Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 175 (18 Sep 2019)
Sequence version 6 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

eIF-2-alpha kinase activator GCN1

Gene

GCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processStress response, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
eIF-2-alpha kinase activator GCN1By similarity
Alternative name(s):
GCN1 eIF-2-alpha kinase activator homologImported
GCN1-like protein 1By similarity
General control of amino-acid synthesis 1-like protein 1By similarity
Translational activator GCN1By similarity
Short name:
HsGCN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCN1Imported
Synonyms:GCN1L1By similarity, KIAA0219
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4199 GCN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605614 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10985

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28616

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3706558

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GCN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000874432 – 2671eIF-2-alpha kinase activator GCN1Add BLAST2670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei729PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei2276PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92616

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92616

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92616

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92616

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92616

PeptideAtlas

More...
PeptideAtlasi
Q92616

PRoteomics IDEntifications database

More...
PRIDEi
Q92616

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75364

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q92616

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92616

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92616

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (PubMed:9039502). Expressed in skeletal muscules, ovary and testis (PubMed:9234705).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089154 Expressed in 245 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92616 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018799
HPA019648
HPA024367

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation.

Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116181, 131 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q92616

Protein interaction database and analysis system

More...
IntActi
Q92616, 63 interactors

Molecular INTeraction database

More...
MINTi
Q92616

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300648

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati140 – 178HEAT 1Sequence analysisAdd BLAST39
Repeati257 – 293HEAT 2Sequence analysisAdd BLAST37
Repeati294 – 331HEAT 3Sequence analysisAdd BLAST38
Repeati385 – 423HEAT 4Sequence analysisAdd BLAST39
Repeati425 – 459HEAT 5Sequence analysisAdd BLAST35
Repeati460 – 503HEAT 6Sequence analysisAdd BLAST44
Repeati560 – 597HEAT 7Sequence analysisAdd BLAST38
Repeati599 – 636HEAT 8Sequence analysisAdd BLAST38
Repeati697 – 732HEAT 9Sequence analysisAdd BLAST36
Repeati733 – 770HEAT 10Sequence analysisAdd BLAST38
Repeati879 – 925HEAT 11Sequence analysisAdd BLAST47
Repeati979 – 1016HEAT 12Sequence analysisAdd BLAST38
Repeati1035 – 1072HEAT 13Sequence analysisAdd BLAST38
Repeati1078 – 1115HEAT 14Sequence analysisAdd BLAST38
Repeati1155 – 1192HEAT 15Sequence analysisAdd BLAST38
Repeati1210 – 1250HEAT 16Sequence analysisAdd BLAST41
Repeati1251 – 1289HEAT 17Sequence analysisAdd BLAST39
Repeati1290 – 1332HEAT 18Sequence analysisAdd BLAST43
Repeati1335 – 1372HEAT 19Sequence analysisAdd BLAST38
Repeati1374 – 1410HEAT 20Sequence analysisAdd BLAST37
Repeati1413 – 1451HEAT 21Sequence analysisAdd BLAST39
Repeati1455 – 1492HEAT 22Sequence analysisAdd BLAST38
Repeati1493 – 1530HEAT 23Sequence analysisAdd BLAST38
Repeati1534 – 1571HEAT 24Sequence analysisAdd BLAST38
Repeati1573 – 1609HEAT 25Sequence analysisAdd BLAST37
Repeati1611 – 1648HEAT 26Sequence analysisAdd BLAST38
Repeati1653 – 1690HEAT 27Sequence analysisAdd BLAST38
Repeati1692 – 1729HEAT 28Sequence analysisAdd BLAST38
Repeati1731 – 1769HEAT 29Sequence analysisAdd BLAST39
Repeati1773 – 1810HEAT 30Sequence analysisAdd BLAST38
Repeati1812 – 1848HEAT 31Sequence analysisAdd BLAST37
Repeati1921 – 1958HEAT 32Sequence analysisAdd BLAST38
Repeati1959 – 1996HEAT 33Sequence analysisAdd BLAST38
Repeati2001 – 2038HEAT 34Sequence analysisAdd BLAST38
Repeati2039 – 2076HEAT 35Sequence analysisAdd BLAST38
Repeati2078 – 2106HEAT 36Sequence analysisAdd BLAST29
Repeati2107 – 2146HEAT 37Sequence analysisAdd BLAST40
Repeati2147 – 2184HEAT 38Sequence analysisAdd BLAST38
Repeati2188 – 2225HEAT 39Sequence analysisAdd BLAST38
Repeati2259 – 2296HEAT 40Sequence analysisAdd BLAST38
Repeati2301 – 2338HEAT 41Sequence analysisAdd BLAST38
Repeati2339 – 2380HEAT 42Sequence analysisAdd BLAST42
Repeati2382 – 2417HEAT 43Sequence analysisAdd BLAST36
Repeati2422 – 2459HEAT 44Sequence analysisAdd BLAST38
Repeati2546 – 2583HEAT 45Sequence analysisAdd BLAST38
Repeati2588 – 2625HEAT 46Sequence analysisAdd BLAST38
Repeati2627 – 2661HEAT 47; degenerateSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili804 – 863Sequence analysisAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GCN1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1242 Eukaryota
ENOG410XPSD LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92616

Database of Orthologous Groups

More...
OrthoDBi
160593at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92616

TreeFam database of animal gene trees

More...
TreeFami
TF105398

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR033173 Gcn1
IPR021133 HEAT_type_2
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR23346:SF7 PTHR23346:SF7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q92616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL
60 70 80 90 100
CKLFCLTLHR YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS
110 120 130 140 150
KAGVPSKSSG SAALLALTWT CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL
160 170 180 190 200
LEVLGGSHKH AVDGAVKKLT KLWKENPGLV EQYLSAILSL EPNQNYAGML
210 220 230 240 250
GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK YLLDSCAPLL
260 270 280 290 300
RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV
310 320 330 340 350
KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE
360 370 380 390 400
GKLTVVAQKM SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE
410 420 430 440 450
GTLVHAVSVL ALWCNRFTME VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM
460 470 480 490 500
LASYRGDTLL QALDLLPLLI QTVEKAASQS TQVPTITEGV AAALLLLKLS
510 520 530 540 550
VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC TVLHLTERLF
560 570 580 590 600
LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL
610 620 630 640 650
AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI
660 670 680 690 700
SGVPGLKGDV TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA
710 720 730 740 750
FITRHLDQII PRMTTQSPLN QSSMNAMGSL SVLSPDRVLP QLISTITASV
760 770 780 790 800
QNPALRLVTR EEFAIMQTPA GELYDKSIIQ SAQQDSIKKA NMKRENKAYS
810 820 830 840 850
FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR EAQVRRRLQE
860 870 880 890 900
LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP
910 920 930 940 950
FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA
960 970 980 990 1000
VMLLHTHTIT SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE
1010 1020 1030 1040 1050
EWMAQILQIL TVQAQLRASP NTPPGRVDEN GPELLPRVAM LRLLTWVIGT
1060 1070 1080 1090 1100
GSPRLQVLAS DTLTTLCASS SGDDGCAFAE QEEVDVLLCA LQSPCASVRE
1110 1120 1130 1140 1150
TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE IRKLAERLWS
1160 1170 1180 1190 1200
MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR
1210 1220 1230 1240 1250
LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS
1260 1270 1280 1290 1300
SQVKPLFQFF VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE
1310 1320 1330 1340 1350
EFLKNAPNDA SYDAVRQSVV VLMGSLAKHL DKSDPKVKPI VAKLIAALST
1360 1370 1380 1390 1400
PSQQVQESVA SCLPPLVPAI KEDAGGMIQR LMQQLLESDK YAERKGAAYG
1410 1420 1430 1440 1450
LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF AFEMLCTMLG
1460 1470 1480 1490 1500
KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP
1510 1520 1530 1540 1550
SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS
1560 1570 1580 1590 1600
HVKVQKAGQQ ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL
1610 1620 1630 1640 1650
DTKFVHFIDA PSLALIMPIV QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD
1660 1670 1680 1690 1700
LAPYLPSVTP GLKASLLDPV PEVRTVSAKA LGAMVKGMGE SCFEDLLPWL
1710 1720 1730 1740 1750
METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV ATASKVDIAP
1760 1770 1780 1790 1800
HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA
1810 1820 1830 1840 1850
GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT
1860 1870 1880 1890 1900
GKMTTETASE DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV
1910 1920 1930 1940 1950
RQASLHVWKI VVSNTPRTLR EILPTLFGLL LGFLASTCAD KRTIAARTLG
1960 1970 1980 1990 2000
DLVRKLGEKI LPEIIPILEE GLRSQKSDER QGVCIGLSEI MKSTSRDAVL
2010 2020 2030 2040 2050
YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA LEDILPFLLK
2060 2070 2080 2090 2100
QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV
2110 2120 2130 2140 2150
AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR
2160 2170 2180 2190 2200
IIIEYLLEAT RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL
2210 2220 2230 2240 2250
FNDSSPVVLE ESWDALNAIT KKLDAGNQLA LIEELHKEIR LIGNESKGEH
2260 2270 2280 2290 2300
VPGFCLPKKG VTSILPVLRE GVLTGSPEQK EEAAKALGLV IRLTSADALR
2310 2320 2330 2340 2350
PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA LKPFLPQLQT
2360 2370 2380 2390 2400
TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV
2410 2420 2430 2440 2450
RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL
2460 2470 2480 2490 2500
GELCAFLTEE ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL
2510 2520 2530 2540 2550
CAGRYSSDVQ EMILSSATAD RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK
2560 2570 2580 2590 2600
LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD PLPPLDPQAI KPILKALLDN
2610 2620 2630 2640 2650
TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS LEVLNEVNRR
2660 2670
SLKKLASQAD STEQVDDTIL T
Length:2,671
Mass (Da):292,758
Last modified:May 18, 2010 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC34F50517DCC2A8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC51648 differs from that shown. Reason: Frameshift at position 2657.Curated
The sequence AAC83183 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA13209 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292L → F in BAA13209 (PubMed:9039502).Curated1
Sequence conflicti292L → F in AAI53882 (PubMed:15489334).Curated1
Sequence conflicti842A → G in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1584A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1683A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti1760F → S in AAD00655 (Ref. 6) Curated1
Sequence conflicti2298A → V in AAC51648 (PubMed:9234705).Curated1
Sequence conflicti2486S → T in AAD00655 (Ref. 6) Curated1
Sequence conflicti2549A → R in AAC51648 (PubMed:9234705).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0622282155Y → DCombined sources4 PublicationsCorresponds to variant dbSNP:rs3864938Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86973 mRNA Translation: BAA13209.2 Different initiation.
AC004812 Genomic DNA Translation: AAC83183.1 Sequence problems.
BC021129 mRNA Translation: AAH21129.1
BC032335 mRNA Translation: AAH32335.1
BC046177 mRNA Translation: AAH46177.1
BC064346 mRNA Translation: AAH64346.1
BC153881 mRNA Translation: AAI53882.1
U88836 mRNA Translation: AAD00655.1
U88837 mRNA Translation: AAD00656.1
U77700 mRNA Translation: AAC51648.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41847.1

NCBI Reference Sequences

More...
RefSeqi
NP_006827.1, NM_006836.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300648; ENSP00000300648; ENSG00000089154

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10985

UCSC genome browser

More...
UCSCi
uc001txo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86973 mRNA Translation: BAA13209.2 Different initiation.
AC004812 Genomic DNA Translation: AAC83183.1 Sequence problems.
BC021129 mRNA Translation: AAH21129.1
BC032335 mRNA Translation: AAH32335.1
BC046177 mRNA Translation: AAH46177.1
BC064346 mRNA Translation: AAH64346.1
BC153881 mRNA Translation: AAI53882.1
U88836 mRNA Translation: AAD00655.1
U88837 mRNA Translation: AAD00656.1
U77700 mRNA Translation: AAC51648.1 Frameshift.
CCDSiCCDS41847.1
RefSeqiNP_006827.1, NM_006836.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116181, 131 interactors
CORUMiQ92616
IntActiQ92616, 63 interactors
MINTiQ92616
STRINGi9606.ENSP00000300648

Chemistry databases

ChEMBLiCHEMBL3706558

PTM databases

CarbonylDBiQ92616
iPTMnetiQ92616
PhosphoSitePlusiQ92616
SwissPalmiQ92616

Polymorphism and mutation databases

BioMutaiGCN1
DMDMi296439506

Proteomic databases

EPDiQ92616
jPOSTiQ92616
MassIVEiQ92616
MaxQBiQ92616
PaxDbiQ92616
PeptideAtlasiQ92616
PRIDEiQ92616
ProteomicsDBi75364

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300648; ENSP00000300648; ENSG00000089154
GeneIDi10985
KEGGihsa:10985
UCSCiuc001txo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10985
DisGeNETi10985

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GCN1
HGNCiHGNC:4199 GCN1
HPAiHPA018799
HPA019648
HPA024367
MIMi605614 gene
neXtProtiNX_Q92616
PharmGKBiPA28616

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1242 Eukaryota
ENOG410XPSD LUCA
InParanoidiQ92616
OrthoDBi160593at2759
PhylomeDBiQ92616
TreeFamiTF105398

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GCN1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GCN1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10985

Pharos

More...
Pharosi
Q92616

Protein Ontology

More...
PROi
PR:Q92616

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089154 Expressed in 245 organ(s), highest expression level in corpus callosum
GenevisibleiQ92616 HS

Family and domain databases

Gene3Di1.25.10.10, 6 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR033173 Gcn1
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR23346:SF7 PTHR23346:SF7, 1 hit
SMARTiView protein in SMART
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 5 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92616
Secondary accession number(s): A8KAY1
, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 175 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again