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Entry version 174 (26 Feb 2020)
Sequence version 4 (23 Jan 2007)
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Protein

Septin-8

Gene

SEPTIN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).By similarity1 Publication
Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei106GTP; via amide nitrogenBy similarity1
Binding sitei241GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei256GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi187 – 195GTPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Septin-8Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEPTIN8Imported
Synonyms:KIAA02021 Publication, SEPT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16511 SEPTIN8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608418 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92599

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000164402

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134879270

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92599 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEPT8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45645200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001735332 – 483Septin-8Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92599

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92599

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92599

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92599

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92599

PeptideAtlas

More...
PeptideAtlasi
Q92599

PRoteomics IDEntifications database

More...
PRIDEi
Q92599

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
28101
75347 [Q92599-1]
75348 [Q92599-2]
75349 [Q92599-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92599

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92599

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92599

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164402 Expressed in middle temporal gyrus and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92599 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92599 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).

Interacts with CDK14 (PubMed:12098780).

Interacts with SEPTIN5 (PubMed:12909369).

Interacts with SEPTIN7 (By similarity).

Interacts with SEPTIN4 (PubMed:15116257).

Interacts with VAMP2; the interaction inhibits interaction of VAMP2 with SYP (By similarity).

Interacts with STX1A (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q997196EBI-958021,EBI-373345

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116788, 41 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q92599

Protein interaction database and analysis system

More...
IntActi
Q92599, 24 interactors

Molecular INTeraction database

More...
MINTi
Q92599

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367991

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92599 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92599

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 307Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni103 – 106G3 motifPROSITE-ProRule annotation4
Regioni186 – 189G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili320 – 413Sequence analysisAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2655 Eukaryota
COG5019 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017718_6_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92599

KEGG Orthology (KO)

More...
KOi
K16939

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASHYESA

Database of Orthologous Groups

More...
OrthoDBi
845354at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92599

TreeFam database of animal gene trees

More...
TreeFami
TF101080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01850 CDC_Septin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00735 Septin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006698 Septin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51719 G_SEPTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92599-1) [UniParc]FASTAAdd to basket
Also known as: KIAA0202b1 Publication, SEPT8_v21 Publication, SEPT8 TV11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT
110 120 130 140 150
IVDAVGFGDQ INKDESYRPI VDYIDAQFEN YLQEELKIRR SLFDYHDTRI
160 170 180 190 200
HVCLYFITPT GHSLKSLDLV TMKKLDSKVN IIPIIAKADT ISKSELHKFK
210 220 230 240 250
IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV GSTEEVKVGN
260 270 280 290 300
KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
310 320 330 340 350
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN
360 370 380 390 400
KVKETELELK EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR
410 420 430 440 450
RKAAVEALQS QALHATSQQP LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT
460 470 480
KASVEPLNCS SWWPAIQCCS CLVRDATWRE GFL
Length:483
Mass (Da):55,756
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35E1ACF95F5DBA6B
GO
Isoform 2 (identifier: Q92599-2) [UniParc]FASTAAdd to basket
Also known as: KIAA0202a1 Publication, SEPT8_v11 Publication, KIAA0202c1 Publication, SEPT8_v1*1 Publication, SEPT8 TV21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     430-483: Missing.

Note: KIAA0202a differs from KIAA0202c at the level of the 3'-UTR.Curated
Show »
Length:429
Mass (Da):49,814
Checksum:iB6900F134CF67474
GO
Isoform 3 (identifier: Q92599-3) [UniParc]FASTAAdd to basket
Also known as: KIAA0202d1 Publication, SEPT8_v31 Publication, SEPT8 TV41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     430-483: Missing.

Show »
Length:369
Mass (Da):43,519
Checksum:i3C85574B0124B3BA
GO
Isoform 4 (identifier: Q92599-4) [UniParc]FASTAAdd to basket
Also known as: SEPT8 TV31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     429-442: NRSDIGAHQPGMSL → KASGWSSIYSVTIP
     443-483: Missing.

Show »
Length:442
Mass (Da):51,178
Checksum:i4A3D69A996FE624C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NFQ9A6NFQ9_HUMAN
Septin-8
SEPTIN8
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8I8F8W8I8_HUMAN
Septin-8
SEPTIN8
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NMH6A6NMH6_HUMAN
Septin-8
SEPTIN8
430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X142A0A087X142_HUMAN
Septin-8
SEPTIN8
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JV02C9JV02_HUMAN
Septin-8
SEPTIN8
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4G8C9J4G8_HUMAN
Septin-8
SEPTIN8
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRP8A0A0A0MRP8_HUMAN
Septin-8
SEPTIN8
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG09407 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH01329 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO13878 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAO13879 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAO13880 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA13193 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116 – 117Missing in AK057797 (PubMed:14702039).Curated2
Sequence conflicti365E → V in AK057797 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0096431 – 60Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_054085429 – 442NRSDI…PGMSL → KASGWSSIYSVTIP in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_009644430 – 483Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST54
Alternative sequenceiVSP_054086443 – 483Missing in isoform 4. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D86957 mRNA Translation: BAA13193.1 Different initiation.
AF179995 mRNA Translation: AAG09407.1 Different initiation.
AF440761 mRNA Translation: AAO13878.1 Different initiation.
AF440762 mRNA Translation: AAO13879.1 Different initiation.
AF440763 mRNA Translation: AAO13880.1 Different initiation.
AK057797 mRNA No translation available.
AC004775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62315.1
CH471062 Genomic DNA Translation: EAW62317.1
BC001329 mRNA Translation: AAH01329.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS43358.1 [Q92599-1]
CCDS43359.1 [Q92599-4]
CCDS43360.1 [Q92599-2]
CCDS47262.1 [Q92599-3]

NCBI Reference Sequences

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RefSeqi
NP_001092281.1, NM_001098811.1 [Q92599-1]
NP_001092282.1, NM_001098812.1 [Q92599-4]
NP_001092283.1, NM_001098813.1 [Q92599-3]
NP_001287727.1, NM_001300798.1
NP_001287728.1, NM_001300799.1
NP_055961.1, NM_015146.1 [Q92599-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296873; ENSP00000296873; ENSG00000164402 [Q92599-2]
ENST00000378699; ENSP00000367971; ENSG00000164402 [Q92599-3]
ENST00000378719; ENSP00000367991; ENSG00000164402 [Q92599-1]
ENST00000448933; ENSP00000399840; ENSG00000164402 [Q92599-3]
ENST00000458488; ENSP00000394766; ENSG00000164402 [Q92599-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23176

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23176

UCSC genome browser

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UCSCi
uc003kxr.2 human [Q92599-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86957 mRNA Translation: BAA13193.1 Different initiation.
AF179995 mRNA Translation: AAG09407.1 Different initiation.
AF440761 mRNA Translation: AAO13878.1 Different initiation.
AF440762 mRNA Translation: AAO13879.1 Different initiation.
AF440763 mRNA Translation: AAO13880.1 Different initiation.
AK057797 mRNA No translation available.
AC004775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62315.1
CH471062 Genomic DNA Translation: EAW62317.1
BC001329 mRNA Translation: AAH01329.1 Different initiation.
CCDSiCCDS43358.1 [Q92599-1]
CCDS43359.1 [Q92599-4]
CCDS43360.1 [Q92599-2]
CCDS47262.1 [Q92599-3]
RefSeqiNP_001092281.1, NM_001098811.1 [Q92599-1]
NP_001092282.1, NM_001098812.1 [Q92599-4]
NP_001092283.1, NM_001098813.1 [Q92599-3]
NP_001287727.1, NM_001300798.1
NP_001287728.1, NM_001300799.1
NP_055961.1, NM_015146.1 [Q92599-2]

3D structure databases

SMRiQ92599
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116788, 41 interactors
CORUMiQ92599
IntActiQ92599, 24 interactors
MINTiQ92599
STRINGi9606.ENSP00000367991

PTM databases

iPTMnetiQ92599
PhosphoSitePlusiQ92599
SwissPalmiQ92599

Polymorphism and mutation databases

BioMutaiSEPT8
DMDMi45645200

Proteomic databases

EPDiQ92599
jPOSTiQ92599
MassIVEiQ92599
MaxQBiQ92599
PaxDbiQ92599
PeptideAtlasiQ92599
PRIDEiQ92599
ProteomicsDBi28101
75347 [Q92599-1]
75348 [Q92599-2]
75349 [Q92599-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23176

Genome annotation databases

EnsembliENST00000296873; ENSP00000296873; ENSG00000164402 [Q92599-2]
ENST00000378699; ENSP00000367971; ENSG00000164402 [Q92599-3]
ENST00000378719; ENSP00000367991; ENSG00000164402 [Q92599-1]
ENST00000448933; ENSP00000399840; ENSG00000164402 [Q92599-3]
ENST00000458488; ENSP00000394766; ENSG00000164402 [Q92599-4]
GeneIDi23176
KEGGihsa:23176
UCSCiuc003kxr.2 human [Q92599-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23176

GeneCards: human genes, protein and diseases

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GeneCardsi
SEPTIN8
HGNCiHGNC:16511 SEPTIN8
HPAiHPA036534
MIMi608418 gene
neXtProtiNX_Q92599
OpenTargetsiENSG00000164402
PharmGKBiPA134879270

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00940000156068
HOGENOMiCLU_017718_6_4_1
InParanoidiQ92599
KOiK16939
OMAiASHYESA
OrthoDBi845354at2759
PhylomeDBiQ92599
TreeFamiTF101080

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEPT8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEPT8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23176
PharosiQ92599 Tbio

Protein Ontology

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PROi
PR:Q92599
RNActiQ92599 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164402 Expressed in middle temporal gyrus and 225 other tissues
ExpressionAtlasiQ92599 baseline and differential
GenevisibleiQ92599 HS

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEPT8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92599
Secondary accession number(s): A6NC65
, A6NKP6, F6W7K9, Q8IX36, Q8IX37, Q9BVB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: February 26, 2020
This is version 174 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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