UniProtKB - Q92570 (NR4A3_HUMAN)
Nuclear receptor subfamily 4 group A member 3
NR4A3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 289 – 364 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 292 – 312 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 328 – 352 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cAMP response element binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- glucocorticoid receptor binding Source: GO_Central
- histone acetyltransferase binding Source: Ensembl
- nuclear receptor activity Source: ProtInc
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central
- RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- steroid hormone receptor activity Source: ProtInc
- transcription coactivator binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- adult behavior Source: Ensembl
- animal organ regeneration Source: Ensembl
- axon guidance Source: Ensembl
- cellular respiration Source: UniProtKB
- cellular response to catecholamine stimulus Source: UniProtKB
- cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
- cellular response to leptin stimulus Source: UniProtKB
- common myeloid progenitor cell proliferation Source: UniProtKB
- energy homeostasis Source: UniProtKB
- fat cell differentiation Source: UniProtKB
- gastrulation Source: UniProtKB
- hippocampus development Source: Ensembl
- mast cell degranulation Source: UniProtKB
- mesoderm formation Source: Ensembl
- negative regulation of hydrogen peroxide-induced neuron death Source: UniProtKB
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuromuscular process controlling balance Source: Ensembl
- platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of cardiac muscle hypertrophy Source: UniProtKB
- positive regulation of cell cycle Source: Ensembl
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of fatty acid oxidation Source: UniProtKB
- positive regulation of feeding behavior Source: UniProtKB
- positive regulation of glucose transmembrane transport Source: UniProtKB
- positive regulation of leukocyte apoptotic process Source: Ensembl
- positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway Source: UniProtKB
- positive regulation of mast cell cytokine production Source: UniProtKB
- positive regulation of monocyte aggregation Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
- positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
- pyruvate oxidation Source: UniProtKB
- regulation of megakaryocyte differentiation Source: Reactome
- regulation of smooth muscle cell proliferation Source: UniProtKB
- regulation of type B pancreatic cell proliferation Source: UniProtKB
- response to hydrogen peroxide Source: Ensembl
- semicircular canal morphogenesis Source: Ensembl
- transcription initiation from RNA polymerase II promoter Source: Reactome
- vestibular reflex Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
SignaLinki | Q92570 |
SIGNORi | Q92570 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 4 group A member 3Alternative name(s): Mitogen-induced nuclear orphan receptor Neuron-derived orphan receptor 1 Nuclear hormone receptor NOR-1 |
Gene namesi | Name:NR4A3 Synonyms:CHN, CSMF, MINOR, NOR1, TEC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7982 NR4A3 |
MIMi | 600542 gene+phenotype |
neXtProti | NX_Q92570 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Lysosome
- mast cell granule Source: GOC
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- transcription factor complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Ewing sarcoma (ES)
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8013 |
MalaCardsi | NR4A3 |
MIMi | 600542 gene+phenotype 612219 phenotype |
OpenTargetsi | ENSG00000119508 |
Orphaneti | 209916 Extraskeletal myxoid chondrosarcoma |
PharmGKBi | PA31763 |
Miscellaneous databases
Pharosi | Q92570 |
Chemistry databases
ChEMBLi | CHEMBL1961792 |
DrugBanki | DB01254 Dasatinib |
Polymorphism and mutation databases
BioMutai | NR4A3 |
DMDMi | 90110039 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053722 | 1 – 626 | Nuclear receptor subfamily 4 group A member 3Add BLAST | 626 |
Post-translational modificationi
Proteomic databases
jPOSTi | Q92570 |
MassIVEi | Q92570 |
MaxQBi | Q92570 |
PaxDbi | Q92570 |
PeptideAtlasi | Q92570 |
PRIDEi | Q92570 |
ProteomicsDBi | 75330 [Q92570-1] 75331 [Q92570-2] 75332 [Q92570-3] |
PTM databases
iPTMneti | Q92570 |
PhosphoSitePlusi | Q92570 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000119508 Expressed in 191 organ(s), highest expression level in pleura |
ExpressionAtlasi | Q92570 baseline and differential |
Genevisiblei | Q92570 HS |
Organism-specific databases
HPAi | HPA043360 |
Interactioni
Subunit structurei
Interacts with SIX3 (via homeobox); differentially regulates the transcriptional activities of NR4A3 (PubMed:12543801).
Interacts with the constituents of DNA-PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083).
Interacts with NCOA2; potentiates the activity of the NR4A3.
Interacts with NCOA1, NCOA3, MED1 and KAT2B.
Interacts with EP300 and NCOA2; mediates the recruitment of MED1 in the coactivator complex (By similarity).
Interacts with NR3C1 (via nuclear receptor DNA-binding domain); the interactions represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE).
Interacts with TRIM28; the interactions potentiates NR4A3 activity on NurRE promoter. Binds DNA as a monomer and homodimer.
Interacts with PARP1; activates PARP1 by improving acetylation of PARP1 and suppressing the interaction between PARP1 and SIRT1 (By similarity).
By similarity2 PublicationsBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
O95343 | 3 | EBI-13644623,EBI-13644574 |
GO - Molecular functioni
- glucocorticoid receptor binding Source: GO_Central
- histone acetyltransferase binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transcription coactivator binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 113713, 6 interactors |
IntActi | Q92570, 39 interactors |
MINTi | Q92570 |
STRINGi | 9606.ENSP00000482027 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 394 – 623 | NR LBDPROSITE-ProRule annotationAdd BLAST | 230 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 291 | Interaction with NCOA1, NCOA2, NCOA3 and KAT2BBy similarityAdd BLAST | 291 | |
Regioni | 1 – 138 | Required for DNA-PK heterotrimer1 PublicationAdd BLAST | 138 | |
Regioni | 1 – 108 | Activation function (AF)-1 domainBy similarityAdd BLAST | 108 | |
Regioni | 379 – 626 | Interaction with KAT2BBy similarityAdd BLAST | 248 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 108 | Poly-HisAdd BLAST | 14 | |
Compositional biasi | 282 – 287 | Poly-Ser | 6 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 312 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 328 – 352 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4217 Eukaryota ENOG410YWNC LUCA |
GeneTreei | ENSGT00950000183038 |
InParanoidi | Q92570 |
KOi | K08559 |
OMAi | FHFKHSP |
OrthoDBi | 454476at2759 |
PhylomeDBi | Q92570 |
TreeFami | TF315430 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR-like_dom_sf IPR003072 NOR1_rcpt IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01286 NORNUCRECPTR PR01284 NUCLEARECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT
60 70 80 90 100
ATTSLPSIST FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH
110 120 130 140 150
HHHHHHHHQQ QHQQPSIPPA SSPEDEVLPS TSMYFKQSPP STPTTPAFPP
160 170 180 190 200
QAGALWDEAL PSAPGCIAPG PLLDPPMKAV PTVAGARFPL FHFKPSPPHP
210 220 230 240 250
PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES HPYGLPLAKR
260 270 280 290 300
AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA
310 320 330 340 350
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ
360 370 380 390 400
KCLSVGMVKE VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN
410 420 430 440 450
ALVRALTDST PRDLDYSRYC PTDQAAAGTD AEHVQQFYNL LTASIDVSRS
460 470 480 490 500
WAEKIPGFTD LPKEDQTLLI ESAFLELFVL RLSIRSNTAE DKFVFCNGLV
510 520 530 540 550
LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL SMITERHGLK
560 570 580 590 600
EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR
610 620
IFYLKLEDLV SPPSIIDKLF LDTLPF
The sequence of this isoform differs from the canonical sequence as follows:
419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
444-626: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 240 | S → G (PubMed:8809112).Curated | 1 | |
Sequence conflicti | 240 | S → G (PubMed:8614405).Curated | 1 | |
Sequence conflicti | 454 | K → R in BAA11419 (PubMed:8809112).Curated | 1 | |
Sequence conflicti | 579 | T → N in BAA11419 (PubMed:8809112).Curated | 1 | |
Sequence conflicti | 585 | G → V in BAA11419 (PubMed:8809112).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037877 | 1 | M → MHDSIRFGNVDM in isoform 3. Curated | 1 | |
Alternative sequenceiVSP_003712 | 419 – 443 | YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta. 2 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_003713 | 444 – 626 | Missing in isoform Beta. 2 PublicationsAdd BLAST | 183 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78579 mRNA Translation: BAA11419.1 U12767 mRNA Translation: AAB02581.1 Frameshift. S81243 mRNA Translation: AAB36006.1 Different initiation. X89894 mRNA Translation: CAA61984.1 AL359710 Genomic DNA No translation available. AL358937 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW58915.1 D85241 mRNA Translation: BAA28608.1 D85242 mRNA Translation: BAA31221.1 |
CCDSi | CCDS6742.1 [Q92570-3] CCDS6743.1 [Q92570-1] CCDS6744.1 [Q92570-2] |
PIRi | S71930 |
RefSeqi | NP_008912.2, NM_006981.3 [Q92570-1] NP_775291.1, NM_173199.2 [Q92570-2] NP_775292.1, NM_173200.2 [Q92570-3] XP_016870651.1, XM_017015162.1 [Q92570-1] |
Genome annotation databases
Ensembli | ENST00000330847; ENSP00000333122; ENSG00000119508 [Q92570-3] ENST00000338488; ENSP00000340301; ENSG00000119508 [Q92570-2] ENST00000395097; ENSP00000378531; ENSG00000119508 [Q92570-1] ENST00000618101; ENSP00000482027; ENSG00000119508 [Q92570-3] |
GeneIDi | 8013 |
KEGGi | hsa:8013 |
UCSCi | uc004bae.3 human [Q92570-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78579 mRNA Translation: BAA11419.1 U12767 mRNA Translation: AAB02581.1 Frameshift. S81243 mRNA Translation: AAB36006.1 Different initiation. X89894 mRNA Translation: CAA61984.1 AL359710 Genomic DNA No translation available. AL358937 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW58915.1 D85241 mRNA Translation: BAA28608.1 D85242 mRNA Translation: BAA31221.1 |
CCDSi | CCDS6742.1 [Q92570-3] CCDS6743.1 [Q92570-1] CCDS6744.1 [Q92570-2] |
PIRi | S71930 |
RefSeqi | NP_008912.2, NM_006981.3 [Q92570-1] NP_775291.1, NM_173199.2 [Q92570-2] NP_775292.1, NM_173200.2 [Q92570-3] XP_016870651.1, XM_017015162.1 [Q92570-1] |
3D structure databases
SMRi | Q92570 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 113713, 6 interactors |
IntActi | Q92570, 39 interactors |
MINTi | Q92570 |
STRINGi | 9606.ENSP00000482027 |
Chemistry databases
ChEMBLi | CHEMBL1961792 |
DrugBanki | DB01254 Dasatinib |
PTM databases
iPTMneti | Q92570 |
PhosphoSitePlusi | Q92570 |
Polymorphism and mutation databases
BioMutai | NR4A3 |
DMDMi | 90110039 |
Proteomic databases
jPOSTi | Q92570 |
MassIVEi | Q92570 |
MaxQBi | Q92570 |
PaxDbi | Q92570 |
PeptideAtlasi | Q92570 |
PRIDEi | Q92570 |
ProteomicsDBi | 75330 [Q92570-1] 75331 [Q92570-2] 75332 [Q92570-3] |
Protocols and materials databases
DNASUi | 8013 |
Genome annotation databases
Ensembli | ENST00000330847; ENSP00000333122; ENSG00000119508 [Q92570-3] ENST00000338488; ENSP00000340301; ENSG00000119508 [Q92570-2] ENST00000395097; ENSP00000378531; ENSG00000119508 [Q92570-1] ENST00000618101; ENSP00000482027; ENSG00000119508 [Q92570-3] |
GeneIDi | 8013 |
KEGGi | hsa:8013 |
UCSCi | uc004bae.3 human [Q92570-1] |
Organism-specific databases
CTDi | 8013 |
DisGeNETi | 8013 |
GeneCardsi | NR4A3 |
HGNCi | HGNC:7982 NR4A3 |
HPAi | HPA043360 |
MalaCardsi | NR4A3 |
MIMi | 600542 gene+phenotype 612219 phenotype |
neXtProti | NX_Q92570 |
OpenTargetsi | ENSG00000119508 |
Orphaneti | 209916 Extraskeletal myxoid chondrosarcoma |
PharmGKBi | PA31763 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4217 Eukaryota ENOG410YWNC LUCA |
GeneTreei | ENSGT00950000183038 |
InParanoidi | Q92570 |
KOi | K08559 |
OMAi | FHFKHSP |
OrthoDBi | 454476at2759 |
PhylomeDBi | Q92570 |
TreeFami | TF315430 |
Enzyme and pathway databases
Reactomei | R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
SignaLinki | Q92570 |
SIGNORi | Q92570 |
Miscellaneous databases
ChiTaRSi | NR4A3 human |
GeneWikii | Neuron-derived_orphan_receptor_1 |
GenomeRNAii | 8013 |
Pharosi | Q92570 |
PROi | PR:Q92570 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119508 Expressed in 191 organ(s), highest expression level in pleura |
ExpressionAtlasi | Q92570 baseline and differential |
Genevisiblei | Q92570 HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR-like_dom_sf IPR003072 NOR1_rcpt IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01286 NORNUCRECPTR PR01284 NUCLEARECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NR4A3_HUMAN | |
Accessioni | Q92570Primary (citable) accession number: Q92570 Secondary accession number(s): A2A3I7 Q9UEK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 21, 2006 | |
Last modified: | October 16, 2019 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot