Glutamate receptor-interacting protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: MGI
• protein C-terminus binding Source: MGI
• receptor signaling complex scaffold activity Source: InterPro
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• dendrite development Source: InterPro
• nervous system development Source: MGI
• positive regulation of neuron projection arborization Source: MGI
• protein localization Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 14730302
• protein transport Source: MGI

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: MGI
• protein C-terminus binding Source: MGI
• receptor signaling complex scaffold activity Source: InterPro
• signaling receptor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 9 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MIAVSFKCRC QILRRLTKDE SPYTKSASQT KPPDGALAVR RQSIPEEFKG 
        60         70         80         90        100
STVVELMKKE GTTLGLTVSG GIDKDGKPRV SNLRQGGIAA RSDQLDVGDY 
       110        120        130        140        150
IKAVNGINLA KFRHDEIISL LKNVGERVVL EVEYELPPVS VQGSSVMFRT 
       160        170        180        190        200
VEVTLHKEGN TFGFVIRGGA HDDRNKSRPV VITCVRPGGP ADREGTIKPG 
       210        220        230        240        250
DRLLSVDGIR LLGTTHAEAM SILKQCGQEA TLLIEYDVSV MDSVATASGP 
       260        270        280        290        300
LLVEVAKTPG ASLGVALTTS VCCNKQVIVI DKIKSASIAD RCGALHVGDH 
       310        320        330        340        350
ILSIDGTSME YCTLAEATQF LANTTDQVKL EILPHHQTRL ALKGPDHVKI 
       360        370        380        390        400
QRSDRQHPWD AWASNQCGVH TNHHHNTYHP DHCRVPALTF PKALPPNSPP 
       410        420        430        440        450
AMVPSSSPTS MSAYSLSSLN MGTLPRSLYS TSPRGTMMRR RLKKKDFKSS 
       460        470        480        490        500
LSLASSTVGL AGQVVHTETT EVVLTADPVT GFGIQLQGSV FATETLSSPP 
       510        520        530        540        550
LISYIEADSP AERCGVLQIG DRVMAINGIP TEDSTFEEAN QLLRDSSITS 
       560        570        580        590        600
KVTLEIEFDV AESVIPSSGT FHVKLPKKHS VELGITISSP SSRKPGDPLV 
       610        620        630        640        650
ISDIKKGSVA HRTGTLELGD KLLAIDNIRL DNCSMEDAVQ ILQQCEDLVK 
       660        670        680        690        700
LKIRKDEDNS DEQESSGAII YTVELKRYGG PLGITISGTE EPFDPIIISS 
       710        720        730        740        750
LTKGGLAERT GAIHIGDRIL AINSSSLKGK PLSEAIHLLQ MAGETVTLKI 
       760        770        780        790        800
KKQTDAQSAS SPKKFPIPGH SGDLGDGEED PSPIQKPGKL SDAYPSTVPS 
       810        820        830        840        850
VDSAVDSWDG SGIDASYGSQ GSTFQTSGYN YNTYDWRSPK QRTSLSPVPK 
       860        870        880        890        900
PRSQTYPDVG LSNEDWDRST ASGFVGASDS ADAEQEENFW SQALEDLETC 
       910        920        930        940        950
GQSGILRELE EKADRRVSLR NMTLLATIMS GSTMSLNHEA PMARSQLGRQ 
       960        970        980        990       1000
ASFQERSSSR PHYSQTTRSN TLPSDVGRKS VTLRKMKQEI KEIMSPTPVE 
      1010       1020       1030       1040       1050
LHKVTLYKDS GMEDFGFSVA DGLLEKGVYV KNIRPAGPGD VGGLKPYDRL 
      1060       1070       1080       1090       1100
LQVNHVRTRD FDCCLVVPLI AESGNKLDLV ISRNPLASQK SIEQPALPSD 
      1110       1120 
WSEQNSAFFQ QPSHGGNLET REPTNTL                          

        10         20         30         40         50
MPGWKKNIPI CLQAEEQERE EFKGSTVVEL MKKEGTTLGL TVSGGIDKDG 
        60         70         80         90        100
KPRVSNLRQG GIAARSDQLD VGDYIKAVNG INLAKFRHDE IISLLKNVGE 
       110        120        130        140        150
RVVLEVEYEL PPVSVQGSSV MFRTVEVTLH KEGNTFGFVI RGGAHDDRNK 
       160        170        180        190        200
SRPVVITCVR PGGPADREGT IKPGDRLLSV DGIRLLGTTH AEAMSILKQC 
       210        220        230        240        250
GQEATLLIEY DVSVMDSVAT ASGPLLVEVA KTPGASLGVA LTTSVCCNKQ 
       260        270        280        290        300
VIVIDKIKSA SIADRCGALH VGDHILSIDG TSMEYCTLAE ATQFLANTTD 
       310        320        330        340        350
QVKLEILPHH QTRLALKGPD HAAMVPSSSP TSMSAYSLSS LNMGTLPRSL 
       360        370        380        390        400
YSTSPRGTMM RRRLKKKDFK SSLSLASSTV GLAGQVVHTE TTEVVLTADP 
       410        420        430        440        450
VTGFGIQLQG SVFATETLSS PPLISYIEAD SPAERCGVLQ IGDRVMAING 
       460        470        480        490        500
IPTEDSTFEE ANQLLRDSSI TSKVTLEIEF DVAESVIPSS GTFHVKLPKK 
       510        520        530        540        550
HSVELGITIS SPSSRKPGDP LVISDIKKGS VAHRTGTLEL GDKLLAIDNI 
       560        570        580        590        600
RLDNCSMEDA VQILQQCEDL VKLKIRKDED NSDEQESSGA IIYTVELKRY 
       610        620        630        640        650
GGPLGITISG TEEPFDPIII SSLTKGGLAE RTGAIHIGDR ILAINSSSLK 
       660        670        680        690        700
GKPLSEAIHL LQMAGETVTL KIKKQTDAQS ASSPKKFPIP GHSGDLGDGE 
       710        720        730        740        750
EDPSPIQKPG KLSDAYPSTV PSVDSAVDSW DGSGIDASYG SQGSTFQTSG 
       760        770        780        790        800
YNYNTYDWRS PKQRTSLSPV PKPRSQTYPD VGLSNEDWDR STASGFVGAS 
       810        820        830        840        850
DSADAEQEEN FWSQALEDLE TCGQSGILRE LEATIMSGST MSLNHEAPMA 
       860        870        880        890        900
RSQLGRQASF QERSSSRPHY SQTTRSNTLP SDVGRKSVTL RKMKQEIKEI 
       910        920        930        940        950
MSPTPVELHK VTLYKDSGME DFGFSVADGL LEKGVYVKNI RPAGPGDVGG 
       960        970        980        990       1000
LKPYDRLLQV NHVRTRDFDC CLVVPLIAES GNKLDLVISR NPLASQKSIE 
      1010       1020       1030 
QPALPSDWSE QNSAFFQQPS HGGNLETREP TNTL                  

        10         20         30         40         50
MIAVSFKCRC QILRRLTKEE FKGSTVVELM KKEGTTLGLT VSGGIDKDGK 
        60         70         80         90        100
PRVSNLRQGG IAARSDQLDV GDYIKAVNGI NLAKFRHDEI ISLLKNVGER 
       110        120        130        140        150
VVLEVEYELP PVSVQGSSVM FRTVEVTLHK EGNTFGFVIR GGAHDDRNKS 
       160        170        180        190        200
RPVVITCVRP GGPADREGTI KPGDRLLSVD GIRLLGTTHA EAMSILKQCG 
       210        220        230        240        250
QEATLLIEYD VSVMDSVATA SGPLLVEVAK TPGASLGVAL TTSVCCNKQV 
       260        270        280        290        300
IVIDKIKSAS IADRCGALHV GDHILSIDGT SMEYCTLAEA TQFLANTTDQ 
       310        320        330        340        350
VKLEILPHHQ TRLALKGPDH AAMVPSSSPT SMSAYSLSSL NMGTLPRSLY 
       360        370        380        390        400
STSPRGTMMR RRLKKKDFKS SLSLASSTVG LAGQVVHTET TEVVLTADPV 
       410        420        430        440        450
TGFGIQLQGS VFATETLSSP PLISYIEADS PAERCGVLQI GDRVMAINGI 
       460        470        480        490        500
PTEDSTFEEA NQLLRDSSIT SKVTLEIEFD VAESVIPSSG TFHVKLPKKH 
       510        520        530        540        550
SVELGITISS PSSRKPGDPL VISDIKKGSV AHRTGTLELG DKLLAIDNIR 
       560        570        580        590        600
LDNCSMEDAV QILQQCEDLV KLKIRKDEDN SDEQESSGAI IYTVELKRYG 
       610        620        630        640        650
GPLGITISGT EEPFDPIIIS SLTKGGLAER TGAIHIGDRI LAINSSSLKG 
       660        670        680        690        700
KPLSEAIHLL QMAGETVTLK IKKQTDAQSA SSPKKFPIPG HSGDLGDGEE 
       710        720        730        740        750
DPSPIQKPGK LSDAYPSTVP SVDSAVDSWD GSGIDASYGS QGSTFQTSGY 
       760        770        780        790        800
NYNTYDWRSP KQRTSLSPVP KPRSQTYPDV GLSNEDWDRS TASGFVGASD 
       810        820        830        840        850
SADAEQEENF WSQALEDLET CGQSGILREL EATIMSGSTM SLNHEAPMAR 
       860        870        880        890        900
SQLGRQASFQ ERSSSRPHYS QTTRSNTLPS DVGRKSVTLR KMKQEIKEIM 
       910        920        930        940        950
SPTPVELHKV TLYKDSGMED FGFSVADGLL EKGVYVKNIR PAGPGDVGGL 
       960        970        980        990       1000
KPYDRLLQVN HVRTRDFDCC LVVPLIAESG NKLDLVISRN PLASQKSIEQ 
      1010       1020       1030 
PALPSDWSEQ NSAFFQQPSH GGNLETREPT NTL                   

        10         20         30         40         50
MTAKRAERKE MKRPNSFHLP FRPSLRKGQK KNAAHVSLAS STVGLAGQVV 
        60         70         80         90        100
HTETTEVVLT ADPVTGFGIQ LQGSVFATET LSSPPLISYI EADSPAERCG 
       110        120        130        140        150
VLQIGDRVMA INGIPTEDST FEEANQLLRD SSITSKVTLE IEFDVAESVI 
       160        170        180        190        200
PSSGTFHVKL PKKHSVELGI TISSPSSRKP GDPLVISDIK KGSVAHRTGT 
       210        220        230        240        250
LELGDKLLAI DNIRLDNCSM EDAVQILQQC EDLVKLKIRK DEDNSDEQES 
       260        270        280        290        300
SGAIIYTVEL KRYGGPLGIT ISGTEEPFDP IIISSLTKGG LAERTGAIHI 
       310        320        330        340        350
GDRILAINSS SLKGKPLSEA IHLLQMAGET VTLKIKKQTD GSTFQTSGYN 
       360        370        380        390        400
YNTYDWRSPK QRTSLSPVPK PRSQTYPDVG LSNEDWDRST ASGFVGASDS 
       410        420        430        440        450
ADAEQEENFW SQALEDLETC GQSGILRELE ATIMSGSTMS LNHEAPMARS 
       460        470        480        490        500
QLGRQASFQE RSSSRPHYSQ TTRSNTLPSD VGRKSVTLRK MKQEIKEIMS 
       510        520        530        540        550
PTPVELHKVT LYKDSGMEDF GFSVADGLLE KGVYVKNIRP AGPGDVGGLK 
       560        570        580        590        600
PYDRLLQVNH VRTRDFDCCL VVPLIAESGN KLDLVISRNP LASQKSIEQP 
       610        620        630 
ALPSDWSEQN SAFFQQPSHG GNLETREPTN TL                    

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ