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Protein

Protein Jade-3

Gene

JADE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 250PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri252 – 286C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri310 – 366PHD-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • histone H4-K12 acetylation Source: UniProtKB
  • histone H4-K5 acetylation Source: UniProtKB
  • histone H4-K8 acetylation Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-3
Alternative name(s):
Jade family PHD finger protein 3
PHD finger protein 16
Gene namesi
Name:JADE3
Synonyms:KIAA0215, PHF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102221.13
HGNCiHGNC:22982 JADE3
MIMi300618 gene
neXtProtiNX_Q92613

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102221
PharmGKBiPA134993233

Polymorphism and mutation databases

DMDMi34098663

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593091 – 823Protein Jade-3Add BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30N6-acetyllysineCombined sources1
Modified residuei32N6-acetyllysineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei601N6-acetyllysineBy similarity1
Modified residuei608PhosphoserineCombined sources1
Modified residuei638N6-acetyllysineCombined sources1
Modified residuei735N6-acetyllysineBy similarity1
Modified residuei774PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei780PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92613
MaxQBiQ92613
PaxDbiQ92613
PeptideAtlasiQ92613
PRIDEiQ92613
ProteomicsDBi75357

PTM databases

iPTMnetiQ92613
PhosphoSitePlusiQ92613

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in placenta and uterus.1 Publication

Inductioni

By estradiol in estrogen-responsive breast cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000102221
CleanExiHS_PHF16
ExpressionAtlasiQ92613 baseline and differential
GenevisibleiQ92613 HS

Organism-specific databases

HPAiHPA006007
HPA064697

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P43364-23EBI-10278909,EBI-10178634

Protein-protein interaction databases

BioGridi115113, 15 interactors
ComplexPortaliCPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CORUMiQ92613
IntActiQ92613, 9 interactors
STRINGi9606.ENSP00000218343

Structurei

3D structure databases

ProteinModelPortaliQ92613
SMRiQ92613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JADE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 250PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri252 – 286C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri310 – 366PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0954 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOGENOMiHOG000220882
HOVERGENiHBG053585
InParanoidiQ92613
KOiK22156
OMAiCHENMNH
OrthoDBiEOG091G0T5C
PhylomeDBiQ92613
TreeFamiTF316118

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513 EPL1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHRPVSSS DSSDESPSTS FTSGSMYRIK SKIPNEHKKP AEVFRKDLIS
60 70 80 90 100
AMKLPDSHHI NPDSYYLFAD TWKEEWEKGV QVPASPDTVP QPSLRIIAEK
110 120 130 140 150
VKDVLFIRPR KYIHCSSPDT TEPGYINIME LAASVCRYDL DDMDIFWLQE
160 170 180 190 200
LNEDLAEMGC GPVDENLMEK TVEVLERHCH ENMNHAIETE EGLGIEYDED
210 220 230 240 250
VICDVCRSPD SEEGNDMVFC DKCNVCVHQA CYGILKVPEG SWLCRSCVLG
260 270 280 290 300
IYPQCVLCPK KGGALKTTKT GTKWAHVSCA LWIPEVSIAC PERMEPITKI
310 320 330 340 350
SHIPPSRWAL VCNLCKLKTG ACIQCSIKSC ITAFHVTCAF EHGLEMKTIL
360 370 380 390 400
DEGDEVKFKS YCLKHSQNRQ KLGEAEYPHH RAKEQSQAKS EKTSLRAQKL
410 420 430 440 450
RELEEEFYSL VRVEDVAAEL GMPTLAVDFI YNYWKLKRKS NFNKPLFPPK
460 470 480 490 500
EDEENGLVQP KEESIHTRMR MFMHLRQDLE RVRNLCYMIS RREKLKLSHN
510 520 530 540 550
KIQEQIFGLQ VQLLNQEIDA GLPLTNALEN SLFYPPPRIT LKLKMPKSTP
560 570 580 590 600
EDHRNSSTET DQQPHSPDSS SSVHSIRNMQ VPQESLEMRT KSYPRYPLES
610 620 630 640 650
KNNRLLASLS HSRSEAKESS PAWRTPSSEC YHGQSLGKPL VLQAALHGQS
660 670 680 690 700
SIGNGKSQPN SKFAKSNGLE GSWSGNVTQK DSSSEMFCDQ EPVFSPHLVS
710 720 730 740 750
QGSFRKSTVE HFSRSFKETT NRWVKNTEDL QCYVKPTKNM SPKEQFWGRQ
760 770 780 790 800
VLRRSAGRAP YQENDGYCPD LELSDSEAES DGNKEKVRVR KDSSDRENPP
810 820
HDSRRDCHGK SKTHPLSHSS MQR
Length:823
Mass (Da):93,808
Last modified:February 1, 1997 - v1
Checksum:i4E47E2A124D0CE38
GO

Sequence cautioni

The sequence BAA13205 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127774 mRNA Translation: AAD51905.1
D86969 mRNA Translation: BAA13205.2 Different initiation.
Z83822 Genomic DNA No translation available.
BC114487 mRNA Translation: AAI14488.1
BC113880 mRNA Translation: AAI13881.1
BN000289 mRNA Translation: CAE30502.1
CCDSiCCDS14271.1
RefSeqiNP_001070913.1, NM_001077445.2
NP_055550.1, NM_014735.4
UniGeneiHs.371977

Genome annotation databases

EnsembliENST00000611250; ENSP00000479377; ENSG00000102221
ENST00000614628; ENSP00000481850; ENSG00000102221
GeneIDi9767
KEGGihsa:9767
UCSCiuc033ebv.1 human

Similar proteinsi

Entry informationi

Entry nameiJADE3_HUMAN
AccessioniPrimary (citable) accession number: Q92613
Secondary accession number(s): Q6IE79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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