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Entry version 168 (26 Feb 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Zinc finger protein 516

Gene

ZNF516

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri34 – 56C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri62 – 84C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 223C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri248 – 270C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 783C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1098 – 1120C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 516Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF516Imported
Synonyms:KIAA0222Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28990 ZNF516

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615114 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92618

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9658

Open Targets

More...
OpenTargetsi
ENSG00000101493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134992707

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92618 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF516

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14548318

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476341 – 1163Zinc finger protein 516Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki681Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1062Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92618

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92618

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92618

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92618

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92618

PeptideAtlas

More...
PeptideAtlasi
Q92618

PRoteomics IDEntifications database

More...
PRIDEi
Q92618

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92618

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92618

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101493 Expressed in testis and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92618 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92618 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015792

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRDM16; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific genes.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115016, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q92618

Protein interaction database and analysis system

More...
IntActi
Q92618, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000394757

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92618 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 431Mediates promoter DNA-binding and activation of transcriptionBy similarityAdd BLAST431

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 56C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri62 – 84C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 223C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri248 – 270C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 783C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1098 – 1120C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009481_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92618

KEGG Orthology (KO)

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KOi
K22411

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDHKTYY

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92618

TreeFam database of animal gene trees

More...
TreeFami
TF332241

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92618-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS
60 70 80 90 100
QHMRKHTGEK PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA
110 120 130 140 150
PLGEMRASEG LDACASPTKS ASACNRLLNG ASQADGARVL NGASQADSGR
160 170 180 190 200
VLLRSSKKGA EGSACAPGEA KAAVQCSFCK SQFERKKDLE LHVHQAHKPF
210 220 230 240 250
KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK PELSPGEFPC
260 270 280 290 300
EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP
310 320 330 340 350
KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL
360 370 380 390 400
NAHNAIHRRV EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG
410 420 430 440 450
TQAGRRVAEL DPVNSYQAWQ LATRGKVAEP AEYLKYGAWD EALAGDVAFD
460 470 480 490 500
KDRREYVLVS QEKRKREQDA PAAQGPPRKR ASGPGDPAPA GHLDPRSAAR
510 520 530 540 550
PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA RRERDSDGDR
560 570 580 590 600
AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE
610 620 630 640 650
PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV
660 670 680 690 700
SILENSSRET SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE
710 720 730 740 750
GQTGHPAEKL SDLHNKEHSG GGKRALAPDL MPLDLSARST RDDPSNKETA
760 770 780 790 800
SSLQAALVVH PCPYCSHKTY YPEVLWMHKR IWHRVSCNSV APPWIQPNGY
810 820 830 840 850
KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV PGGMPGSKSG
860 870 880 890 900
SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA
910 920 930 940 950
TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV
960 970 980 990 1000
EKFGVPPAGA GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR
1010 1020 1030 1040 1050
EPPSKAAQEL RTLATCAAGS RGDAALQAQP GVAGAPPVLH SIKQEPVAEG
1060 1070 1080 1090 1100
HEKRLDILNI FKTYIPKDFA TLYQGWGVSG PGLEHRGTLR TQARPGEFVC
1110 1120 1130 1140 1150
IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD APKQGRDHSN
1160
TGTVQTVPLR KGT
Length:1,163
Mass (Da):124,289
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D6DDDE2D70236A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUJ4A0A087WUJ4_HUMAN
Zinc finger protein 516
ZNF516
517Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2K2F5H2K2_HUMAN
Zinc finger protein 516
ZNF516
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH41H0YH41_HUMAN
Zinc finger protein 516
ZNF516
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13211 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0528524N → S. Corresponds to variant dbSNP:rs3752097Ensembl.1
Natural variantiVAR_052853239G → S. Corresponds to variant dbSNP:rs12961584Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86975 mRNA Translation: BAA13211.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74234.1

NCBI Reference Sequences

More...
RefSeqi
NP_055458.1, NM_014643.3
XP_011524571.1, XM_011526269.1
XP_011524572.1, XM_011526270.2
XP_011524573.1, XM_011526271.2
XP_011524574.1, XM_011526272.2
XP_011524575.1, XM_011526273.2
XP_011524576.1, XM_011526274.2
XP_011524577.1, XM_011526275.2
XP_016881586.1, XM_017026097.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000443185; ENSP00000394757; ENSG00000101493

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9658

UCSC genome browser

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UCSCi
uc032hhr.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86975 mRNA Translation: BAA13211.2 Different initiation.
CCDSiCCDS74234.1
RefSeqiNP_055458.1, NM_014643.3
XP_011524571.1, XM_011526269.1
XP_011524572.1, XM_011526270.2
XP_011524573.1, XM_011526271.2
XP_011524574.1, XM_011526272.2
XP_011524575.1, XM_011526273.2
XP_011524576.1, XM_011526274.2
XP_011524577.1, XM_011526275.2
XP_016881586.1, XM_017026097.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115016, 12 interactors
CORUMiQ92618
IntActiQ92618, 8 interactors
STRINGi9606.ENSP00000394757

PTM databases

iPTMnetiQ92618
PhosphoSitePlusiQ92618

Polymorphism and mutation databases

BioMutaiZNF516
DMDMi14548318

Proteomic databases

EPDiQ92618
jPOSTiQ92618
MassIVEiQ92618
MaxQBiQ92618
PaxDbiQ92618
PeptideAtlasiQ92618
PRIDEiQ92618
ProteomicsDBi75371

Genome annotation databases

EnsembliENST00000443185; ENSP00000394757; ENSG00000101493
GeneIDi9658
KEGGihsa:9658
UCSCiuc032hhr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9658
DisGeNETi9658

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF516
HGNCiHGNC:28990 ZNF516
HPAiHPA015792
MIMi615114 gene
neXtProtiNX_Q92618
OpenTargetsiENSG00000101493
PharmGKBiPA134992707

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160839
HOGENOMiCLU_009481_0_0_1
InParanoidiQ92618
KOiK22411
OMAiCDHKTYY
OrthoDBi1318335at2759
PhylomeDBiQ92618
TreeFamiTF332241

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF516 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9658
PharosiQ92618 Tbio

Protein Ontology

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PROi
PR:Q92618
RNActiQ92618 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101493 Expressed in testis and 186 other tissues
ExpressionAtlasiQ92618 baseline and differential
GenevisibleiQ92618 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN516_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92618
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 1, 1997
Last modified: February 26, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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