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UniProtKB - Q925Q3 (NCLX_MOUSE)

Entry version 120 (16 Oct 2019)
Sequence version 2 (10 Jan 2006)
Previous versions | rss
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Protein

Mitochondrial sodium/calcium exchanger protein

Gene

Slc8b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:28445457). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:24067497, PubMed:28445457). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (By similarity). In contrast to other members of the family its function is independent of K+ (By similarity).By similarity4 Publications

Caution

Isoform 1 was reported to not have cation exchanger activity (PubMed:12080145). However, such result is unclear.1 Publication
Isoform 1 and isoform 2 were reported to localize to the endoplasmic reticulum membrane and cell membrane, respectively (PubMed:14625281). This result is however not supported by other studies that report localization to the mitochondrial membrane (PubMed:20018762, PubMed:24067497).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the sodium/calcium exchanger inhibitor CGP-37157 (PubMed:28445457). Strongly inhibited by zinc (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport
LigandCalcium, Lithium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-425561 Sodium/Calcium exchangers
R-MMU-8949215 Mitochondrial calcium ion transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial sodium/calcium exchanger proteinCurated
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 61 Publication
Sodium/calcium exchanger protein, mitochondrial1 Publication
Sodium/potassium/calcium exchanger 61 Publication
Solute carrier family 24 member 6Imported
Solute carrier family 8 member B1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc8b1Imported
Synonyms:Nckx61 Publication, Nclx1 Publication, Slc24a6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2180781 Slc8b1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 95ExtracellularSequence analysisAdd BLAST69
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 116Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini117 – 140CytoplasmicSequence analysisAdd BLAST24
Transmembranei141 – 161Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini162 – 168ExtracellularSequence analysis7
Transmembranei169 – 189Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini190 – 205CytoplasmicSequence analysisAdd BLAST16
Transmembranei206 – 226Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini227 – 229ExtracellularSequence analysis3
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini251 – 325CytoplasmicSequence analysisAdd BLAST75
Transmembranei326 – 346Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini347 – 360ExtracellularSequence analysisAdd BLAST14
Transmembranei361 – 381Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini382 – 383CytoplasmicSequence analysis2
Transmembranei384 – 404Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini405 – 416ExtracellularSequence analysisAdd BLAST12
Transmembranei417 – 437Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini438 – 445CytoplasmicSequence analysis8
Transmembranei446 – 466Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini467 – 491ExtracellularSequence analysisAdd BLAST25
Transmembranei492 – 512Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini513 – 525CytoplasmicSequence analysisAdd BLAST13
Transmembranei526 – 546Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini547 – 559ExtracellularSequence analysisAdd BLAST13
Transmembranei560 – 580Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini581 – 585CytoplasmicSequence analysis5

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional deletion in adult hearts causes sudden death in 87% of the mice. Hearts show substantial cardiac remodeling, including an increase in heart mass and correlative change in cardiomyocyte cross-sectional area, as well as a significant increase in cardiac fibrosis. Defects are probably due to mitochondrial calcium overload leading to increased generation of superoxide and necrotic cell death.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004575727 – 585Mitochondrial sodium/calcium exchanger proteinAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258Phosphoserine; by PKABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-258 by PKA prevents calcium overload.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q925Q3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q925Q3

PRoteomics IDEntifications database

More...PRIDEi		Q925Q3

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q925Q3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q925Q3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed in dental tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032754 Expressed in 202 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q925Q3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q925Q3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000064714

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. [View classification]Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2399 Eukaryota
COG0530 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113743

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q925Q3

KEGG Orthology (KO)

More...KOi		K13754

Identification of Orthologs from Complete Genome Data

More...OMAi		TASKFFC

Database of Orthologous Groups

More...OrthoDBi		478735at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q925Q3

TreeFam database of animal gene trees

More...TreeFami		TF323444

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004837 NaCa_Exmemb

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01699 Na_Ca_ex, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q925Q3-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication, Long1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRWLALLW APVFLCVALI LETASGTGDP STKAHGHIQF SAGSVNQTAM 
        60         70         80         90        100
ADCRAVCGLN TSDRCDFVRR NPDCRSEAGY LDYLEGIFCY FPPNLLPLAI 
       110        120        130        140        150
TLYVFWLLYL FLILGVTAAK FFCPNLSAIS TNLKLSHNVA GVTFLAFGNG 
       160        170        180        190        200
APDIFSALVA FSDPRTAGLA IGALFGAGVL VTTVVAGGIT ILHPFMAASR 
       210        220        230        240        250
PFLRDIAFYM VAVFLTFTAL YLGRITLTWA LGYLGLYVFY VVTVIICTWV 
       260        270        280        290        300
YQRQRSRSLV HSISETPELL SESEEDQMSS NTNSYDYGDE YRPLLLGRET 
       310        320        330        340        350
TVQILIQALN PLDYRKWRTQ SISWRVLKVV KLPVEFLLLL TVPVVDPDKD 
       360        370        380        390        400
DRNWKRPLNC LQLVISPLVL VLTLQSGVYG IYEIGGLLPV WAVVVIVGTA 
       410        420        430        440        450
LASVTFFATS NREPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVI 
       460        470        480        490        500
FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL 
       510        520        530        540        550
VGVGLGCLLQ IIRNHVVEVK LEPDGLLVWV LASALGLSLI FSLVSVPLQC 
       560        570        580 
FQLSKAYGLC LLLFYICFLV VVLLTEFGVI HLKKA
Length:585
Mass (Da):64,365
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83B001A9C78B2620
GO
Isoform 2 (identifier: Q925Q3-2) [UniParc]FASTAAdd to basket
Also known as: S1 Publication, Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     471-585: DAFSDFTLAR...EFGVIHLKKA → AGARRITGVG...RGVGAILLAS

Show »
Length:552
Mass (Da):60,182
Checksum:i979CDD6786E80281
GO
Isoform 3 (identifier: Q925Q3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-140: FCPNLSAISTNLKLSHNVA → PH

Show »
Length:568
Mass (Da):62,588
Checksum:i1C3E0D1C9833FAEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z226D3Z226_MOUSE
Mitochondrial sodium/calcium exchan...
Slc8b1 Slc24a6
529Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5E7D3Z5E7_MOUSE
Mitochondrial sodium/calcium exchan...
Slc8b1 Slc24a6
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20I → L in AAK49407 (PubMed:12080145).Curated1
Sequence conflicti228T → A in AAK49407 (PubMed:12080145).Curated1
Sequence conflicti298R → Q in AAK49407 (PubMed:12080145).Curated1
Sequence conflicti381I → L in AAK49407 (PubMed:12080145).Curated1
Sequence conflicti451F → L in AAK49407 (PubMed:12080145).Curated1
Sequence conflicti566I → V in AAK49407 (PubMed:12080145).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016997122 – 140FCPNL…SHNVA → PH in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_016998471 – 585DAFSD…HLKKA → AGARRITGVGAGQCPGPQLD LLPGLRAASVFPAQQGLRPL PPPLLHLFPCCGPAHRVWGD SPEEGVTEAAWPRGVGAILL AS in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF261233 mRNA Translation: AAK49407.1
AK157173 mRNA Translation: BAE33988.1
BC043689 mRNA Translation: AAH43689.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39238.1 [Q925Q3-1]
CCDS51633.1 [Q925Q3-2]
CCDS51634.1 [Q925Q3-3]

NCBI Reference Sequences

More...RefSeqi		NP_001171065.1, NM_001177594.1 [Q925Q3-3]
NP_001171066.1, NM_001177595.1 [Q925Q3-2]
NP_573484.2, NM_133221.2 [Q925Q3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000068326; ENSMUSP00000064714; ENSMUSG00000032754 [Q925Q3-1]
ENSMUST00000076051; ENSMUSP00000075428; ENSMUSG00000032754 [Q925Q3-2]
ENSMUST00000111890; ENSMUSP00000107521; ENSMUSG00000032754 [Q925Q3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		170756

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:170756

UCSC genome browser

More...UCSCi		uc008zhj.2 mouse [Q925Q3-1]
uc012eco.1 mouse [Q925Q3-3]
uc012ecp.1 mouse [Q925Q3-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261233 mRNA Translation: AAK49407.1
AK157173 mRNA Translation: BAE33988.1
BC043689 mRNA Translation: AAH43689.1
CCDSiCCDS39238.1 [Q925Q3-1]
CCDS51633.1 [Q925Q3-2]
CCDS51634.1 [Q925Q3-3]
RefSeqiNP_001171065.1, NM_001177594.1 [Q925Q3-3]
NP_001171066.1, NM_001177595.1 [Q925Q3-2]
NP_573484.2, NM_133221.2 [Q925Q3-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064714

PTM databases

PhosphoSitePlusiQ925Q3
SwissPalmiQ925Q3

Proteomic databases

jPOSTiQ925Q3
PaxDbiQ925Q3
PRIDEiQ925Q3

Genome annotation databases

EnsembliENSMUST00000068326; ENSMUSP00000064714; ENSMUSG00000032754 [Q925Q3-1]
ENSMUST00000076051; ENSMUSP00000075428; ENSMUSG00000032754 [Q925Q3-2]
ENSMUST00000111890; ENSMUSP00000107521; ENSMUSG00000032754 [Q925Q3-3]
GeneIDi170756
KEGGimmu:170756
UCSCiuc008zhj.2 mouse [Q925Q3-1]
uc012eco.1 mouse [Q925Q3-3]
uc012ecp.1 mouse [Q925Q3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80024
MGIiMGI:2180781 Slc8b1

Phylogenomic databases

eggNOGiKOG2399 Eukaryota
COG0530 LUCA
GeneTreeiENSGT00940000157433
HOGENOMiHOG000113743
InParanoidiQ925Q3
KOiK13754
OMAiTASKFFC
OrthoDBi478735at2759
PhylomeDBiQ925Q3
TreeFamiTF323444

Enzyme and pathway databases

ReactomeiR-MMU-425561 Sodium/Calcium exchangers
R-MMU-8949215 Mitochondrial calcium ion transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc8b1 mouse

Protein Ontology

More...PROi		PR:Q925Q3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032754 Expressed in 202 organ(s), highest expression level in liver
ExpressionAtlasiQ925Q3 baseline and differential
GenevisibleiQ925Q3 MM

Family and domain databases

InterProiView protein in InterPro
IPR004837 NaCa_Exmemb
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCLX_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q925Q3
Secondary accession number(s): Q3U067, Q80XM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 16, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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