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Entry version 172 (12 Aug 2020)
Sequence version 2 (19 Jul 2004)
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Protein

Amyloid protein-binding protein 2

Gene

APPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule motor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q92624

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Protein interacting with APP tail 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APPBP2
Synonyms:KIAA0228, PAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000062725.9

Human Gene Nomenclature Database

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HGNCi
HGNC:622, APPBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605324, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q92624

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10513

Open Targets

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OpenTargetsi
ENSG00000062725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24912

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92624, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APPBP2

Domain mapping of disease mutations (DMDM)

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DMDMi
50400598

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062591 – 585Amyloid protein-binding protein 2Add BLAST585

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92624

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92624

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92624

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92624

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92624

PeptideAtlas

More...
PeptideAtlasi
Q92624

PRoteomics IDEntifications database

More...
PRIDEi
Q92624

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75379

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92624

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92624

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000062725, Expressed in endothelial cell and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92624, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92624, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000062725, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds APP.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92624
With#Exp.IntAct
AADAC [P22760]3EBI-743771,EBI-13217105
ACTN1 [P12814]3EBI-743771,EBI-351710
AHCY [P23526]3EBI-743771,EBI-1053240
AK3 [Q9UIJ7]6EBI-743771,EBI-3916527
ALDH1L1 - isoform 4 [O75891-4]3EBI-743771,EBI-12400198
ANKRD10 [Q8IUW1]3EBI-743771,EBI-10261416
ANKRD10 [Q9NXR5]3EBI-743771,EBI-10316475
ARMCX5 [Q6P1M9]6EBI-743771,EBI-10252512
ATP13A1 - isoform C [Q9HD20-3]3EBI-743771,EBI-12069500
BCL7A - isoform 2 [Q4VC05-2]3EBI-743771,EBI-12065992
BIN2 [Q9UBW5]3EBI-743771,EBI-2042570
C16orf35 [Q9BTE2]3EBI-743771,EBI-10298364
C1orf50 [Q9BV19]6EBI-743771,EBI-2874661
C6orf226 [Q5I0X4]6EBI-743771,EBI-10244057
CALM1 [B4DJ51]3EBI-743771,EBI-10171450
CCDC167 [Q9P0B6]3EBI-743771,EBI-9083477
CCNL1 [Q9UK58]3EBI-743771,EBI-2836773
CDK16 [Q00536]3EBI-743771,EBI-726261
CLCN1 [P35523]6EBI-743771,EBI-10206780
COL24A1 [Q17RW2]6EBI-743771,EBI-2529266
CORO2B [Q9UQ03]6EBI-743771,EBI-723376
CSNK1G2 [P78368]3EBI-743771,EBI-748380
CST2 [P09228]3EBI-743771,EBI-8832659
CTC1 [Q2NKJ3]3EBI-743771,EBI-2562802
DCD [P81605]3EBI-743771,EBI-395625
DHRS2 [Q13268]3EBI-743771,EBI-354324
DOLK [Q9UPQ8]3EBI-743771,EBI-8645574
DPEP1 [P16444]3EBI-743771,EBI-749514
DPYS [Q14117]3EBI-743771,EBI-12275416
ERO1A [Q96HE7]3EBI-743771,EBI-2564539
FSTL1 [Q12841]8EBI-743771,EBI-2349801
FXYD7 [P58549]6EBI-743771,EBI-10216171
GALNT3 - isoform 2 [Q14435-2]3EBI-743771,EBI-10232904
GCSAM [Q8N6F7]6EBI-743771,EBI-10267082
GPRC5C [A0A0C4DFY5]3EBI-743771,EBI-12364679
GSTP1 [P09211]6EBI-743771,EBI-353467
HGFAC [Q04756]3EBI-743771,EBI-1041722
HIPK4 [Q8NE63]3EBI-743771,EBI-6381114
HIST1H2AK [A4FTV9]3EBI-743771,EBI-10173457
HSD3B7 [Q9H2F3]3EBI-743771,EBI-3918847
HSPA4 [P34932]6EBI-743771,EBI-356933
IKBKE [Q14164]4EBI-743771,EBI-307369
ITGB4 - isoform Beta-4A [P16144-2]3EBI-743771,EBI-11051601
ITGB5 [P18084]3EBI-743771,EBI-1223434
KHK - isoform A [P50053-2]3EBI-743771,EBI-12204387
KIF6 [Q6ZMV9]3EBI-743771,EBI-751100
KLF11 [O14901]3EBI-743771,EBI-948266
KLHL35 [Q6PF15]6EBI-743771,EBI-9477654
LANCL2 [Q9NS86]6EBI-743771,EBI-2510837
LONRF3 [Q496Y0]3EBI-743771,EBI-2690768
LUC7L2 [Q9Y383]6EBI-743771,EBI-352851
LUZP4 [Q9P127]6EBI-743771,EBI-10198848
MAN2B2 [Q9Y2E5]3EBI-743771,EBI-12243024
MCOLN1 [Q9GZU1]3EBI-743771,EBI-721209
MGAT4B [Q9UQ53]3EBI-743771,EBI-725713
MLLT3 [P42568]4EBI-743771,EBI-716132
MMP28 [C0H5X0]3EBI-743771,EBI-12286419
MSH2 [P43246]3EBI-743771,EBI-355888
MSLN - isoform 2 [Q13421-3]3EBI-743771,EBI-12303989
MUL1 [Q969V5]6EBI-743771,EBI-744120
MYLK - isoform 5 [Q15746-7]3EBI-743771,EBI-12189939
NFYA [P23511]3EBI-743771,EBI-389739
PCTK1 [Q9BRL4]3EBI-743771,EBI-10296950
PNPLA5 [Q7Z6Z6]3EBI-743771,EBI-12241582
PPIL6 [Q8IXY8]3EBI-743771,EBI-12226639
PPP1R8 [Q12972]3EBI-743771,EBI-716633
PPP1R8 - isoform Beta [Q12972-2]3EBI-743771,EBI-12252736
PRKAA2 [P54646]3EBI-743771,EBI-1383852
PRKACB [P22694]3EBI-743771,EBI-2679622
PSAP [P07602]3EBI-743771,EBI-716699
PTCH1 - isoform M [Q13635-3]3EBI-743771,EBI-14199621
PYROXD2 [Q8N2H3]3EBI-743771,EBI-3919450
RAB7B [Q96AH8]3EBI-743771,EBI-3924400
RHEB [Q15382]3EBI-743771,EBI-1055287
RILPL1 - isoform 3 [Q5EBL4-3]3EBI-743771,EBI-12072024
RNF128 [Q8TEB7]3EBI-743771,EBI-2341619
RNF34 [Q969K3]3EBI-743771,EBI-2340642
RNGTT [O60942]3EBI-743771,EBI-1237132
RRS1 [Q15050]7EBI-743771,EBI-749186
SELENOV [P59797]3EBI-743771,EBI-10216195
SELI [Q8WU57]3EBI-743771,EBI-751012
SLC22A6 [Q4U2R8]3EBI-743771,EBI-749741
SLC25A23 [Q9BV35]3EBI-743771,EBI-2933255
SLC7A10 [Q9NS82]3EBI-743771,EBI-12068238
SLC9A3R1 [O14745]3EBI-743771,EBI-349787
SNX5 [Q9Y5X3]3EBI-743771,EBI-715760
SNX5 - isoform 2 [Q9Y5X3-2]3EBI-743771,EBI-12229025
SPDYE6 [P0CI01]3EBI-743771,EBI-11960469
ST8SIA5 [O15466]3EBI-743771,EBI-10182857
SYNRG [Q9UMZ2]3EBI-743771,EBI-7240490
SYNRG - isoform 7 [Q9UMZ2-8]3EBI-743771,EBI-12353261
SYT11 [Q9BT88]3EBI-743771,EBI-751770
TAF11 [Q15544]6EBI-743771,EBI-1027005
TAFA4 [Q96LR4]3EBI-743771,EBI-10290841
TBL3 [Q12788]4EBI-743771,EBI-715766
TCF25 [Q9BQ70]3EBI-743771,EBI-745182
TNP2 [Q05952]3EBI-743771,EBI-12039775
TRMT2A [Q8IZ69]3EBI-743771,EBI-2515774
UBE2R2 [Q712K3]3EBI-743771,EBI-2340879
UGGT2 [Q9NYU1]3EBI-743771,EBI-1054215
WAS [P42768]3EBI-743771,EBI-346375
WDR24 [Q96S15]4EBI-743771,EBI-746424
WFIKKN1 [Q96NZ8]3EBI-743771,EBI-2363713
ZC3H10 [Q96K80]3EBI-743771,EBI-742550
ZNF747 [Q9BV97]3EBI-743771,EBI-4395497
Q9H6693EBI-743771,EBI-10307430

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115769, 125 interactors

Protein interaction database and analysis system

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IntActi
Q92624, 149 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000083182

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92624, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati50 – 83TPR 1Add BLAST34
Repeati120 – 153TPR 2Add BLAST34
Repeati206 – 239TPR 3Add BLAST34
Repeati288 – 321TPR 4Add BLAST34
Repeati333 – 367TPR 5Add BLAST35
Repeati429 – 462TPR 6Add BLAST34
Repeati471 – 505TPR 7Add BLAST35
Repeati514 – 547TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1840, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019378_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92624

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDCCHKL

Database of Orthologous Groups

More...
OrthoDBi
578212at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92624

TreeFam database of animal gene trees

More...
TreeFami
TF314010

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042476, APPBP2
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR46575, PTHR46575, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC
Length:585
Mass (Da):66,853
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i849A120807DA2438
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIZ9K7EIZ9_HUMAN
Amyloid protein-binding protein 2
APPBP2
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN61K7EN61_HUMAN
Amyloid protein-binding protein 2
APPBP2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENN3K7ENN3_HUMAN
Amyloid protein-binding protein 2
APPBP2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13217 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti296F → L in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti325K → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti340S → C in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti354L → V in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti369P → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti542N → K in AAC83973 (PubMed:9843960).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052606561S → N. Corresponds to variant dbSNP:rs34146848Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32699.1

NCBI Reference Sequences

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RefSeqi
NP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000083182; ENSP00000083182; ENSG00000062725

Database of genes from NCBI RefSeq genomes

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GeneIDi
10513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10513

UCSC genome browser

More...
UCSCi
uc002iys.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1
CCDSiCCDS32699.1
RefSeqiNP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115769, 125 interactors
IntActiQ92624, 149 interactors
STRINGi9606.ENSP00000083182

PTM databases

iPTMnetiQ92624
PhosphoSitePlusiQ92624

Polymorphism and mutation databases

BioMutaiAPPBP2
DMDMi50400598

Proteomic databases

EPDiQ92624
jPOSTiQ92624
MassIVEiQ92624
MaxQBiQ92624
PaxDbiQ92624
PeptideAtlasiQ92624
PRIDEiQ92624
ProteomicsDBi75379

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31181, 317 antibodies

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725
GeneIDi10513
KEGGihsa:10513
UCSCiuc002iys.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10513
DisGeNETi10513
EuPathDBiHostDB:ENSG00000062725.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APPBP2
HGNCiHGNC:622, APPBP2
HPAiENSG00000062725, Low tissue specificity
MIMi605324, gene
neXtProtiNX_Q92624
OpenTargetsiENSG00000062725
PharmGKBiPA24912

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1840, Eukaryota
GeneTreeiENSGT00390000010722
HOGENOMiCLU_019378_1_0_1
InParanoidiQ92624
OMAiLDCCHKL
OrthoDBi578212at2759
PhylomeDBiQ92624
TreeFamiTF314010

Enzyme and pathway databases

PathwayCommonsiQ92624

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10513, 3 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
APPBP2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
APPBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10513
PharosiQ92624, Tbio

Protein Ontology

More...
PROi
PR:Q92624
RNActiQ92624, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000062725, Expressed in endothelial cell and 248 other tissues
ExpressionAtlasiQ92624, baseline and differential
GenevisibleiQ92624, HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR042476, APPBP2
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR46575, PTHR46575, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 3 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPBP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: August 12, 2020
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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