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Protein

Glycoprotein hormone alpha-2

Gene

Gpha2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormone alpha-2
Alternative name(s):
Putative secreted protein Zsig51
Thyrostimulin subunit alpha
Gene namesi
Name:Gpha2
Synonyms:Gpa2, Zsig51
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2156541 Gpha2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001167321 – 128Glycoprotein hormone alpha-2Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 88PROSITE-ProRule annotation
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 102PROSITE-ProRule annotation
Disulfide bondi56 ↔ 118PROSITE-ProRule annotation
Disulfide bondi60 ↔ 120PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ925Q5
PRIDEiQ925Q5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024784 Expressed in 31 organ(s), highest expression level in cornea
CleanExiMM_GPHA2
ExpressionAtlasiQ925Q5 baseline and differential
GenevisibleiQ925Q5 MM

Interactioni

Subunit structurei

Heterodimer with GPHB5; this heterodimer interacts with thyroid-stimulating hormone receptor (TSHR), and hence stimulates cAMP production.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025698

Structurei

3D structure databases

ProteinModelPortaliQ925Q5
SMRiQ925Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYM3 Eukaryota
ENOG4112671 LUCA
GeneTreeiENSGT00390000009379
HOGENOMiHOG000236306
HOVERGENiHBG051795
InParanoidiQ925Q5
OMAiKVQLQCV
OrthoDBiEOG091G0UTF
PhylomeDBiQ925Q5
TreeFamiTF332313

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR000476 Glyco_hormone
PfamiView protein in Pfam
PF03045 DAN, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q925Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMAPRVLLL CLLGLAVTEG HSPETAIPGC HLHPFNVTVR SDRLGTCQGS
60 70 80 90 100
HVAQACVGHC ESSAFPSRYS VLVASGYRHN ITSSSQCCTI SSLRKVRVWL
110 120
QCVGNQRGEL EIFTARACQC DMCRFSRY
Length:128
Mass (Da):14,030
Last modified:December 1, 2001 - v1
Checksum:iB4008BA348D3EF82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260740 mRNA Translation: AAK51639.1
BC062804 mRNA Translation: AAH62804.1
CCDSiCCDS29498.1
RefSeqiNP_569720.1, NM_130453.3
UniGeneiMm.379306

Genome annotation databases

EnsembliENSMUST00000025698; ENSMUSP00000025698; ENSMUSG00000024784
ENSMUST00000113526; ENSMUSP00000109154; ENSMUSG00000024784
ENSMUST00000201025; ENSMUSP00000144417; ENSMUSG00000107297
ENSMUST00000201279; ENSMUSP00000144211; ENSMUSG00000107297
GeneIDi170458
KEGGimmu:170458
UCSCiuc008ghs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260740 mRNA Translation: AAK51639.1
BC062804 mRNA Translation: AAH62804.1
CCDSiCCDS29498.1
RefSeqiNP_569720.1, NM_130453.3
UniGeneiMm.379306

3D structure databases

ProteinModelPortaliQ925Q5
SMRiQ925Q5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025698

Proteomic databases

PaxDbiQ925Q5
PRIDEiQ925Q5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025698; ENSMUSP00000025698; ENSMUSG00000024784
ENSMUST00000113526; ENSMUSP00000109154; ENSMUSG00000024784
ENSMUST00000201025; ENSMUSP00000144417; ENSMUSG00000107297
ENSMUST00000201279; ENSMUSP00000144211; ENSMUSG00000107297
GeneIDi170458
KEGGimmu:170458
UCSCiuc008ghs.1 mouse

Organism-specific databases

CTDi170589
MGIiMGI:2156541 Gpha2

Phylogenomic databases

eggNOGiENOG410IYM3 Eukaryota
ENOG4112671 LUCA
GeneTreeiENSGT00390000009379
HOGENOMiHOG000236306
HOVERGENiHBG051795
InParanoidiQ925Q5
OMAiKVQLQCV
OrthoDBiEOG091G0UTF
PhylomeDBiQ925Q5
TreeFamiTF332313

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q925Q5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024784 Expressed in 31 organ(s), highest expression level in cornea
CleanExiMM_GPHA2
ExpressionAtlasiQ925Q5 baseline and differential
GenevisibleiQ925Q5 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR000476 Glyco_hormone
PfamiView protein in Pfam
PF03045 DAN, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPHA2_MOUSE
AccessioniPrimary (citable) accession number: Q925Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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