 520 530 540 550
    ECQAVNIIGS QKVVAHLTVQ PRVTPVFASI PSDTTVEVGA NVQLPCSSQG
    560 570 580 590 600
    EPEPAITWNK DGVQVTESGK FHISPEGFLT INDVGPADAG RYECVARNTI
    610 620 630 640 650
    GSASVSMVLS VNVPDVSRNG DPFVATSIVE AIATVDRAIN STRTHLFDSR
    660 670 680 690 700
    PRSPNDLLAL FRYPRDPYTV EQARAGEIFE RTLQLIQEHV QHGLMVDLNG
    710 720 730 740 750
    TSYHYNDLVS PQYLNLIANL SGCTAHRRVN NCSDMCFHQK YRTHDGTCNN
    760 770 780 790 800
    LQHPMWGASL TAFERLLKSV YENGFNTPRG INPHRLYNGH ALPMPRLVST
    810 820 830 840 850
    TLIGTETVTP DEQFTHMLMQ WGQFLDHDLD STVVALSQAR FSDGQHCSNV
    860 870 880 890 900
    CSNDPPCFSV MIPPNDSRAR SGARCMFFVR SSPVCGSGMT SLLMNSVYPR
    910 920 930 940 950
    EQINQLTSYI DASNVYGSTE HEARSIRDLA SHRGLLRQGI VQRSGKPLLP
    960 970 980 990 1000
    FATGPPTECM RDENESPIPC FLAGDHRANE QLGLTSMHTL WFREHNRIAT
    1010 1020 1030 1040 1050
    ELLKLNPHWD GDTIYYETRK IVGAEIQHIT YQHWLPKILG EVGMRTLGEY
    1060 1070 1080 1090 1100
    HGYDPGINAG IFNAFATAAF RFGHTLVNPL LYRLDENFQP IAQDHLPLHK
    1110 1120 1130 1140 1150
    AFFSPFRIVN EGGIDPLLRG LFGVAGKMRV PSQLLNTELT ERLFSMAHTV
    1160 1170 1180 1190 1200
    ALDLAAINIQ RGRDHGIPPY HDYRVYCNLS AAHTFEDLKN EIKNPEIREK
    1210 1220 1230 1240 1250
    LKRLYGSTLN IDLFPALVVE DLVPGSRLGP TLMCLLSTQF KRLRDGDRLW
    1260 1270 1280 1290 1300
    YENPGVFSPA QLTQIKQTSL ARILCDNADN ITRVQSDVFR VAEFPHGYGS
    1310 1320 1330 1340 1350
    CDEIPRVDLR VWQDCCEDCR TRGQFNAFSY HFRGRRSLEF SYQEDKPTKK
    1360 1370 1380 1390 1400
    TRPRKIPSVG RQGEHLSNST SAFSTRSDAS GTNDFREFVL EMQKTITDLR
    1410 1420 1430 1440 1450
    TQIKKLESRL STTECVDAGG ESHANNTKWK KDACTICECK DGQVTCFVEA
    1460 1470
    CPPATCAVPV NIPGACCPVC LQKRAEEKP
    Length:1,479
    Mass (Da):165,275
    Last modified:February 26, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A75F533D89C6AAD
    GO
    Isoform 2 (identifier: Q92626-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-727: YHYNDLVSPQYLNLIANLSGCTAHR → QCQSLFFLLHGLSNGVEHASVKSHS
         728-1479: Missing.

    Show »
    Length:727
    Mass (Da):80,329
    Checksum:i16391EA8B7F61878
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7C1W1H7C1W1_HUMAN
    Peroxidasin homolog
    PXDN
    723Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J4I9C9J4I9_HUMAN
    Peroxidasin homolog
    PXDN
    224Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C300H7C300_HUMAN
    Peroxidasin homolog
    PXDN
    196Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C3W2H7C3W2_HUMAN
    Peroxidasin homolog
    PXDN
    76Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAF06354 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence BAA13219 differs from that shown. Reason: Erroneous initiation.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_071389880R → C in ASGD7. 1 PublicationCorresponds to variant dbSNP:rs587777572EnsemblClinVar.1
    Natural variantiVAR_0504871198R → Q. Corresponds to variant dbSNP:rs6723697EnsemblClinVar.1
    Natural variantiVAR_0390481261Q → R. Corresponds to variant dbSNP:rs6723697EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031516703 – 727YHYND…CTAHR → QCQSLFFLLHGLSNGVEHAS VKSHS in isoform 2. 1 PublicationAdd BLAST25
    Alternative sequenceiVSP_031517728 – 1479Missing in isoform 2. 1 PublicationAdd BLAST752

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF200348 mRNA Translation: AAF06354.1 Different initiation.
    EF090903 mRNA Translation: ABO25865.1
    D86983 mRNA Translation: BAA13219.1 Different initiation.
    CH471053 Genomic DNA Translation: EAX01084.1
    CH471053 Genomic DNA Translation: EAX01085.1
    BC098579 mRNA Translation: AAH98579.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS46221.1 [Q92626-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_036425.1, NM_012293.2 [Q92626-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000252804; ENSP00000252804; ENSG00000130508 [Q92626-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    7837

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:7837

    UCSC genome browser

    More...
    UCSCi
    uc002qxa.4 human [Q92626-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200348 mRNA Translation: AAF06354.1 Different initiation.
    EF090903 mRNA Translation: ABO25865.1
    D86983 mRNA Translation: BAA13219.1 Different initiation.
    CH471053 Genomic DNA Translation: EAX01084.1
    CH471053 Genomic DNA Translation: EAX01085.1
    BC098579 mRNA Translation: AAH98579.1
    CCDSiCCDS46221.1 [Q92626-1]
    RefSeqiNP_036425.1, NM_012293.2 [Q92626-1]

    3D structure databases

    SMRiQ92626
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi113596, 35 interactors
    IntActiQ92626, 20 interactors
    STRINGi9606.ENSP00000252804

    Protein family/group databases

    PeroxiBasei3355 HsPxd01

    PTM databases

    GlyConnecti1600
    iPTMnetiQ92626
    PhosphoSitePlusiQ92626
    SwissPalmiQ92626

    Polymorphism and mutation databases

    BioMutaiPXDN
    DMDMi172045828

    Proteomic databases

    EPDiQ92626
    jPOSTiQ92626
    MassIVEiQ92626
    MaxQBiQ92626
    PaxDbiQ92626
    PeptideAtlasiQ92626
    PRIDEiQ92626
    ProteomicsDBi75381 [Q92626-1]
    75382 [Q92626-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    7837

    Genome annotation databases

    EnsembliENST00000252804; ENSP00000252804; ENSG00000130508 [Q92626-1]
    GeneIDi7837
    KEGGihsa:7837
    UCSCiuc002qxa.4 human [Q92626-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    7837
    DisGeNETi7837

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PXDN
    HGNCiHGNC:14966 PXDN
    HPAiHPA012375
    MalaCardsiPXDN
    MIMi269400 phenotype
    605158 gene
    neXtProtiNX_Q92626
    OpenTargetsiENSG00000130508
    Orphaneti289499 Congenital cataract microcornea with corneal opacity
    PharmGKBiPA128394535

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2408 Eukaryota
    ENOG410XPZ3 LUCA
    GeneTreeiENSGT00940000157666
    HOGENOMiHOG000016084
    InParanoidiQ92626
    KOiK19511
    OMAiQPIAQGH
    OrthoDBi276568at2759
    PhylomeDBiQ92626
    TreeFamiTF314316

    Enzyme and pathway databases

    BRENDAi1.11.1.7 2681
    ReactomeiR-HSA-2243919 Crosslinking of collagen fibrils

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PXDN human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PXDN

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    7837
    PharosiQ92626

    Protein Ontology

    More...
    PROi
    PR:Q92626

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000130508 Expressed in 218 organ(s), highest expression level in lung
    ExpressionAtlasiQ92626 baseline and differential
    GenevisibleiQ92626 HS

    Family and domain databases

    CDDicd09826 peroxidasin_like, 1 hit
    Gene3Di1.10.640.10, 1 hit
    2.60.40.10, 4 hits
    3.80.10.10, 1 hit
    InterProiView protein in InterPro
    IPR000483 Cys-rich_flank_reg_C
    IPR019791 Haem_peroxidase_animal
    IPR010255 Haem_peroxidase_sf
    IPR037120 Haem_peroxidase_sf_animal
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR034828 Peroxidasin
    IPR034824 Peroxidasin_peroxidase
    IPR001007 VWF_dom
    PANTHERiPTHR11475:SF75 PTHR11475:SF75, 1 hit
    PfamiView protein in Pfam
    PF03098 An_peroxidase, 1 hit
    PF07679 I-set, 4 hits
    PF13855 LRR_8, 1 hit
    PF00093 VWC, 1 hit
    PRINTSiPR00457 ANPEROXIDASE
    SMARTiView protein in SMART
    SM00409 IG, 4 hits
    SM00408 IGc2, 4 hits
    SM00369 LRR_TYP, 5 hits
    SM00082 LRRCT, 1 hit
    SM00214 VWC, 1 hit
    SUPFAMiSSF48113 SSF48113, 1 hit
    SSF48726 SSF48726, 4 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 4 hits
    PS51450 LRR, 5 hits
    PS50292 PEROXIDASE_3, 1 hit
    PS01208 VWFC_1, 1 hit
    PS50184 VWFC_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDN_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92626
    Secondary accession number(s): A8QM65, D6W4Y0, Q4KMG2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 16, 2019
    This is version 179 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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