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Protein

Peroxidasin homolog

Gene

PXDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays low peroxidase activity and is likely to participate in H2O2 metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.2 Publications

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.2 Publications

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
  • heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.

Kineticsi

  1. KM=0.15 mM for H2O21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei826Heme (covalent; via 2 links)By similarity1
    Active sitei827Proton acceptorPROSITE-ProRule annotation1
    Metal bindingi828CalciumPROSITE-ProRule annotation1
    Metal bindingi907CalciumPROSITE-ProRule annotation1
    Metal bindingi909Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
    Metal bindingi911CalciumPROSITE-ProRule annotation1
    Metal bindingi913CalciumPROSITE-ProRule annotation1
    Sitei977Transition state stabilizerPROSITE-ProRule annotation1
    Binding sitei980Heme (covalent; via 2 links)By similarity1
    Metal bindingi1074Iron (heme axial ligand)PROSITE-ProRule annotation1

    GO - Molecular functioni

    • extracellular matrix structural constituent Source: UniProtKB
    • heme binding Source: UniProtKB
    • interleukin-1 receptor antagonist activity Source: UniProtKB
    • metal ion binding Source: UniProtKB-KW
    • peroxidase activity Source: UniProtKB

    GO - Biological processi

    Keywordsi

    Molecular functionOxidoreductase, Peroxidase
    Biological processHydrogen peroxide
    LigandCalcium, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi1.11.1.7 2681
    ReactomeiR-HSA-2243919 Crosslinking of collagen fibrils

    Protein family/group databases

    PeroxiBasei3355 HsPxd01

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxidasin homolog (EC:1.11.1.7)
    Alternative name(s):
    Melanoma-associated antigen MG50
    Vascular peroxidase 1
    p53-responsive gene 2 protein
    Gene namesi
    Name:PXDN
    Synonyms:KIAA0230, MG50, PRG2, VPO, VPO1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 2

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000130508.10
    HGNCiHGNC:14966 PXDN
    MIMi605158 gene
    neXtProtiNX_Q92626

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Anterior segment dysgenesis 7 (ASGD7)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of anterior segment dysgenesis, a group of defects affecting anterior structures of the eye including cornea, iris, lens, trabecular meshwork, and Schlemm canal. Anterior segment dysgeneses result from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to components of the anterior chamber during eye development. Different anterior segment anomalies may exist alone or in combination, including iris hypoplasia, enlarged or reduced corneal diameter, corneal vascularization and opacity, posterior embryotoxon, corectopia, polycoria, abnormal iridocorneal angle, ectopia lentis, and anterior synechiae between the iris and posterior corneal surface. Clinical conditions falling within the phenotypic spectrum of anterior segment dysgeneses include aniridia, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. ASGD7 is an autosomal recessive disease.
    See also OMIM:269400
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_071389880R → C in ASGD7. 1 PublicationCorresponds to variant dbSNP:rs587777572EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi7837
    MalaCardsiPXDN
    MIMi269400 phenotype
    OpenTargetsiENSG00000130508
    Orphaneti289499 Congenital cataract microcornea with corneal opacity
    PharmGKBiPA128394535

    Polymorphism and mutation databases

    BioMutaiPXDN
    DMDMi172045828

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Signal peptidei1 – 26Sequence analysisAdd BLAST26
    ChainiPRO_000031961927 – 1479Peroxidasin homologAdd BLAST1453

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Disulfide bondi267 ↔ 317By similarity
    Disulfide bondi363 ↔ 412By similarity
    Disulfide bondi454 ↔ 502By similarity
    Disulfide bondi546 ↔ 594By similarity
    Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi732 ↔ 748By similarity
    Disulfide bondi847 ↔ 857By similarity
    Disulfide bondi851 ↔ 875By similarity
    Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi959 ↔ 970By similarity
    Modified residuei1176PhosphotyrosineCombined sources1
    Disulfide bondi1177 ↔ 1234By similarity
    Glycosylationi1178N-linked (GlcNAc...) asparagine1 Publication1
    Modified residuei1180PhosphoserineCombined sources1
    Disulfide bondi1275 ↔ 1301By similarity
    Glycosylationi1280N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi1368N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi1425N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiQ92626
    MaxQBiQ92626
    PaxDbiQ92626
    PeptideAtlasiQ92626
    PRIDEiQ92626
    ProteomicsDBi75381
    75382 [Q92626-2]

    PTM databases

    GlyConnecti1600
    iPTMnetiQ92626
    PhosphoSitePlusiQ92626
    SwissPalmiQ92626

    Expressioni

    Tissue specificityi

    Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis.4 Publications

    Developmental stagei

    Expressed in fetal liver and spleen.1 Publication

    Inductioni

    By TGFB1 in fibroblasts and up-regulated in apoptotic cells.2 Publications

    Gene expression databases

    BgeeiENSG00000130508 Expressed in 218 organ(s), highest expression level in lung
    CleanExiHS_PRG2
    HS_PXDN
    ExpressionAtlasiQ92626 baseline and differential
    GenevisibleiQ92626 HS

    Organism-specific databases

    HPAiHPA012375

    Interactioni

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi113596, 33 interactors
    IntActiQ92626, 1 interactor
    STRINGi9606.ENSP00000252804

    Structurei

    3D structure databases

    ProteinModelPortaliQ92626
    SMRiQ92626
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini27 – 63LRRNTAdd BLAST37
    Repeati87 – 108LRR 1Add BLAST22
    Repeati111 – 132LRR 2Add BLAST22
    Repeati135 – 156LRR 3Add BLAST22
    Repeati159 – 180LRR 4Add BLAST22
    Domaini192 – 245LRRCTAdd BLAST54
    Domaini246 – 332Ig-like C2-type 1Add BLAST87
    Domaini342 – 428Ig-like C2-type 2Add BLAST87
    Domaini433 – 520Ig-like C2-type 3Add BLAST88
    Domaini521 – 610Ig-like C2-type 4Add BLAST90
    Domaini1413 – 1471VWFCPROSITE-ProRule annotationAdd BLAST59

    Sequence similaritiesi

    Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiKOG2408 Eukaryota
    ENOG410XPZ3 LUCA
    GeneTreeiENSGT00550000074325
    HOGENOMiHOG000016084
    HOVERGENiHBG108312
    InParanoidiQ92626
    KOiK19511
    OMAiVDFPCEA
    OrthoDBiEOG091G0236
    PhylomeDBiQ92626
    TreeFamiTF314316

    Family and domain databases

    CDDicd09826 peroxidasin_like, 1 hit
    Gene3Di1.10.640.10, 1 hit
    2.60.40.10, 4 hits
    3.80.10.10, 1 hit
    InterProiView protein in InterPro
    IPR000483 Cys-rich_flank_reg_C
    IPR010255 Haem_peroxidase
    IPR019791 Haem_peroxidase_animal
    IPR037120 Haem_peroxidase_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR034828 Peroxidasin
    IPR034824 Peroxidasin_peroxidase
    IPR001007 VWF_dom
    PANTHERiPTHR11475:SF75 PTHR11475:SF75, 3 hits
    PfamiView protein in Pfam
    PF03098 An_peroxidase, 1 hit
    PF07679 I-set, 4 hits
    PF13855 LRR_8, 1 hit
    PF00093 VWC, 1 hit
    PRINTSiPR00457 ANPEROXIDASE
    SMARTiView protein in SMART
    SM00409 IG, 4 hits
    SM00408 IGc2, 4 hits
    SM00369 LRR_TYP, 5 hits
    SM00082 LRRCT, 1 hit
    SM00214 VWC, 1 hit
    SUPFAMiSSF48113 SSF48113, 1 hit
    SSF48726 SSF48726, 4 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 4 hits
    PS51450 LRR, 5 hits
    PS50292 PEROXIDASE_3, 1 hit
    PS01208 VWFC_1, 1 hit
    PS50184 VWFC_2, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
    Note: Additional isoforms seem to exist.

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q92626-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAKRSRGPGR RCLLALVLFC AWGTLAVVAQ KPGAGCPSRC LCFRTTVRCM
    60 70 80 90 100
    HLLLEAVPAV APQTSILDLR FNRIREIQPG AFRRLRNLNT LLLNNNQIKR
    110 120 130 140 150
    IPSGAFEDLE NLKYLYLYKN EIQSIDRQAF KGLASLEQLY LHFNQIETLD
    160 170 180 190 200
    PDSFQHLPKL ERLFLHNNRI THLVPGTFNH LESMKRLRLD SNTLHCDCEI
    210 220 230 240 250
    LWLADLLKTY AESGNAQAAA ICEYPRRIQG RSVATITPEE LNCERPRITS
    260 270 280 290 300
    EPQDADVTSG NTVYFTCRAE GNPKPEIIWL RNNNELSMKT DSRLNLLDDG
    310 320 330 340 350
    TLMIQNTQET DQGIYQCMAK NVAGEVKTQE VTLRYFGSPA RPTFVIQPQN
    360 370 380 390 400
    TEVLVGESVT LECSATGHPP PRISWTRGDR TPLPVDPRVN ITPSGGLYIQ
    410 420 430 440 450
    NVVQGDSGEY ACSATNNIDS VHATAFIIVQ ALPQFTVTPQ DRVVIEGQTV
    460 470 480 490 500
    DFQCEAKGNP PPVIAWTKGG SQLSVDRRHL VLSSGTLRIS GVALHDQGQY
    510 520 530 540 550
    ECQAVNIIGS QKVVAHLTVQ PRVTPVFASI PSDTTVEVGA NVQLPCSSQG
    560 570 580 590 600
    EPEPAITWNK DGVQVTESGK FHISPEGFLT INDVGPADAG RYECVARNTI
    610 620 630 640 650
    GSASVSMVLS VNVPDVSRNG DPFVATSIVE AIATVDRAIN STRTHLFDSR
    660 670 680 690 700
    PRSPNDLLAL FRYPRDPYTV EQARAGEIFE RTLQLIQEHV QHGLMVDLNG
    710 720 730 740 750
    TSYHYNDLVS PQYLNLIANL SGCTAHRRVN NCSDMCFHQK YRTHDGTCNN
    760 770 780 790 800
    LQHPMWGASL TAFERLLKSV YENGFNTPRG INPHRLYNGH ALPMPRLVST
    810 820 830 840 850
    TLIGTETVTP DEQFTHMLMQ WGQFLDHDLD STVVALSQAR FSDGQHCSNV
    860 870 880 890 900
    CSNDPPCFSV MIPPNDSRAR SGARCMFFVR SSPVCGSGMT SLLMNSVYPR
    910 920 930 940 950
    EQINQLTSYI DASNVYGSTE HEARSIRDLA SHRGLLRQGI VQRSGKPLLP
    960 970 980 990 1000
    FATGPPTECM RDENESPIPC FLAGDHRANE QLGLTSMHTL WFREHNRIAT
    1010 1020 1030 1040 1050
    ELLKLNPHWD GDTIYYETRK IVGAEIQHIT YQHWLPKILG EVGMRTLGEY
    1060 1070 1080 1090 1100
    HGYDPGINAG IFNAFATAAF RFGHTLVNPL LYRLDENFQP IAQDHLPLHK
    1110 1120 1130 1140 1150
    AFFSPFRIVN EGGIDPLLRG LFGVAGKMRV PSQLLNTELT ERLFSMAHTV
    1160 1170 1180 1190 1200
    ALDLAAINIQ RGRDHGIPPY HDYRVYCNLS AAHTFEDLKN EIKNPEIREK
    1210 1220 1230 1240 1250
    LKRLYGSTLN IDLFPALVVE DLVPGSRLGP TLMCLLSTQF KRLRDGDRLW
    1260 1270 1280 1290 1300
    YENPGVFSPA QLTQIKQTSL ARILCDNADN ITRVQSDVFR VAEFPHGYGS
    1310 1320 1330 1340 1350
    CDEIPRVDLR VWQDCCEDCR TRGQFNAFSY HFRGRRSLEF SYQEDKPTKK
    1360 1370 1380 1390 1400
    TRPRKIPSVG RQGEHLSNST SAFSTRSDAS GTNDFREFVL EMQKTITDLR
    1410 1420 1430 1440 1450
    TQIKKLESRL STTECVDAGG ESHANNTKWK KDACTICECK DGQVTCFVEA
    1460 1470
    CPPATCAVPV NIPGACCPVC LQKRAEEKP
    Length:1,479
    Mass (Da):165,275
    Last modified:February 26, 2008 - v2
    Checksum:i7A75F533D89C6AAD
    GO
    Isoform 2 (identifier: Q92626-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-727: YHYNDLVSPQYLNLIANLSGCTAHR → QCQSLFFLLHGLSNGVEHASVKSHS
         728-1479: Missing.

    Show »
    Length:727
    Mass (Da):80,329
    Checksum:i16391EA8B7F61878
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7C1W1H7C1W1_HUMAN
    Peroxidasin homolog
    PXDN
    723Annotation score:
    C9J4I9C9J4I9_HUMAN
    Peroxidasin homolog
    PXDN
    224Annotation score:
    H7C300H7C300_HUMAN
    Peroxidasin homolog
    PXDN
    196Annotation score:
    H7C3W2H7C3W2_HUMAN
    Peroxidasin homolog
    PXDN
    76Annotation score:

    Sequence cautioni

    The sequence AAF06354 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence BAA13219 differs from that shown. Reason: Erroneous initiation.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_071389880R → C in ASGD7. 1 PublicationCorresponds to variant dbSNP:rs587777572EnsemblClinVar.1
    Natural variantiVAR_0504871198R → Q. Corresponds to variant dbSNP:rs6723697EnsemblClinVar.1
    Natural variantiVAR_0390481261Q → R. Corresponds to variant dbSNP:rs6723697EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_031516703 – 727YHYND…CTAHR → QCQSLFFLLHGLSNGVEHAS VKSHS in isoform 2. 1 PublicationAdd BLAST25
    Alternative sequenceiVSP_031517728 – 1479Missing in isoform 2. 1 PublicationAdd BLAST752

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200348 mRNA Translation: AAF06354.1 Different initiation.
    EF090903 mRNA Translation: ABO25865.1
    D86983 mRNA Translation: BAA13219.1 Different initiation.
    CH471053 Genomic DNA Translation: EAX01084.1
    CH471053 Genomic DNA Translation: EAX01085.1
    BC098579 mRNA Translation: AAH98579.1
    CCDSiCCDS46221.1 [Q92626-1]
    RefSeqiNP_036425.1, NM_012293.2 [Q92626-1]
    UniGeneiHs.332197

    Genome annotation databases

    EnsembliENST00000252804; ENSP00000252804; ENSG00000130508 [Q92626-1]
    GeneIDi7837
    KEGGihsa:7837
    UCSCiuc002qxa.4 human [Q92626-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF200348 mRNA Translation: AAF06354.1 Different initiation.
    EF090903 mRNA Translation: ABO25865.1
    D86983 mRNA Translation: BAA13219.1 Different initiation.
    CH471053 Genomic DNA Translation: EAX01084.1
    CH471053 Genomic DNA Translation: EAX01085.1
    BC098579 mRNA Translation: AAH98579.1
    CCDSiCCDS46221.1 [Q92626-1]
    RefSeqiNP_036425.1, NM_012293.2 [Q92626-1]
    UniGeneiHs.332197

    3D structure databases

    ProteinModelPortaliQ92626
    SMRiQ92626
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi113596, 33 interactors
    IntActiQ92626, 1 interactor
    STRINGi9606.ENSP00000252804

    Protein family/group databases

    PeroxiBasei3355 HsPxd01

    PTM databases

    GlyConnecti1600
    iPTMnetiQ92626
    PhosphoSitePlusiQ92626
    SwissPalmiQ92626

    Polymorphism and mutation databases

    BioMutaiPXDN
    DMDMi172045828

    Proteomic databases

    EPDiQ92626
    MaxQBiQ92626
    PaxDbiQ92626
    PeptideAtlasiQ92626
    PRIDEiQ92626
    ProteomicsDBi75381
    75382 [Q92626-2]

    Protocols and materials databases

    DNASUi7837
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000252804; ENSP00000252804; ENSG00000130508 [Q92626-1]
    GeneIDi7837
    KEGGihsa:7837
    UCSCiuc002qxa.4 human [Q92626-1]

    Organism-specific databases

    CTDi7837
    DisGeNETi7837
    EuPathDBiHostDB:ENSG00000130508.10
    GeneCardsiPXDN
    HGNCiHGNC:14966 PXDN
    HPAiHPA012375
    MalaCardsiPXDN
    MIMi269400 phenotype
    605158 gene
    neXtProtiNX_Q92626
    OpenTargetsiENSG00000130508
    Orphaneti289499 Congenital cataract microcornea with corneal opacity
    PharmGKBiPA128394535
    HUGEiSearch...
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2408 Eukaryota
    ENOG410XPZ3 LUCA
    GeneTreeiENSGT00550000074325
    HOGENOMiHOG000016084
    HOVERGENiHBG108312
    InParanoidiQ92626
    KOiK19511
    OMAiVDFPCEA
    OrthoDBiEOG091G0236
    PhylomeDBiQ92626
    TreeFamiTF314316

    Enzyme and pathway databases

    BRENDAi1.11.1.7 2681
    ReactomeiR-HSA-2243919 Crosslinking of collagen fibrils

    Miscellaneous databases

    ChiTaRSiPXDN human
    GeneWikiiPXDN
    GenomeRNAii7837
    PROiPR:Q92626
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000130508 Expressed in 218 organ(s), highest expression level in lung
    CleanExiHS_PRG2
    HS_PXDN
    ExpressionAtlasiQ92626 baseline and differential
    GenevisibleiQ92626 HS

    Family and domain databases

    CDDicd09826 peroxidasin_like, 1 hit
    Gene3Di1.10.640.10, 1 hit
    2.60.40.10, 4 hits
    3.80.10.10, 1 hit
    InterProiView protein in InterPro
    IPR000483 Cys-rich_flank_reg_C
    IPR010255 Haem_peroxidase
    IPR019791 Haem_peroxidase_animal
    IPR037120 Haem_peroxidase_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR001611 Leu-rich_rpt
    IPR003591 Leu-rich_rpt_typical-subtyp
    IPR032675 LRR_dom_sf
    IPR034828 Peroxidasin
    IPR034824 Peroxidasin_peroxidase
    IPR001007 VWF_dom
    PANTHERiPTHR11475:SF75 PTHR11475:SF75, 3 hits
    PfamiView protein in Pfam
    PF03098 An_peroxidase, 1 hit
    PF07679 I-set, 4 hits
    PF13855 LRR_8, 1 hit
    PF00093 VWC, 1 hit
    PRINTSiPR00457 ANPEROXIDASE
    SMARTiView protein in SMART
    SM00409 IG, 4 hits
    SM00408 IGc2, 4 hits
    SM00369 LRR_TYP, 5 hits
    SM00082 LRRCT, 1 hit
    SM00214 VWC, 1 hit
    SUPFAMiSSF48113 SSF48113, 1 hit
    SSF48726 SSF48726, 4 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 4 hits
    PS51450 LRR, 5 hits
    PS50292 PEROXIDASE_3, 1 hit
    PS01208 VWFC_1, 1 hit
    PS50184 VWFC_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPXDN_HUMAN
    AccessioniPrimary (citable) accession number: Q92626
    Secondary accession number(s): A8QM65, D6W4Y0, Q4KMG2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: November 7, 2018
    This is version 172 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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