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Entry version 186 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
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Protein

Ankyrin repeat and SAM domain-containing protein 1A

Gene

ANKS1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ephrin receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q92625

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and SAM domain-containing protein 1A
Alternative name(s):
Odin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKS1A
Synonyms:ANKS1, KIAA0229, ODIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20961, ANKS1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608994, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92625

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000064999.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23294

Open Targets

More...
OpenTargetsi
ENSG00000064999

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134958476

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92625, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKS1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62511243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669212 – 1134Ankyrin repeat and SAM domain-containing protein 1AAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei622PhosphoserineCombined sources1
Modified residuei624PhosphoserineBy similarity1
Modified residuei626PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei666PhosphoserineBy similarity1
Modified residuei677PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues in response to EGF and PDGF.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92625

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92625

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92625

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92625

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92625

PeptideAtlas

More...
PeptideAtlasi
Q92625

PRoteomics IDEntifications database

More...
PRIDEi
Q92625

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4910
75380 [Q92625-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92625

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q92625

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92625

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (at protein level).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064999, Expressed in visceral pleura and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92625, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92625, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000064999, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SAM domain) with EPHA2 (via SAM domain) (PubMed:22332920).

Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.

Interacts (via SAM domain) with EPHA6 (via SAM domain) (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116889, 119 interactors

Protein interaction database and analysis system

More...
IntActi
Q92625, 28 interactors

Molecular INTeraction database

More...
MINTi
Q92625

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353518

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92625, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q92625

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92625

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati79 – 108ANK 1Add BLAST30
Repeati112 – 141ANK 2Add BLAST30
Repeati148 – 177ANK 3Add BLAST30
Repeati181 – 210ANK 4Add BLAST30
Repeati214 – 243ANK 5Add BLAST30
Repeati246 – 275ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini696 – 762SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini770 – 837SAM 2PROSITE-ProRule annotationAdd BLAST68
Domaini936 – 1091PIDPROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 57DisorderedSequence analysisAdd BLAST25
Regioni305 – 338DisorderedSequence analysisAdd BLAST34
Regioni375 – 422DisorderedSequence analysisAdd BLAST48
Regioni469 – 498DisorderedSequence analysisAdd BLAST30
Regioni569 – 650DisorderedSequence analysisAdd BLAST82
Regioni856 – 896DisorderedSequence analysisAdd BLAST41
Regioni1079 – 1134DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi469 – 483Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi569 – 586Polar residuesSequence analysisAdd BLAST18
Compositional biasi624 – 650Polar residuesSequence analysisAdd BLAST27
Compositional biasi878 – 896Basic and acidic residuesSequence analysisAdd BLAST19

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0507, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010379_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92625

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLERMLF

Database of Orthologous Groups

More...
OrthoDBi
549581at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92625

TreeFam database of animal gene trees

More...
TreeFami
TF320582

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09499, SAM_AIDA1AB-like_repeat1, 1 hit
cd09500, SAM_AIDA1AB-like_repeat2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033637, ANKS1A
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR041880, SAM_ANKS1_repeat1
IPR041882, SAM_ANKS1_repeat2

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF4, PTHR24174:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF00640, PID, 1 hit
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00462, PTB, 1 hit
SM00454, SAM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS01179, PID, 1 hit
PS50105, SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92625-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKEQELLEA ARTGHLPAVE KLLSGKRLSS GFGGGGGGGS GGGGGGSGGG
60 70 80 90 100
GGGLGSSSHP LSSLLSMWRG PNVNCVDSTG YTPLHHAALN GHKDVVEVLL
110 120 130 140 150
RNDALTNVAD SKGCYPLHLA AWKGDAQIVR LLIHQGPSHT RVNEQNNDNE
160 170 180 190 200
TALHCAAQYG HTEVVKVLLE ELTDPTMRNN KFETPLDLAA LYGRLEVVKM
210 220 230 240 250
LLNAHPNLLS CNTKKHTPLH LAARNGHKAV VQVLLDAGMD SNYQTEMGSA
260 270 280 290 300
LHEAALFGKT DVVQILLAAG TDVNIKDNHG LTALDTVREL PSQKSQQIAA
310 320 330 340 350
LIEDHMTGKR STKEVDKTPP PQPPLISSMD SISQKSQGDV EKAVTELIID
360 370 380 390 400
FDANAEEEGP YEALYNAISC HSLDSMASGR SSDQDSTNKE AEAAGVKPAG
410 420 430 440 450
VRPRERPPPP AKPPPDEEEE DHIDKKYFPL TASEVLSMRP RIHGSAAREE
460 470 480 490 500
DEHPYELLLT AETKKVVLVD GKTKDHRRSS SSRSQDSAEG QDGQVPEQFS
510 520 530 540 550
GLLHGSSPVC EVGQDPFQLL CTAGQSHPDG SPQQGACHKA SMQLEETGVH
560 570 580 590 600
APGASQPSAL DQSKRVGYLT GLPTTNSRSH PETLTHTASP HPGGAEEGDR
610 620 630 640 650
SGARSRAPPT SKPKAELKLS RSLSKSDSDL LTCSPTEDAT MGSRSESLSN
660 670 680 690 700
CSIGKKRLEK SPSFASEWDE IEKIMSSIGE GIDFSQERQK ISGLRTLEQS
710 720 730 740 750
VGEWLESIGL QQYESKLLLN GFDDVHFLGS NVMEEQDLRD IGISDPQHRR
760 770 780 790 800
KLLQAARSLP KVKALGYDGN SPPSVPSWLD SLGLQDYVHS FLSSGYSSID
810 820 830 840 850
TVKNLWELEL VNVLKVQLLG HRKRIIASLA DRPYEEPPQK PPRFSQLRCQ
860 870 880 890 900
DLLSQTSSPL SQNDSCTGRS ADLLLPPGDT GRRRHDSLHD PAAPSRAERF
910 920 930 940 950
RIQEEHREAK LTLRPPSLAA PYAPVQSWQH QPEKLIFESC GYEANYLGSM
960 970 980 990 1000
LIKDLRGTES TQDACAKMRK STEHMKKIPT IILSITYKGV KFIDASNKNV
1010 1020 1030 1040 1050
IAEHEIRNIS CAAQDPEDLC TFAYITKDLQ TSHHYCHVFS TVDVNLTYEI
1060 1070 1080 1090 1100
ILTLGQAFEV AYQLALQAQK SRATGASAAE MIETKSSKPV PKPRVGVRKS
1110 1120 1130
ALEPPDMDQD AQSHASVSWV VDPKPDSKRS LSTN
Length:1,134
Mass (Da):123,108
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE519844AD56EE414
GO
Isoform 2 (identifier: Q92625-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-320: HMTGKRSTKEVDKTPP → LDTLQFYFISCPFQGL
     321-1134: Missing.

Show »
Length:320
Mass (Da):33,882
Checksum:i596CAD2B08649EB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISP1A0A3B3ISP1_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS1A
1,194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITU5A0A3B3ITU5_HUMAN
Ankyrin repeat and SAM domain-conta...
ANKS1A
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048282355A → D. Corresponds to variant dbSNP:rs6930932Ensembl.1
Natural variantiVAR_021168694L → SCombined sources3 PublicationsCorresponds to variant dbSNP:rs820085Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056512305 – 320HMTGK…DKTPP → LDTLQFYFISCPFQGL in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_056513321 – 1134Missing in isoform 2. 1 PublicationAdd BLAST814

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D86982 mRNA Translation: BAA13218.1 Different initiation.
AK298987 mRNA Translation: BAG61080.1
AL033520 Genomic DNA No translation available.
AL138721 Genomic DNA No translation available.
AL591002 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03804.1
BC132832 mRNA Translation: AAI32833.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4798.1 [Q92625-1]

NCBI Reference Sequences

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RefSeqi
NP_056060.2, NM_015245.2 [Q92625-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360359; ENSP00000353518; ENSG00000064999 [Q92625-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23294

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23294

UCSC genome browser

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UCSCi
uc003ojx.5, human [Q92625-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86982 mRNA Translation: BAA13218.1 Different initiation.
AK298987 mRNA Translation: BAG61080.1
AL033520 Genomic DNA No translation available.
AL138721 Genomic DNA No translation available.
AL591002 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03804.1
BC132832 mRNA Translation: AAI32833.1
CCDSiCCDS4798.1 [Q92625-1]
RefSeqiNP_056060.2, NM_015245.2 [Q92625-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMRNMR-A691-770[»]
2MYQNMR-A715-757[»]
6F7ONMR-A745-757[»]
BMRBiQ92625
SMRiQ92625
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116889, 119 interactors
IntActiQ92625, 28 interactors
MINTiQ92625
STRINGi9606.ENSP00000353518

PTM databases

iPTMnetiQ92625
MetOSiteiQ92625
PhosphoSitePlusiQ92625

Genetic variation databases

BioMutaiANKS1A
DMDMi62511243

Proteomic databases

EPDiQ92625
jPOSTiQ92625
MassIVEiQ92625
MaxQBiQ92625
PaxDbiQ92625
PeptideAtlasiQ92625
PRIDEiQ92625
ProteomicsDBi4910
75380 [Q92625-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29433, 100 antibodies

The DNASU plasmid repository

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DNASUi
23294

Genome annotation databases

EnsembliENST00000360359; ENSP00000353518; ENSG00000064999 [Q92625-1]
GeneIDi23294
KEGGihsa:23294
UCSCiuc003ojx.5, human [Q92625-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23294
DisGeNETi23294

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKS1A
HGNCiHGNC:20961, ANKS1A
HPAiENSG00000064999, Low tissue specificity
MIMi608994, gene
neXtProtiNX_Q92625
OpenTargetsiENSG00000064999
PharmGKBiPA134958476
VEuPathDBiHostDB:ENSG00000064999.13

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0507, Eukaryota
GeneTreeiENSGT00940000155806
HOGENOMiCLU_010379_0_0_1
InParanoidiQ92625
OMAiHLERMLF
OrthoDBi549581at2759
PhylomeDBiQ92625
TreeFamiTF320582

Enzyme and pathway databases

PathwayCommonsiQ92625

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23294, 15 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKS1A, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANKS1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23294
PharosiQ92625, Tbio

Protein Ontology

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PROi
PR:Q92625
RNActiQ92625, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064999, Expressed in visceral pleura and 252 other tissues
ExpressionAtlasiQ92625, baseline and differential
GenevisibleiQ92625, HS

Family and domain databases

CDDicd09499, SAM_AIDA1AB-like_repeat1, 1 hit
cd09500, SAM_AIDA1AB-like_repeat2, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033637, ANKS1A
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR041880, SAM_ANKS1_repeat1
IPR041882, SAM_ANKS1_repeat2
PANTHERiPTHR24174:SF4, PTHR24174:SF4, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF00640, PID, 1 hit
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00462, PTB, 1 hit
SM00454, SAM, 2 hits
SUPFAMiSSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS01179, PID, 1 hit
PS50105, SAM_DOMAIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANS1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92625
Secondary accession number(s): A2RUC1
, B4DQW8, Q5JYI9, Q5SYR2, Q86WQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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