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Protein

Amyloid protein-binding protein 2

Gene

APPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.1 Publication

GO - Molecular functioni

  • microtubule motor activity Source: ProtInc

GO - Biological processi

  • intracellular protein transport Source: ProtInc
  • intracellular transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Protein interacting with APP tail 1
Gene namesi
Name:APPBP2
Synonyms:KIAA0228, PAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000062725.9
HGNCiHGNC:622 APPBP2
MIMi605324 gene
neXtProtiNX_Q92624

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10513
OpenTargetsiENSG00000062725
PharmGKBiPA24912

Polymorphism and mutation databases

DMDMi50400598

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001062591 – 585Amyloid protein-binding protein 2Add BLAST585

Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Proteomic databases

EPDiQ92624
MaxQBiQ92624
PaxDbiQ92624
PeptideAtlasiQ92624
PRIDEiQ92624
ProteomicsDBi75379

PTM databases

iPTMnetiQ92624
PhosphoSitePlusiQ92624

Expressioni

Gene expression databases

BgeeiENSG00000062725 Expressed in 237 organ(s), highest expression level in endothelial cell
CleanExiHS_APPBP2
ExpressionAtlasiQ92624 baseline and differential
GenevisibleiQ92624 HS

Interactioni

Subunit structurei

Binds APP.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6693EBI-743771,EBI-10307430
AHCYP235263EBI-743771,EBI-1053240
AK3Q9UIJ75EBI-743771,EBI-3916527
ANKRD10Q8IUW13EBI-743771,EBI-10261416
ANKRD10Q9NXR53EBI-743771,EBI-10316475
ARMCX5Q6P1M95EBI-743771,EBI-10252512
C16orf35Q9BTE23EBI-743771,EBI-10298364
C1orf50Q9BV195EBI-743771,EBI-2874661
C6orf226Q5I0X45EBI-743771,EBI-10244057
CALM1B4DJ513EBI-743771,EBI-10171450
CCNL1Q9UK583EBI-743771,EBI-2836773
CDK16Q005363EBI-743771,EBI-726261
CLCN1P355235EBI-743771,EBI-10206780
COL24A1Q17RW25EBI-743771,EBI-2529266
CORO2BQ9UQ035EBI-743771,EBI-723376
CSNK1G2P783683EBI-743771,EBI-748380
CTC1Q2NKJ33EBI-743771,EBI-2562802
DCDP816053EBI-743771,EBI-395625
DHRS2Q132683EBI-743771,EBI-354324
DPEP1P164443EBI-743771,EBI-749514
ERO1AQ96HE73EBI-743771,EBI-2564539
FAM19A4Q96LR43EBI-743771,EBI-10290841
FSTL1Q128417EBI-743771,EBI-2349801
FXYD7P585495EBI-743771,EBI-10216171
GALNT3Q14435-23EBI-743771,EBI-10232904
GCSAMQ8N6F75EBI-743771,EBI-10267082
GSTP1P092115EBI-743771,EBI-353467
HIPK4Q8NE633EBI-743771,EBI-6381114
HIST1H2AKA4FTV93EBI-743771,EBI-10173457
HSPA4P349325EBI-743771,EBI-356933
IKBKEQ141644EBI-743771,EBI-307369
KIF6Q6ZMV93EBI-743771,EBI-751100
KLF11O149013EBI-743771,EBI-948266
KLHL35Q6PF155EBI-743771,EBI-9477654
LANCL2Q9NS865EBI-743771,EBI-2510837
LONRF3Q496Y03EBI-743771,EBI-2690768
LUC7L2Q9Y3835EBI-743771,EBI-352851
LUZP4Q9P1275EBI-743771,EBI-10198848
MLLT3P425683EBI-743771,EBI-716132
MUL1Q969V55EBI-743771,EBI-744120
NFYAP235113EBI-743771,EBI-389739
PCTK1Q9BRL43EBI-743771,EBI-10296950
PPP1R8Q129723EBI-743771,EBI-716633
PRKAA2P546463EBI-743771,EBI-1383852
PRKACBP226943EBI-743771,EBI-2679622
PYROXD2Q8N2H33EBI-743771,EBI-3919450
RNF128Q8TEB73EBI-743771,EBI-2341619
RNF34Q969K33EBI-743771,EBI-2340642
RRS1Q150506EBI-743771,EBI-749186
SELENOVP597973EBI-743771,EBI-10216195
SELIQ8WU573EBI-743771,EBI-751012
SLC22A6Q4U2R83EBI-743771,EBI-749741
SLC25A23Q9BV353EBI-743771,EBI-2933255
SNX5Q9Y5X33EBI-743771,EBI-715760
ST8SIA5O154663EBI-743771,EBI-10182857
SYNRGQ9UMZ23EBI-743771,EBI-7240490
SYT11Q9BT883EBI-743771,EBI-751770
TAF11Q155445EBI-743771,EBI-1027005
TBL3Q127884EBI-743771,EBI-715766
TCF25Q9BQ703EBI-743771,EBI-745182
UBE2R2Q712K33EBI-743771,EBI-2340879
UGGT2Q9NYU13EBI-743771,EBI-1054215
WASP427683EBI-743771,EBI-346375
WDR24Q96S154EBI-743771,EBI-746424
ZC3H10Q96K803EBI-743771,EBI-742550
ZNF747Q9BV973EBI-743771,EBI-4395497

Protein-protein interaction databases

BioGridi115769, 119 interactors
IntActiQ92624, 123 interactors
STRINGi9606.ENSP00000083182

Structurei

3D structure databases

ProteinModelPortaliQ92624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 83TPR 1Add BLAST34
Repeati120 – 153TPR 2Add BLAST34
Repeati206 – 239TPR 3Add BLAST34
Repeati288 – 321TPR 4Add BLAST34
Repeati333 – 367TPR 5Add BLAST35
Repeati429 – 462TPR 6Add BLAST34
Repeati471 – 505TPR 7Add BLAST35
Repeati514 – 547TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000010722
HOGENOMiHOG000007799
HOVERGENiHBG050527
InParanoidiQ92624
OMAiEHFGHKH
OrthoDBiEOG091G057R
PhylomeDBiQ92624
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC
Length:585
Mass (Da):66,853
Last modified:July 19, 2004 - v2
Checksum:i849A120807DA2438
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIZ9K7EIZ9_HUMAN
Amyloid protein-binding protein 2
APPBP2
123Annotation score:
K7EN61K7EN61_HUMAN
Amyloid protein-binding protein 2
APPBP2
95Annotation score:
K7ENN3K7ENN3_HUMAN
Amyloid protein-binding protein 2
APPBP2
61Annotation score:

Sequence cautioni

The sequence BAA13217 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296F → L in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti325K → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti340S → C in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti354L → V in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti369P → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti542N → K in AAC83973 (PubMed:9843960).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052606561S → N. Corresponds to variant dbSNP:rs34146848Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1
CCDSiCCDS32699.1
RefSeqiNP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3
UniGeneiHs.84084

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725
GeneIDi10513
KEGGihsa:10513
UCSCiuc002iys.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1
CCDSiCCDS32699.1
RefSeqiNP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3
UniGeneiHs.84084

3D structure databases

ProteinModelPortaliQ92624
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115769, 119 interactors
IntActiQ92624, 123 interactors
STRINGi9606.ENSP00000083182

PTM databases

iPTMnetiQ92624
PhosphoSitePlusiQ92624

Polymorphism and mutation databases

DMDMi50400598

Proteomic databases

EPDiQ92624
MaxQBiQ92624
PaxDbiQ92624
PeptideAtlasiQ92624
PRIDEiQ92624
ProteomicsDBi75379

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725
GeneIDi10513
KEGGihsa:10513
UCSCiuc002iys.3 human

Organism-specific databases

CTDi10513
DisGeNETi10513
EuPathDBiHostDB:ENSG00000062725.9
GeneCardsiAPPBP2
HGNCiHGNC:622 APPBP2
MIMi605324 gene
neXtProtiNX_Q92624
OpenTargetsiENSG00000062725
PharmGKBiPA24912
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000010722
HOGENOMiHOG000007799
HOVERGENiHBG050527
InParanoidiQ92624
OMAiEHFGHKH
OrthoDBiEOG091G057R
PhylomeDBiQ92624
TreeFamiTF314010

Miscellaneous databases

ChiTaRSiAPPBP2 human
GeneWikiiAPPBP2
GenomeRNAii10513
PROiPR:Q92624
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062725 Expressed in 237 organ(s), highest expression level in endothelial cell
CleanExiHS_APPBP2
ExpressionAtlasiQ92624 baseline and differential
GenevisibleiQ92624 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBP2_HUMAN
AccessioniPrimary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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