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UniProtKB - Q92610 (ZN592_HUMAN)

Entry version 183 (25 May 2022)
Sequence version 2 (14 Oct 2008)
Previous versions | rss
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Protein

Zinc finger protein 592

Gene

ZNF592

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri587 – 612C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri615 – 639C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri711 – 731C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri740 – 764C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri799 – 822C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 850C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri892 – 915C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri983 – 1006C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1013 – 1036C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1043 – 1069C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1124 – 1146C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1153 – 1176C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92610

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92610

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 592
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF592
Synonyms:KIAA0211
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28986, ZNF592

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613624, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92610

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166716

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9640

MalaCards human disease database

More...MalaCardsi		ZNF592

Open Targets

More...OpenTargetsi		ENSG00000166716

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		83472, CAMOS syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134918837

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92610, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF592

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572705

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476821 – 1267Zinc finger protein 592Add BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei529PhosphoserineCombined sources1
Cross-linki546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei573PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1205PhosphoserineBy similarity1
Modified residuei1250PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1216

Encyclopedia of Proteome Dynamics

More...EPDi		Q92610

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92610

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92610

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92610

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92610

PeptideAtlas

More...PeptideAtlasi		Q92610

PRoteomics IDEntifications database

More...PRIDEi		Q92610

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75355

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92610, 3 sites, 2 O-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in skeletal muscle. Expressed throughout the central nervous system, including in the cerebellum and cerebellar vermis, with higher expression in the substantia nigra. Widely expressed in fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166716, Expressed in gastrocnemius and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92610, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92610, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166716, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114999, 54 interactors

Protein interaction database and analysis system

More...IntActi		Q92610, 21 interactors

Molecular INTeraction database

More...MINTi		Q92610

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000452877

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92610, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q92610

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62
Regioni124 – 153DisorderedSequence analysisAdd BLAST30
Regioni205 – 280DisorderedSequence analysisAdd BLAST76
Regioni295 – 488DisorderedSequence analysisAdd BLAST194
Regioni673 – 696DisorderedSequence analysisAdd BLAST24
Regioni918 – 970DisorderedSequence analysisAdd BLAST53
Regioni1195 – 1267DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi223 – 237Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi300 – 314Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi345 – 365Polar residuesSequence analysisAdd BLAST21
Compositional biasi673 – 687Polar residuesSequence analysisAdd BLAST15
Compositional biasi919 – 957Polar residuesSequence analysisAdd BLAST39
Compositional biasi1249 – 1267Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri587 – 612C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri615 – 639C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri711 – 731C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri740 – 764C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri799 – 822C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 850C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri892 – 915C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri983 – 1006C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1013 – 1036C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1043 – 1069C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1124 – 1146C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1153 – 1176C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158357

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006283_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92610

Identification of Orthologs from Complete Genome Data

More...OMAi		SVKKYPC

Database of Orthologous Groups

More...OrthoDBi		180681at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92610

TreeFam database of animal gene trees

More...TreeFami		TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045914, Zn532-like
IPR041697, Znf-C2H2_11
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR47222, PTHR47222, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 2 hits
PF16622, zf-C2H2_11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QTPSEENESP LKPPGICMDE 
        60         70         80         90        100
SVSLSHSGSA PDVPAVSVIV KNTSRQESFE AEKDHITPSL LHNGFRGSDL 
       110        120        130        140        150
PPDPHNCGKF DSTFMNGDSA RSFPGKLEPP KSEPLPTFNQ FSPISSPEPE 
       160        170        180        190        200
DPIKDNGFGI KPKHSDSYFP PPLGCGAVGG PVLEALAKFP VPELHMFDHF 
       210        220        230        240        250
CKKEPKPEPL PLGSQQEHEQ SGQNTVEPHK DPDATRFFGE ALEFNSHPSN 
       260        270        280        290        300
SIGESKGLAR ELGTCSSVPP RQRLKPAHSK LSSCVAALVA LQAKRVASVT 
       310        320        330        340        350
KEDQPGHTKD LSGPTKESSK GSPKMPKSPK SPRSPLEATR KSIKPSDSPR 
       360        370        380        390        400
SICSDSSSKG SPSVAASSPP AIPKVRIKTI KTSSGEIKRT VTRILPDPDD 
       410        420        430        440        450
PSKSPVGSPL GSAIAEAPSE MPGDEVPVEE HFPEAGTNSG SPQGARKGDE 
       460        470        480        490        500
SMTKASDSSS PSCSSGPRVP KGAAPGSQTG KKQQSTALQA STLAPANLLP 
       510        520        530        540        550
KAVHLANLNL VPHSVAASVT AKSSVQRRSQ PQLTQMSVPL VHQVKKAAPL 
       560        570        580        590        600
IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK 
       610        620        630        640        650
SLSQHYGRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ 
       660        670        680        690        700
LLVKPISADQ MFVSAPVNST APAAPAPSSS PKHGLTSGSA SPPPPALPLY 
       710        720        730        740        750
PDPVRLIRYS IKCLECHKQM RDYMVLAAHF QRTTEETEGL TCQVCQMLLP 
       760        770        780        790        800
NQCSFCAHQR IHAHKSPYCC PECGVLCRSA YFQTHVKENC LHYARKVGYR 
       810        820        830        840        850
CIHCGVVHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS STADHSATQH 
       860        870        880        890        900
PTQPHRPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQVG VFKCPECPLL 
       910        920        930        940        950
FVQKPELMQH VKSTHGVPRN VDELSSLQSS ADTSSSRPGS RVPTEPPATS 
       960        970        980        990       1000
VAARSSSLPS GRWGRPEAHR RVEARPRLRN TGWTCQECQE WVPDRESYVS 
      1010       1020       1030       1040       1050
HMKKSHGRTL KRYPCRQCEQ SFHTPNSLRK HIRNNHDTVK KFYTCGYCTE 
      1060       1070       1080       1090       1100
DSPSFPRPSL LESHISLMHG IRNPDLSQTS KVKPPGGHSP QVNHLKRPVS 
      1110       1120       1130       1140       1150
GVGDAPGTSN GATVSSTKRH KSLFQCAKCS FATDSGLEFQ SHIPQHQVDS 
      1160       1170       1180       1190       1200
STAQCLLCGL CYTSASSLSR HLFIVHKVRD QEEEEEEEAA AAEMAVEVAE 
      1210       1220       1230       1240       1250
PEEGSGEEVP METRENGLEE CAGEPLSADP EARRLLGPAP EDDGGHNDHS 
      1260 
QPQASQDQDS HTLSPQV
Length:1,267
Mass (Da):137,528
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BD1CF586BB30E53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM74H0YM74_HUMAN
Zinc finger protein 592
ZNF592 hCG_1991191
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13202 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047033926S → N2 PublicationsCorresponds to variant dbSNP:rs8182086EnsemblClinVar.1
Natural variantiVAR_0645831046G → R Found in a patient with clinical features of Galloway-Mowat syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs150829393EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D86966 mRNA Translation: BAA13202.2 Different initiation.
CH471101 Genomic DNA Translation: EAX01957.1
BC094688 mRNA Translation: AAH94688.1
BC112232 mRNA Translation: AAI12233.1
BC112234 mRNA Translation: AAI12235.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32317.1

NCBI Reference Sequences

More...RefSeqi		NP_055445.2, NM_014630.2
XP_005255053.1, XM_005254996.3
XP_011520548.1, XM_011522246.2
XP_011520549.1, XM_011522247.2
XP_016878223.1, XM_017022734.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299927.4; ENSP00000299927.3; ENSG00000166716.10
ENST00000560079.7; ENSP00000452877.2; ENSG00000166716.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9640

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000560079.7; ENSP00000452877.2; NM_014630.3; NP_055445.2

UCSC genome browser

More...UCSCi		uc002bld.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86966 mRNA Translation: BAA13202.2 Different initiation.
CH471101 Genomic DNA Translation: EAX01957.1
BC094688 mRNA Translation: AAH94688.1
BC112232 mRNA Translation: AAI12233.1
BC112234 mRNA Translation: AAI12235.1
CCDSiCCDS32317.1
RefSeqiNP_055445.2, NM_014630.2
XP_005255053.1, XM_005254996.3
XP_011520548.1, XM_011522246.2
XP_011520549.1, XM_011522247.2
XP_016878223.1, XM_017022734.1

3D structure databases

AlphaFoldDBiQ92610
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi114999, 54 interactors
IntActiQ92610, 21 interactors
MINTiQ92610
STRINGi9606.ENSP00000452877

PTM databases

GlyGeniQ92610, 3 sites, 2 O-linked glycans (3 sites)
iPTMnetiQ92610
PhosphoSitePlusiQ92610

Genetic variation databases

BioMutaiZNF592
DMDMi209572705

Proteomic databases

CPTACiCPTAC-1216
EPDiQ92610
jPOSTiQ92610
MassIVEiQ92610
MaxQBiQ92610
PaxDbiQ92610
PeptideAtlasiQ92610
PRIDEiQ92610
ProteomicsDBi75355

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15495, 121 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		9640

Genome annotation databases

EnsembliENST00000299927.4; ENSP00000299927.3; ENSG00000166716.10
ENST00000560079.7; ENSP00000452877.2; ENSG00000166716.10
GeneIDi9640
KEGGihsa:9640
MANE-SelectiENST00000560079.7; ENSP00000452877.2; NM_014630.3; NP_055445.2
UCSCiuc002bld.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9640
DisGeNETi9640

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF592
HGNCiHGNC:28986, ZNF592
HPAiENSG00000166716, Low tissue specificity
MalaCardsiZNF592
MIMi613624, gene
neXtProtiNX_Q92610
OpenTargetsiENSG00000166716
Orphaneti83472, CAMOS syndrome
PharmGKBiPA134918837
VEuPathDBiHostDB:ENSG00000166716

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158357
HOGENOMiCLU_006283_0_0_1
InParanoidiQ92610
OMAiSVKKYPC
OrthoDBi180681at2759
PhylomeDBiQ92610
TreeFamiTF329009

Enzyme and pathway databases

PathwayCommonsiQ92610
SignaLinkiQ92610

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9640, 28 hits in 1101 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF592, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9640
PharosiQ92610, Tbio

Protein Ontology

More...PROi		PR:Q92610
RNActiQ92610, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166716, Expressed in gastrocnemius and 210 other tissues
ExpressionAtlasiQ92610, baseline and differential
GenevisibleiQ92610, HS

Family and domain databases

InterProiView protein in InterPro
IPR045914, Zn532-like
IPR041697, Znf-C2H2_11
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR47222, PTHR47222, 1 hit
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
PF16622, zf-C2H2_11, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN592_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92610
Secondary accession number(s): Q2M1T2, Q504Y9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 14, 2008
Last modified: May 25, 2022
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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