UniProtKB - Q92609 (TBCD5_HUMAN)
TBC1 domain family member 5
TBC1D5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 169 | Arginine fingerBy similarity | 1 | |
Sitei | 204 | Glutamine fingerBy similarity | 1 |
GO - Molecular functioni
- AP-2 adaptor complex binding Source: UniProtKB
- GTPase activator activity Source: GO_Central
- protein-containing complex binding Source: GO_Central
- retromer complex binding Source: ParkinsonsUK-UCL
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- autophagy Source: GO_Central
- intracellular protein transport Source: GO_Central
- macroautophagy Source: ParkinsonsUK-UCL
- positive regulation of receptor internalization Source: UniProtKB
- response to starvation Source: UniProtKB
- retrograde transport, endosome to Golgi Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Biological process | Autophagy, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q92609 |
Protein family/group databases
TCDBi | 8.A.87.2.1, the tbc1 domain (tbc1) family |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 5 |
Gene namesi | Name:TBC1D5 Synonyms:KIAA0210 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19166, TBC1D5 |
MIMi | 615740, gene |
neXtProti | NX_Q92609 |
VEuPathDBi | HostDB:ENSG00000131374.14 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication
Other locations
- autophagosome 1 Publication
Note: During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes.1 Publication
Cytosol
- cytosol Source: GOC
Endosome
- endosome membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- autophagosome Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- retromer complex Source: MGI
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 59 | W → A: Disrupts interaction with VPS29. 1 Publication | 1 | |
Mutagenesisi | 169 | R → A: Abolishes retromer displacement from endosome membrane; no effect on interaction with VPS29; when associated with A-204. 1 Publication | 1 | |
Mutagenesisi | 204 | Q → A: Abolishes retromer displacement from endosome membrane; no effect on interaction with VPS29; when associated with A-169. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9779 |
OpenTargetsi | ENSG00000131374 |
PharmGKBi | PA38808 |
Miscellaneous databases
Pharosi | Q92609, Tbio |
Genetic variation databases
BioMutai | TBC1D5 |
DMDMi | 2495720 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208028 | 1 – 795 | TBC1 domain family member 5Add BLAST | 795 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 43 | PhosphoserineCombined sources | 1 | |
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 460 | PhosphoserineCombined sources | 1 | |
Modified residuei | 522 | PhosphoserineCombined sources | 1 | |
Modified residuei | 539 | PhosphoserineCombined sources | 1 | |
Modified residuei | 541 | PhosphoserineCombined sources | 1 | |
Modified residuei | 544 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 | |
Modified residuei | 570 | PhosphoserineCombined sources | 1 | |
Modified residuei | 584 | PhosphoserineBy similarity | 1 | |
Modified residuei | 730 | PhosphoserineCombined sources | 1 | |
Modified residuei | 791 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q92609 |
jPOSTi | Q92609 |
MassIVEi | Q92609 |
MaxQBi | Q92609 |
PaxDbi | Q92609 |
PeptideAtlasi | Q92609 |
PRIDEi | Q92609 |
ProteomicsDBi | 11067 75354 [Q92609-1] |
PTM databases
iPTMneti | Q92609 |
MetOSitei | Q92609 |
PhosphoSitePlusi | Q92609 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131374, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | Q92609, baseline and differential |
Genevisiblei | Q92609, HS |
Organism-specific databases
HPAi | ENSG00000131374, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1, GABARAPL2.
Interacts with VPS29 and VPS35; indicative for an association with retromer CSC subcomplex. MAP1LC3A and VPS29 compete for binding to TBC1D5 (PubMed:20923837, PubMed:22354992).
Interacts with AP2M1; indicative for an association with the AP2 complex.
Interacts with ULK1 and ATG13 (phosphorylated); indicative for an association with the activated ULK1-ATG13-FIP200 complex.
Interacts with ATG9A; the interactions seems to be restricted to the AP2-clathrin-associated fraction of ATG9A (PubMed:24603492).
1 Publication3 PublicationsBinary interactionsi
Hide detailsQ92609
Protein-protein interaction databases
BioGRIDi | 115123, 42 interactors |
ELMi | Q92609 |
IntActi | Q92609, 33 interactors |
MINTi | Q92609 |
STRINGi | 9606.ENSP00000402935 |
Miscellaneous databases
RNActi | Q92609, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92609 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 359 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 279 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 56 – 64 | Required for interaction with retromer; involved in interaction with ATG8 family proteins1 Publication | 9 | |
Regioni | 786 – 791 | Required for interaction with ATG8 family proteins1 Publication | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 57 – 62 | LIR 12 Publications | 6 | |
Motifi | 785 – 789 | LIR 22 Publications | 5 |
Domaini
Phylogenomic databases
eggNOGi | KOG1091, Eukaryota |
GeneTreei | ENSGT00940000157121 |
HOGENOMi | CLU_020460_1_0_1 |
InParanoidi | Q92609 |
OMAi | FHQNLDY |
OrthoDBi | 1373244at2759 |
PhylomeDBi | Q92609 |
TreeFami | TF105784 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG
60 70 80 90 100
TFNSYRKEWE ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ
110 120 130 140 150
DKSQWISRIE ELRAWYSNIK EIHITNPRKV VGQQDLMINN PLSQDEGSLW
160 170 180 190 200
NKFFQDKELR SMIEQDVKRT FPEMQFFQQE NVRKILTDVL FCYARENEQL
210 220 230 240 250
LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV LNPEYLEHDA
260 270 280 290 300
YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK
310 320 330 340 350
VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV
360 370 380 390 400
VWDALFADGL SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD
410 420 430 440 450
VHSLILKALF LRDPKRNPRP VTYQFHPNLD YYKARGADLM NKSRTNAKGA
460 470 480 490 500
PLNINKVSNS LINFGRKLIS PAMAPGSAGG PVPGGNSSSS SSVVIPTRTS
510 520 530 540 550
AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP SVESLPGGRE
560 570 580 590 600
FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN
610 620 630 640 650
DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK
660 670 680 690 700
GSLRFNQSQL EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS
710 720 730 740 750
SETPGCTDRG NSDDFILISK DDDGSSARGS FSGQAQPLRT LRSTSGKSQA
760 770 780 790
PVCSPLVFSD PLMGPASASS SNPSSSPDDD SSKDSGFTIV SPLDI
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J3F6 | C9J3F6_HUMAN | TBC1 domain family member 5 | TBC1D5 | 593 | Annotation score: | ||
C9JDR8 | C9JDR8_HUMAN | TBC1 domain family member 5 | TBC1D5 | 183 | Annotation score: | ||
C9JWX0 | C9JWX0_HUMAN | TBC1 domain family member 5 | TBC1D5 | 140 | Annotation score: | ||
F2Z3C3 | F2Z3C3_HUMAN | TBC1 domain family member 5 | TBC1D5 | 88 | Annotation score: | ||
C9J397 | C9J397_HUMAN | TBC1 domain family member 5 | TBC1D5 | 129 | Annotation score: | ||
C9JED7 | C9JED7_HUMAN | TBC1 domain family member 5 | TBC1D5 | 79 | Annotation score: | ||
C9JNM0 | C9JNM0_HUMAN | TBC1 domain family member 5 | TBC1D5 | 74 | Annotation score: | ||
C9K0P2 | C9K0P2_HUMAN | TBC1 domain family member 5 | TBC1D5 | 110 | Annotation score: | ||
F2Z3I5 | F2Z3I5_HUMAN | TBC1 domain family member 5 | TBC1D5 | 40 | Annotation score: | ||
C9JW04 | C9JW04_HUMAN | TBC1 domain family member 5 | TBC1D5 | 142 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052536 | 696 | I → V. Corresponds to variant dbSNP:rs1138454Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045039 | 529 | K → KGDVVTGSDAQVSVPVQTLT DLQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86965 mRNA Translation: BAA13201.2 Different initiation. AK310539 mRNA No translation available. AC090644 Genomic DNA No translation available. AC090960 Genomic DNA No translation available. AC099543 Genomic DNA No translation available. AC104297 Genomic DNA No translation available. AC104451 Genomic DNA No translation available. AC132807 Genomic DNA No translation available. AC137672 Genomic DNA No translation available. AC139618 Genomic DNA No translation available. AC140076 Genomic DNA No translation available. AC144521 Genomic DNA No translation available. AC144531 Genomic DNA No translation available. BC013145 mRNA Translation: AAH13145.1 |
CCDSi | CCDS33714.1 [Q92609-1] CCDS46770.1 [Q92609-2] |
RefSeqi | NP_001127853.1, NM_001134381.1 [Q92609-2] NP_055559.1, NM_014744.2 [Q92609-1] XP_006713493.1, XM_006713430.1 XP_011532583.1, XM_011534281.1 [Q92609-2] XP_011532585.1, XM_011534283.2 [Q92609-2] XP_011532586.1, XM_011534284.2 [Q92609-2] XP_016863041.1, XM_017007552.1 [Q92609-2] XP_016863042.1, XM_017007553.1 [Q92609-2] XP_016863043.1, XM_017007554.1 [Q92609-2] XP_016863044.1, XM_017007555.1 [Q92609-2] XP_016863045.1, XM_017007556.1 [Q92609-2] XP_016863046.1, XM_017007557.1 [Q92609-1] |
Genome annotation databases
Ensembli | ENST00000253692; ENSP00000253692; ENSG00000131374 [Q92609-1] ENST00000429383; ENSP00000398127; ENSG00000131374 [Q92609-1] ENST00000446818; ENSP00000402935; ENSG00000131374 [Q92609-2] |
GeneIDi | 9779 |
KEGGi | hsa:9779 |
UCSCi | uc003cbf.3, human [Q92609-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86965 mRNA Translation: BAA13201.2 Different initiation. AK310539 mRNA No translation available. AC090644 Genomic DNA No translation available. AC090960 Genomic DNA No translation available. AC099543 Genomic DNA No translation available. AC104297 Genomic DNA No translation available. AC104451 Genomic DNA No translation available. AC132807 Genomic DNA No translation available. AC137672 Genomic DNA No translation available. AC139618 Genomic DNA No translation available. AC140076 Genomic DNA No translation available. AC144521 Genomic DNA No translation available. AC144531 Genomic DNA No translation available. BC013145 mRNA Translation: AAH13145.1 |
CCDSi | CCDS33714.1 [Q92609-1] CCDS46770.1 [Q92609-2] |
RefSeqi | NP_001127853.1, NM_001134381.1 [Q92609-2] NP_055559.1, NM_014744.2 [Q92609-1] XP_006713493.1, XM_006713430.1 XP_011532583.1, XM_011534281.1 [Q92609-2] XP_011532585.1, XM_011534283.2 [Q92609-2] XP_011532586.1, XM_011534284.2 [Q92609-2] XP_016863041.1, XM_017007552.1 [Q92609-2] XP_016863042.1, XM_017007553.1 [Q92609-2] XP_016863043.1, XM_017007554.1 [Q92609-2] XP_016863044.1, XM_017007555.1 [Q92609-2] XP_016863045.1, XM_017007556.1 [Q92609-2] XP_016863046.1, XM_017007557.1 [Q92609-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GTU | X-ray | 1.50 | B | 132-158 | [»] | |
SMRi | Q92609 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115123, 42 interactors |
ELMi | Q92609 |
IntActi | Q92609, 33 interactors |
MINTi | Q92609 |
STRINGi | 9606.ENSP00000402935 |
Protein family/group databases
TCDBi | 8.A.87.2.1, the tbc1 domain (tbc1) family |
PTM databases
iPTMneti | Q92609 |
MetOSitei | Q92609 |
PhosphoSitePlusi | Q92609 |
Genetic variation databases
BioMutai | TBC1D5 |
DMDMi | 2495720 |
Proteomic databases
EPDi | Q92609 |
jPOSTi | Q92609 |
MassIVEi | Q92609 |
MaxQBi | Q92609 |
PaxDbi | Q92609 |
PeptideAtlasi | Q92609 |
PRIDEi | Q92609 |
ProteomicsDBi | 11067 75354 [Q92609-1] |
Protocols and materials databases
Antibodypediai | 45185, 42 antibodies |
Genome annotation databases
Ensembli | ENST00000253692; ENSP00000253692; ENSG00000131374 [Q92609-1] ENST00000429383; ENSP00000398127; ENSG00000131374 [Q92609-1] ENST00000446818; ENSP00000402935; ENSG00000131374 [Q92609-2] |
GeneIDi | 9779 |
KEGGi | hsa:9779 |
UCSCi | uc003cbf.3, human [Q92609-1] |
Organism-specific databases
CTDi | 9779 |
DisGeNETi | 9779 |
GeneCardsi | TBC1D5 |
HGNCi | HGNC:19166, TBC1D5 |
HPAi | ENSG00000131374, Low tissue specificity |
MIMi | 615740, gene |
neXtProti | NX_Q92609 |
OpenTargetsi | ENSG00000131374 |
PharmGKBi | PA38808 |
VEuPathDBi | HostDB:ENSG00000131374.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1091, Eukaryota |
GeneTreei | ENSGT00940000157121 |
HOGENOMi | CLU_020460_1_0_1 |
InParanoidi | Q92609 |
OMAi | FHQNLDY |
OrthoDBi | 1373244at2759 |
PhylomeDBi | Q92609 |
TreeFami | TF105784 |
Enzyme and pathway databases
PathwayCommonsi | Q92609 |
Miscellaneous databases
BioGRID-ORCSi | 9779, 11 hits in 996 CRISPR screens |
ChiTaRSi | TBC1D5, human |
GenomeRNAii | 9779 |
Pharosi | Q92609, Tbio |
PROi | PR:Q92609 |
RNActi | Q92609, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131374, Expressed in corpus callosum and 239 other tissues |
ExpressionAtlasi | Q92609, baseline and differential |
Genevisiblei | Q92609, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBCD5_HUMAN | |
Accessioni | Q92609Primary (citable) accession number: Q92609 Secondary accession number(s): A6NP25, C9JP52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references