Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PHD finger protein 3

Gene

PHF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • transcription, DNA-templated Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 3
Gene namesi
Name:PHF3
Synonyms:KIAA0244
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118482.11
HGNCiHGNC:8921 PHF3
MIMi607789 gene
neXtProtiNX_Q92576

Pathology & Biotechi

Organism-specific databases

DisGeNETi23469
OpenTargetsiENSG00000118482
PharmGKBiPA33261

Polymorphism and mutation databases

BioMutaiPHF3
DMDMi34098662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000592921 – 2039PHD finger protein 3Add BLAST2039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Cross-linki644Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei680PhosphoserineCombined sources1
Cross-linki964Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1642PhosphoserineCombined sources1
Modified residuei1867Asymmetric dimethylarginineCombined sources1
Modified residuei1877Asymmetric dimethylarginineCombined sources1
Modified residuei1898PhosphoserineCombined sources1
Modified residuei1925PhosphoserineCombined sources1
Cross-linki1931Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92576
MaxQBiQ92576
PaxDbiQ92576
PeptideAtlasiQ92576
PRIDEiQ92576
ProteomicsDBi75337
75338 [Q92576-2]

PTM databases

iPTMnetiQ92576
PhosphoSitePlusiQ92576

Expressioni

Tissue specificityi

Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.1 Publication

Gene expression databases

BgeeiENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PHF3
ExpressionAtlasiQ92576 baseline and differential
GenevisibleiQ92576 HS

Organism-specific databases

HPAiHPA024676
HPA025763

Interactioni

Protein-protein interaction databases

BioGridi117031, 14 interactors
IntActiQ92576, 10 interactors
STRINGi9606.ENSP00000262043

Structurei

Secondary structure

12039
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92576
SMRiQ92576
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92576

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini927 – 1046TFIIS centralPROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1797 – 1865Pro-richAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA
GeneTreeiENSGT00530000063844
HOVERGENiHBG039623
InParanoidiQ92576
OMAiKVRKKQV
OrthoDBiEOG091G00O9
PhylomeDBiQ92576
TreeFamiTF350578

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS
60 70 80 90 100
DKDPMLGSAS NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND
110 120 130 140 150
TIDEEELILP NRNLRDKVEE NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS
160 170 180 190 200
NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ VKEEVCMSLK PEYHKENRRC
210 220 230 240 250
SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC NNPGEIDVPS
260 270 280 290 300
HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI
310 320 330 340 350
SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC
360 370 380 390 400
TNPNKTENSL VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG
410 420 430 440 450
YCEDAESNRQ LESTEFNKSN LEVVDTSTFG PESNILENAI CDVPDQNSKQ
460 470 480 490 500
LNAIESTKIE SHETANLQDD RNSQSSSVSY LESKSVKSKH TKPVIHSKQN
510 520 530 540 550
MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN FHRPVKVRKK
560 570 580 590 600
QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS
610 620 630 640 650
HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP
660 670 680 690 700
GVEHFKEEDK LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE
710 720 730 740 750
GSDHSSSFES KYMWTPSKQC GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS
760 770 780 790 800
LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL DPDTLENQAT VEFHSGDKTM
810 820 830 840 850
ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS SDCRDNEIKK
860 870 880 890 900
WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE
910 920 930 940 950
MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV
960 970 980 990 1000
PEEKAAKVAT KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV
1010 1020 1030 1040 1050
LKGEVTPDHL IRMSPEELAS KELAAWRRRE NRHTIEMIEK EQREVERRPI
1060 1070 1080 1090 1100
TKITHKGEIE IESDAPMKEQ EAAMEIQEPA ANKSLEKPEG SEKQKEEVDS
1110 1120 1130 1140 1150
MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV VGVARKHSDN
1160 1170 1180 1190 1200
EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST
1210 1220 1230 1240 1250
FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS
1260 1270 1280 1290 1300
PQTVWDYVEK IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV
1310 1320 1330 1340 1350
AANNMKQVKD MYLIPLGATD KIPHPLVPFD GPGLELHRPN LLLGLIIRQK
1360 1370 1380 1390 1400
LKRQHSACAS TSHIAETPES APPIALPPDK KSKIEVSTEE APEEENDFFN
1410 1420 1430 1440 1450
SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL RFLPGVLIGW
1460 1470 1480 1490 1500
ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN
1510 1520 1530 1540 1550
EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI
1560 1570 1580 1590 1600
SAGSLTSLSL RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED
1610 1620 1630 1640 1650
QENNLQDNQT SNSSPCRSNV GKGNIDGNVS CSENLVANTA RSPQFINLKR
1660 1670 1680 1690 1700
DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM LPGLSHNKEH LTEQINVEEK
1710 1720 1730 1740 1750
LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ EDILMQNIET
1760 1770 1780 1790 1800
VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP
1810 1820 1830 1840 1850
QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN
1860 1870 1880 1890 1900
PMVPWPPVVH LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP
1910 1920 1930 1940 1950
WGRQDQQQLD RPFNRGKGDR QRFYSDSHHL KRERHEKEWE QESERHRRRD
1960 1970 1980 1990 2000
RSQDKDRDRK SREEGHKDKE RARLSHGDRG TDGKASRDSR NVDKKPDKPK
2010 2020 2030
SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR
Length:2,039
Mass (Da):229,481
Last modified:August 15, 2003 - v3
Checksum:iFDAFF00576005E9B
GO
Isoform 2 (identifier: Q92576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:1,951
Mass (Da):219,808
Checksum:iEC2F49C1B80A2ED5
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVH3E7EVH3_HUMAN
PHD finger protein 3
PHF3
1,072Annotation score:
E7ER40E7ER40_HUMAN
PHD finger protein 3
PHF3
860Annotation score:
E9PE34E9PE34_HUMAN
PHD finger protein 3
PHF3
813Annotation score:
A0A1B0GX99A0A1B0GX99_HUMAN
PHD finger protein 3
PHF3
821Annotation score:
D6R9X2D6R9X2_HUMAN
PHD finger protein 3
PHF3
736Annotation score:
H0Y8L0H0Y8L0_HUMAN
PHD finger protein 3
PHF3
169Annotation score:
D6RBF0D6RBF0_HUMAN
PHD finger protein 3
PHF3
104Annotation score:
D6REP0D6REP0_HUMAN
PHD finger protein 3
PHF3
82Annotation score:

Sequence cautioni

The sequence BAA13438 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1394E → G in CAI56715 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051599525V → I. Corresponds to variant dbSNP:rs34288820Ensembl.1
Natural variantiVAR_0220401834H → Y. Corresponds to variant dbSNP:rs3734881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264341 – 88Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1
CCDSiCCDS4966.1 [Q92576-1]
RefSeqiNP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3 [Q92576-1]
XP_005248759.1, XM_005248702.3 [Q92576-2]
XP_006715489.1, XM_006715426.3 [Q92576-1]
UniGeneiHs.348921
Hs.731957

Genome annotation databases

EnsembliENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]
GeneIDi23469
KEGGihsa:23469
UCSCiuc003pep.2 human [Q92576-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1
CCDSiCCDS4966.1 [Q92576-1]
RefSeqiNP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3 [Q92576-1]
XP_005248759.1, XM_005248702.3 [Q92576-2]
XP_006715489.1, XM_006715426.3 [Q92576-1]
UniGeneiHs.348921
Hs.731957

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMENMR-A923-1029[»]
ProteinModelPortaliQ92576
SMRiQ92576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117031, 14 interactors
IntActiQ92576, 10 interactors
STRINGi9606.ENSP00000262043

PTM databases

iPTMnetiQ92576
PhosphoSitePlusiQ92576

Polymorphism and mutation databases

BioMutaiPHF3
DMDMi34098662

Proteomic databases

EPDiQ92576
MaxQBiQ92576
PaxDbiQ92576
PeptideAtlasiQ92576
PRIDEiQ92576
ProteomicsDBi75337
75338 [Q92576-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]
GeneIDi23469
KEGGihsa:23469
UCSCiuc003pep.2 human [Q92576-1]

Organism-specific databases

CTDi23469
DisGeNETi23469
EuPathDBiHostDB:ENSG00000118482.11
GeneCardsiPHF3
HGNCiHGNC:8921 PHF3
HPAiHPA024676
HPA025763
MIMi607789 gene
neXtProtiNX_Q92576
OpenTargetsiENSG00000118482
PharmGKBiPA33261
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA
GeneTreeiENSGT00530000063844
HOVERGENiHBG039623
InParanoidiQ92576
OMAiKVRKKQV
OrthoDBiEOG091G00O9
PhylomeDBiQ92576
TreeFamiTF350578

Miscellaneous databases

ChiTaRSiPHF3 human
EvolutionaryTraceiQ92576
GeneWikiiPHF3
GenomeRNAii23469
PROiPR:Q92576
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PHF3
ExpressionAtlasiQ92576 baseline and differential
GenevisibleiQ92576 HS

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHF3_HUMAN
AccessioniPrimary (citable) accession number: Q92576
Secondary accession number(s): A3KFI8
, Q14CR5, Q5CZI1, Q5T1T6, Q9NQ16, Q9UI45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: September 12, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again