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UniProtKB - Q92610 (ZN592_HUMAN)
Protein
Zinc finger protein 592
Gene
ZNF592
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 587 – 612 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 615 – 639 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 711 – 731 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 740 – 764 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 768 – 790 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 799 – 822 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 827 – 850 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 892 – 915 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 983 – 1006 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1013 – 1036 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1043 – 1069 | C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1124 – 1146 | C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1153 – 1176 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q92610 |
SignaLinki | Q92610 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 592 |
Gene namesi | Name:ZNF592 Synonyms:KIAA0211 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28986, ZNF592 |
MIMi | 613624, gene |
neXtProti | NX_Q92610 |
VEuPathDBi | HostDB:ENSG00000166716 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9640 |
MalaCardsi | ZNF592 |
OpenTargetsi | ENSG00000166716 |
Orphaneti | 83472, CAMOS syndrome |
PharmGKBi | PA134918837 |
Miscellaneous databases
Pharosi | Q92610, Tbio |
Genetic variation databases
BioMutai | ZNF592 |
DMDMi | 209572705 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047682 | 1 – 1267 | Zinc finger protein 592Add BLAST | 1267 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 145 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Cross-linki | 202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 206 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 529 | PhosphoserineCombined sources | 1 | |
Cross-linki | 546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 689 | PhosphoserineCombined sources | 1 | |
Modified residuei | 691 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1089 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1205 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1250 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1216 |
EPDi | Q92610 |
jPOSTi | Q92610 |
MassIVEi | Q92610 |
MaxQBi | Q92610 |
PaxDbi | Q92610 |
PeptideAtlasi | Q92610 |
PRIDEi | Q92610 |
ProteomicsDBi | 75355 |
PTM databases
GlyGeni | Q92610, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q92610 |
PhosphoSitePlusi | Q92610 |
Expressioni
Tissue specificityi
Widely expressed, with highest levels in skeletal muscle. Expressed throughout the central nervous system, including in the cerebellum and cerebellar vermis, with higher expression in the substantia nigra. Widely expressed in fetal tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000166716, Expressed in gastrocnemius and 210 other tissues |
ExpressionAtlasi | Q92610, baseline and differential |
Genevisiblei | Q92610, HS |
Organism-specific databases
HPAi | ENSG00000166716, Low tissue specificity |
Interactioni
Binary interactionsi
Q92610
With | #Exp. | IntAct |
---|---|---|
TCAF1 [Q9Y4C2] | 3 | EBI-1210420,EBI-750484 |
Protein-protein interaction databases
BioGRIDi | 114999, 54 interactors |
IntActi | Q92610, 21 interactors |
MINTi | Q92610 |
STRINGi | 9606.ENSP00000452877 |
Miscellaneous databases
RNActi | Q92610, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q92610 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 124 – 153 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 205 – 280 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 295 – 488 | DisorderedSequence analysisAdd BLAST | 194 | |
Regioni | 673 – 696 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 918 – 970 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 1195 – 1267 | DisorderedSequence analysisAdd BLAST | 73 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 237 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 300 – 314 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 345 – 365 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 673 – 687 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 919 – 957 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1249 – 1267 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 587 – 612 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 615 – 639 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 711 – 731 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 740 – 764 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 768 – 790 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 799 – 822 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 827 – 850 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 892 – 915 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 983 – 1006 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1013 – 1036 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1043 – 1069 | C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1124 – 1146 | C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1153 – 1176 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158357 |
HOGENOMi | CLU_006283_0_0_1 |
InParanoidi | Q92610 |
OMAi | SVKKYPC |
OrthoDBi | 180681at2759 |
PhylomeDBi | Q92610 |
TreeFami | TF329009 |
Family and domain databases
InterProi | View protein in InterPro IPR045914, Zn532-like IPR041697, Znf-C2H2_11 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR47222, PTHR47222, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF16622, zf-C2H2_11, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q92610-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QTPSEENESP LKPPGICMDE
60 70 80 90 100
SVSLSHSGSA PDVPAVSVIV KNTSRQESFE AEKDHITPSL LHNGFRGSDL
110 120 130 140 150
PPDPHNCGKF DSTFMNGDSA RSFPGKLEPP KSEPLPTFNQ FSPISSPEPE
160 170 180 190 200
DPIKDNGFGI KPKHSDSYFP PPLGCGAVGG PVLEALAKFP VPELHMFDHF
210 220 230 240 250
CKKEPKPEPL PLGSQQEHEQ SGQNTVEPHK DPDATRFFGE ALEFNSHPSN
260 270 280 290 300
SIGESKGLAR ELGTCSSVPP RQRLKPAHSK LSSCVAALVA LQAKRVASVT
310 320 330 340 350
KEDQPGHTKD LSGPTKESSK GSPKMPKSPK SPRSPLEATR KSIKPSDSPR
360 370 380 390 400
SICSDSSSKG SPSVAASSPP AIPKVRIKTI KTSSGEIKRT VTRILPDPDD
410 420 430 440 450
PSKSPVGSPL GSAIAEAPSE MPGDEVPVEE HFPEAGTNSG SPQGARKGDE
460 470 480 490 500
SMTKASDSSS PSCSSGPRVP KGAAPGSQTG KKQQSTALQA STLAPANLLP
510 520 530 540 550
KAVHLANLNL VPHSVAASVT AKSSVQRRSQ PQLTQMSVPL VHQVKKAAPL
560 570 580 590 600
IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK
610 620 630 640 650
SLSQHYGRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ
660 670 680 690 700
LLVKPISADQ MFVSAPVNST APAAPAPSSS PKHGLTSGSA SPPPPALPLY
710 720 730 740 750
PDPVRLIRYS IKCLECHKQM RDYMVLAAHF QRTTEETEGL TCQVCQMLLP
760 770 780 790 800
NQCSFCAHQR IHAHKSPYCC PECGVLCRSA YFQTHVKENC LHYARKVGYR
810 820 830 840 850
CIHCGVVHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS STADHSATQH
860 870 880 890 900
PTQPHRPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQVG VFKCPECPLL
910 920 930 940 950
FVQKPELMQH VKSTHGVPRN VDELSSLQSS ADTSSSRPGS RVPTEPPATS
960 970 980 990 1000
VAARSSSLPS GRWGRPEAHR RVEARPRLRN TGWTCQECQE WVPDRESYVS
1010 1020 1030 1040 1050
HMKKSHGRTL KRYPCRQCEQ SFHTPNSLRK HIRNNHDTVK KFYTCGYCTE
1060 1070 1080 1090 1100
DSPSFPRPSL LESHISLMHG IRNPDLSQTS KVKPPGGHSP QVNHLKRPVS
1110 1120 1130 1140 1150
GVGDAPGTSN GATVSSTKRH KSLFQCAKCS FATDSGLEFQ SHIPQHQVDS
1160 1170 1180 1190 1200
STAQCLLCGL CYTSASSLSR HLFIVHKVRD QEEEEEEEAA AAEMAVEVAE
1210 1220 1230 1240 1250
PEEGSGEEVP METRENGLEE CAGEPLSADP EARRLLGPAP EDDGGHNDHS
1260
QPQASQDQDS HTLSPQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YM74 | H0YM74_HUMAN | Zinc finger protein 592 | ZNF592 hCG_1991191 | 858 | Annotation score: |
Sequence cautioni
The sequence BAA13202 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047033 | 926 | S → N2 PublicationsCorresponds to variant dbSNP:rs8182086EnsemblClinVar. | 1 | |
Natural variantiVAR_064583 | 1046 | G → R Found in a patient with clinical features of Galloway-Mowat syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs150829393EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86966 mRNA Translation: BAA13202.2 Different initiation. CH471101 Genomic DNA Translation: EAX01957.1 BC094688 mRNA Translation: AAH94688.1 BC112232 mRNA Translation: AAI12233.1 BC112234 mRNA Translation: AAI12235.1 |
CCDSi | CCDS32317.1 |
RefSeqi | NP_055445.2, NM_014630.2 XP_005255053.1, XM_005254996.3 XP_011520548.1, XM_011522246.2 XP_011520549.1, XM_011522247.2 XP_016878223.1, XM_017022734.1 |
Genome annotation databases
Ensembli | ENST00000299927.4; ENSP00000299927.3; ENSG00000166716.10 ENST00000560079.7; ENSP00000452877.2; ENSG00000166716.10 |
GeneIDi | 9640 |
KEGGi | hsa:9640 |
MANE-Selecti | ENST00000560079.7; ENSP00000452877.2; NM_014630.3; NP_055445.2 |
UCSCi | uc002bld.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86966 mRNA Translation: BAA13202.2 Different initiation. CH471101 Genomic DNA Translation: EAX01957.1 BC094688 mRNA Translation: AAH94688.1 BC112232 mRNA Translation: AAI12233.1 BC112234 mRNA Translation: AAI12235.1 |
CCDSi | CCDS32317.1 |
RefSeqi | NP_055445.2, NM_014630.2 XP_005255053.1, XM_005254996.3 XP_011520548.1, XM_011522246.2 XP_011520549.1, XM_011522247.2 XP_016878223.1, XM_017022734.1 |
3D structure databases
AlphaFoldDBi | Q92610 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114999, 54 interactors |
IntActi | Q92610, 21 interactors |
MINTi | Q92610 |
STRINGi | 9606.ENSP00000452877 |
PTM databases
GlyGeni | Q92610, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q92610 |
PhosphoSitePlusi | Q92610 |
Genetic variation databases
BioMutai | ZNF592 |
DMDMi | 209572705 |
Proteomic databases
CPTACi | CPTAC-1216 |
EPDi | Q92610 |
jPOSTi | Q92610 |
MassIVEi | Q92610 |
MaxQBi | Q92610 |
PaxDbi | Q92610 |
PeptideAtlasi | Q92610 |
PRIDEi | Q92610 |
ProteomicsDBi | 75355 |
Protocols and materials databases
Antibodypediai | 15495, 121 antibodies from 19 providers |
DNASUi | 9640 |
Genome annotation databases
Ensembli | ENST00000299927.4; ENSP00000299927.3; ENSG00000166716.10 ENST00000560079.7; ENSP00000452877.2; ENSG00000166716.10 |
GeneIDi | 9640 |
KEGGi | hsa:9640 |
MANE-Selecti | ENST00000560079.7; ENSP00000452877.2; NM_014630.3; NP_055445.2 |
UCSCi | uc002bld.4, human |
Organism-specific databases
CTDi | 9640 |
DisGeNETi | 9640 |
GeneCardsi | ZNF592 |
HGNCi | HGNC:28986, ZNF592 |
HPAi | ENSG00000166716, Low tissue specificity |
MalaCardsi | ZNF592 |
MIMi | 613624, gene |
neXtProti | NX_Q92610 |
OpenTargetsi | ENSG00000166716 |
Orphaneti | 83472, CAMOS syndrome |
PharmGKBi | PA134918837 |
VEuPathDBi | HostDB:ENSG00000166716 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158357 |
HOGENOMi | CLU_006283_0_0_1 |
InParanoidi | Q92610 |
OMAi | SVKKYPC |
OrthoDBi | 180681at2759 |
PhylomeDBi | Q92610 |
TreeFami | TF329009 |
Enzyme and pathway databases
PathwayCommonsi | Q92610 |
SignaLinki | Q92610 |
Miscellaneous databases
BioGRID-ORCSi | 9640, 28 hits in 1101 CRISPR screens |
ChiTaRSi | ZNF592, human |
GenomeRNAii | 9640 |
Pharosi | Q92610, Tbio |
PROi | PR:Q92610 |
RNActi | Q92610, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166716, Expressed in gastrocnemius and 210 other tissues |
ExpressionAtlasi | Q92610, baseline and differential |
Genevisiblei | Q92610, HS |
Family and domain databases
InterProi | View protein in InterPro IPR045914, Zn532-like IPR041697, Znf-C2H2_11 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR47222, PTHR47222, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF16622, zf-C2H2_11, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN592_HUMAN | |
Accessioni | Q92610Primary (citable) accession number: Q92610 Secondary accession number(s): Q2M1T2, Q504Y9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families