UniProtKB - Q925N1 (SFXN4_MOUSE)
Protein
Sideroflexin-4
Gene
Sfxn4
Organism
Mus musculus (Mouse)
Status
Functioni
Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity).By similarity
GO - Molecular functioni
- ion transmembrane transporter activity Source: InterPro
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid transport Source: UniProtKB-KW
- mitochondrial transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sideroflexin-41 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2137680, Sfxn4 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Mitochondrion
- integral component of mitochondrial inner membrane Source: GO_Central
- mitochondrion Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 175 – 191 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 230 – 247 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000177042 | 1 – 313 | Sideroflexin-4Add BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | Q925N1 |
PaxDbi | Q925N1 |
PRIDEi | Q925N1 |
PTM databases
iPTMneti | Q925N1 |
PhosphoSitePlusi | Q925N1 |
Expressioni
Tissue specificityi
Largely restricted to kidney, brain and heart.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000063698, Expressed in embryo and 235 other tissues |
ExpressionAtlasi | Q925N1, baseline and differential |
Genevisiblei | Q925N1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000118743 |
Miscellaneous databases
RNActi | Q925N1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the sideroflexin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3767, Eukaryota |
GeneTreei | ENSGT01010000222377 |
HOGENOMi | CLU_039425_3_0_1 |
InParanoidi | Q925N1 |
OMAi | KPALFWQ |
OrthoDBi | 881974at2759 |
TreeFami | TF313205 |
Family and domain databases
InterProi | View protein in InterPro IPR004686, Mtc IPR028825, SFXN4 |
PANTHERi | PTHR11153, PTHR11153, 1 hit PTHR11153:SF3, PTHR11153:SF3, 1 hit |
Pfami | View protein in Pfam PF03820, SFXNs, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q925N1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPNLQFWIS ERQAFFRRFC QWMDLLDPVN MFISIGSIEK SRQLLFTTED
60 70 80 90 100
APKHYLDNQV IKDAWNKSLS TVHPDSSKLI PHLFRPAAFL PVTAPMVFLL
110 120 130 140 150
MMPDTGIKSI ILTQGCLYGY TTAFNITNGN ASYSHGPVER TLLGAGVSVS
160 170 180 190 200
STFIGLIPHL FQMKYPPNNF WLKRTLPIVF LAQVSGMNVF ASRSFENHRG
210 220 230 240 250
IEVMDKEGHV VGHSRKAGRK AIKDTAKSRA VLFGTSALAP ELFIHIFKRT
260 270 280 290 300
RFYPQTLLSL VILRMSSTFF MMGLMVPVSF SMFPQIGQIQ CSQLEEKIQS
310
STEEKELFYY RGV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RHK7 | D6RHK7_MOUSE | Sideroflexin-4 | Sfxn4 | 115 | Annotation score: | ||
F8WI63 | F8WI63_MOUSE | Sideroflexin-4 | Sfxn4 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 115 | G → S in AAK39431 (PubMed:11274051).Curated | 1 | |
Sequence conflicti | 148 | S → F in AAK39431 (PubMed:11274051).Curated | 1 | |
Sequence conflicti | 167 | P → L in AAK39431 (PubMed:11274051).Curated | 1 | |
Sequence conflicti | 177 | P → S in AAH89535 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 194 | S → G in AAH89535 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF325263 mRNA Translation: AAK39431.1 AC102432 Genomic DNA No translation available. AC163019 Genomic DNA No translation available. BC089535 mRNA Translation: AAH89535.1 |
CCDSi | CCDS29943.1 |
RefSeqi | NP_444428.3, NM_053198.3 |
Genome annotation databases
Ensembli | ENSMUST00000135808; ENSMUSP00000118743; ENSMUSG00000063698 |
GeneIDi | 94281 |
KEGGi | mmu:94281 |
UCSCi | uc008icc.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF325263 mRNA Translation: AAK39431.1 AC102432 Genomic DNA No translation available. AC163019 Genomic DNA No translation available. BC089535 mRNA Translation: AAH89535.1 |
CCDSi | CCDS29943.1 |
RefSeqi | NP_444428.3, NM_053198.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000118743 |
PTM databases
iPTMneti | Q925N1 |
PhosphoSitePlusi | Q925N1 |
Proteomic databases
MaxQBi | Q925N1 |
PaxDbi | Q925N1 |
PRIDEi | Q925N1 |
Protocols and materials databases
Antibodypediai | 18795, 115 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000135808; ENSMUSP00000118743; ENSMUSG00000063698 |
GeneIDi | 94281 |
KEGGi | mmu:94281 |
UCSCi | uc008icc.2, mouse |
Organism-specific databases
CTDi | 119559 |
MGIi | MGI:2137680, Sfxn4 |
Phylogenomic databases
eggNOGi | KOG3767, Eukaryota |
GeneTreei | ENSGT01010000222377 |
HOGENOMi | CLU_039425_3_0_1 |
InParanoidi | Q925N1 |
OMAi | KPALFWQ |
OrthoDBi | 881974at2759 |
TreeFami | TF313205 |
Miscellaneous databases
BioGRID-ORCSi | 94281, 1 hit in 17 CRISPR screens |
ChiTaRSi | Sfxn4, mouse |
PROi | PR:Q925N1 |
RNActi | Q925N1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063698, Expressed in embryo and 235 other tissues |
ExpressionAtlasi | Q925N1, baseline and differential |
Genevisiblei | Q925N1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004686, Mtc IPR028825, SFXN4 |
PANTHERi | PTHR11153, PTHR11153, 1 hit PTHR11153:SF3, PTHR11153:SF3, 1 hit |
Pfami | View protein in Pfam PF03820, SFXNs, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFXN4_MOUSE | |
Accessioni | Q925N1Primary (citable) accession number: Q925N1 Secondary accession number(s): E9QKN7, Q5FW99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families