UniProtKB - Q92604 (LGAT1_HUMAN)
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
LPGAT1
Functioni
Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity).
Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor. Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity).
Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873).
Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity).
Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) (By similarity).
By similarityCaution
Catalytic activityi
- a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1ʼ-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1ʼ-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1ʼ-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.3.1.22By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
- 2-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
- 2-acylglycerol O-acyltransferase activity Source: UniProtKB
- acyltransferase activity Source: GO_Central
- lysophospholipid acyltransferase activity Source: UniProtKB
GO - Biological processi
- phosphatidylglycerol acyl-chain remodeling Source: Reactome
- phosphatidylinositol acyl-chain remodeling Source: GO_Central
- phospholipid biosynthetic process Source: UniProtKB-KW
- positive regulation of fatty acid biosynthetic process Source: BHF-UCL
- triglyceride biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q92604 |
Reactomei | R-HSA-1482925, Acyl chain remodelling of PG |
SignaLinki | Q92604 |
Chemistry databases
SwissLipidsi | SLP:000000128 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA:lysophosphatidylglycerol acyltransferase 1CuratedAlternative name(s): |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28985, LPGAT1 |
MIMi | 610473, gene |
neXtProti | NX_Q92604 |
VEuPathDBi | HostDB:ENSG00000123684 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- endomembrane system Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9926 |
OpenTargetsi | ENSG00000123684 |
PharmGKBi | PA134869091 |
Miscellaneous databases
Pharosi | Q92604, Tbio |
Genetic variation databases
BioMutai | LPGAT1 |
DMDMi | 6136501 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208204 | 1 – 370 | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1Add BLAST | 370 |
Proteomic databases
EPDi | Q92604 |
jPOSTi | Q92604 |
MassIVEi | Q92604 |
MaxQBi | Q92604 |
PaxDbi | Q92604 |
PeptideAtlasi | Q92604 |
PRIDEi | Q92604 |
ProteomicsDBi | 75351 |
PTM databases
iPTMneti | Q92604 |
PhosphoSitePlusi | Q92604 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000123684, Expressed in intestine and 220 other tissues |
Genevisiblei | Q92604, HS |
Organism-specific databases
HPAi | ENSG00000123684, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115254, 98 interactors |
IntActi | Q92604, 21 interactors |
MINTi | Q92604 |
STRINGi | 9606.ENSP00000355964 |
Miscellaneous databases
RNActi | Q92604, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q92604 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 101 – 106 | HXXXXD motif | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1505, Eukaryota |
GeneTreei | ENSGT00950000182836 |
HOGENOMi | CLU_046804_2_0_1 |
InParanoidi | Q92604 |
OMAi | MEWGEDV |
OrthoDBi | 836124at2759 |
PhylomeDBi | Q92604 |
TreeFami | TF314346 |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAITLEEAPW LGWLLVKALM RFAFMVVNNL VAIPSYICYV IILQPLRVLD
60 70 80 90 100
SKRFWYIEGI MYKWLLGMVA SWGWYAGYTV MEWGEDIKAV SKDEAVMLVN
110 120 130 140 150
HQATGDVCTL MMCLQDKGLV VAQMMWLMDH IFKYTNFGIV SLVHGDFFIR
160 170 180 190 200
QGRSYRDQQL LLLKKHLENN YRSRDRKWIV LFPEGGFLRK RRETSQAFAK
210 220 230 240 250
KNNLPFLTNV TLPRSGATKI ILNALVAQQK NGSPAGGDAK ELDSKSKGLQ
260 270 280 290 300
WIIDTTIAYP KAEPIDIQTW ILGYRKPTVT HVHYRIFPIK DVPLETDDLT
310 320 330 340 350
TWLYQRFVEK EDLLSHFYET GAFPPSKGHK EAVSREMTLS NLWIFLIQSF
360 370
AFLSGYMWYN IIQYFYHCLF
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86960 mRNA Translation: BAA13196.2 Different initiation. AY561706 mRNA Translation: AAS66979.1 AC096637 Genomic DNA No translation available. AL445488 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93407.1 CH471100 Genomic DNA Translation: EAW93408.1 BC034621 mRNA Translation: AAH34621.1 |
CCDSi | CCDS31018.1 |
RefSeqi | NP_001307737.1, NM_001320808.1 NP_055688.1, NM_014873.2 XP_011508530.1, XM_011510228.2 XP_011508531.1, XM_011510229.2 |
Genome annotation databases
Ensembli | ENST00000366996.1; ENSP00000355963.1; ENSG00000123684.13 ENST00000366997.9; ENSP00000355964.4; ENSG00000123684.13 |
GeneIDi | 9926 |
KEGGi | hsa:9926 |
MANE-Selecti | ENST00000366997.9; ENSP00000355964.4; NM_014873.3; NP_055688.1 |
UCSCi | uc001hiu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86960 mRNA Translation: BAA13196.2 Different initiation. AY561706 mRNA Translation: AAS66979.1 AC096637 Genomic DNA No translation available. AL445488 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93407.1 CH471100 Genomic DNA Translation: EAW93408.1 BC034621 mRNA Translation: AAH34621.1 |
CCDSi | CCDS31018.1 |
RefSeqi | NP_001307737.1, NM_001320808.1 NP_055688.1, NM_014873.2 XP_011508530.1, XM_011510228.2 XP_011508531.1, XM_011510229.2 |
3D structure databases
AlphaFoldDBi | Q92604 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115254, 98 interactors |
IntActi | Q92604, 21 interactors |
MINTi | Q92604 |
STRINGi | 9606.ENSP00000355964 |
Chemistry databases
SwissLipidsi | SLP:000000128 |
PTM databases
iPTMneti | Q92604 |
PhosphoSitePlusi | Q92604 |
Genetic variation databases
BioMutai | LPGAT1 |
DMDMi | 6136501 |
Proteomic databases
EPDi | Q92604 |
jPOSTi | Q92604 |
MassIVEi | Q92604 |
MaxQBi | Q92604 |
PaxDbi | Q92604 |
PeptideAtlasi | Q92604 |
PRIDEi | Q92604 |
ProteomicsDBi | 75351 |
Protocols and materials databases
Antibodypediai | 1888, 96 antibodies from 21 providers |
DNASUi | 9926 |
Genome annotation databases
Ensembli | ENST00000366996.1; ENSP00000355963.1; ENSG00000123684.13 ENST00000366997.9; ENSP00000355964.4; ENSG00000123684.13 |
GeneIDi | 9926 |
KEGGi | hsa:9926 |
MANE-Selecti | ENST00000366997.9; ENSP00000355964.4; NM_014873.3; NP_055688.1 |
UCSCi | uc001hiu.4, human |
Organism-specific databases
CTDi | 9926 |
DisGeNETi | 9926 |
GeneCardsi | LPGAT1 |
HGNCi | HGNC:28985, LPGAT1 |
HPAi | ENSG00000123684, Low tissue specificity |
MIMi | 610473, gene |
neXtProti | NX_Q92604 |
OpenTargetsi | ENSG00000123684 |
PharmGKBi | PA134869091 |
VEuPathDBi | HostDB:ENSG00000123684 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1505, Eukaryota |
GeneTreei | ENSGT00950000182836 |
HOGENOMi | CLU_046804_2_0_1 |
InParanoidi | Q92604 |
OMAi | MEWGEDV |
OrthoDBi | 836124at2759 |
PhylomeDBi | Q92604 |
TreeFami | TF314346 |
Enzyme and pathway databases
PathwayCommonsi | Q92604 |
Reactomei | R-HSA-1482925, Acyl chain remodelling of PG |
SignaLinki | Q92604 |
Miscellaneous databases
BioGRID-ORCSi | 9926, 29 hits in 1074 CRISPR screens |
ChiTaRSi | LPGAT1, human |
GenomeRNAii | 9926 |
Pharosi | Q92604, Tbio |
PROi | PR:Q92604 |
RNActi | Q92604, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123684, Expressed in intestine and 220 other tissues |
Genevisiblei | Q92604, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032098, Acyltransf_C IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF16076, Acyltransf_C, 1 hit PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LGAT1_HUMAN | |
Accessioni | Q92604Primary (citable) accession number: Q92604 Secondary accession number(s): Q53YL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families