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Protein

UBX domain-containing protein 4

Gene

UBXN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).2 Publications

GO - Biological processi

  • response to unfolded protein Source: UniProtKB-KW
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 4
Alternative name(s):
Erasin
UBX domain-containing protein 2
Gene namesi
Name:UBXN4
Synonyms:KIAA0242, UBXD2, UBXDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144224.16
HGNCiHGNC:14860 UBXN4
MIMi611216 gene
neXtProtiNX_Q92575

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 413CytoplasmicSequence analysisAdd BLAST413
Intramembranei414 – 434Sequence analysisAdd BLAST21
Topological domaini435 – 508CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23190
OpenTargetsiENSG00000144224
PharmGKBiPA37912

Polymorphism and mutation databases

BioMutaiUBXN4
DMDMi30913402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110271 – 508UBX domain-containing protein 4Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei489PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92575
MaxQBiQ92575
PaxDbiQ92575
PeptideAtlasiQ92575
PRIDEiQ92575
ProteomicsDBi75336

PTM databases

iPTMnetiQ92575
PhosphoSitePlusiQ92575

Expressioni

Tissue specificityi

Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).1 Publication

Inductioni

By ER stress-inducing agents such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000144224 Expressed in 242 organ(s), highest expression level in sperm
CleanExiHS_UBXN4
ExpressionAtlasiQ92575 baseline and differential
GenevisibleiQ92575 HS

Organism-specific databases

HPAiHPA036325

Interactioni

Subunit structurei

Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116799, 33 interactors
CORUMiQ92575
IntActiQ92575, 18 interactors
STRINGi9606.ENSP00000272638

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92575
SMRiQ92575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 393UBXPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 200Interaction with UBQLN11 PublicationAdd BLAST200

Domaini

The UBX domain is required for interaction with VCP.1 Publication
The intramembrane domain also contains the signal for ER targeting.1 Publication

Phylogenomic databases

eggNOGiKOG2507 Eukaryota
ENOG410ZR21 LUCA
GeneTreeiENSGT00530000063500
HOGENOMiHOG000007283
HOVERGENiHBG056020
InParanoidiQ92575
OMAiYPLLAVW
OrthoDBiEOG091G0DHC
PhylomeDBiQ92575
TreeFamiTF317466

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWFQGAIPA AIATAKRSGA VFVVFVAGDD EQSTQMAASW EDDKVTEASS
60 70 80 90 100
NSFVAIKIDT KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD
110 120 130 140 150
ELVTRIHKVR QMHLLKSETS VANGSQSESS VSTPSASFEP NNTCENSQSR
160 170 180 190 200
NAELCEIPPT SDTKSDTATG GESAGHATSS QEPSGCSDQR PAEDLNIRVE
210 220 230 240 250
RLTKKLEERR EEKRKEEEQR EIKKEIERRK TGKEMLDYKR KQEEELTKRM
260 270 280 290 300
LEERNREKAE DRAARERIKQ QIALDRAERA ARFAKTKEEV EAAKAAALLA
310 320 330 340 350
KQAEMEVKRE SYARERSTVA RIQFRLPDGS SFTNQFPSDA PLEEARQFAA
360 370 380 390 400
QTVGNTYGNF SLATMFPRRE FTKEDYKKKL LDLELAPSAS VVLLPAGRPT
410 420 430 440 450
ASIVHSSSGD IWTLLGTVLY PFLAIWRLIS NFLFSNPPPT QTSVRVTSSE
460 470 480 490 500
PPNPASSSKS EKREPVRKRV LEKRGDDFKK EGKIYRLRTQ DDGEDENNTW

NGNSTQQM
Length:508
Mass (Da):56,778
Last modified:May 16, 2003 - v2
Checksum:i2C3ABCF4D36124CC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLR4C9JLR4_HUMAN
UBX domain-containing protein 4
UBXN4
117Annotation score:
F8WB86F8WB86_HUMAN
UBX domain-containing protein 4
UBXN4
65Annotation score:
Q6PJ80Q6PJ80_HUMAN
UBX domain-containing protein 4
UBXN4
95Annotation score:

Sequence cautioni

The sequence BAA13437 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052686458S → R. Corresponds to variant dbSNP:rs2304602Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292829 mRNA Translation: BAF85518.1
EF199840 mRNA Translation: ABM90426.1
D87684 mRNA Translation: BAA13437.1 Different initiation.
BX647662 mRNA No translation available.
AC011893 Genomic DNA Translation: AAX88923.1
CH471058 Genomic DNA Translation: EAX11623.1
BC035594 mRNA Translation: AAH35594.1
CCDSiCCDS42761.1
RefSeqiNP_055422.1, NM_014607.3
UniGeneiHs.591242

Genome annotation databases

EnsembliENST00000272638; ENSP00000272638; ENSG00000144224
GeneIDi23190
KEGGihsa:23190
UCSCiuc002tur.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292829 mRNA Translation: BAF85518.1
EF199840 mRNA Translation: ABM90426.1
D87684 mRNA Translation: BAA13437.1 Different initiation.
BX647662 mRNA No translation available.
AC011893 Genomic DNA Translation: AAX88923.1
CH471058 Genomic DNA Translation: EAX11623.1
BC035594 mRNA Translation: AAH35594.1
CCDSiCCDS42761.1
RefSeqiNP_055422.1, NM_014607.3
UniGeneiHs.591242

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXJNMR-A317-397[»]
ProteinModelPortaliQ92575
SMRiQ92575
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116799, 33 interactors
CORUMiQ92575
IntActiQ92575, 18 interactors
STRINGi9606.ENSP00000272638

PTM databases

iPTMnetiQ92575
PhosphoSitePlusiQ92575

Polymorphism and mutation databases

BioMutaiUBXN4
DMDMi30913402

Proteomic databases

EPDiQ92575
MaxQBiQ92575
PaxDbiQ92575
PeptideAtlasiQ92575
PRIDEiQ92575
ProteomicsDBi75336

Protocols and materials databases

DNASUi23190
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272638; ENSP00000272638; ENSG00000144224
GeneIDi23190
KEGGihsa:23190
UCSCiuc002tur.4 human

Organism-specific databases

CTDi23190
DisGeNETi23190
EuPathDBiHostDB:ENSG00000144224.16
GeneCardsiUBXN4
HGNCiHGNC:14860 UBXN4
HPAiHPA036325
MIMi611216 gene
neXtProtiNX_Q92575
OpenTargetsiENSG00000144224
PharmGKBiPA37912
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2507 Eukaryota
ENOG410ZR21 LUCA
GeneTreeiENSGT00530000063500
HOGENOMiHOG000007283
HOVERGENiHBG056020
InParanoidiQ92575
OMAiYPLLAVW
OrthoDBiEOG091G0DHC
PhylomeDBiQ92575
TreeFamiTF317466

Miscellaneous databases

ChiTaRSiUBXN4 human
GeneWikiiUBXD2
GenomeRNAii23190
PROiPR:Q92575
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144224 Expressed in 242 organ(s), highest expression level in sperm
CleanExiHS_UBXN4
ExpressionAtlasiQ92575 baseline and differential
GenevisibleiQ92575 HS

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBXN4_HUMAN
AccessioniPrimary (citable) accession number: Q92575
Secondary accession number(s): A8K9W4, Q4ZG56, Q8IYM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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