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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: ProtInc
  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
  • phosphotyrosine residue binding Source: CAFA

GO - Biological processi

  • cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • insulin receptor signaling pathway Source: GO_Central
  • phosphatidylinositol phosphorylation Source: GO_Central
  • positive regulation of cell migration Source: ARUK-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of protein phosphorylation Source: BHF-UCL
  • protein kinase B signaling Source: BHF-UCL
  • regulation of phosphatidylinositol 3-kinase activity Source: GO_Central

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000117461-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853659 RET signaling
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q92569

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92569

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q92569 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117461.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8981 PIK3R3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606076 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92569

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8503

Open Targets

More...
OpenTargetsi
ENSG00000117461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33314

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3559703

Drug and drug target database

More...
DrugBanki
DB01064 Isoprenaline
DB05210 SF1126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIK3R3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000807671 – 461Phosphatidylinositol 3-kinase regulatory subunit gammaAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphotyrosineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92569

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92569

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92569

PeptideAtlas

More...
PeptideAtlasi
Q92569

PRoteomics IDEntifications database

More...
PRIDEi
Q92569

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75327
75328 [Q92569-2]
75329 [Q92569-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92569

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117461 Expressed in 213 organ(s), highest expression level in nasal cavity epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_PIK3R3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92569 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92569 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005751
HPA071988

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114075, 124 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1918 Phosphatidylinositol 3-kinase complex class I, variant 2

Database of interacting proteins

More...
DIPi
DIP-30925N

Protein interaction database and analysis system

More...
IntActi
Q92569, 145 interactors

Molecular INTeraction database

More...
MINTi
Q92569

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q92569

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92569

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 160SH2 1PROSITE-ProRule annotationAdd BLAST96
Domaini358 – 452SH2 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 44Pro-richAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4637 Eukaryota
ENOG410XP6R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156259

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082100

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92569

KEGG Orthology (KO)

More...
KOi
K02649

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0C3Z

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92569

TreeFam database of animal gene trees

More...
TreeFami
TF102033

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09930 SH2_cSH2_p85_like, 1 hit
cd09942 SH2_nSH2_p85_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032498 PI3K_P85_iSH2
IPR035020 PI3kinase_P85_cSH2
IPR035022 PI3kinase_P85_nSH2
IPR001720 PI3kinase_P85_p55
IPR000980 SH2
IPR036860 SH2_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10155 PTHR10155, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16454 PI3K_P85_iSH2, 1 hit
PF00017 SH2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55550 SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP
60 70 80 90 100
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,448
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i303BCC2F9EEE5364
GO
Isoform 2 (identifier: Q92569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.

Show »
Length:402
Mass (Da):47,348
Checksum:i054C2111B68F17A6
GO
Isoform 3 (identifier: Q92569-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Show »
Length:366
Mass (Da):43,465
Checksum:iF8B6B90E29AA2DF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4P3Q5T4P3_HUMAN
Phosphatidylinositol 3-kinase regul...
PIK3R3
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21P → L in AAC39696 (PubMed:9524259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047153283N → K4 PublicationsCorresponds to variant dbSNP:rs785467Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00471336 – 71Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_004714256 – 314Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF028785 mRNA Translation: AAC39696.1
D88532 mRNA Translation: BAA13636.1
AK313726 mRNA Translation: BAG36468.1
AL358075 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06946.1
CH471059 Genomic DNA Translation: EAX06947.1
CH471059 Genomic DNA Translation: EAX06944.1
CH471059 Genomic DNA Translation: EAX06945.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS529.1 [Q92569-1]
CCDS76154.1 [Q92569-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001107644.1, NM_001114172.1 [Q92569-1]
NP_001290358.1, NM_001303429.1 [Q92569-2]
NP_003620.3, NM_003629.3 [Q92569-1]
XP_016858103.1, XM_017002614.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655387

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262741; ENSP00000262741; ENSG00000117461 [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461 [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461 [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461 [Q92569-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8503

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8503

UCSC genome browser

More...
UCSCi
uc001cpb.5 human [Q92569-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA Translation: AAC39696.1
D88532 mRNA Translation: BAA13636.1
AK313726 mRNA Translation: BAG36468.1
AL358075 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06946.1
CH471059 Genomic DNA Translation: EAX06947.1
CH471059 Genomic DNA Translation: EAX06944.1
CH471059 Genomic DNA Translation: EAX06945.1
CCDSiCCDS529.1 [Q92569-1]
CCDS76154.1 [Q92569-2]
RefSeqiNP_001107644.1, NM_001114172.1 [Q92569-1]
NP_001290358.1, NM_001303429.1 [Q92569-2]
NP_003620.3, NM_003629.3 [Q92569-1]
XP_016858103.1, XM_017002614.1
UniGeneiHs.655387

3D structure databases

ProteinModelPortaliQ92569
SMRiQ92569
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114075, 124 interactors
ComplexPortaliCPX-1918 Phosphatidylinositol 3-kinase complex class I, variant 2
DIPiDIP-30925N
IntActiQ92569, 145 interactors
MINTiQ92569
STRINGi9606.ENSP00000262741

Chemistry databases

ChEMBLiCHEMBL3559703
DrugBankiDB01064 Isoprenaline
DB05210 SF1126

Protein family/group databases

MoonDBiQ92569 Predicted

PTM databases

iPTMnetiQ92569
PhosphoSitePlusiQ92569

Polymorphism and mutation databases

BioMutaiPIK3R3
DMDMi317373310

Proteomic databases

EPDiQ92569
MaxQBiQ92569
PaxDbiQ92569
PeptideAtlasiQ92569
PRIDEiQ92569
ProteomicsDBi75327
75328 [Q92569-2]
75329 [Q92569-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8503
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461 [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461 [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461 [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461 [Q92569-2]
GeneIDi8503
KEGGihsa:8503
UCSCiuc001cpb.5 human [Q92569-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8503
DisGeNETi8503
EuPathDBiHostDB:ENSG00000117461.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PIK3R3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000542
HGNCiHGNC:8981 PIK3R3
HPAiHPA005751
HPA071988
MIMi606076 gene
neXtProtiNX_Q92569
OpenTargetsiENSG00000117461
PharmGKBiPA33314

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4637 Eukaryota
ENOG410XP6R LUCA
GeneTreeiENSGT00940000156259
HOVERGENiHBG082100
InParanoidiQ92569
KOiK02649
OrthoDBiEOG091G0C3Z
PhylomeDBiQ92569
TreeFamiTF102033

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853659 RET signaling
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL
SignaLinkiQ92569
SIGNORiQ92569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIK3R3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIK3R3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8503

Protein Ontology

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PROi
PR:Q92569

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117461 Expressed in 213 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_PIK3R3
ExpressionAtlasiQ92569 baseline and differential
GenevisibleiQ92569 HS

Family and domain databases

CDDicd09930 SH2_cSH2_p85_like, 1 hit
cd09942 SH2_nSH2_p85_like, 1 hit
Gene3Di3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR032498 PI3K_P85_iSH2
IPR035020 PI3kinase_P85_cSH2
IPR035022 PI3kinase_P85_nSH2
IPR001720 PI3kinase_P85_p55
IPR000980 SH2
IPR036860 SH2_dom_sf
PANTHERiPTHR10155 PTHR10155, 1 hit
PfamiView protein in Pfam
PF16454 PI3K_P85_iSH2, 1 hit
PF00017 SH2, 2 hits
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 2 hits
SUPFAMiSSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP55G_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1
, D3DQ12, O60482, Q5T4P1, Q5T4P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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