Asic2

Functionⁱ

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li⁺ and K⁺. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.1 Publication

Miscellaneous

Regulated by Zn²⁺. Inhibited by anti-inflammatory drugs like salicylic acid (By similarity).By similarity

GO - Molecular functionⁱ

cation channel activity
Source: MGI
Inferred from direct assayⁱ
- 11854527
ion channel activity
Source: MGI
Inferred from direct assayⁱ
- 18256271
ion gated channel activity
Source: MGI
Inferred from direct assayⁱ
- 14960591
ligand-gated sodium channel activity
Source: MGI
Inferred from direct assayⁱ
- 11306621
- 9368048
voltage-gated sodium channel activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cation transport
Source: MGI
Inferred from direct assayⁱ
- 11854527
cellular response to acidic pH Source: MGI
cellular response to drug Source: MGI
detection of mechanical stimulus involved in sensory perception
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069180
ion transmembrane transport
Source: MGI
Inferred from direct assayⁱ
- 14960591
- 18256271
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 14762118
phototransduction
Source: MGI
Inferred from mutant phenotypeⁱ
- 14762118
positive regulation of cation channel activity Source: MGI
positive regulation of synapse assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 19571134
protein localization to synapse
Source: MGI
Inferred from mutant phenotypeⁱ
- 19571134
regulation of ion transmembrane transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 14960591
regulation of membrane potential
Source: MGI
Inferred from mutant phenotypeⁱ
- 19590043
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
Source: MGI
Inferred from mutant phenotypeⁱ
- 20064394
regulation of vasoconstriction
Source: MGI
Inferred from mutant phenotypeⁱ
- 18296560
response to acidic pH
Source: MGI
Inferred from direct assayⁱ
- 11306621
- 11854527
response to mechanical stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069180
sensory perception of sound
Source: MGI
Inferred from mutant phenotypeⁱ
- 15537887
sensory perception of sour taste Source: MGI
sodium ion transport
Source: MGI
Inferred from direct assayⁱ
- 11306621
- 9368048

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Sodium channel
Biological process	Ion transport, Sodium transport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Protein family/group databases

TCDBⁱ	1.A.6.1.8 the epithelial na(+) channel (enac) family

TCDBⁱ

1.A.6.1.8 the epithelial na(+) channel (enac) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acid-sensing ion channel 2 Short name: ASIC2 Alternative name(s): Amiloride-sensitive brain sodium channel Amiloride-sensitive cation channel 1, neuronal Brain sodium channel 11 Publication Short name: BNC1 Short name: BNaC11 Publication
Gene namesⁱ	Name:Asic2 Synonyms:Accn1, Bnac1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1100867 Asic2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 37	CytoplasmicBy similarityAdd BLAST	37
Transmembraneⁱ	38 – 58	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	59 – 427	ExtracellularBy similarityAdd BLAST	369
Transmembraneⁱ	428 – 448	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	449 – 512	CytoplasmicBy similarityAdd BLAST	64

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice display altered rod phototransduction and neurotransmission, associated with increased light-induced retina damages.1 Publication

Chemistry databases

ChEMBLⁱ	CHEMBL3232695

ChEMBLⁱ

CHEMBL3232695

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181291	1 – 512	Acid-sensing ion channel 2Add BLAST		512

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	PhosphoserineBy similarity	1
Modified residueⁱ	11	PhosphoserineBy similarity	1
Disulfide bondⁱ	92 ↔ 193	By similarity
Disulfide bondⁱ	171 ↔ 178	By similarity
Disulfide bondⁱ	289 ↔ 364	By similarity
Disulfide bondⁱ	307 ↔ 360	By similarity
Disulfide bondⁱ	311 ↔ 358	By similarity
Disulfide bondⁱ	320 ↔ 342	By similarity
Disulfide bondⁱ	322 ↔ 334	By similarity
Glycosylationⁱ	365	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	392	N-linked (GlcNAc...) asparagineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEⁱ	Q925H0

PRIDEⁱ

Q925H0

PTM databases

PhosphoSitePlusⁱ	Q925H0

PhosphoSitePlusⁱ

Q925H0

Expressionⁱ

Tissue specificityⁱ

Expressed by sensory neurons. Expressed by nociceptive sensory neurons, spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer.2 Publications

Developmental stageⁱ

Expression changes dramatically during cochlear development. Expression is detected at E11.5 in otocyst and increases in the SG neurons after E18.5. Also detected in the lumen side of all cells forming the vestibular cavity and at the top of the macula of saccule and utricle. Before birth expressed by epithelial cells facing the endolymphatic space. Post-natally expressed by cells in the apical turn of the cochlea, while expression on the lumen side of the membranous labyrinth decreases. Expression shifts gradually toward the top of supporting cells and the spiral limbus. Also expressed by vestibular ganglion neurons. Restricted to the SG neurons in the mature cochlea (at protein level).1 Publication

Inductionⁱ

Expression in a subset of neurons may be regulated by neurotrophins.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020704 Expressed in 123 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasⁱ	Q925H0 baseline and differential
Genevisibleⁱ	Q925H0 MM

Interactionⁱ

Subunit structureⁱ

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP and ASIC3 (By similarity). Interacts with STOM; this regulates channel activity (PubMed:15471860, PubMed:22850675). Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1, mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	197917, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q925H0

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q925H0
SMRⁱ	Q925H0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119120
HOGENOMⁱ	HOG000247010
HOVERGENⁱ	HBG004150
InParanoidⁱ	Q925H0
KEGG Orthology (KO) More...KOⁱ	K04828
OMAⁱ	HPNTRYE
TreeFamⁱ	TF330663

Family and domain databases

InterProⁱ	View protein in InterPro IPR001873 ENaC IPR004724 ENaC_chordates IPR020903 ENaC_CS
PANTHERⁱ	PTHR11690 PTHR11690, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00858 ASC, 1 hit
PRINTSⁱ	PR01078 AMINACHANNEL
TIGRFAMsⁱ	TIGR00859 ENaC, 1 hit
PROSITEⁱ	View protein in PROSITE PS01206 ASC, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q925H0-1) [UniParc]FASTA Add to basket

Also known as: BNaC1-alpha1 Publication, Asic2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV 
        60         70         80         90        100
GSLGLLLVES SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS 
       110        120        130        140        150
RLTTNDLYHA GELLALLDVN LQIPDPHLAD PTVLEALRQK ANFKHYKPKQ 
       160        170        180        190        200
FSMLEFLHRV GHDLKDMMLY CKFKGQECGH QDFTTVFTKY GKCYMFNSGE 
       210        220        230        240        250
DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF EAGVKVQIHS 
       260        270        280        290        300
QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP 
       310        320        330        340        350
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL 
       360        370        380        390        400
AEKDSNYCLC RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE 
       410        420        430        440        450
NILVLDIFFE ALNYETIEQK KAYEVAALLG DIGGQMGLFI GASILTILEL 
       460        470        480        490        500
FDYIYELIKE KLLDLLGKEE EEGSHDENMS TCDTMPNHSE TISHTVNVPL 
       510 
QTALGTLEEI AC

Length:512

Mass (Da):57,739

Last modified:December 1, 2001 - v1

Checksum:ⁱ7D81A77C3B347B04

GO

Isoform 2 (identifier: Q925H0-2) [UniParc]FASTA Add to basket

Also known as: Mdeg21 Publication, Asic2b

The sequence of this isoform differs from the canonical sequence as follows:
1-184: Missing.
185-185: T → MSRSGGARLP...ELCGPHNFSS

« Hide

        10         20         30         40         50
MSRSGGARLP ATALSGPGRF RMAREQPAPA AVAAARQPGG DRSGDRELQG 
        60         70         80         90        100
PGVARRGRPS LSRTKLHGLR HMCAGRTAAG GSFQRRALWV LAFCTSLGLL 
       110        120        130        140        150
LSWSSNRLLY WLSFPSHTRV HREWSRQLPF PAVTVCNNNP LRFPRLSKGD 
       160        170        180        190        200
LYYAGHWLGL LLPNRTARPL VSELLRGDEP RRQWFRKLAD FRLFLPPRHF 
       210        220        230        240        250
EGISAAFMDR LGHQLEDMLL SCKYRGELCG PHNFSSVFTK YGKCYMFNSG 
       260        270        280        290        300
EDGKPLLTTV KGGTGNGLEI MLDIQQDEYL PIWGETEETT FEAGVKVQIH 
       310        320        330        340        350
SQSEPPFIQE LGFGVAPGFQ TFVATQEQRL TYLPPPWGEC RSSEMGLDFF 
       360        370        380        390        400
PVYSITACRI DCETRYIVEN CNCRMVHMPG DAPFCTPEQH KECAEPALGL 
       410        420        430        440        450
LAEKDSNYCL CRTPCNLTRY NKELSMVKIP SKTSAKYLEK KFNKSEKYIS 
       460        470        480        490        500
ENILVLDIFF EALNYETIEQ KKAYEVAALL GDIGGQMGLF IGASILTILE 
       510        520        530        540        550
LFDYIYELIK EKLLDLLGKE EEEGSHDENM STCDTMPNHS ETISHTVNVP 
       560 
LQTALGTLEE IAC

Show »

Length:563

Mass (Da):63,204

Checksum:ⁱ56F7B4A0A214BA39

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015592	1 – 184	Missing in isoform 2. 1 PublicationAdd BLAST		184
Alternative sequenceⁱVSP_015593	185	T → MSRSGGARLPATALSGPGRF RMAREQPAPAAVAAARQPGG DRSGDRELQGPGVARRGRPS LSRTKLHGLRHMCAGRTAAG GSFQRRALWVLAFCTSLGLL LSWSSNRLLYWLSFPSHTRV HREWSRQLPFPAVTVCNNNP LRFPRLSKGDLYYAGHWLGL LLPNRTARPLVSELLRGDEP RRQWFRKLADFRLFLPPRHF EGISAAFMDRLGHQLEDMLL SCKYRGELCGPHNFSS in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14634 mRNA Translation: CAA74978.1 AF348465 mRNA Translation: AAK40101.1 AL645842, AL626807, AL663025 Genomic DNA Translation: CAI24499.1 AL645842, AL645626, AL663025 Genomic DNA Translation: CAI24500.1 AL626807, AL645842, AL663025 Genomic DNA Translation: CAI25306.1 AL645626, AL645842, AL663025 Genomic DNA Translation: CAI25540.1 AL663025, AL626807, AL645842 Genomic DNA Translation: CAI25600.1 AL663025, AL645626, AL645842 Genomic DNA Translation: CAI25602.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25137.1 [Q925H0-2] CCDS36243.1 [Q925H0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001029185.1, NM_001034013.2 [Q925H0-1] NP_031410.1, NM_007384.3 [Q925H0-2]
UniGeneⁱ	Mm.234998 Mm.259072 Mm.330264 Mm.366419 Mm.392269 Mm.473675

Genome annotation databases

Ensemblⁱ	ENSMUST00000021045; ENSMUSP00000021045; ENSMUSG00000020704 [Q925H0-2] ENSMUST00000066197; ENSMUSP00000067095; ENSMUSG00000020704 [Q925H0-1]
GeneIDⁱ	11418
KEGGⁱ	mmu:11418
UCSC genome browser More...UCSCⁱ	uc007kmm.2 mouse [Q925H0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q925H0	Uncharacterized protein		MOUSE		512	UniRef100_Q925H0
ASIC2a (Fragment)		MUSSP		328
Uncharacterized protein		HORSE		176
Q925H0-2	Amiloride-sensitive cation channel 1, neuronal (Degenerin)		MOUSE		563	UniRef100_B2RRQ1

Protein	Similar proteins		Species	Score	Length	Source
Q925H0	Acid-sensing ion channel 2		RAT		512	UniRef90_Q62962
Acid-sensing ion channel 2		HUMAN		512
Uncharacterized protein		PANPA		512
Amiloride-sensitive cation channel 1, neuronal isoform MDEG1 (Fragment)		MACMU		62
Uncharacterized protein		MOUSE		512
+108
Q925H0-2	Isoform 2 of Acid-sensing ion channel 2		HUMAN		563	UniRef90_Q16515-2
acid-sensing ion channel 2 isoform X1		NEOSC		565
acid-sensing ion channel 2		ODORO		565
Uncharacterized protein		FELCA		565
Acid sensing ion channel subunit 2		CANLF		565
+52

Protein	Similar proteins		Species	Score	Length	Source
Q925H0	Acid-sensing ion channel 2		RAT		512	UniRef50_Q62962
Acid-sensing ion channel 2		HUMAN		512
Amiloride-sensitive cation channel 1, neuronal		BOVIN		512
Uncharacterized protein		MOUSE		512
ASIC2a (Fragment)		MUSSP		328
+172
Q925H0-2	Acid-sensing ion channel 1		RAT		526	UniRef50_P55926
Acid-sensing ion channel 1		HUMAN		528
Acid-sensing ion channel 1		MOUSE		526
Uncharacterized protein		AOTNA		594
Uncharacterized protein		PAPAN		594
+177

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14634 mRNA Translation: CAA74978.1 AF348465 mRNA Translation: AAK40101.1 AL645842, AL626807, AL663025 Genomic DNA Translation: CAI24499.1 AL645842, AL645626, AL663025 Genomic DNA Translation: CAI24500.1 AL626807, AL645842, AL663025 Genomic DNA Translation: CAI25306.1 AL645626, AL645842, AL663025 Genomic DNA Translation: CAI25540.1 AL663025, AL626807, AL645842 Genomic DNA Translation: CAI25600.1 AL663025, AL645626, AL645842 Genomic DNA Translation: CAI25602.1
CCDSⁱ	CCDS25137.1 [Q925H0-2] CCDS36243.1 [Q925H0-1]
RefSeqⁱ	NP_001029185.1, NM_001034013.2 [Q925H0-1] NP_031410.1, NM_007384.3 [Q925H0-2]
UniGeneⁱ	Mm.234998 Mm.259072 Mm.330264 Mm.366419 Mm.392269 Mm.473675

3D structure databases

ProteinModelPortalⁱ	Q925H0
SMRⁱ	Q925H0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	197917, 2 interactors
MINTⁱ	Q925H0

Chemistry databases

ChEMBLⁱ	CHEMBL3232695

ChEMBLⁱ

CHEMBL3232695

Protein family/group databases

TCDBⁱ	1.A.6.1.8 the epithelial na(+) channel (enac) family

TCDBⁱ

1.A.6.1.8 the epithelial na(+) channel (enac) family

PTM databases

PhosphoSitePlusⁱ	Q925H0

PhosphoSitePlusⁱ

Q925H0

Proteomic databases

PRIDEⁱ	Q925H0

PRIDEⁱ

Q925H0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021045; ENSMUSP00000021045; ENSMUSG00000020704 [Q925H0-2] ENSMUST00000066197; ENSMUSP00000067095; ENSMUSG00000020704 [Q925H0-1]
GeneIDⁱ	11418
KEGGⁱ	mmu:11418
UCSCⁱ	uc007kmm.2 mouse [Q925H0-1]

Organism-specific databases

CTDⁱ	40
MGIⁱ	MGI:1100867 Asic2

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119120
HOGENOMⁱ	HOG000247010
HOVERGENⁱ	HBG004150
InParanoidⁱ	Q925H0
KOⁱ	K04828
OMAⁱ	HPNTRYE
TreeFamⁱ	TF330663

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q925H0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020704 Expressed in 123 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasⁱ	Q925H0 baseline and differential
Genevisibleⁱ	Q925H0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001873 ENaC IPR004724 ENaC_chordates IPR020903 ENaC_CS
PANTHERⁱ	PTHR11690 PTHR11690, 1 hit
Pfamⁱ	View protein in Pfam PF00858 ASC, 1 hit
PRINTSⁱ	PR01078 AMINACHANNEL
TIGRFAMsⁱ	TIGR00859 ENaC, 1 hit
PROSITEⁱ	View protein in PROSITE PS01206 ASC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASIC2_MOUSE
Accessionⁱ	Q925H0Primary (citable) accession number: Q925H0 Secondary accession number(s): Q5SUU2, Q61203
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q925H0 (ASIC2_MOUSE)

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Acid-sensing ion channel 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ