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Entry version 164 (13 Feb 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Zinc finger protein 592

Gene

ZNF592

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri587 – 612C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri615 – 639C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri711 – 731C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri740 – 764C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri799 – 822C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 850C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri892 – 915C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri983 – 1006C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1013 – 1036C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1043 – 1069C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1124 – 1146C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1153 – 1176C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 592
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF592
Synonyms:KIAA0211
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166716.9

Human Gene Nomenclature Database

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HGNCi
HGNC:28986 ZNF592

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613624 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9640

MalaCards human disease database

More...
MalaCardsi
ZNF592

Open Targets

More...
OpenTargetsi
ENSG00000166716

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
83472 CAMOS syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918837

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF592

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572705

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476821 – 1267Zinc finger protein 592Add BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei529PhosphoserineCombined sources1
Cross-linki546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei573PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1205PhosphoserineBy similarity1
Modified residuei1250PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92610

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92610

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92610

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92610

PeptideAtlas

More...
PeptideAtlasi
Q92610

PRoteomics IDEntifications database

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PRIDEi
Q92610

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75355

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in skeletal muscle. Expressed throughout the central nervous system, including in the cerebellum and cerebellar vermis, with higher expression in the substantia nigra. Widely expressed in fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166716 Expressed in 191 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92610 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92610 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020332
HPA021600

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TCAF1Q9Y4C23EBI-1210420,EBI-750484

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114999, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q92610, 12 interactors

Molecular INTeraction database

More...
MINTi
Q92610

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299927

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92610

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92610

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri587 – 612C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri615 – 639C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri711 – 731C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri740 – 764C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri799 – 822C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri827 – 850C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri892 – 915C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri983 – 1006C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1013 – 1036C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1043 – 1069C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1124 – 1146C2H2-type 12; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1153 – 1176C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158357

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010306

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062228

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92610

KEGG Orthology (KO)

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KOi
K19325

Identification of Orthologs from Complete Genome Data

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OMAi
CGALCRS

Database of Orthologous Groups

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OrthoDBi
180681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92610

TreeFam database of animal gene trees

More...
TreeFami
TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QTPSEENESP LKPPGICMDE
60 70 80 90 100
SVSLSHSGSA PDVPAVSVIV KNTSRQESFE AEKDHITPSL LHNGFRGSDL
110 120 130 140 150
PPDPHNCGKF DSTFMNGDSA RSFPGKLEPP KSEPLPTFNQ FSPISSPEPE
160 170 180 190 200
DPIKDNGFGI KPKHSDSYFP PPLGCGAVGG PVLEALAKFP VPELHMFDHF
210 220 230 240 250
CKKEPKPEPL PLGSQQEHEQ SGQNTVEPHK DPDATRFFGE ALEFNSHPSN
260 270 280 290 300
SIGESKGLAR ELGTCSSVPP RQRLKPAHSK LSSCVAALVA LQAKRVASVT
310 320 330 340 350
KEDQPGHTKD LSGPTKESSK GSPKMPKSPK SPRSPLEATR KSIKPSDSPR
360 370 380 390 400
SICSDSSSKG SPSVAASSPP AIPKVRIKTI KTSSGEIKRT VTRILPDPDD
410 420 430 440 450
PSKSPVGSPL GSAIAEAPSE MPGDEVPVEE HFPEAGTNSG SPQGARKGDE
460 470 480 490 500
SMTKASDSSS PSCSSGPRVP KGAAPGSQTG KKQQSTALQA STLAPANLLP
510 520 530 540 550
KAVHLANLNL VPHSVAASVT AKSSVQRRSQ PQLTQMSVPL VHQVKKAAPL
560 570 580 590 600
IVEVFNKVLH SSNPVPLYAP NLSPPADSRI HVPASGYCCL ECGDAFALEK
610 620 630 640 650
SLSQHYGRRS VHIEVLCTLC SKTLLFFNKC SLLRHARDHK SKGLVMQCSQ
660 670 680 690 700
LLVKPISADQ MFVSAPVNST APAAPAPSSS PKHGLTSGSA SPPPPALPLY
710 720 730 740 750
PDPVRLIRYS IKCLECHKQM RDYMVLAAHF QRTTEETEGL TCQVCQMLLP
760 770 780 790 800
NQCSFCAHQR IHAHKSPYCC PECGVLCRSA YFQTHVKENC LHYARKVGYR
810 820 830 840 850
CIHCGVVHLT LALLKSHIQE RHCQVFHKCA FCPMAFKTAS STADHSATQH
860 870 880 890 900
PTQPHRPSQL IYKCSCEMVF NKKRHIQQHF YQNVSKTQVG VFKCPECPLL
910 920 930 940 950
FVQKPELMQH VKSTHGVPRN VDELSSLQSS ADTSSSRPGS RVPTEPPATS
960 970 980 990 1000
VAARSSSLPS GRWGRPEAHR RVEARPRLRN TGWTCQECQE WVPDRESYVS
1010 1020 1030 1040 1050
HMKKSHGRTL KRYPCRQCEQ SFHTPNSLRK HIRNNHDTVK KFYTCGYCTE
1060 1070 1080 1090 1100
DSPSFPRPSL LESHISLMHG IRNPDLSQTS KVKPPGGHSP QVNHLKRPVS
1110 1120 1130 1140 1150
GVGDAPGTSN GATVSSTKRH KSLFQCAKCS FATDSGLEFQ SHIPQHQVDS
1160 1170 1180 1190 1200
STAQCLLCGL CYTSASSLSR HLFIVHKVRD QEEEEEEEAA AAEMAVEVAE
1210 1220 1230 1240 1250
PEEGSGEEVP METRENGLEE CAGEPLSADP EARRLLGPAP EDDGGHNDHS
1260
QPQASQDQDS HTLSPQV
Length:1,267
Mass (Da):137,528
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BD1CF586BB30E53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM74H0YM74_HUMAN
Zinc finger protein 592, isoform CR...
ZNF592 hCG_1991191
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13202 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047033926S → N2 PublicationsCorresponds to variant dbSNP:rs8182086EnsemblClinVar.1
Natural variantiVAR_0645831046G → R Found in a patient with clinical features of Galloway-Mowat syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs150829393EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D86966 mRNA Translation: BAA13202.2 Different initiation.
CH471101 Genomic DNA Translation: EAX01957.1
BC094688 mRNA Translation: AAH94688.1
BC112232 mRNA Translation: AAI12233.1
BC112234 mRNA Translation: AAI12235.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32317.1

NCBI Reference Sequences

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RefSeqi
NP_055445.2, NM_014630.2
XP_005255053.1, XM_005254996.3
XP_011520548.1, XM_011522246.2
XP_011520549.1, XM_011522247.2
XP_016878223.1, XM_017022734.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.79347

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299927; ENSP00000299927; ENSG00000166716
ENST00000560079; ENSP00000452877; ENSG00000166716

Database of genes from NCBI RefSeq genomes

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GeneIDi
9640

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9640

UCSC genome browser

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UCSCi
uc002bld.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86966 mRNA Translation: BAA13202.2 Different initiation.
CH471101 Genomic DNA Translation: EAX01957.1
BC094688 mRNA Translation: AAH94688.1
BC112232 mRNA Translation: AAI12233.1
BC112234 mRNA Translation: AAI12235.1
CCDSiCCDS32317.1
RefSeqiNP_055445.2, NM_014630.2
XP_005255053.1, XM_005254996.3
XP_011520548.1, XM_011522246.2
XP_011520549.1, XM_011522247.2
XP_016878223.1, XM_017022734.1
UniGeneiHs.79347

3D structure databases

ProteinModelPortaliQ92610
SMRiQ92610
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114999, 21 interactors
IntActiQ92610, 12 interactors
MINTiQ92610
STRINGi9606.ENSP00000299927

PTM databases

iPTMnetiQ92610
PhosphoSitePlusiQ92610

Polymorphism and mutation databases

BioMutaiZNF592
DMDMi209572705

Proteomic databases

EPDiQ92610
jPOSTiQ92610
MaxQBiQ92610
PaxDbiQ92610
PeptideAtlasiQ92610
PRIDEiQ92610
ProteomicsDBi75355

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299927; ENSP00000299927; ENSG00000166716
ENST00000560079; ENSP00000452877; ENSG00000166716
GeneIDi9640
KEGGihsa:9640
UCSCiuc002bld.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9640
DisGeNETi9640
EuPathDBiHostDB:ENSG00000166716.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF592
HGNCiHGNC:28986 ZNF592
HPAiHPA020332
HPA021600
MalaCardsiZNF592
MIMi613624 gene
neXtProtiNX_Q92610
OpenTargetsiENSG00000166716
Orphaneti83472 CAMOS syndrome
PharmGKBiPA134918837

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158357
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ92610
KOiK19325
OMAiCGALCRS
OrthoDBi180681at2759
PhylomeDBiQ92610
TreeFamiTF329009

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF592 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9640

Protein Ontology

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PROi
PR:Q92610

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166716 Expressed in 191 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ92610 baseline and differential
GenevisibleiQ92610 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN592_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92610
Secondary accession number(s): Q2M1T2, Q504Y9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 14, 2008
Last modified: February 13, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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