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Protein

C-C motif chemokine 17

Gene

CCL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.1 Publication

Caution

Was originally thought to be a ligand for CCR8.1 Publication

GO - Molecular functioni

  • CCR4 chemokine receptor binding Source: Ensembl
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 17
Alternative name(s):
CC chemokine TARC
Small-inducible cytokine A17
Thymus and activation-regulated chemokine
Gene namesi
Name:CCL17
Synonyms:SCYA17, TARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102970.10
HGNCiHGNC:10615 CCL17
MIMi601520 gene
neXtProtiNX_Q92583

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6361
OpenTargetsiENSG00000102970
PharmGKBiPA35548

Polymorphism and mutation databases

BioMutaiCCL17
DMDMi3024711

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000521124 – 94C-C motif chemokine 17Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 571 Publication
Disulfide bondi34 ↔ 731 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ92583
PeptideAtlasiQ92583
PRIDEiQ92583
ProteomicsDBi75341

PTM databases

iPTMnetiQ92583
PhosphoSitePlusiQ92583

Expressioni

Tissue specificityi

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Inductioni

By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Gene expression databases

BgeeiENSG00000102970 Expressed in 93 organ(s), highest expression level in lymph node
CleanExiHS_CCL17
GenevisibleiQ92583 HS

Organism-specific databases

HPAiCAB002583

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112264, 6 interactors
DIPiDIP-5842N
IntActiQ92583, 10 interactors
STRINGi9606.ENSP00000219244

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92583
SMRiQ92583
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92583

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QF Eukaryota
ENOG41113EM LUCA
GeneTreeiENSGT00530000064258
HOGENOMiHOG000036685
HOVERGENiHBG098492
InParanoidiQ92583
KOiK21083
OMAiCSDPKDT
OrthoDBiEOG091G11AP
PhylomeDBiQ92583
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW
60 70 80 90
YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
Length:94
Mass (Da):10,507
Last modified:February 1, 1997 - v1
Checksum:i7959C56BA8FDAF08
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0487085K → N. Corresponds to variant dbSNP:rs34693308Ensembl.1
Natural variantiVAR_04870967V → M. Corresponds to variant dbSNP:rs34379253Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43767 mRNA Translation: BAA07824.1
EF064767 Genomic DNA Translation: ABK41950.1
AC004382 Genomic DNA Translation: AAC24308.1
CH471092 Genomic DNA Translation: EAW82921.1
BC069107 mRNA Translation: AAH69107.1
BC112066 mRNA Translation: AAI12067.1
BC112068 mRNA Translation: AAI12069.1
CCDSiCCDS10780.1
RefSeqiNP_002978.1, NM_002987.2
UniGeneiHs.546294

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970
ENST00000616880; ENSP00000480147; ENSG00000102970
GeneIDi6361
KEGGihsa:6361
UCSCiuc002elj.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43767 mRNA Translation: BAA07824.1
EF064767 Genomic DNA Translation: ABK41950.1
AC004382 Genomic DNA Translation: AAC24308.1
CH471092 Genomic DNA Translation: EAW82921.1
BC069107 mRNA Translation: AAH69107.1
BC112066 mRNA Translation: AAI12067.1
BC112068 mRNA Translation: AAI12069.1
CCDSiCCDS10780.1
RefSeqiNP_002978.1, NM_002987.2
UniGeneiHs.546294

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NR2X-ray2.18A/B24-94[»]
1NR4X-ray1.72A/B/C/D/E/F/G/H24-94[»]
5WK3X-ray1.90A/B/C/D24-94[»]
ProteinModelPortaliQ92583
SMRiQ92583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112264, 6 interactors
DIPiDIP-5842N
IntActiQ92583, 10 interactors
STRINGi9606.ENSP00000219244

PTM databases

iPTMnetiQ92583
PhosphoSitePlusiQ92583

Polymorphism and mutation databases

BioMutaiCCL17
DMDMi3024711

Proteomic databases

PaxDbiQ92583
PeptideAtlasiQ92583
PRIDEiQ92583
ProteomicsDBi75341

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219244; ENSP00000219244; ENSG00000102970
ENST00000616880; ENSP00000480147; ENSG00000102970
GeneIDi6361
KEGGihsa:6361
UCSCiuc002elj.1 human

Organism-specific databases

CTDi6361
DisGeNETi6361
EuPathDBiHostDB:ENSG00000102970.10
GeneCardsiCCL17
HGNCiHGNC:10615 CCL17
HPAiCAB002583
MIMi601520 gene
neXtProtiNX_Q92583
OpenTargetsiENSG00000102970
PharmGKBiPA35548
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0QF Eukaryota
ENOG41113EM LUCA
GeneTreeiENSGT00530000064258
HOGENOMiHOG000036685
HOVERGENiHBG098492
InParanoidiQ92583
KOiK21083
OMAiCSDPKDT
OrthoDBiEOG091G11AP
PhylomeDBiQ92583
TreeFamiTF334888

Miscellaneous databases

ChiTaRSiCCL17 human
EvolutionaryTraceiQ92583
GeneWikiiCCL17
GenomeRNAii6361
PROiPR:Q92583
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102970 Expressed in 93 organ(s), highest expression level in lymph node
CleanExiHS_CCL17
GenevisibleiQ92583 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL17_HUMAN
AccessioniPrimary (citable) accession number: Q92583
Secondary accession number(s): A0N0Q9, Q2M287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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