UniProtKB - Q925H0 (ASIC2_MOUSE)
Acid-sensing ion channel 2
Asic2
Functioni
Miscellaneous
GO - Molecular functioni
- cation channel activity Source: MGI
- ion channel activity Source: MGI
- ion gated channel activity Source: MGI
- ligand-gated sodium channel activity Source: MGI
- voltage-gated sodium channel activity Source: MGI
GO - Biological processi
- cation transport Source: MGI
- cellular response to acidic pH Source: MGI
- cellular response to drug Source: MGI
- detection of mechanical stimulus involved in sensory perception Source: MGI
- ion transmembrane transport Source: MGI
- negative regulation of apoptotic process Source: MGI
- phototransduction Source: MGI
- positive regulation of cation channel activity Source: MGI
- positive regulation of synapse assembly Source: MGI
- protein localization to synapse Source: MGI
- regulation of ion transmembrane transport Source: MGI
- regulation of membrane potential Source: MGI
- regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback Source: MGI
- regulation of vasoconstriction Source: MGI
- response to acidic pH Source: MGI
- response to mechanical stimulus Source: MGI
- sensory perception of sound Source: MGI
- sensory perception of sour taste Source: MGI
- sodium ion transmembrane transport Source: GO_Central
- sodium ion transport Source: MGI
Keywordsi
Molecular function | Ion channel, Sodium channel |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Protein family/group databases
TCDBi | 1.A.6.1.8, the epithelial na(+) channel (enac) family |
Names & Taxonomyi
Protein namesi | Recommended name: Acid-sensing ion channel 2Short name: ASIC2 Alternative name(s): Amiloride-sensitive brain sodium channel Amiloride-sensitive cation channel 1, neuronal Brain sodium channel 11 Publication Short name: BNC1 Short name: BNaC11 Publication |
Gene namesi | Name:Asic2 Synonyms:Accn1, Bnac1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1100867, Asic2 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.
Plasma Membrane
- integral component of plasma membrane Source: MGI
Other locations
- dendritic spine Source: MGI
- integral component of membrane Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | CytoplasmicBy similarityAdd BLAST | 37 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 427 | ExtracellularBy similarityAdd BLAST | 369 | |
Transmembranei | 428 – 448 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 449 – 512 | CytoplasmicBy similarityAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL3232695 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181291 | 1 – 512 | Acid-sensing ion channel 2Add BLAST | 512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 92 ↔ 193 | By similarity | ||
Disulfide bondi | 171 ↔ 178 | By similarity | ||
Disulfide bondi | 289 ↔ 364 | By similarity | ||
Disulfide bondi | 307 ↔ 360 | By similarity | ||
Disulfide bondi | 311 ↔ 358 | By similarity | ||
Disulfide bondi | 320 ↔ 342 | By similarity | ||
Disulfide bondi | 322 ↔ 334 | By similarity | ||
Glycosylationi | 365 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 392 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PRIDEi | Q925H0 |
PTM databases
GlyConnecti | 2417, 1 N-Linked glycan (1 site) [Q925H0-2] |
GlyGeni | Q925H0, 2 sites |
PhosphoSitePlusi | Q925H0 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000020704, Expressed in CA1 field of hippocampus and 149 other tissues |
ExpressionAtlasi | Q925H0, baseline and differential |
Genevisiblei | Q925H0, MM |
Interactioni
Subunit structurei
Homotrimer or heterotrimer with other ASIC proteins (By similarity).
Interacts with PRKCABP and ASIC3 (By similarity).
Interacts with STOM; this regulates channel activity (PubMed:15471860, PubMed:22850675). Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1, mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 197917, 2 interactors |
MINTi | Q925H0 |
Miscellaneous databases
RNActi | Q925H0, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000154991 |
HOGENOMi | CLU_020415_1_2_1 |
InParanoidi | Q925H0 |
OMAi | ANCENEC |
OrthoDBi | 686369at2759 |
TreeFami | TF330663 |
Family and domain databases
InterProi | View protein in InterPro IPR001873, ENaC IPR004724, ENaC_chordates IPR020903, ENaC_CS |
PANTHERi | PTHR11690, PTHR11690, 1 hit |
Pfami | View protein in Pfam PF00858, ASC, 1 hit |
PRINTSi | PR01078, AMINACHANNEL |
TIGRFAMsi | TIGR00859, ENaC, 1 hit |
PROSITEi | View protein in PROSITE PS01206, ASC, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV
60 70 80 90 100
GSLGLLLVES SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS
110 120 130 140 150
RLTTNDLYHA GELLALLDVN LQIPDPHLAD PTVLEALRQK ANFKHYKPKQ
160 170 180 190 200
FSMLEFLHRV GHDLKDMMLY CKFKGQECGH QDFTTVFTKY GKCYMFNSGE
210 220 230 240 250
DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF EAGVKVQIHS
260 270 280 290 300
QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP
310 320 330 340 350
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL
360 370 380 390 400
AEKDSNYCLC RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE
410 420 430 440 450
NILVLDIFFE ALNYETIEQK KAYEVAALLG DIGGQMGLFI GASILTILEL
460 470 480 490 500
FDYIYELIKE KLLDLLGKEE EEGSHDENMS TCDTMPNHSE TISHTVNVPL
510
QTALGTLEEI AC
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015592 | 1 – 184 | Missing in isoform 2. 1 PublicationAdd BLAST | 184 | |
Alternative sequenceiVSP_015593 | 185 | T → MSRSGGARLPATALSGPGRF RMAREQPAPAAVAAARQPGG DRSGDRELQGPGVARRGRPS LSRTKLHGLRHMCAGRTAAG GSFQRRALWVLAFCTSLGLL LSWSSNRLLYWLSFPSHTRV HREWSRQLPFPAVTVCNNNP LRFPRLSKGDLYYAGHWLGL LLPNRTARPLVSELLRGDEP RRQWFRKLADFRLFLPPRHF EGISAAFMDRLGHQLEDMLL SCKYRGELCGPHNFSS in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14634 mRNA Translation: CAA74978.1 AF348465 mRNA Translation: AAK40101.1 AL626807 Genomic DNA No translation available. AL645626 Genomic DNA No translation available. AL645842 Genomic DNA No translation available. AL663025 Genomic DNA No translation available. |
CCDSi | CCDS25137.1 [Q925H0-2] CCDS36243.1 [Q925H0-1] |
RefSeqi | NP_001029185.1, NM_001034013.2 [Q925H0-1] NP_031410.1, NM_007384.3 [Q925H0-2] |
Genome annotation databases
Ensembli | ENSMUST00000021045; ENSMUSP00000021045; ENSMUSG00000020704 [Q925H0-2] ENSMUST00000066197; ENSMUSP00000067095; ENSMUSG00000020704 [Q925H0-1] |
GeneIDi | 11418 |
KEGGi | mmu:11418 |
UCSCi | uc007kmm.2, mouse [Q925H0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14634 mRNA Translation: CAA74978.1 AF348465 mRNA Translation: AAK40101.1 AL626807 Genomic DNA No translation available. AL645626 Genomic DNA No translation available. AL645842 Genomic DNA No translation available. AL663025 Genomic DNA No translation available. |
CCDSi | CCDS25137.1 [Q925H0-2] CCDS36243.1 [Q925H0-1] |
RefSeqi | NP_001029185.1, NM_001034013.2 [Q925H0-1] NP_031410.1, NM_007384.3 [Q925H0-2] |
3D structure databases
SMRi | Q925H0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197917, 2 interactors |
MINTi | Q925H0 |
Chemistry databases
ChEMBLi | CHEMBL3232695 |
Protein family/group databases
TCDBi | 1.A.6.1.8, the epithelial na(+) channel (enac) family |
PTM databases
GlyConnecti | 2417, 1 N-Linked glycan (1 site) [Q925H0-2] |
GlyGeni | Q925H0, 2 sites |
PhosphoSitePlusi | Q925H0 |
Proteomic databases
PRIDEi | Q925H0 |
Protocols and materials databases
Antibodypediai | 15465, 200 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021045; ENSMUSP00000021045; ENSMUSG00000020704 [Q925H0-2] ENSMUST00000066197; ENSMUSP00000067095; ENSMUSG00000020704 [Q925H0-1] |
GeneIDi | 11418 |
KEGGi | mmu:11418 |
UCSCi | uc007kmm.2, mouse [Q925H0-1] |
Organism-specific databases
CTDi | 40 |
MGIi | MGI:1100867, Asic2 |
Phylogenomic databases
GeneTreei | ENSGT00940000154991 |
HOGENOMi | CLU_020415_1_2_1 |
InParanoidi | Q925H0 |
OMAi | ANCENEC |
OrthoDBi | 686369at2759 |
TreeFami | TF330663 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 11418, 0 hits in 17 CRISPR screens |
ChiTaRSi | Asic2, mouse |
PROi | PR:Q925H0 |
RNActi | Q925H0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020704, Expressed in CA1 field of hippocampus and 149 other tissues |
ExpressionAtlasi | Q925H0, baseline and differential |
Genevisiblei | Q925H0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001873, ENaC IPR004724, ENaC_chordates IPR020903, ENaC_CS |
PANTHERi | PTHR11690, PTHR11690, 1 hit |
Pfami | View protein in Pfam PF00858, ASC, 1 hit |
PRINTSi | PR01078, AMINACHANNEL |
TIGRFAMsi | TIGR00859, ENaC, 1 hit |
PROSITEi | View protein in PROSITE PS01206, ASC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ASIC2_MOUSE | |
Accessioni | Q925H0Primary (citable) accession number: Q925H0 Secondary accession number(s): Q5SUU2, Q61203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families