UniProtKB - Q925H1 (TRPS1_MOUSE)
Zinc finger transcription factor Trps1
Trps1
Functioni
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 247 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 333 – 358 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 614 – 637 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 666 – 689 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 692 – 715 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 896 – 920 | GATA-typePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1215 – 1237 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1243 – 1267 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- protein domain specific binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- chondrocyte differentiation Source: MGI
- hair follicle development Source: CACAO
- negative regulation of transcription, DNA-templated Source: CACAO
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- regulation of chondrocyte differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal system development Source: MGI
- transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger transcription factor Trps1 |
Gene namesi | Name:Trps1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927616, Trps1 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- chromatin Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083509 | 1 – 1281 | Zinc finger transcription factor Trps1Add BLAST | 1281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 29 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 90 | PhosphoserineBy similarity | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 178 | PhosphoserineBy similarity | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Cross-linki | 263 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 418 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 457 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 474 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 488 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 645 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 737 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 755 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 766 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 766 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 825 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 850 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 877 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 879 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 925 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 937 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 965 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 978 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1003 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1012 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1030 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1040 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1041 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1066 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1070 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1085 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1192 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity | ||
Cross-linki | 1192 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 1201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity | ||
Cross-linki | 1201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 1201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q925H1 |
PaxDbi | Q925H1 |
PRIDEi | Q925H1 |
ProteomicsDBi | 298139 |
PTM databases
iPTMneti | Q925H1 |
PhosphoSitePlusi | Q925H1 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Interacts with RNF4; regulates TRPS1 repressor activity.
Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).
2 PublicationsGO - Molecular functioni
- protein domain specific binding Source: MGI
Protein-protein interaction databases
IntActi | Q925H1, 2 interactors |
MINTi | Q925H1 |
STRINGi | 10090.ENSMUSP00000129779 |
Miscellaneous databases
RNActi | Q925H1, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 101 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 116 – 204 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 365 – 393 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 484 – 515 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 635 – 819 | Mediates interaction with GLI3By similarityAdd BLAST | 185 | |
Regioni | 856 – 885 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 961 – 1000 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 985 – 1184 | Mediates interaction with RNF41 PublicationAdd BLAST | 200 | |
Regioni | 1040 – 1078 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1163 – 1281 | Transcriptional repressor domainBy similarityAdd BLAST | 119 | |
Regioni | 1169 – 1195 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 50 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 51 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 162 – 188 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 371 – 386 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 492 – 514 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 860 – 879 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 978 – 993 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1040 – 1061 | Polar residuesSequence analysisAdd BLAST | 22 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 247 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 333 – 358 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 614 – 637 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 666 – 689 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 692 – 715 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 896 – 920 | GATA-typePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1215 – 1237 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1243 – 1267 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1601, Eukaryota |
InParanoidi | Q925H1 |
PhylomeDBi | Q925H1 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR028440, TRPS1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR47034, PTHR47034, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 1 hit PS50114, GATA_ZN_FINGER_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD
60 70 80 90 100
VAELNSKEEH STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF
110 120 130 140 150
PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET
160 170 180 190 200
KEEHKMSPKA TEETGPVQSG QANCQGLSPV SVASKNPQVP SDGGVRLSKP
210 220 230 240 250
KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL
260 270 280 290 300
HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA
310 320 330 340 350
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL
360 370 380 390 400
EQHFLQTHPN KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK
410 420 430 440 450
MTVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK
460 470 480 490 500
LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV INQNDLAKSV EGEPLTKPEK
510 520 530 540 550
GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY
560 570 580 590 600
QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL
610 620 630 640 650
HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH
660 670 680 690 700
LLGSDGQQAV RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT
710 720 730 740 750
AADTQSLLEH FNTVHCQEQE ITTANGEEGG HAIPTIKEEP KIDLKVYSLL
760 770 780 790 800
NPDSKMGETV PESIVKREKL DDKEGLKDKI WTESSTDDLR GVAWRGADIL
810 820 830 840 850
RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR PMYGLAVDTK
860 870 880 890 900
GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL
910 920 930 940 950
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR
960 970 980 990 1000
KRLNPEALQA EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS
1010 1020 1030 1040 1050
LSKYEAQGSL TKSHSAQQPV LVSQALDIHK RMQPLHIQIK SPQESTGDPG
1060 1070 1080 1090 1100
NSSSVSDGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGVPFV
1110 1120 1130 1140 1150
HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP
1160 1170 1180 1190 1200
PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV
1210 1220 1230 1240 1250
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH
1260 1270 1280
LCTDKYDFTT HIQRGLHRNN AQAEKNGKPK E
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GX74 | V9GX74_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 1,285 | Annotation score: | ||
V9GXE9 | V9GXE9_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 1,096 | Annotation score: | ||
G3UW90 | G3UW90_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 1,281 | Annotation score: | ||
V9GXA5 | V9GXA5_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 994 | Annotation score: | ||
Q80V18 | Q80V18_MOUSE | Trps1 protein | Trps1 | 1,035 | Annotation score: | ||
V9GX39 | V9GX39_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 255 | Annotation score: | ||
Q8BZ62 | Q8BZ62_MOUSE | Zinc finger transcription factor Tr... | Trps1 | 229 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF346836 mRNA Translation: AAK39508.1 |
CCDSi | CCDS27460.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF346836 mRNA Translation: AAK39508.1 |
CCDSi | CCDS27460.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q925H1, 2 interactors |
MINTi | Q925H1 |
STRINGi | 10090.ENSMUSP00000129779 |
PTM databases
iPTMneti | Q925H1 |
PhosphoSitePlusi | Q925H1 |
Proteomic databases
MaxQBi | Q925H1 |
PaxDbi | Q925H1 |
PRIDEi | Q925H1 |
ProteomicsDBi | 298139 |
Organism-specific databases
MGIi | MGI:1927616, Trps1 |
Phylogenomic databases
eggNOGi | KOG1601, Eukaryota |
InParanoidi | Q925H1 |
PhylomeDBi | Q925H1 |
Miscellaneous databases
ChiTaRSi | Trps1, mouse |
PROi | PR:Q925H1 |
RNActi | Q925H1, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR028440, TRPS1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR47034, PTHR47034, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 1 hit PS50114, GATA_ZN_FINGER_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPS1_MOUSE | |
Accessioni | Q925H1Primary (citable) accession number: Q925H1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | June 2, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot