UniProtKB - Q92576 (PHF3_HUMAN)
Protein
PHD finger protein 3
Gene
PHF3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 717 – 772 | PHD-typePROSITE-ProRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- multicellular organism development Source: UniProtKB
- transcription, DNA-templated Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q92576 |
Names & Taxonomyi
Protein namesi | Recommended name: PHD finger protein 3 |
Gene namesi | Name:PHF3 Synonyms:KIAA0244 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8921, PHF3 |
MIMi | 607789, gene |
neXtProti | NX_Q92576 |
VEuPathDBi | HostDB:ENSG00000118482.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23469 |
OpenTargetsi | ENSG00000118482 |
PharmGKBi | PA33261 |
Miscellaneous databases
Pharosi | Q92576, Tbio |
Genetic variation databases
BioMutai | PHF3 |
DMDMi | 34098662 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059292 | 1 – 2039 | PHD finger protein 3Add BLAST | 2039 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 283 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Cross-linki | 644 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Cross-linki | 964 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1014 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1133 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1178 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1642 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1867 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1877 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1898 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1925 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1931 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q92576 |
jPOSTi | Q92576 |
MassIVEi | Q92576 |
MaxQBi | Q92576 |
PaxDbi | Q92576 |
PeptideAtlasi | Q92576 |
PRIDEi | Q92576 |
ProteomicsDBi | 75337 [Q92576-1] 75338 [Q92576-2] |
PTM databases
iPTMneti | Q92576 |
MetOSitei | Q92576 |
PhosphoSitePlusi | Q92576 |
Expressioni
Tissue specificityi
Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.1 Publication
Gene expression databases
Bgeei | ENSG00000118482, Expressed in tendon of biceps brachii and 255 other tissues |
ExpressionAtlasi | Q92576, baseline and differential |
Genevisiblei | Q92576, HS |
Organism-specific databases
HPAi | ENSG00000118482, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117031, 38 interactors |
IntActi | Q92576, 24 interactors |
STRINGi | 9606.ENSP00000262043 |
Miscellaneous databases
RNActi | Q92576, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q92576 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92576 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 927 – 1046 | TFIIS centralPROSITE-ProRule annotationAdd BLAST | 120 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1797 – 1865 | Pro-richAdd BLAST | 69 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 717 – 772 | PHD-typePROSITE-ProRule annotationAdd BLAST | 56 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1634, Eukaryota |
GeneTreei | ENSGT00940000155080 |
HOGENOMi | CLU_001663_0_0_1 |
InParanoidi | Q92576 |
OMAi | DKTMECE |
OrthoDBi | 174961at2759 |
PhylomeDBi | Q92576 |
TreeFami | TF350578 |
Family and domain databases
Gene3Di | 1.10.472.30, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR012921, SPOC_C IPR003618, TFIIS_cen_dom IPR036575, TFIIS_cen_dom_sf IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF07744, SPOC, 1 hit PF07500, TFIIS_M, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00510, TFS2M, 1 hit |
SUPFAMi | SSF46942, SSF46942, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51321, TFIIS_CENTRAL, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q92576-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS
60 70 80 90 100
DKDPMLGSAS NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND
110 120 130 140 150
TIDEEELILP NRNLRDKVEE NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS
160 170 180 190 200
NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ VKEEVCMSLK PEYHKENRRC
210 220 230 240 250
SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC NNPGEIDVPS
260 270 280 290 300
HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI
310 320 330 340 350
SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC
360 370 380 390 400
TNPNKTENSL VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG
410 420 430 440 450
YCEDAESNRQ LESTEFNKSN LEVVDTSTFG PESNILENAI CDVPDQNSKQ
460 470 480 490 500
LNAIESTKIE SHETANLQDD RNSQSSSVSY LESKSVKSKH TKPVIHSKQN
510 520 530 540 550
MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN FHRPVKVRKK
560 570 580 590 600
QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS
610 620 630 640 650
HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP
660 670 680 690 700
GVEHFKEEDK LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE
710 720 730 740 750
GSDHSSSFES KYMWTPSKQC GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS
760 770 780 790 800
LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL DPDTLENQAT VEFHSGDKTM
810 820 830 840 850
ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS SDCRDNEIKK
860 870 880 890 900
WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE
910 920 930 940 950
MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV
960 970 980 990 1000
PEEKAAKVAT KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV
1010 1020 1030 1040 1050
LKGEVTPDHL IRMSPEELAS KELAAWRRRE NRHTIEMIEK EQREVERRPI
1060 1070 1080 1090 1100
TKITHKGEIE IESDAPMKEQ EAAMEIQEPA ANKSLEKPEG SEKQKEEVDS
1110 1120 1130 1140 1150
MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV VGVARKHSDN
1160 1170 1180 1190 1200
EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST
1210 1220 1230 1240 1250
FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS
1260 1270 1280 1290 1300
PQTVWDYVEK IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV
1310 1320 1330 1340 1350
AANNMKQVKD MYLIPLGATD KIPHPLVPFD GPGLELHRPN LLLGLIIRQK
1360 1370 1380 1390 1400
LKRQHSACAS TSHIAETPES APPIALPPDK KSKIEVSTEE APEEENDFFN
1410 1420 1430 1440 1450
SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL RFLPGVLIGW
1460 1470 1480 1490 1500
ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN
1510 1520 1530 1540 1550
EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI
1560 1570 1580 1590 1600
SAGSLTSLSL RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED
1610 1620 1630 1640 1650
QENNLQDNQT SNSSPCRSNV GKGNIDGNVS CSENLVANTA RSPQFINLKR
1660 1670 1680 1690 1700
DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM LPGLSHNKEH LTEQINVEEK
1710 1720 1730 1740 1750
LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ EDILMQNIET
1760 1770 1780 1790 1800
VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP
1810 1820 1830 1840 1850
QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN
1860 1870 1880 1890 1900
PMVPWPPVVH LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP
1910 1920 1930 1940 1950
WGRQDQQQLD RPFNRGKGDR QRFYSDSHHL KRERHEKEWE QESERHRRRD
1960 1970 1980 1990 2000
RSQDKDRDRK SREEGHKDKE RARLSHGDRG TDGKASRDSR NVDKKPDKPK
2010 2020 2030
SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ER40 | E7ER40_HUMAN | PHD finger protein 3 | PHF3 | 860 | Annotation score: | ||
E7EVH3 | E7EVH3_HUMAN | PHD finger protein 3 | PHF3 | 1,072 | Annotation score: | ||
E9PE34 | E9PE34_HUMAN | PHD finger protein 3 | PHF3 | 813 | Annotation score: | ||
A0A1B0GX99 | A0A1B0GX99_HUMAN | PHD finger protein 3 | PHF3 | 821 | Annotation score: | ||
D6R9X2 | D6R9X2_HUMAN | PHD finger protein 3 | PHF3 | 736 | Annotation score: | ||
D6RBF0 | D6RBF0_HUMAN | PHD finger protein 3 | PHF3 | 104 | Annotation score: | ||
H0Y8L0 | H0Y8L0_HUMAN | PHD finger protein 3 | PHF3 | 169 | Annotation score: | ||
D6REP0 | D6REP0_HUMAN | PHD finger protein 3 | PHF3 | 82 | Annotation score: |
Sequence cautioni
The sequence BAA13438 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1394 | E → G in CAI56715 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051599 | 525 | V → I. Corresponds to variant dbSNP:rs34288820Ensembl. | 1 | |
Natural variantiVAR_022040 | 1834 | H → Y. Corresponds to variant dbSNP:rs3734881Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026434 | 1 – 88 | Missing in isoform 2. 1 PublicationAdd BLAST | 88 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091622 mRNA Translation: AAF21292.1 D87685 mRNA Translation: BAA13438.2 Different initiation. BX648268 mRNA Translation: CAI56715.1 AL050329, AL354719 Genomic DNA Translation: CAM45842.1 BC113650 mRNA Translation: AAI13651.1 BC113652 mRNA Translation: AAI13653.1 |
CCDSi | CCDS4966.1 [Q92576-1] |
RefSeqi | NP_001277188.1, NM_001290259.1 [Q92576-2] NP_001277189.1, NM_001290260.1 NP_055968.1, NM_015153.3 [Q92576-1] XP_005248758.1, XM_005248701.3 XP_005248759.1, XM_005248702.3 XP_006715489.1, XM_006715426.3 [Q92576-1] |
Genome annotation databases
Ensembli | ENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1] ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1] |
GeneIDi | 23469 |
KEGGi | hsa:23469 |
UCSCi | uc003pep.2, human [Q92576-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091622 mRNA Translation: AAF21292.1 D87685 mRNA Translation: BAA13438.2 Different initiation. BX648268 mRNA Translation: CAI56715.1 AL050329, AL354719 Genomic DNA Translation: CAM45842.1 BC113650 mRNA Translation: AAI13651.1 BC113652 mRNA Translation: AAI13653.1 |
CCDSi | CCDS4966.1 [Q92576-1] |
RefSeqi | NP_001277188.1, NM_001290259.1 [Q92576-2] NP_001277189.1, NM_001290260.1 NP_055968.1, NM_015153.3 [Q92576-1] XP_005248758.1, XM_005248701.3 XP_005248759.1, XM_005248702.3 XP_006715489.1, XM_006715426.3 [Q92576-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DME | NMR | - | A | 923-1029 | [»] | |
6IC8 | X-ray | 1.93 | A/B | 1199-1356 | [»] | |
6IC9 | X-ray | 1.75 | A/B | 1199-1356 | [»] | |
6Q2V | X-ray | 2.59 | A/B/C/D/E/F/G/H | 1199-1356 | [»] | |
6Q5Y | X-ray | 2.85 | A/B/C/D | 1199-1356 | [»] | |
SMRi | Q92576 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117031, 38 interactors |
IntActi | Q92576, 24 interactors |
STRINGi | 9606.ENSP00000262043 |
PTM databases
iPTMneti | Q92576 |
MetOSitei | Q92576 |
PhosphoSitePlusi | Q92576 |
Genetic variation databases
BioMutai | PHF3 |
DMDMi | 34098662 |
Proteomic databases
EPDi | Q92576 |
jPOSTi | Q92576 |
MassIVEi | Q92576 |
MaxQBi | Q92576 |
PaxDbi | Q92576 |
PeptideAtlasi | Q92576 |
PRIDEi | Q92576 |
ProteomicsDBi | 75337 [Q92576-1] 75338 [Q92576-2] |
Protocols and materials databases
Antibodypediai | 31168, 74 antibodies |
Genome annotation databases
Ensembli | ENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1] ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1] |
GeneIDi | 23469 |
KEGGi | hsa:23469 |
UCSCi | uc003pep.2, human [Q92576-1] |
Organism-specific databases
CTDi | 23469 |
DisGeNETi | 23469 |
GeneCardsi | PHF3 |
HGNCi | HGNC:8921, PHF3 |
HPAi | ENSG00000118482, Low tissue specificity |
MIMi | 607789, gene |
neXtProti | NX_Q92576 |
OpenTargetsi | ENSG00000118482 |
PharmGKBi | PA33261 |
VEuPathDBi | HostDB:ENSG00000118482.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1634, Eukaryota |
GeneTreei | ENSGT00940000155080 |
HOGENOMi | CLU_001663_0_0_1 |
InParanoidi | Q92576 |
OMAi | DKTMECE |
OrthoDBi | 174961at2759 |
PhylomeDBi | Q92576 |
TreeFami | TF350578 |
Enzyme and pathway databases
PathwayCommonsi | Q92576 |
Miscellaneous databases
BioGRID-ORCSi | 23469, 8 hits in 877 CRISPR screens |
ChiTaRSi | PHF3, human |
EvolutionaryTracei | Q92576 |
GeneWikii | PHF3 |
GenomeRNAii | 23469 |
Pharosi | Q92576, Tbio |
PROi | PR:Q92576 |
RNActi | Q92576, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118482, Expressed in tendon of biceps brachii and 255 other tissues |
ExpressionAtlasi | Q92576, baseline and differential |
Genevisiblei | Q92576, HS |
Family and domain databases
Gene3Di | 1.10.472.30, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR012921, SPOC_C IPR003618, TFIIS_cen_dom IPR036575, TFIIS_cen_dom_sf IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF07744, SPOC, 1 hit PF07500, TFIIS_M, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00510, TFS2M, 1 hit |
SUPFAMi | SSF46942, SSF46942, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51321, TFIIS_CENTRAL, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHF3_HUMAN | |
Accessioni | Q92576Primary (citable) accession number: Q92576 Secondary accession number(s): A3KFI8 Q9UI45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 15, 2003 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants