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Entry version 162 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

Nuclear pore complex protein Nup205

Gene

NUP205

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of nuclear pore Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup205
Alternative name(s):
205 kDa nucleoporin
Nucleoporin Nup205
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP205
Synonyms:C7orf14, KIAA0225
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18658 NUP205

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614352 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92621

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephrotic syndrome 13 (NPHS13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0764711995F → S in NPHS13; abrogates interaction with NUP93. 1 PublicationCorresponds to variant dbSNP:rs869312984EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23165

MalaCards human disease database

More...
MalaCardsi
NUP205
MIMi616893 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000155561

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38624

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP205

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048592 – 2012Nuclear pore complex protein Nup205Add BLAST2011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1167PhosphoserineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1942PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92621

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92621

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92621

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92621

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92621

PeptideAtlas

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PeptideAtlasi
Q92621

PRoteomics IDEntifications database

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PRIDEi
Q92621

ProteomicsDB human proteome resource

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ProteomicsDBi
75374

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92621

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92621

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000155561 Expressed in 204 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92621 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92621 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC) (PubMed:9348540, PubMed:15229283).

Forms a complex with NUP35, NUP93, NUP155 and lamin B (PubMed:15703211, PubMed:26878725). Does not interact with TPR (PubMed:12802065).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116777, 98 interactors

Database of interacting proteins

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DIPi
DIP-44021N

Protein interaction database and analysis system

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IntActi
Q92621, 77 interactors

Molecular INTeraction database

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MINTi
Q92621

STRING: functional protein association networks

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STRINGi
9606.ENSP00000285968

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92621

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP186/NUP192/NUP205 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1835 Eukaryota
ENOG410XSBR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000044863

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92621

KEGG Orthology (KO)

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KOi
K14310

Identification of Orthologs from Complete Genome Data

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OMAi
YHGNSNP

Database of Orthologous Groups

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OrthoDBi
90119at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92621

TreeFam database of animal gene trees

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TreeFami
TF313397

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021827 Nup186/Nup192/Nup205

The PANTHER Classification System

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PANTHERi
PTHR31344:SF0 PTHR31344:SF0, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11894 Nup192, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q92621-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF
60 70 80 90 100
ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQL IKEAFILSDL
110 120 130 140 150
FDIGELAAVE LLLAGEHQQP HFPGLTRGLV AVLLYWDGKR CIANSLKALI
160 170 180 190 200
QSRRGKTWTL ELSPELASMT TRFTDELMEQ GLTYKVLTLV SQIDVNNEFE
210 220 230 240 250
KLQRERGLGS EKHRKEVSDL IKECRQSLAE SLFAWACQSP LGKEDTLLLI
260 270 280 290 300
GHLERVTVEA NGSLDAVNLA LLMALLYCFD ISFIEQSTEE RDDMIHQLPL
310 320 330 340 350
LTEKQYIATI HSRLQDSQLW KLPGLQATVR LAWALALRGI SQLPDVTALA
360 370 380 390 400
EFTEADEAMA ELAIADNVFL FLMESVVVSE YFYQEEFYIR RVHNLITDFL
410 420 430 440 450
ALMPMKVKQL RNRADEDARM IHMSMQMGNE PPISLRRDLE HLMLLIGELY
460 470 480 490 500
KKNPFHLELA LEYWCPTEPL QTPTIMGSYL GVAHQRPPQR QVVLSKFVRQ
510 520 530 540 550
MGDLLPPTIY IPYLKMLQGL ANGPQCAHYC FSLLKVNGSS HVENIQGAGG
560 570 580 590 600
SPVSWEHFFH SLMLYHEHLR KDLPSADSVQ YRHLPSRGIT QKEQDGLIAF
610 620 630 640 650
LQLTSTIITW SENARLALCE HPQWTPVVVI LGLLQCSIPP VLKAELLKTL
660 670 680 690 700
AAFGKSPEIA ASLWQSLEYT QILQTVRIPS QRQAIGIEVE LNEIESRCEE
710 720 730 740 750
YPLTRAFCQL ISTLVESSFP SNLGAGLRPP GFDPYLQFLR DSVFLRFRTR
760 770 780 790 800
AYRRAAEKWE VAEVVLEVFY KLLRDYEPQL EDFVDQFVEL QGEEIIAYKP
810 820 830 840 850
PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK HLEKAVQHCL
860 870 880 890 900
ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPRT KKADNVVNIA
910 920 930 940 950
RYLYHGNTNP ELAFESAKIL CCISCNSNIQ IKLVGDFTHD QSISQKLMAG
960 970 980 990 1000
FVECLDCEDA EEFVRLEEGS ELEKKLVAIR HETRIHILNL LITSLECNPP
1010 1020 1030 1040 1050
NLALYLLGFE LKKPVSTTNL QDPGVLGCPR TCLHAILNIL EKGTEGRTGP
1060 1070 1080 1090 1100
VAVRESPQLA ELCYQVIYQL CACSDTSGPT MRYLRTSQDF LFSQLQYLPF
1110 1120 1130 1140 1150
SNKEYEISML NQMSWLMKTA SIELRVTSLN RQRSHTQRLL HLLLDDMPVK
1160 1170 1180 1190 1200
PYSDGEGGIE DENRSVSGFL HFDTATKVRR KILNILDSID FSQEIPEPLQ
1210 1220 1230 1240 1250
LDFFDRAQIE QVIANCEHKN LRGQTVCNVK LLHRVLVAEV NALQGMAAIG
1260 1270 1280 1290 1300
QRPLLMEEIS TVLQYVVGRN KLLQCLHAKR HALESWRQLV EIILTACPQD
1310 1320 1330 1340 1350
LIQAEDRQLI IRDILQDVHD KILDDEAAQE LMPVVAGAVF TLTAHLSQAV
1360 1370 1380 1390 1400
LTEQKETSVL GPAEAHYAFM LDSCFTSPPP EENPLVGFAS IGDSSLYIIL
1410 1420 1430 1440 1450
KKLLDFILKT GGGFQRVRTH LYGSLLYYLQ IAQRPDEPDT LEAAKKTMWE
1460 1470 1480 1490 1500
RLTAPEDVFS KLQRENIAII ESYGAALMEV VCRDACDGHE IGRMLALALL
1510 1520 1530 1540 1550
DRIVSVDKQQ QWLLYLSNSG YLKVLVDSLV EDDRTLQSLL TPQPPLLKAL
1560 1570 1580 1590 1600
YTYESKMAFL TRVAKIQQGA LELLRSGVIV RLAQCQVYDM RPETDPQSMF
1610 1620 1630 1640 1650
GMRDPPMFIP TPVDRYRQIL LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI
1660 1670 1680 1690 1700
SHSDTIQAIL RCQDVSAGSL QELALLTGII SKAALPGILS ELDVDVNEGS
1710 1720 1730 1740 1750
LMELQGHIGR FQRQCLGLLS RFGGSDRLRQ FKFQDDNVEG DKVSKKDEIE
1760 1770 1780 1790 1800
LAMQQICANV MEYCQSLMLQ SSPTFQHAVC LFTPSLSETV NRDGPRQDTQ
1810 1820 1830 1840 1850
APVVPYWRLP GLGIIIYLLK QSANDFFSYY DSHRQSVSKL QNVEQLPPDE
1860 1870 1880 1890 1900
IKELCQSVMP AGVDKISTAQ KYVLARRRLV KVINNRAKLL SLCSFIIETC
1910 1920 1930 1940 1950
LFILWRHLEY YLLHCMPTDS QDSLFASRTL FKSRRLQDSF ASETNLDFRS
1960 1970 1980 1990 2000
GLAIVSQHDL DQLQADAINA FGESLQKKLL DIEGLYSKVR SRYSFIQALV
2010
RRIRGLLRIS RN
Length:2,012
Mass (Da):227,922
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3B268881000FBAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPX2U3KPX2_HUMAN
Nuclear pore complex protein Nup205
NUP205
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ97U3KQ97_HUMAN
Nuclear pore complex protein Nup205
NUP205
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ47U3KQ47_HUMAN
Nuclear pore complex protein Nup205
NUP205
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQH5U3KQH5_HUMAN
Nuclear pore complex protein Nup205
NUP205
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13214 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05056733P → S. Corresponds to variant dbSNP:rs7797639Ensembl.1
Natural variantiVAR_0505681356E → Q3 PublicationsCorresponds to variant dbSNP:rs7810767Ensembl.1
Natural variantiVAR_0764711995F → S in NPHS13; abrogates interaction with NUP93. 1 PublicationCorresponds to variant dbSNP:rs869312984EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D86978 mRNA Translation: BAA13214.1 Different initiation.
AC093107 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83855.1
BC044255 mRNA Translation: AAH44255.1
BC136624 mRNA Translation: AAI36625.1
BC146784 mRNA Translation: AAI46785.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34759.1

NCBI Reference Sequences

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RefSeqi
NP_001316363.1, NM_001329434.1
NP_055950.1, NM_015135.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000285968; ENSP00000285968; ENSG00000155561

Database of genes from NCBI RefSeq genomes

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GeneIDi
23165

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23165

UCSC genome browser

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UCSCi
uc003vsw.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86978 mRNA Translation: BAA13214.1 Different initiation.
AC093107 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83855.1
BC044255 mRNA Translation: AAH44255.1
BC136624 mRNA Translation: AAI36625.1
BC146784 mRNA Translation: AAI46785.1
CCDSiCCDS34759.1
RefSeqiNP_001316363.1, NM_001329434.1
NP_055950.1, NM_015135.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJNelectron microscopy21.40D/J/P/V1-2012[»]
5IJOelectron microscopy21.40D/P1-2012[»]
SMRiQ92621
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116777, 98 interactors
DIPiDIP-44021N
IntActiQ92621, 77 interactors
MINTiQ92621
STRINGi9606.ENSP00000285968

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ92621
PhosphoSitePlusiQ92621
SwissPalmiQ92621

Polymorphism and mutation databases

BioMutaiNUP205
DMDMi296439283

Proteomic databases

EPDiQ92621
jPOSTiQ92621
MassIVEiQ92621
MaxQBiQ92621
PaxDbiQ92621
PeptideAtlasiQ92621
PRIDEiQ92621
ProteomicsDBi75374

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285968; ENSP00000285968; ENSG00000155561
GeneIDi23165
KEGGihsa:23165
UCSCiuc003vsw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23165
DisGeNETi23165

GeneCards: human genes, protein and diseases

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GeneCardsi
NUP205
HGNCiHGNC:18658 NUP205
MalaCardsiNUP205
MIMi614352 gene
616893 phenotype
neXtProtiNX_Q92621
OpenTargetsiENSG00000155561
Orphaneti93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
PharmGKBiPA38624

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1835 Eukaryota
ENOG410XSBR LUCA
GeneTreeiENSGT00390000004003
HOGENOMiHOG000044863
InParanoidiQ92621
KOiK14310
OMAiYHGNSNP
OrthoDBi90119at2759
PhylomeDBiQ92621
TreeFamiTF313397

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NUP205 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NUP205

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23165

Pharos

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Pharosi
Q92621

Protein Ontology

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PROi
PR:Q92621

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155561 Expressed in 204 organ(s), highest expression level in kidney
ExpressionAtlasiQ92621 baseline and differential
GenevisibleiQ92621 HS

Family and domain databases

InterProiView protein in InterPro
IPR021827 Nup186/Nup192/Nup205
PANTHERiPTHR31344:SF0 PTHR31344:SF0, 1 hit
PfamiView protein in Pfam
PF11894 Nup192, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU205_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92621
Secondary accession number(s): A6H8X3, Q86YC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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