UniProtKB - Q92600 (CNOT9_HUMAN)
CCR4-NOT transcription complex subunit 9
CNOT9
Functioni
GO - Molecular functioni
- epidermal growth factor receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- protein domain specific binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
GO - Biological processi
- cytokine-mediated signaling pathway Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
- gene silencing by RNA Source: UniProtKB-KW
- negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- negative regulation of translation Source: GO_Central
- nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
- positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of nuclear receptor transcription coactivator activity Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- sex differentiation Source: ProtInc
Keywordsi
Molecular function | Activator, Repressor |
Biological process | RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q92600 |
Reactomei | R-HSA-429947, Deadenylation of mRNA R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
SIGNORi | Q92600 |
Names & Taxonomyi
Protein namesi | Recommended name: CCR4-NOT transcription complex subunit 9ImportedAlternative name(s): Cell differentiation protein RQCD1 homolog Short name: Rcd-1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144580.13 |
HGNCi | HGNC:10445, CNOT9 |
MIMi | 612054, gene |
neXtProti | NX_Q92600 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- CCR4-NOT complex Source: UniProtKB
- CCR4-NOT core complex Source: GO_Central
- membrane Source: UniProtKB
- P-body Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 227 | R → E: Loss of DNA binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9125 |
OpenTargetsi | ENSG00000144580 |
PharmGKBi | PA34859 |
Miscellaneous databases
Pharosi | Q92600, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105961 |
Polymorphism and mutation databases
BioMutai | CNOT9 |
DMDMi | 74716599 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327224 | 1 – 299 | CCR4-NOT transcription complex subunit 9Add BLAST | 299 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q92600 |
jPOSTi | Q92600 |
MassIVEi | Q92600 |
MaxQBi | Q92600 |
PaxDbi | Q92600 |
PeptideAtlasi | Q92600 |
PRIDEi | Q92600 |
ProteomicsDBi | 6190 6324 75350 [Q92600-1] |
PTM databases
iPTMneti | Q92600 |
PhosphoSitePlusi | Q92600 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144580, Expressed in kidney and 230 other tissues |
ExpressionAtlasi | Q92600, baseline and differential |
Genevisiblei | Q92600, HS |
Organism-specific databases
HPAi | ENSG00000144580, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits.
Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG.
Identified in a complex with ATF2 bound to target DNA (By similarity).
Interacts with NANOS2 (By similarity). Directly interacts with ZNF335.
By similarity3 PublicationsBinary interactionsi
Hide detailsIsoform 3 [Q92600-3]
With | #Exp. | IntAct |
---|---|---|
GADD45A [P24522] | 5 | EBI-12907584,EBI-448167 |
GADD45B [O75293] | 3 | EBI-12907584,EBI-448187 |
GADD45G [O95257] | 3 | EBI-12907584,EBI-448202 |
MESD [Q14696] | 3 | EBI-12907584,EBI-6165891 |
GO - Molecular functioni
- epidermal growth factor receptor binding Source: UniProtKB
- kinase binding Source: UniProtKB
- protein domain specific binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 114573, 71 interactors |
CORUMi | Q92600 |
DIPi | DIP-46840N |
IntActi | Q92600, 40 interactors |
STRINGi | 9606.ENSP00000273064 |
Miscellaneous databases
RNActi | Q92600, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92600 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92600 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3036, Eukaryota |
GeneTreei | ENSGT00390000001225 |
HOGENOMi | CLU_039962_2_0_1 |
InParanoidi | Q92600 |
OMAi | QHYNRIA |
OrthoDBi | 1129961at2759 |
PhylomeDBi | Q92600 |
TreeFami | TF105734 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR007216, CNOT9 |
PANTHERi | PTHR12262:SF0, PTHR12262:SF0, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP
60 70 80 90 100
DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV
110 120 130 140 150
ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD
160 170 180 190 200
EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC
210 220 230 240 250
QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR
260 270 280 290
QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C0W0 | H7C0W0_HUMAN | CCR4-NOT transcription complex subu... | CNOT9 | 61 | Annotation score: | ||
F8WBZ6 | F8WBZ6_HUMAN | CCR4-NOT transcription complex subu... | CNOT9 | 75 | Annotation score: | ||
F8WCV7 | F8WCV7_HUMAN | CCR4-NOT transcription complex subu... | CNOT9 | 41 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042429 | 143 | I → T1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054371 | 143 | I → IVETGFHHVGQADLELPTSS DLPASASQSAGIT in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_055744 | 245 – 258 | AREAL…PDQLK → FSDLTFCWSSFQRK in isoform 3. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_055745 | 259 – 299 | Missing in isoform 3. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87957 Genomic DNA Translation: BAA13508.1 AK293281 mRNA Translation: BAH11481.1 AC012510 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70625.1 CH471063 Genomic DNA Translation: EAW70624.1 BC007102 mRNA Translation: AAH07102.2 Different initiation. BC137455 mRNA Translation: AAI37456.1 BC137456 mRNA Translation: AAI37457.1 |
CCDSi | CCDS33379.1 [Q92600-1] CCDS63122.1 [Q92600-2] CCDS63123.1 [Q92600-3] |
RefSeqi | NP_001258563.1, NM_001271634.1 [Q92600-2] NP_001258564.1, NM_001271635.1 [Q92600-3] NP_005435.1, NM_005444.2 [Q92600-1] |
Genome annotation databases
Ensembli | ENST00000273064; ENSP00000273064; ENSG00000144580 [Q92600-1] ENST00000295701; ENSP00000295701; ENSG00000144580 [Q92600-3] ENST00000542068; ENSP00000443687; ENSG00000144580 [Q92600-1] ENST00000627282; ENSP00000486540; ENSG00000144580 [Q92600-2] |
GeneIDi | 9125 |
KEGGi | hsa:9125 |
UCSCi | uc002vih.3, human [Q92600-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87957 Genomic DNA Translation: BAA13508.1 AK293281 mRNA Translation: BAH11481.1 AC012510 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70625.1 CH471063 Genomic DNA Translation: EAW70624.1 BC007102 mRNA Translation: AAH07102.2 Different initiation. BC137455 mRNA Translation: AAI37456.1 BC137456 mRNA Translation: AAI37457.1 |
CCDSi | CCDS33379.1 [Q92600-1] CCDS63122.1 [Q92600-2] CCDS63123.1 [Q92600-3] |
RefSeqi | NP_001258563.1, NM_001271634.1 [Q92600-2] NP_001258564.1, NM_001271635.1 [Q92600-3] NP_005435.1, NM_005444.2 [Q92600-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FV2 | X-ray | 2.20 | A/B/C/D | 18-285 | [»] | |
4CRU | X-ray | 1.65 | B | 19-285 | [»] | |
4CRV | X-ray | 2.05 | B | 19-285 | [»] | |
4CT6 | X-ray | 2.10 | B | 18-285 | [»] | |
4CT7 | X-ray | 1.90 | B | 16-285 | [»] | |
5LSW | X-ray | 2.15 | A/C | 19-285 | [»] | |
5ONA | X-ray | 2.70 | B/E | 19-285 | [»] | |
5ONB | X-ray | 3.00 | A/C/E/G | 19-285 | [»] | |
6HOM | X-ray | 2.10 | A/C | 19-285 | [»] | |
6HON | X-ray | 2.20 | A/C | 19-285 | [»] | |
SMRi | Q92600 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114573, 71 interactors |
CORUMi | Q92600 |
DIPi | DIP-46840N |
IntActi | Q92600, 40 interactors |
STRINGi | 9606.ENSP00000273064 |
Chemistry databases
ChEMBLi | CHEMBL4105961 |
PTM databases
iPTMneti | Q92600 |
PhosphoSitePlusi | Q92600 |
Polymorphism and mutation databases
BioMutai | CNOT9 |
DMDMi | 74716599 |
Proteomic databases
EPDi | Q92600 |
jPOSTi | Q92600 |
MassIVEi | Q92600 |
MaxQBi | Q92600 |
PaxDbi | Q92600 |
PeptideAtlasi | Q92600 |
PRIDEi | Q92600 |
ProteomicsDBi | 6190 6324 75350 [Q92600-1] |
Protocols and materials databases
Antibodypediai | 51420, 115 antibodies |
DNASUi | 9125 |
Genome annotation databases
Ensembli | ENST00000273064; ENSP00000273064; ENSG00000144580 [Q92600-1] ENST00000295701; ENSP00000295701; ENSG00000144580 [Q92600-3] ENST00000542068; ENSP00000443687; ENSG00000144580 [Q92600-1] ENST00000627282; ENSP00000486540; ENSG00000144580 [Q92600-2] |
GeneIDi | 9125 |
KEGGi | hsa:9125 |
UCSCi | uc002vih.3, human [Q92600-1] |
Organism-specific databases
CTDi | 9125 |
DisGeNETi | 9125 |
EuPathDBi | HostDB:ENSG00000144580.13 |
GeneCardsi | CNOT9 |
HGNCi | HGNC:10445, CNOT9 |
HPAi | ENSG00000144580, Low tissue specificity |
MIMi | 612054, gene |
neXtProti | NX_Q92600 |
OpenTargetsi | ENSG00000144580 |
PharmGKBi | PA34859 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3036, Eukaryota |
GeneTreei | ENSGT00390000001225 |
HOGENOMi | CLU_039962_2_0_1 |
InParanoidi | Q92600 |
OMAi | QHYNRIA |
OrthoDBi | 1129961at2759 |
PhylomeDBi | Q92600 |
TreeFami | TF105734 |
Enzyme and pathway databases
PathwayCommonsi | Q92600 |
Reactomei | R-HSA-429947, Deadenylation of mRNA R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
SIGNORi | Q92600 |
Miscellaneous databases
BioGRID-ORCSi | 9125, 375 hits in 848 CRISPR screens |
ChiTaRSi | CNOT9, human |
EvolutionaryTracei | Q92600 |
GenomeRNAii | 9125 |
Pharosi | Q92600, Tbio |
PROi | PR:Q92600 |
RNActi | Q92600, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144580, Expressed in kidney and 230 other tissues |
ExpressionAtlasi | Q92600, baseline and differential |
Genevisiblei | Q92600, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR007216, CNOT9 |
PANTHERi | PTHR12262:SF0, PTHR12262:SF0, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNOT9_HUMAN | |
Accessioni | Q92600Primary (citable) accession number: Q92600 Secondary accession number(s): B2RPI0 Q96IX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations