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UniProtKB - Q92600 (CNOT9_HUMAN)

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Protein

CCR4-NOT transcription complex subunit 9

Gene

CNOT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.By similarity2 Publications

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • protein domain specific binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 9Imported
Alternative name(s):
Cell differentiation protein RQCD1 homolog
Short name:
Rcd-1
Gene namesi
Name:CNOT9Imported
Synonyms:RCD1, RQCD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144580.13
HGNCiHGNC:10445 CNOT9
MIMi612054 gene
neXtProtiNX_Q92600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi227R → E: Loss of DNA binding. 1 Publication1

Organism-specific databases

DisGeNETi9125
OpenTargetsiENSG00000144580
PharmGKBiPA34859

Polymorphism and mutation databases

DMDMi74716599

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272241 – 299CCR4-NOT transcription complex subunit 9Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ92600
MaxQBiQ92600
PaxDbiQ92600
PeptideAtlasiQ92600
PRIDEiQ92600
ProteomicsDBi75350

PTM databases

iPTMnetiQ92600
PhosphoSitePlusiQ92600

Expressioni

Tissue specificityi

Detected in spleen, thymus, prostate, testis, ovary and intestine.1 Publication

Gene expression databases

BgeeiENSG00000144580
CleanExiHS_RQCD1
ExpressionAtlasiQ92600 baseline and differential
GenevisibleiQ92600 HS

Organism-specific databases

HPAiHPA046622

Interactioni

Subunit structurei

Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA (By similarity). Interacts with NANOS2 (By similarity). Directly interacts with ZNF335.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45AP245224EBI-12907584,EBI-448167

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • protein domain specific binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114573, 54 interactors
CORUMiQ92600
DIPiDIP-46840N
IntActiQ92600, 19 interactors
STRINGi9606.ENSP00000273064

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 27Combined sources9
Beta strandi29 – 31Combined sources3
Helixi32 – 43Combined sources12
Turni44 – 48Combined sources5
Helixi52 – 58Combined sources7
Beta strandi59 – 61Combined sources3
Helixi62 – 71Combined sources10
Helixi72 – 76Combined sources5
Turni77 – 80Combined sources4
Helixi84 – 102Combined sources19
Turni104 – 106Combined sources3
Helixi107 – 112Combined sources6
Helixi115 – 118Combined sources4
Helixi120 – 123Combined sources4
Helixi130 – 147Combined sources18
Helixi152 – 160Combined sources9
Helixi164 – 173Combined sources10
Helixi176 – 191Combined sources16
Helixi193 – 199Combined sources7
Helixi203 – 222Combined sources20
Helixi226 – 239Combined sources14
Helixi243 – 252Combined sources10
Helixi255 – 257Combined sources3
Turni261 – 268Combined sources8
Helixi270 – 284Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FV2X-ray2.20A/B/C/D18-285[»]
4CRUX-ray1.65B19-285[»]
4CRVX-ray2.05B19-285[»]
4CT6X-ray2.10B18-285[»]
4CT7X-ray1.90B16-285[»]
5LSWX-ray2.15A/C19-285[»]
5ONAX-ray2.70B/E19-285[»]
5ONBX-ray3.00A/C/E/G19-285[»]
ProteinModelPortaliQ92600
SMRiQ92600
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92600

Family & Domainsi

Sequence similaritiesi

Belongs to the CNOT9 family.Curated

Phylogenomic databases

eggNOGiKOG3036 Eukaryota
COG5209 LUCA
GeneTreeiENSGT00390000001225
HOGENOMiHOG000192069
HOVERGENiHBG056785
InParanoidiQ92600
KOiK12606
OMAiMVTKRCL
OrthoDBiEOG091G0BAM
PhylomeDBiQ92600
TreeFamiTF105734

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR007216 CNOT9
PANTHERiPTHR12262:SF0 PTHR12262:SF0, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92600-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP 
        60         70         80         90        100
DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV 
       110        120        130        140        150
ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD 
       160        170        180        190        200
EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC 
       210        220        230        240        250
QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR 
       260        270        280        290 
QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
Length:299
Mass (Da):33,631
Last modified:February 1, 1997 - v1
Checksum:iCFA0E108F5E9D8F2
GO
Isoform 2 (identifier: Q92600-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-143: I → IVETGFHHVGQADLELPTSSDLPASASQSAGIT

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):36,837
Checksum:iAD81339464CE9A5C
GO
Isoform 3 (identifier: Q92600-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-258: AREALRQCLPDQLK → FSDLTFCWSSFQRK
     259-299: Missing.

Show »
Length:258
Mass (Da):29,140
Checksum:iAA7F7A655A9AFD3E
GO

Sequence cautioni

The sequence AAH07102 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042429143I → T1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054371143I → IVETGFHHVGQADLELPTSS DLPASASQSAGIT in isoform 2. 1 Publication1
Alternative sequenceiVSP_055744245 – 258AREAL…PDQLK → FSDLTFCWSSFQRK in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_055745259 – 299Missing in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87957 Genomic DNA Translation: BAA13508.1
AK293281 mRNA Translation: BAH11481.1
AC012510 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70625.1
CH471063 Genomic DNA Translation: EAW70624.1
BC007102 mRNA Translation: AAH07102.2 Different initiation.
BC137455 mRNA Translation: AAI37456.1
BC137456 mRNA Translation: AAI37457.1
CCDSiCCDS33379.1 [Q92600-1]
CCDS63122.1 [Q92600-2]
CCDS63123.1 [Q92600-3]
RefSeqiNP_001258563.1, NM_001271634.1 [Q92600-2]
NP_001258564.1, NM_001271635.1 [Q92600-3]
NP_005435.1, NM_005444.2 [Q92600-1]
UniGeneiHs.148767

Genome annotation databases

EnsembliENST00000273064; ENSP00000273064; ENSG00000144580 [Q92600-1]
ENST00000295701; ENSP00000295701; ENSG00000144580 [Q92600-3]
ENST00000542068; ENSP00000443687; ENSG00000144580 [Q92600-1]
ENST00000627282; ENSP00000486540; ENSG00000144580 [Q92600-2]
GeneIDi9125
KEGGihsa:9125
UCSCiuc002vih.3 human [Q92600-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNOT9_HUMAN
AccessioniPrimary (citable) accession number: Q92600
Secondary accession number(s): B2RPI0
, B5MDQ4, B7Z1E5, Q96IX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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