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UniProtKB - Q92576 (PHF3_HUMAN)

Protein

PHD finger protein 3

Gene

PHF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • transcription, DNA-templated Source: InterPro
View the complete GO annotation on QuickGO ...

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 3
Gene namesi
Name:PHF3
Synonyms:KIAA0244
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118482.11
HGNCiHGNC:8921 PHF3
MIMi607789 gene
neXtProtiNX_Q92576

Pathology & Biotechi

Organism-specific databases

DisGeNETi23469
OpenTargetsiENSG00000118482
PharmGKBiPA33261

Polymorphism and mutation databases

BioMutaiPHF3
DMDMi34098662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000592921 – 2039PHD finger protein 3Add BLAST2039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Cross-linki644Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei680PhosphoserineCombined sources1
Cross-linki964Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1642PhosphoserineCombined sources1
Modified residuei1867Asymmetric dimethylarginineCombined sources1
Modified residuei1877Asymmetric dimethylarginineCombined sources1
Modified residuei1898PhosphoserineCombined sources1
Modified residuei1925PhosphoserineCombined sources1
Cross-linki1931Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92576
MaxQBiQ92576
PaxDbiQ92576
PeptideAtlasiQ92576
PRIDEiQ92576
ProteomicsDBi75337
75338 [Q92576-2]

PTM databases

iPTMnetiQ92576
PhosphoSitePlusiQ92576

Expressioni

Tissue specificityi

Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.1 Publication

Gene expression databases

BgeeiENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PHF3
ExpressionAtlasiQ92576 baseline and differential
GenevisibleiQ92576 HS

Organism-specific databases

HPAiHPA024676
HPA025763

Interactioni

Protein-protein interaction databases

BioGridi117031, 14 interactors
IntActiQ92576, 10 interactors
STRINGi9606.ENSP00000262043

Structurei

Secondary structure

12039
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92576
SMRiQ92576
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92576

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini927 – 1046TFIIS centralPROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1797 – 1865Pro-richAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 772PHD-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA
GeneTreeiENSGT00530000063844
HOVERGENiHBG039623
InParanoidiQ92576
OMAiKVRKKQV
OrthoDBiEOG091G00O9
PhylomeDBiQ92576
TreeFamiTF350578

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS 
        60         70         80         90        100
DKDPMLGSAS NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND 
       110        120        130        140        150
TIDEEELILP NRNLRDKVEE NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS 
       160        170        180        190        200
NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ VKEEVCMSLK PEYHKENRRC 
       210        220        230        240        250
SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC NNPGEIDVPS 
       260        270        280        290        300
HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI 
       310        320        330        340        350
SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC 
       360        370        380        390        400
TNPNKTENSL VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG 
       410        420        430        440        450
YCEDAESNRQ LESTEFNKSN LEVVDTSTFG PESNILENAI CDVPDQNSKQ 
       460        470        480        490        500
LNAIESTKIE SHETANLQDD RNSQSSSVSY LESKSVKSKH TKPVIHSKQN 
       510        520        530        540        550
MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN FHRPVKVRKK 
       560        570        580        590        600
QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS 
       610        620        630        640        650
HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP 
       660        670        680        690        700
GVEHFKEEDK LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE 
       710        720        730        740        750
GSDHSSSFES KYMWTPSKQC GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS 
       760        770        780        790        800
LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL DPDTLENQAT VEFHSGDKTM 
       810        820        830        840        850
ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS SDCRDNEIKK 
       860        870        880        890        900
WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE 
       910        920        930        940        950
MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV 
       960        970        980        990       1000
PEEKAAKVAT KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV 
      1010       1020       1030       1040       1050
LKGEVTPDHL IRMSPEELAS KELAAWRRRE NRHTIEMIEK EQREVERRPI 
      1060       1070       1080       1090       1100
TKITHKGEIE IESDAPMKEQ EAAMEIQEPA ANKSLEKPEG SEKQKEEVDS 
      1110       1120       1130       1140       1150
MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV VGVARKHSDN 
      1160       1170       1180       1190       1200
EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST 
      1210       1220       1230       1240       1250
FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS 
      1260       1270       1280       1290       1300
PQTVWDYVEK IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV 
      1310       1320       1330       1340       1350
AANNMKQVKD MYLIPLGATD KIPHPLVPFD GPGLELHRPN LLLGLIIRQK 
      1360       1370       1380       1390       1400
LKRQHSACAS TSHIAETPES APPIALPPDK KSKIEVSTEE APEEENDFFN 
      1410       1420       1430       1440       1450
SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL RFLPGVLIGW 
      1460       1470       1480       1490       1500
ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN 
      1510       1520       1530       1540       1550
EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI 
      1560       1570       1580       1590       1600
SAGSLTSLSL RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED 
      1610       1620       1630       1640       1650
QENNLQDNQT SNSSPCRSNV GKGNIDGNVS CSENLVANTA RSPQFINLKR 
      1660       1670       1680       1690       1700
DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM LPGLSHNKEH LTEQINVEEK 
      1710       1720       1730       1740       1750
LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ EDILMQNIET 
      1760       1770       1780       1790       1800
VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP 
      1810       1820       1830       1840       1850
QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN 
      1860       1870       1880       1890       1900
PMVPWPPVVH LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP 
      1910       1920       1930       1940       1950
WGRQDQQQLD RPFNRGKGDR QRFYSDSHHL KRERHEKEWE QESERHRRRD 
      1960       1970       1980       1990       2000
RSQDKDRDRK SREEGHKDKE RARLSHGDRG TDGKASRDSR NVDKKPDKPK 
      2010       2020       2030 
SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR
Length:2,039
Mass (Da):229,481
Last modified:August 15, 2003 - v3
Checksum:iFDAFF00576005E9B
GO
Isoform 2 (identifier: Q92576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Note: No experimental confirmation available.
Show »
Length:1,951
Mass (Da):219,808
Checksum:iEC2F49C1B80A2ED5
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVH3E7EVH3_HUMAN
PHD finger protein 3
PHF3
1,072Annotation score:
E7ER40E7ER40_HUMAN
PHD finger protein 3
PHF3
860Annotation score:
E9PE34E9PE34_HUMAN
PHD finger protein 3
PHF3
813Annotation score:
A0A1B0GX99A0A1B0GX99_HUMAN
PHD finger protein 3
PHF3
821Annotation score:
D6R9X2D6R9X2_HUMAN
PHD finger protein 3
PHF3
736Annotation score:
H0Y8L0H0Y8L0_HUMAN
PHD finger protein 3
PHF3
169Annotation score:
D6RBF0D6RBF0_HUMAN
PHD finger protein 3
PHF3
104Annotation score:
D6REP0D6REP0_HUMAN
PHD finger protein 3
PHF3
82Annotation score:

Sequence cautioni

The sequence BAA13438 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1394E → G in CAI56715 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051599525V → I. Corresponds to variant dbSNP:rs34288820Ensembl.1
Natural variantiVAR_0220401834H → Y. Corresponds to variant dbSNP:rs3734881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264341 – 88Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1
CCDSiCCDS4966.1 [Q92576-1]
RefSeqiNP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3 [Q92576-1]
XP_005248759.1, XM_005248702.3 [Q92576-2]
XP_006715489.1, XM_006715426.3 [Q92576-1]
UniGeneiHs.348921
Hs.731957

Genome annotation databases

EnsembliENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]
GeneIDi23469
KEGGihsa:23469
UCSCiuc003pep.2 human [Q92576-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091622 mRNA Translation: AAF21292.1
D87685 mRNA Translation: BAA13438.2 Different initiation.
BX648268 mRNA Translation: CAI56715.1
AL050329, AL354719 Genomic DNA Translation: CAM45842.1
BC113650 mRNA Translation: AAI13651.1
BC113652 mRNA Translation: AAI13653.1
CCDSiCCDS4966.1 [Q92576-1]
RefSeqiNP_001277188.1, NM_001290259.1 [Q92576-2]
NP_001277189.1, NM_001290260.1
NP_055968.1, NM_015153.3 [Q92576-1]
XP_005248758.1, XM_005248701.3 [Q92576-1]
XP_005248759.1, XM_005248702.3 [Q92576-2]
XP_006715489.1, XM_006715426.3 [Q92576-1]
UniGeneiHs.348921
Hs.731957

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMENMR-A923-1029[»]
ProteinModelPortaliQ92576
SMRiQ92576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117031, 14 interactors
IntActiQ92576, 10 interactors
STRINGi9606.ENSP00000262043

PTM databases

iPTMnetiQ92576
PhosphoSitePlusiQ92576

Polymorphism and mutation databases

BioMutaiPHF3
DMDMi34098662

Proteomic databases

EPDiQ92576
MaxQBiQ92576
PaxDbiQ92576
PeptideAtlasiQ92576
PRIDEiQ92576
ProteomicsDBi75337
75338 [Q92576-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262043; ENSP00000262043; ENSG00000118482 [Q92576-1]
ENST00000393387; ENSP00000377048; ENSG00000118482 [Q92576-1]
GeneIDi23469
KEGGihsa:23469
UCSCiuc003pep.2 human [Q92576-1]

Organism-specific databases

CTDi23469
DisGeNETi23469
EuPathDBiHostDB:ENSG00000118482.11
GeneCardsiPHF3
HGNCiHGNC:8921 PHF3
HPAiHPA024676
HPA025763
MIMi607789 gene
neXtProtiNX_Q92576
OpenTargetsiENSG00000118482
PharmGKBiPA33261
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ8Y Eukaryota
ENOG4111K1A LUCA
GeneTreeiENSGT00530000063844
HOVERGENiHBG039623
InParanoidiQ92576
OMAiKVRKKQV
OrthoDBiEOG091G00O9
PhylomeDBiQ92576
TreeFamiTF350578

Miscellaneous databases

ChiTaRSiPHF3 human
EvolutionaryTraceiQ92576
GeneWikiiPHF3
GenomeRNAii23469
PROiPR:Q92576
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118482 Expressed in 245 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PHF3
ExpressionAtlasiQ92576 baseline and differential
GenevisibleiQ92576 HS

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHF3_HUMAN
AccessioniPrimary (citable) accession number: Q92576
Secondary accession number(s): A3KFI8
, Q14CR5, Q5CZI1, Q5T1T6, Q9NQ16, Q9UI45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: September 12, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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