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Entry version 163 (11 Dec 2019)
Sequence version 3 (15 Aug 2003)
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Protein

PHD finger protein 3

Gene

PHF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PHD finger protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHF3
Synonyms:KIAA0244
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118482.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8921 PHF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607789 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92576

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23469

Open Targets

More...
OpenTargetsi
ENSG00000118482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33261

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92576 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34098662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000592921 – 2039PHD finger protein 3Add BLAST2039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki644Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei680PhosphoserineCombined sources1
Cross-linki964Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1642PhosphoserineCombined sources1
Modified residuei1867Asymmetric dimethylarginineCombined sources1
Modified residuei1877Asymmetric dimethylarginineCombined sources1
Modified residuei1898PhosphoserineCombined sources1
Modified residuei1925PhosphoserineCombined sources1
Cross-linki1931Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92576

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92576

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92576

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92576

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92576

PeptideAtlas

More...
PeptideAtlasi
Q92576

PRoteomics IDEntifications database

More...
PRIDEi
Q92576

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75337 [Q92576-1]
75338 [Q92576-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92576

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92576

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92576 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92576 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024676
HPA025763

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117031, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q92576, 24 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262043

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92576 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12039
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92576

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92576

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini927 – 1046TFIIS centralPROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1797 – 1865Pro-richAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155080

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92576

Identification of Orthologs from Complete Genome Data

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OMAi
NQATVEF

Database of Orthologous Groups

More...
OrthoDBi
174961at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92576

TreeFam database of animal gene trees

More...
TreeFami
TF350578

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.472.30, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS
60 70 80 90 100
DKDPMLGSAS NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND
110 120 130 140 150
TIDEEELILP NRNLRDKVEE NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS
160 170 180 190 200
NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ VKEEVCMSLK PEYHKENRRC
210 220 230 240 250
SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC NNPGEIDVPS
260 270 280 290 300
HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI
310 320 330 340 350
SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC
360 370 380 390 400
TNPNKTENSL VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG
410 420 430 440 450
YCEDAESNRQ LESTEFNKSN LEVVDTSTFG PESNILENAI CDVPDQNSKQ
460 470 480 490 500
LNAIESTKIE SHETANLQDD RNSQSSSVSY LESKSVKSKH TKPVIHSKQN
510 520 530 540 550
MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN FHRPVKVRKK
560 570 580 590 600
QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS
610 620 630 640 650
HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP
660 670 680 690 700
GVEHFKEEDK LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE
710 720 730 740 750
GSDHSSSFES KYMWTPSKQC GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS
760 770 780 790 800
LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL DPDTLENQAT VEFHSGDKTM
810 820 830 840 850
ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS SDCRDNEIKK
860 870 880 890 900
WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE
910 920 930 940 950
MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV
960 970 980 990 1000
PEEKAAKVAT KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV
1010 1020 1030 1040 1050
LKGEVTPDHL IRMSPEELAS KELAAWRRRE NRHTIEMIEK EQREVERRPI
1060 1070 1080 1090 1100
TKITHKGEIE IESDAPMKEQ EAAMEIQEPA ANKSLEKPEG SEKQKEEVDS
1110 1120 1130 1140 1150
MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV VGVARKHSDN
1160 1170 1180 1190 1200
EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST
1210 1220 1230 1240 1250
FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS
1260 1270 1280 1290 1300
PQTVWDYVEK IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV
1310 1320 1330 1340 1350
AANNMKQVKD MYLIPLGATD KIPHPLVPFD GPGLELHRPN LLLGLIIRQK
1360 1370 1380 1390 1400
LKRQHSACAS TSHIAETPES APPIALPPDK KSKIEVSTEE APEEENDFFN
1410 1420 1430 1440 1450
SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL RFLPGVLIGW
1460 1470 1480 1490 1500
ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN
1510 1520 1530 1540 1550
EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI
1560 1570 1580 1590 1600
SAGSLTSLSL RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED
1610 1620 1630 1640 1650
QENNLQDNQT SNSSPCRSNV GKGNIDGNVS CSENLVANTA RSPQFINLKR
1660 1670 1680 1690 1700
DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM LPGLSHNKEH LTEQINVEEK
1710 1720 1730 1740 1750
LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ EDILMQNIET
1760 1770 1780 1790 1800
VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP
1810 1820 1830 1840 1850
QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN
1860 1870 1880 1890 1900
PMVPWPPVVH LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP
1910 1920 1930 1940 1950
WGRQDQQQLD RPFNRGKGDR QRFYSDSHHL KRERHEKEWE QESERHRRRD
1960 1970 1980 1990 2000
RSQDKDRDRK SREEGHKDKE RARLSHGDRG TDGKASRDSR NVDKKPDKPK
2010 2020 2030
SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR
Length:2,039
Mass (Da):229,481
Last modified:August 15, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDAFF00576005E9B
GO
Isoform 2 (identifier: Q92576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:1,951
Mass (Da):219,808
Checksum:iEC2F49C1B80A2ED5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVH3E7EVH3_HUMAN
PHD finger protein 3
PHF3
1,072Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER40E7ER40_HUMAN
PHD finger protein 3
PHF3
860Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PE34E9PE34_HUMAN
PHD finger protein 3
PHF3
813Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GX99A0A1B0GX99_HUMAN
PHD finger protein 3
PHF3
821Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9X2D6R9X2_HUMAN
PHD finger protein 3
PHF3
736Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBF0D6RBF0_HUMAN
PHD finger protein 3
PHF3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8L0H0Y8L0_HUMAN
PHD finger protein 3
PHF3
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REP0D6REP0_HUMAN
PHD finger protein 3
PHF3
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13438 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1394E → G in CAI56715 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051599525V → I. Corresponds to variant dbSNP:rs34288820Ensembl.1
Natural variantiVAR_0220401834H → Y. Corresponds to variant dbSNP:rs3734881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0264341 – 88Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4966.1 [Q92576-1]

NCBI Reference Sequences

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RefSeqi
NP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3
XP_005248759.1, XM_005248702.3
XP_006715489.1, XM_006715426.3 [Q92576-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23469

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23469

UCSC genome browser

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UCSCi
uc003pep.2 human [Q92576-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1
CCDSiCCDS4966.1 [Q92576-1]
RefSeqiNP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3
XP_005248759.1, XM_005248702.3
XP_006715489.1, XM_006715426.3 [Q92576-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMENMR-A923-1029[»]
SMRiQ92576
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117031, 24 interactors
IntActiQ92576, 24 interactors
STRINGi9606.ENSP00000262043

PTM databases

iPTMnetiQ92576
PhosphoSitePlusiQ92576

Polymorphism and mutation databases

BioMutaiPHF3
DMDMi34098662

Proteomic databases

EPDiQ92576
jPOSTiQ92576
MassIVEiQ92576
MaxQBiQ92576
PaxDbiQ92576
PeptideAtlasiQ92576
PRIDEiQ92576
ProteomicsDBi75337 [Q92576-1]
75338 [Q92576-2]

Genome annotation databases

EnsembliENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]
GeneIDi23469
KEGGihsa:23469
UCSCiuc003pep.2 human [Q92576-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23469
DisGeNETi23469
EuPathDBiHostDB:ENSG00000118482.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PHF3
HGNCiHGNC:8921 PHF3
HPAiHPA024676
HPA025763
MIMi607789 gene
neXtProtiNX_Q92576
OpenTargetsiENSG00000118482
PharmGKBiPA33261

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA
GeneTreeiENSGT00940000155080
InParanoidiQ92576
OMAiNQATVEF
OrthoDBi174961at2759
PhylomeDBiQ92576
TreeFamiTF350578

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHF3 human
EvolutionaryTraceiQ92576

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PHF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23469
PharosiQ92576 Tbio

Protein Ontology

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PROi
PR:Q92576
RNActiQ92576 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ92576 baseline and differential
GenevisibleiQ92576 HS

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92576
Secondary accession number(s): A3KFI8
, Q14CR5, Q5CZI1, Q5T1T6, Q9NQ16, Q9UI45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: December 11, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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