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UniProtKB - Q925G2 (CYBR1_MOUSE)

Entry version 122 (23 Feb 2022)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
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Protein

Plasma membrane ascorbate-dependent reductase CYBRD1

Gene

Cybrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe3+ into Fe2+ (PubMed:17068337).

Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe2+, the divalent form of iron that can be transported into enterocytes (PubMed:11230685, PubMed:12547225).

It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337).

May also act as a ferrireductase in airway epithelial cells (By similarity).

May also function as a cupric transmembrane reductase (PubMed:18498772).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme bBy similarityNote: Binds 2 heme b groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi50Iron 1 (heme b 1 axial ligand); via tele nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei70Heme b 2By similarity1
Binding sitei79AscorbateBy similarity1
Binding sitei79Heme b 2By similarity1
Binding sitei83AscorbateBy similarity1
Metal bindingi86Iron 2 (heme b 2 axial ligand); via tele nitrogenBy similarity1
Metal bindingi108Fe(3+); substrate; via tele nitrogenBy similarity1
Metal bindingi120Iron 1 (heme b 1 axial ligand); via tele nitrogenBy similarity1
Binding sitei152AscorbateBy similarity1
Metal bindingi159Iron 2 (heme b 2 axial ligand); via tele nitrogenBy similarity1
Binding sitei180Heme b 1By similarity1
Binding sitei225Heme b 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Translocase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-917937, Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasma membrane ascorbate-dependent reductase CYBRD1By similarity (EC:7.2.1.3By similarity)
Alternative name(s):
Cytochrome b reductase 1
Duodenal cytochrome b1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cybrd1Imported
Synonyms:Dcytb1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2654575, Cybrd1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000027015

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicBy similarity7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 32Helical; Name=1By similarityAdd BLAST25
Topological domaini33 – 47ExtracellularBy similarityAdd BLAST15
Transmembranei48 – 69Helical; Name=2By similarityAdd BLAST22
Topological domaini70 – 78CytoplasmicBy similarity9
Transmembranei79 – 105Helical; Name=3By similarityAdd BLAST27
Topological domaini106 – 118ExtracellularBy similarityAdd BLAST13
Transmembranei119 – 144Helical; Name=4By similarityAdd BLAST26
Topological domaini145 – 151CytoplasmicBy similarity7
Transmembranei152 – 179Helical; Name=5By similarityAdd BLAST28
Topological domaini180 – 197ExtracellularBy similarityAdd BLAST18
Transmembranei198 – 222Helical; Name=6By similarityAdd BLAST25
Topological domaini223 – 290CytoplasmicBy similarityAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are normal and do not display iron stores defects, even in the setting of iron deficiency. These results, reported by PubMed:15961514, suggest that Cybrd1 is not an essential component of intestinal iron apparatus. However, according to PubMed:16326980, no direct measurements of iron absorption were made by PubMed:15961514, suggesting that final conclusions can be drawn only when direct iron absorption studies are carried out or mice are maintained on a diet containing ferric iron only.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148311 – 290Plasma membrane ascorbate-dependent reductase CYBRD1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineBy similarity1
Modified residuei289PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q925G2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q925G2

PRoteomics IDEntifications database

More...PRIDEi		Q925G2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		283995 [Q925G2-1]
283996 [Q925G2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q925G2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q925G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brush-border membrane of duodenal enterocytes (at protein level). Also expressed in liver and spleen.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By iron deficiency. Up-regulated in duodenal mucosa of mice lacking transferrin or Hfe (at protein level).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000027015, Expressed in epithelium of cochlear duct and 212 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q925G2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028403

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q925G2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q925G2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 220Cytochrome b561PROSITE-ProRule annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni115 – 118Heme b 1 bindingBy similarity4
Regioni257 – 290DisorderedSequence analysisAdd BLAST34

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183197

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069712_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q925G2

Identification of Orthologs from Complete Genome Data

More...OMAi		TGFIFIQ

Database of Orthologous Groups

More...OrthoDBi		1503869at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q925G2

TreeFam database of animal gene trees

More...TreeFami		TF314222

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043205, CYB561/CYBRD1-like
IPR028838, CYBRD1
IPR006593, Cyt_b561/ferric_Rdtase_TM

The PANTHER Classification System

More...PANTHERi		PTHR10106, PTHR10106, 1 hit
PTHR10106:SF12, PTHR10106:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03188, Cytochrom_B561, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00665, B561, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q925G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMEGYRGFL GLLVSALLVG FLSVIFVLIW VLHFREGLGW NGSGLEFNWH 
        60         70         80         90        100
PVLAVTGFVF IQGIAIIVYR LPWTWKCSKL LMKSIHAGLN AVAAILAIIS 
       110        120        130        140        150
VVAVFEYHNV QKVPHMYSLH SWVGLTALIL YIQQLVVGFF VFLLPWAPPS 
       160        170        180        190        200
LRAIVMPIHV YSGLLLFGTV IATVLMGVTE KLFFVLKHPS YHSFPPEGVF 
       210        220        230        240        250
TNTLGLLILV FGALIFWIVT RPQWKRPREP GSVPLQLNGG NAECRMEGAI 
       260        270        280        290
AISSAHSMDA ADPADAESSS EGAARKRTLG LADSGQRSTM
Length:290
Mass (Da):31,844
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5098086F0EA937E
GO
Isoform 2 (identifier: Q925G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-244: EC → D
     261-263: Missing.

Show »
Length:286
Mass (Da):31,443
Checksum:i22EBD0B3FFE1A487
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188H → R in AAK50909 (PubMed:11230685).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030396243 – 244EC → D in isoform 2. 1 Publication2
Alternative sequenceiVSP_030397261 – 263Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF354666 mRNA Translation: AAK50909.1
AK008849 mRNA Translation: BAB25928.1
AK029112 mRNA Translation: BAC26304.1
AL929228 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS50603.1 [Q925G2-1]

NCBI Reference Sequences

More...RefSeqi		NP_082869.2, NM_028593.2 [Q925G2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028403; ENSMUSP00000028403; ENSMUSG00000027015 [Q925G2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		73649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:73649

UCSC genome browser

More...UCSCi		uc008kaf.2, mouse [Q925G2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354666 mRNA Translation: AAK50909.1
AK008849 mRNA Translation: BAB25928.1
AK029112 mRNA Translation: BAC26304.1
AL929228 Genomic DNA No translation available.
CCDSiCCDS50603.1 [Q925G2-1]
RefSeqiNP_082869.2, NM_028593.2 [Q925G2-1]

3D structure databases

SMRiQ925G2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028403

PTM databases

iPTMnetiQ925G2
PhosphoSitePlusiQ925G2

Proteomic databases

MaxQBiQ925G2
PaxDbiQ925G2
PRIDEiQ925G2
ProteomicsDBi283995 [Q925G2-1]
283996 [Q925G2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19375, 107 antibodies from 29 providers

Genome annotation databases

EnsembliENSMUST00000028403; ENSMUSP00000028403; ENSMUSG00000027015 [Q925G2-1]
GeneIDi73649
KEGGimmu:73649
UCSCiuc008kaf.2, mouse [Q925G2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79901
MGIiMGI:2654575, Cybrd1
VEuPathDBiHostDB:ENSMUSG00000027015

Phylogenomic databases

eggNOGiKOG1619, Eukaryota
GeneTreeiENSGT00950000183197
HOGENOMiCLU_069712_1_2_1
InParanoidiQ925G2
OMAiTGFIFIQ
OrthoDBi1503869at2759
PhylomeDBiQ925G2
TreeFamiTF314222

Enzyme and pathway databases

ReactomeiR-MMU-917937, Iron uptake and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		73649, 1 hit in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cybrd1, mouse

Protein Ontology

More...PROi		PR:Q925G2
RNActiQ925G2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000027015, Expressed in epithelium of cochlear duct and 212 other tissues
GenevisibleiQ925G2, MM

Family and domain databases

InterProiView protein in InterPro
IPR043205, CYB561/CYBRD1-like
IPR028838, CYBRD1
IPR006593, Cyt_b561/ferric_Rdtase_TM
PANTHERiPTHR10106, PTHR10106, 1 hit
PTHR10106:SF12, PTHR10106:SF12, 1 hit
PfamiView protein in Pfam
PF03188, Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665, B561, 1 hit
PROSITEiView protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYBR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q925G2
Secondary accession number(s): A2AUU8, Q9D7U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 23, 2022
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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