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Protein

Gamma-1-syntrophin

Gene

Sntg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
Gene namesi
Name:Sntg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918346 Sntg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840141 – 517Gamma-1-syntrophinAdd BLAST517

Proteomic databases

PaxDbiQ925E1
PRIDEiQ925E1

PTM databases

iPTMnetiQ925E1
PhosphoSitePlusiQ925E1

Expressioni

Gene expression databases

CleanExiMM_SNTG1

Interactioni

Subunit structurei

Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB. Interacts with DGKZ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214473, 1 interactor
STRINGi10090.ENSMUSP00000111151

Structurei

3D structure databases

ProteinModelPortaliQ925E1
SMRiQ925E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 140PDZPROSITE-ProRule annotationAdd BLAST84
Domaini283 – 390PHPROSITE-ProRule annotationAdd BLAST108

Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

eggNOGiKOG3549 Eukaryota
ENOG410XQXQ LUCA
HOGENOMiHOG000230749
HOVERGENiHBG060412
InParanoidiQ925E1
PhylomeDBiQ925E1

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
IPR015483 Syntrophin_gamma
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF2 PTHR10554:SF2, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q925E1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFRTTCEET KTGVCLLQDG NQEPFKVRLH LARDLLMLQE QDVLCVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVISKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPV
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHARFSQYV PGTDLSRQNE SQVVAVDGVC SGILQCLSAE
260 270 280 290 300
DCMDWLQAIA SNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQESLQD
310 320 330 340 350
RVYTPVFLAL RGSCLYRFLS PPVTTWDWTR AEKTFSVCEI MCKVLKDSDL
360 370 380 390 400
LDRRKHCFTM QSECGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAA
510
TTAAVSSAST SKAKHLA
Length:517
Mass (Da):57,982
Last modified:October 10, 2002 - v2
Checksum:i20133EFD3ED9EF6D
GO
Isoform 2 (identifier: Q925E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     276-283: RNFPVNQQ → MIKHLPSY

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):27,579
Checksum:i7C30E4B8F5091C52
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BNW6Q8BNW6_MOUSE
Gamma-1-syntrophin
Sntg1
517Annotation score:
Q8C415Q8C415_MOUSE
Gamma-1-syntrophin
Sntg1
516Annotation score:
D6REU8D6REU8_MOUSE
Gamma-1-syntrophin
Sntg1
187Annotation score:
D6RJM3D6RJM3_MOUSE
Gamma-1-syntrophin
Sntg1
71Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0063611 – 275Missing in isoform 2. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_006362276 – 283RNFPVNQQ → MIKHLPSY in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367759 mRNA Translation: AAK53399.1
AK016927 mRNA Translation: BAB30501.1
CCDSiCCDS35509.1 [Q925E1-1]
RefSeqiNP_001277322.1, NM_001290393.1
UniGeneiMm.336395
Mm.388998

Genome annotation databases

GeneIDi71096
KEGGimmu:71096
UCSCiuc007agg.2 mouse [Q925E1-2]
uc011whz.2 mouse [Q925E1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367759 mRNA Translation: AAK53399.1
AK016927 mRNA Translation: BAB30501.1
CCDSiCCDS35509.1 [Q925E1-1]
RefSeqiNP_001277322.1, NM_001290393.1
UniGeneiMm.336395
Mm.388998

3D structure databases

ProteinModelPortaliQ925E1
SMRiQ925E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214473, 1 interactor
STRINGi10090.ENSMUSP00000111151

PTM databases

iPTMnetiQ925E1
PhosphoSitePlusiQ925E1

Proteomic databases

PaxDbiQ925E1
PRIDEiQ925E1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71096
KEGGimmu:71096
UCSCiuc007agg.2 mouse [Q925E1-2]
uc011whz.2 mouse [Q925E1-1]

Organism-specific databases

CTDi54212
MGIiMGI:1918346 Sntg1

Phylogenomic databases

eggNOGiKOG3549 Eukaryota
ENOG410XQXQ LUCA
HOGENOMiHOG000230749
HOVERGENiHBG060412
InParanoidiQ925E1
PhylomeDBiQ925E1

Miscellaneous databases

ChiTaRSiSntg1 mouse
PROiPR:Q925E1
SOURCEiSearch...

Gene expression databases

CleanExiMM_SNTG1

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015482 Syntrophin
IPR015483 Syntrophin_gamma
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF2 PTHR10554:SF2, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNTG1_MOUSE
AccessioniPrimary (citable) accession number: Q925E1
Secondary accession number(s): Q9D3Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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