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Entry version 167 (16 Oct 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Amyloid protein-binding protein 2

Gene

APPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule motor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Protein interacting with APP tail 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APPBP2
Synonyms:KIAA0228, PAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:622 APPBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605324 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92624

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10513

Open Targets

More...
OpenTargetsi
ENSG00000062725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24912

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92624

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APPBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400598

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062591 – 585Amyloid protein-binding protein 2Add BLAST585

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92624

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92624

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92624

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92624

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92624

PeptideAtlas

More...
PeptideAtlasi
Q92624

PRoteomics IDEntifications database

More...
PRIDEi
Q92624

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75379

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92624

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92624

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000062725 Expressed in 237 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92624 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92624 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds APP.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6693EBI-743771,EBI-10307430
P235263EBI-743771,EBI-1053240
Q9UIJ75EBI-743771,EBI-3916527
Q8IUW13EBI-743771,EBI-10261416
Q9NXR53EBI-743771,EBI-10316475
Q6P1M95EBI-743771,EBI-10252512
Q9BTE23EBI-743771,EBI-10298364
Q9BV195EBI-743771,EBI-2874661
Q5I0X45EBI-743771,EBI-10244057
Q9UK583EBI-743771,EBI-2836773
Q005363EBI-743771,EBI-726261
P355235EBI-743771,EBI-10206780
Q17RW25EBI-743771,EBI-2529266
Q9UQ035EBI-743771,EBI-723376
P783683EBI-743771,EBI-748380
Q2NKJ33EBI-743771,EBI-2562802
P816053EBI-743771,EBI-395625
Q132683EBI-743771,EBI-354324
P164443EBI-743771,EBI-749514
Q96HE73EBI-743771,EBI-2564539
Q128417EBI-743771,EBI-2349801
P585495EBI-743771,EBI-10216171
Q14435-23EBI-743771,EBI-10232904
Q8N6F75EBI-743771,EBI-10267082
P092115EBI-743771,EBI-353467
B4DJ513EBI-743771,EBI-10171450
Q8NE633EBI-743771,EBI-6381114
A4FTV93EBI-743771,EBI-10173457
P349325EBI-743771,EBI-356933
Q141644EBI-743771,EBI-307369
Q6ZMV93EBI-743771,EBI-751100
O149013EBI-743771,EBI-948266
Q6PF155EBI-743771,EBI-9477654
Q9NS865EBI-743771,EBI-2510837
Q496Y03EBI-743771,EBI-2690768
Q9Y3835EBI-743771,EBI-352851
Q9P1275EBI-743771,EBI-10198848
P425683EBI-743771,EBI-716132
Q969V55EBI-743771,EBI-744120
P235113EBI-743771,EBI-389739
Q9BRL43EBI-743771,EBI-10296950
Q129723EBI-743771,EBI-716633
P546463EBI-743771,EBI-1383852
P226943EBI-743771,EBI-2679622
Q8N2H33EBI-743771,EBI-3919450
Q8TEB73EBI-743771,EBI-2341619
Q969K33EBI-743771,EBI-2340642
Q150506EBI-743771,EBI-749186
P597973EBI-743771,EBI-10216195
Q8WU573EBI-743771,EBI-751012
Q4U2R83EBI-743771,EBI-749741
Q9BV353EBI-743771,EBI-2933255
Q9Y5X33EBI-743771,EBI-715760
O154663EBI-743771,EBI-10182857
Q9UMZ23EBI-743771,EBI-7240490
Q9BT883EBI-743771,EBI-751770
Q155445EBI-743771,EBI-1027005
Q96LR43EBI-743771,EBI-10290841
Q127884EBI-743771,EBI-715766
Q9BQ703EBI-743771,EBI-745182
Q712K33EBI-743771,EBI-2340879
Q9NYU13EBI-743771,EBI-1054215
P427683EBI-743771,EBI-346375
Q96S154EBI-743771,EBI-746424
Q96K803EBI-743771,EBI-742550
Q9BV973EBI-743771,EBI-4395497

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115769, 125 interactors

Protein interaction database and analysis system

More...
IntActi
Q92624, 147 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000083182

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati50 – 83TPR 1Add BLAST34
Repeati120 – 153TPR 2Add BLAST34
Repeati206 – 239TPR 3Add BLAST34
Repeati288 – 321TPR 4Add BLAST34
Repeati333 – 367TPR 5Add BLAST35
Repeati429 – 462TPR 6Add BLAST34
Repeati471 – 505TPR 7Add BLAST35
Repeati514 – 547TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1840 Eukaryota
COG0457 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007799

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92624

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHFGHKH

Database of Orthologous Groups

More...
OrthoDBi
578212at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92624

TreeFam database of animal gene trees

More...
TreeFami
TF314010

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042476 APPBP2
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR46575 PTHR46575, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC
Length:585
Mass (Da):66,853
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i849A120807DA2438
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIZ9K7EIZ9_HUMAN
Amyloid protein-binding protein 2
APPBP2
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN61K7EN61_HUMAN
Amyloid protein-binding protein 2
APPBP2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENN3K7ENN3_HUMAN
Amyloid protein-binding protein 2
APPBP2
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13217 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti296F → L in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti325K → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti340S → C in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti354L → V in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti369P → R in AAC83973 (PubMed:9843960).Curated1
Sequence conflicti542N → K in AAC83973 (PubMed:9843960).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052606561S → N. Corresponds to variant dbSNP:rs34146848Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32699.1

NCBI Reference Sequences

More...
RefSeqi
NP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000083182; ENSP00000083182; ENSG00000062725

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10513

UCSC genome browser

More...
UCSCi
uc002iys.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017782 mRNA Translation: AAC83973.1
D86981 mRNA Translation: BAA13217.1 Different initiation.
AK292227 mRNA Translation: BAF84916.1
CH471179 Genomic DNA Translation: EAW51406.1
BC018121 mRNA Translation: AAH18121.1
CCDSiCCDS32699.1
RefSeqiNP_001269405.1, NM_001282476.1
NP_006371.2, NM_006380.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115769, 125 interactors
IntActiQ92624, 147 interactors
STRINGi9606.ENSP00000083182

PTM databases

iPTMnetiQ92624
PhosphoSitePlusiQ92624

Polymorphism and mutation databases

BioMutaiAPPBP2
DMDMi50400598

Proteomic databases

EPDiQ92624
jPOSTiQ92624
MassIVEiQ92624
MaxQBiQ92624
PaxDbiQ92624
PeptideAtlasiQ92624
PRIDEiQ92624
ProteomicsDBi75379

Genome annotation databases

EnsembliENST00000083182; ENSP00000083182; ENSG00000062725
GeneIDi10513
KEGGihsa:10513
UCSCiuc002iys.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10513
DisGeNETi10513

GeneCards: human genes, protein and diseases

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GeneCardsi
APPBP2
HGNCiHGNC:622 APPBP2
MIMi605324 gene
neXtProtiNX_Q92624
OpenTargetsiENSG00000062725
PharmGKBiPA24912

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000010722
HOGENOMiHOG000007799
InParanoidiQ92624
OMAiEHFGHKH
OrthoDBi578212at2759
PhylomeDBiQ92624
TreeFamiTF314010

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
APPBP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
APPBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10513
PharosiQ92624

Protein Ontology

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PROi
PR:Q92624

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000062725 Expressed in 237 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ92624 baseline and differential
GenevisibleiQ92624 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR042476 APPBP2
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR46575 PTHR46575, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92624
Secondary accession number(s): A8K862, O95095, Q8WVC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 16, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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