MAML1

Functionⁱ

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.5 Publications

GO - Molecular functionⁱ

peptide antigen binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17317671
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15546612
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11101851

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

atrioventricular node cell development Source: BHF-UCL
atrioventricular node development Source: BHF-UCL
myoblast differentiation Source: Ensembl
Notch signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11101851
positive regulation of myotube differentiation
Source: UniProtKB
Inferred from genetic interactionⁱ
- 16510869
positive regulation of Notch signaling pathway Source: Reactome
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11101851
- 16510869
positive regulation of transcription of Notch receptor target Source: GO_Central
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 16510869
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563 NOTCH2 intracellular domain regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054 Notch-HLH transcription pathway R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SIGNORⁱ	Q92585

Reactomeⁱ

R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

SIGNORⁱ

Q92585

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mastermind-like protein 1 Short name: Mam-1
Gene namesⁱ	Name:MAML1Imported Synonyms:KIAA0200Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161021.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13632 MAML1
MIMⁱ	605424 gene
neXtProtⁱ	NX_Q92585

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9794
Open Targets More...OpenTargetsⁱ	ENSG00000161021
PharmGKBⁱ	PA30569

Polymorphism and mutation databases

BioMutaⁱ	MAML1
DMDMⁱ	68565602

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000129493	1 – 1016	Mastermind-like protein 1Add BLAST		1016

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	45	PhosphoserineCombined sources	1
Modified residueⁱ	120	PhosphoserineBy similarity	1
Modified residueⁱ	303	PhosphoserineBy similarity	1
Modified residueⁱ	314	PhosphoserineCombined sources	1
Modified residueⁱ	360	PhosphoserineCombined sources	1
Modified residueⁱ	822	N6-acetyllysineCombined sources	1
Modified residueⁱ	1015	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q92585
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92585
PaxDbⁱ	Q92585
PeptideAtlas More...PeptideAtlasⁱ	Q92585
PRIDEⁱ	Q92585
ProteomicsDBⁱ	75342

PTM databases

iPTMnetⁱ	Q92585
PhosphoSitePlusⁱ	Q92585

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000161021 Expressed in 233 organ(s), highest expression level in adrenal cortex
CleanExⁱ	HS_MAML1
Genevisibleⁱ	Q92585 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037687 HPA057531

HPAⁱ

HPA037687
HPA057531

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NOTCH1	P46531	14	EBI-908250,EBI-636374

With

Entry

#Exp.

IntAct

Notes

NOTCH1

P46531

14

EBI-908250,EBI-636374

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15546612

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115138, 24 interactors
CORUMⁱ	Q92585
Database of interacting proteins More...DIPⁱ	DIP-29920N
IntActⁱ	Q92585, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q92585
STRINGⁱ	9606.ENSP00000292599

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	17 – 69	Combined sources		53

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92585
SMRⁱ	Q92585
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92585

EvolutionaryTraceⁱ

Q92585

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 123	Required for interaction with NOTCH proteins1 PublicationAdd BLAST		123

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	642 – 645	Poly-Gln		4

Domainⁱ

The C-terminal region is required for transcriptional activation.1 Publication

Sequence similaritiesⁱ

Belongs to the mastermind family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IHPP Eukaryota ENOG4111N9A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063317
HOGENOMⁱ	HOG000113473
HOVERGENⁱ	HBG058017
InParanoidⁱ	Q92585
KEGG Orthology (KO) More...KOⁱ	K06061
OMAⁱ	SEEWMND
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01SE
PhylomeDBⁱ	Q92585
TreeFamⁱ	TF332922

Family and domain databases

InterProⁱ	View protein in InterPro IPR019082 Neuroggenic_mastermind-like_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09596 MamL-1, 1 hit
SMARTⁱ	View protein in SMART SM01275 MamL-1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q92585-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLPTCPMAE FALPRHSAVM ERLRRRIELC RRHHSTCEAR YEAVSPERLE 
        60         70         80         90        100
LERQHTFALH QRCIQAKAKR AGKHRQPPAA TAPAPAAPAP RLDAADGPEH 
       110        120        130        140        150
GRPATHLHDT VKRNLDSATS PQNGDQQNGY GDLFPGHKKT RREAPLGVAI 
       160        170        180        190        200
SSNGLPPASP LGQSDKPSGA DALQSSGKHS LGLDSLNKKR LADSSLHLNG 
       210        220        230        240        250
GSNPSESFPL SLNKELKQEP VEDLPCMITG TVGSISQSNL MPDLNLNEQE 
       260        270        280        290        300
WKELIEELNR SVPDEDMKDL FNEDFEEKKD PESSGSATQT PLAQDINIKT 
       310        320        330        340        350
EFSPAAFEQE QLGSPQVRAG SAGQTFLGPS SAPVSTDSPS LGGSQTLFHT 
       360        370        380        390        400
SGQPRADNPS PNLMPASAQA QNAQRALAGV VLPSQGPGGA SELSSAHQLQ 
       410        420        430        440        450
QIAAKQKREQ MLQNPQQATP APAPGQMSTW QQTGPSHSSL DVPYPMEKPA 
       460        470        480        490        500
SPSSYKQDFT NSKLLMMPSV NKSSPRPGGP YLQPSHVNLL SHQPPSNLNQ 
       510        520        530        540        550
NSANNQGSVL DYGNTKPLSH YKADCGQGSP GSGQSKPALM AYLPQQLSHI 
       560        570        580        590        600
SHEQNSLFLM KPKPGNMPFR SLVPPGQEQN PSSVPVQAQA TSVGTQPPAV 
       610        620        630        640        650
SVASSHNSSP YLSSQQQAAV MKQHQLLLDQ QKQREQQQKH LQQQQFLQRQ 
       660        670        680        690        700
QHLLAEQEKQ QFQRHLTRPP PQYQDPTQGS FPQQVGQFTG SSAAVPGMNT 
       710        720        730        740        750
LGPSNSSCPR VFPQAGNLMP MGPGHASVSS LPTNSGQQDR GVAQFPGSQN 
       760        770        780        790        800
MPQSSLYGMA SGITQIVAQP PPQATNGHAH IPRQTNVGQN TSVSAAYGQN 
       810        820        830        840        850
SLGSSGLSQQ HNKGTLNPGL TKPPVPRVSP AMGGQNSSWQ HQGMPNLSGQ 
       860        870        880        890        900
TPGNSNVSPF TAASSFHMQQ QAHLKMSSPQ FSQAVPNRPM APMSSAAAVG 
       910        920        930        940        950
SLLPPVSAQQ RTSAPAPAPP PTAPQQGLPG LSPAGPELGA FSQSPASQMG 
       960        970        980        990       1000
GRAGLHCTQA YPVRTAGQEL PFAYSGQPGG SGLSSVAGHT DLIDSLLKNR 
      1010 
TSEEWMSDLD DLLGSQ

Length:1,016

Mass (Da):108,054

Last modified:July 5, 2005 - v3

Checksum:ⁱC683CB81B73A2A61

GO

Sequence cautionⁱ

The sequence BAA12114 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061335	583	S → N. Corresponds to variant dbSNP:rs41285557Ensembl.		1
Natural variantⁱVAR_029010	1007	S → N1 PublicationCorresponds to variant dbSNP:rs6895902Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83785 mRNA Translation: BAA12114.2 Different initiation. AF221759 mRNA Translation: AAF34658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34315.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055572.1, NM_014757.4
UniGeneⁱ	Hs.631951

Genome annotation databases

Ensemblⁱ	ENST00000292599; ENSP00000292599; ENSG00000161021 ENST00000638220; ENSP00000491444; ENSG00000283780
GeneIDⁱ	9794
KEGGⁱ	hsa:9794
UCSC genome browser More...UCSCⁱ	uc003mkm.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92585	MAML1 isoform 1		PONAB		1023	UniRef90_Q92585
MAML1 isoform 1		PANTR		1023
Mastermind-like protein 1		CASCN		1019
mastermind-like protein 1		PHYCD		1018
Uncharacterized protein		PAPAN		1016
+43

Protein	Similar proteins		Species	Score	Length	Source
Q92585	Mastermind-like protein 1		MOUSE		1020	UniRef50_Q92585
MAML1 isoform 1		PONAB		1023
MAML1 isoform 1		PANTR		1023
Mastermind-like protein 1		CASCN		1019
mastermind-like protein 1		PHYCD		1018
+249

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83785 mRNA Translation: BAA12114.2 Different initiation. AF221759 mRNA Translation: AAF34658.1
CCDSⁱ	CCDS34315.1
RefSeqⁱ	NP_055572.1, NM_014757.4
UniGeneⁱ	Hs.631951

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F8X	X-ray	3.25	M	13-74	[»]
	3NBN	X-ray	3.45	C/F	13-74	[»]
	3V79	X-ray	3.85	M	13-74	[»]
ProteinModelPortalⁱ	Q92585
SMRⁱ	Q92585
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115138, 24 interactors
CORUMⁱ	Q92585
DIPⁱ	DIP-29920N
IntActⁱ	Q92585, 14 interactors
MINTⁱ	Q92585
STRINGⁱ	9606.ENSP00000292599

PTM databases

iPTMnetⁱ	Q92585
PhosphoSitePlusⁱ	Q92585

Polymorphism and mutation databases

BioMutaⁱ	MAML1
DMDMⁱ	68565602

Proteomic databases

EPDⁱ	Q92585
MaxQBⁱ	Q92585
PaxDbⁱ	Q92585
PeptideAtlasⁱ	Q92585
PRIDEⁱ	Q92585
ProteomicsDBⁱ	75342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000292599; ENSP00000292599; ENSG00000161021 ENST00000638220; ENSP00000491444; ENSG00000283780
GeneIDⁱ	9794
KEGGⁱ	hsa:9794
UCSCⁱ	uc003mkm.3 human

Organism-specific databases

CTDⁱ	9794
DisGeNETⁱ	9794
EuPathDBⁱ	HostDB:ENSG00000161021.11
GeneCardsⁱ	MAML1
HGNCⁱ	HGNC:13632 MAML1
HPAⁱ	HPA037687 HPA057531
MIMⁱ	605424 gene
neXtProtⁱ	NX_Q92585
OpenTargetsⁱ	ENSG00000161021
PharmGKBⁱ	PA30569
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHPP Eukaryota ENOG4111N9A LUCA
GeneTreeⁱ	ENSGT00530000063317
HOGENOMⁱ	HOG000113473
HOVERGENⁱ	HBG058017
InParanoidⁱ	Q92585
KOⁱ	K06061
OMAⁱ	SEEWMND
OrthoDBⁱ	EOG091G01SE
PhylomeDBⁱ	Q92585
TreeFamⁱ	TF332922

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563 NOTCH2 intracellular domain regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-350054 Notch-HLH transcription pathway R-HSA-8941856 RUNX3 regulates NOTCH signaling R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SIGNORⁱ	Q92585

Reactomeⁱ

R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

SIGNORⁱ

Q92585

Miscellaneous databases

ChiTaRSⁱ	MAML1 human
EvolutionaryTraceⁱ	Q92585
GeneWikiⁱ	MAML1
GenomeRNAiⁱ	9794
Protein Ontology More...PROⁱ	PR:Q92585
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161021 Expressed in 233 organ(s), highest expression level in adrenal cortex
CleanExⁱ	HS_MAML1
Genevisibleⁱ	Q92585 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019082 Neuroggenic_mastermind-like_N
Pfamⁱ	View protein in Pfam PF09596 MamL-1, 1 hit
SMARTⁱ	View protein in SMART SM01275 MamL-1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAML1_HUMAN
Accessionⁱ	Q92585Primary (citable) accession number: Q92585 Secondary accession number(s): Q9NZ12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	July 5, 2005
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q92585 (MAML1_HUMAN)

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Mastermind-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ