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Entry version 181 (07 Oct 2020)
Sequence version 2 (11 Jan 2011)
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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000117461-MONOMER

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q92569

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114604, GPVI-mediated activation cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1266695, Interleukin-7 signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-388841, Costimulation by the CD28 family
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-416476, G alpha (q) signalling events
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853659, RET signaling
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-912526, Interleukin receptor SHC signaling
R-HSA-912631, Regulation of signaling by CBL

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q92569

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92569

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q92569, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000117461.14

Human Gene Nomenclature Database

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HGNCi
HGNC:8981, PIK3R3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606076, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q92569

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
8503

Open Targets

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OpenTargetsi
ENSG00000117461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33314

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q92569, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3559703

Drug and drug target database

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DrugBanki
DB01064, Isoprenaline
DB05210, SF1126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PIK3R3

Domain mapping of disease mutations (DMDM)

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DMDMi
317373310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000807671 – 461Phosphatidylinositol 3-kinase regulatory subunit gammaAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphotyrosineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92569

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92569

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92569

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92569

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92569

PeptideAtlas

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PeptideAtlasi
Q92569

PRoteomics IDEntifications database

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PRIDEi
Q92569

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75327 [Q92569-1]
75328 [Q92569-2]
75329 [Q92569-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q92569

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117461, Expressed in nasal cavity epithelium and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92569, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92569, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000117461, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD).

Interacts with AXL.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92569
With#Exp.IntAct
ABI1 [Q8IZP0]2EBI-79893,EBI-375446
ANTKMT [Q9BQD7]3EBI-79893,EBI-713602
AR [P10275]37EBI-79893,EBI-608057
ARID4B - isoform 3 [Q4LE39-3]3EBI-79893,EBI-11957452
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-79893,EBI-5280499
BLK [P51451]3EBI-79893,EBI-2105445
BLZF1 [Q9H2G9]5EBI-79893,EBI-2548012
C3orf36 [Q3SXR2]3EBI-79893,EBI-18036948
CBL [P22681]4EBI-79893,EBI-518228
CCDC196 [A0A1B0GWI1]3EBI-79893,EBI-10181422
CCDC89 [Q8N998]3EBI-79893,EBI-12814117
CEP19 [Q96LK0]4EBI-79893,EBI-741885
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-79893,EBI-12593838
CRK [P46108]3EBI-79893,EBI-886
CRYBA2 [P53672]4EBI-79893,EBI-750444
DISC1 - isoform 2 [Q9NRI5-2]3EBI-79893,EBI-11988027
DRAP1 [Q14919]4EBI-79893,EBI-712941
EGFR [P00533]7EBI-79893,EBI-297353
ENKD1 [Q9H0I2]3EBI-79893,EBI-744099
ERBB2 [P04626]9EBI-79893,EBI-641062
ERBB3 [P21860]22EBI-79893,EBI-720706
FAM166B - isoform 2 [A8MTA8-2]3EBI-79893,EBI-12160437
FNDC8 [Q8TC99]3EBI-79893,EBI-12903902
FRS3 [O43559]3EBI-79893,EBI-725515
GAB1 [Q13480]36EBI-79893,EBI-517684
GRB2 [P62993]4EBI-79893,EBI-401755
HCK - isoform 2 [P08631-2]4EBI-79893,EBI-9834454
HTT [P42858]6EBI-79893,EBI-466029
IGF1R [P08069]2EBI-79893,EBI-475981
IRS1 [P35568]4EBI-79893,EBI-517592
ITGB3BP [Q13352]3EBI-79893,EBI-712105
KIAA0408 [Q6ZU52]3EBI-79893,EBI-739493
KIT [P10721]31EBI-79893,EBI-1379503
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-79893,EBI-11985629
LAP3 [P28838]3EBI-79893,EBI-2339312
MET [P08581]11EBI-79893,EBI-1039152
METTL27 [Q8N6F8]3EBI-79893,EBI-8487781
NAB2 [Q15742]3EBI-79893,EBI-8641936
NEBL [O76041]3EBI-79893,EBI-2880203
NEDD9 - isoform 2 [Q14511-2]3EBI-79893,EBI-11746523
OLIG1 [Q8TAK6]2EBI-79893,EBI-3867416
OTUD7B [Q6GQQ9]3EBI-79893,EBI-527784
PARD6A - isoform 2 [Q9NPB6-2]3EBI-79893,EBI-10693102
PBX4 [Q9BYU1]3EBI-79893,EBI-10302990
PELI3 [Q8N2H9]3EBI-79893,EBI-448457
PIK3CA [P42336]5EBI-79893,EBI-2116585
PIK3CB [P42338]3EBI-79893,EBI-2609540
PIK3CD [O00329]4EBI-79893,EBI-718309
PLAAT4 [Q9UL19]3EBI-79893,EBI-10323452
PLEKHF2 [Q9H8W4]3EBI-79893,EBI-742388
PLEKHS1 [Q5SXH7]5EBI-79893,EBI-10691507
PPP1R12B - isoform 2 [O60237-2]2EBI-79893,EBI-10700351
PRKAR1B [P31321]3EBI-79893,EBI-2805516
PTK2 [I6L996]3EBI-79893,EBI-10181089
PTK2 [Q05397]3EBI-79893,EBI-702142
RBP7 [Q96R05]3EBI-79893,EBI-2856326
RUSC1 [Q9BVN2]3EBI-79893,EBI-6257312
SERTAD2 [Q14140]3EBI-79893,EBI-2822051
SH2D2A [Q9NP31]4EBI-79893,EBI-490630
SMRP1 [Q8NCR6]3EBI-79893,EBI-10269322
SOCS4 [Q8WXH5]3EBI-79893,EBI-3942425
SPATA32 [Q96LK8]3EBI-79893,EBI-12849978
SPSB2 [Q99619]3EBI-79893,EBI-2323209
SRC [P12931]3EBI-79893,EBI-621482
SSBP4 [Q9BWG4]3EBI-79893,EBI-744719
STAT5B [P51692]3EBI-79893,EBI-1186119
TASOR2 [Q5VWN6]5EBI-79893,EBI-745958
TNK2 - isoform 2 [Q07912-2]3EBI-79893,EBI-11994780
TNNI1 [P19237]3EBI-79893,EBI-746692
TSPAN2 [O60636]3EBI-79893,EBI-3914288
WDFY3 [Q8IZQ1]2EBI-79893,EBI-1569256
YES1 [P07947]3EBI-79893,EBI-515331
ZBTB18 [Q99592]3EBI-79893,EBI-3232046
ZNF620 [Q6ZNG0]3EBI-79893,EBI-4395669

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114075, 160 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1918, Phosphatidylinositol 3-kinase complex class I, variant 2

Database of interacting proteins

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DIPi
DIP-30925N

Protein interaction database and analysis system

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IntActi
Q92569, 186 interactors

Molecular INTeraction database

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MINTi
Q92569

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262741

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q92569, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92569

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 160SH2 1PROSITE-ProRule annotationAdd BLAST96
Domaini358 – 452SH2 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 44Pro-richAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4637, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_041839_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92569

KEGG Orthology (KO)

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KOi
K02649

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92569

TreeFam database of animal gene trees

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TreeFami
TF102033

Family and domain databases

Conserved Domains Database

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CDDi
cd09930, SH2_cSH2_p85_like, 1 hit
cd09942, SH2_nSH2_p85_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032498, PI3K_P85_iSH2
IPR035020, PI3kinase_P85_cSH2
IPR035022, PI3kinase_P85_nSH2
IPR000980, SH2
IPR036860, SH2_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16454, PI3K_P85_iSH2, 1 hit
PF00017, SH2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55550, SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP
60 70 80 90 100
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,448
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i303BCC2F9EEE5364
GO
Isoform 2 (identifier: Q92569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.

Show »
Length:402
Mass (Da):47,348
Checksum:i054C2111B68F17A6
GO
Isoform 3 (identifier: Q92569-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Show »
Length:366
Mass (Da):43,465
Checksum:iF8B6B90E29AA2DF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4P3Q5T4P3_HUMAN
Phosphatidylinositol 3-kinase regul...
PIK3R3
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21P → L in AAC39696 (PubMed:9524259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047153283N → K4 PublicationsCorresponds to variant dbSNP:rs785467Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00471336 – 71Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_004714256 – 314Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF028785 mRNA Translation: AAC39696.1
D88532 mRNA Translation: BAA13636.1
AK313726 mRNA Translation: BAG36468.1
AL358075 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06946.1
CH471059 Genomic DNA Translation: EAX06947.1
CH471059 Genomic DNA Translation: EAX06944.1
CH471059 Genomic DNA Translation: EAX06945.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS529.1 [Q92569-1]
CCDS76154.1 [Q92569-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001107644.1, NM_001114172.1 [Q92569-1]
NP_001290358.1, NM_001303429.1 [Q92569-2]
NP_003620.3, NM_003629.3 [Q92569-1]
XP_016858103.1, XM_017002614.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262741; ENSP00000262741; ENSG00000117461 [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461 [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461 [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461 [Q92569-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8503

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8503

UCSC genome browser

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UCSCi
uc001cpb.5, human [Q92569-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA Translation: AAC39696.1
D88532 mRNA Translation: BAA13636.1
AK313726 mRNA Translation: BAG36468.1
AL358075 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06946.1
CH471059 Genomic DNA Translation: EAX06947.1
CH471059 Genomic DNA Translation: EAX06944.1
CH471059 Genomic DNA Translation: EAX06945.1
CCDSiCCDS529.1 [Q92569-1]
CCDS76154.1 [Q92569-2]
RefSeqiNP_001107644.1, NM_001114172.1 [Q92569-1]
NP_001290358.1, NM_001303429.1 [Q92569-2]
NP_003620.3, NM_003629.3 [Q92569-1]
XP_016858103.1, XM_017002614.1

3D structure databases

SMRiQ92569
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114075, 160 interactors
ComplexPortaliCPX-1918, Phosphatidylinositol 3-kinase complex class I, variant 2
DIPiDIP-30925N
IntActiQ92569, 186 interactors
MINTiQ92569
STRINGi9606.ENSP00000262741

Chemistry databases

ChEMBLiCHEMBL3559703
DrugBankiDB01064, Isoprenaline
DB05210, SF1126

Protein family/group databases

MoonDBiQ92569, Predicted

PTM databases

iPTMnetiQ92569
PhosphoSitePlusiQ92569

Polymorphism and mutation databases

BioMutaiPIK3R3
DMDMi317373310

Proteomic databases

EPDiQ92569
jPOSTiQ92569
MassIVEiQ92569
MaxQBiQ92569
PaxDbiQ92569
PeptideAtlasiQ92569
PRIDEiQ92569
ProteomicsDBi75327 [Q92569-1]
75328 [Q92569-2]
75329 [Q92569-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1490, 251 antibodies

The DNASU plasmid repository

More...
DNASUi
8503

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461 [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461 [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461 [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461 [Q92569-2]
GeneIDi8503
KEGGihsa:8503
UCSCiuc001cpb.5, human [Q92569-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8503
DisGeNETi8503
EuPathDBiHostDB:ENSG00000117461.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIK3R3
HGNCiHGNC:8981, PIK3R3
HPAiENSG00000117461, Low tissue specificity
MIMi606076, gene
neXtProtiNX_Q92569
OpenTargetsiENSG00000117461
PharmGKBiPA33314

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4637, Eukaryota
GeneTreeiENSGT00940000156259
HOGENOMiCLU_041839_0_0_1
InParanoidiQ92569
KOiK02649
PhylomeDBiQ92569
TreeFamiTF102033

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER
PathwayCommonsiQ92569
ReactomeiR-HSA-114604, GPVI-mediated activation cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1266695, Interleukin-7 signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-388841, Costimulation by the CD28 family
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-416476, G alpha (q) signalling events
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853659, RET signaling
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-912526, Interleukin receptor SHC signaling
R-HSA-912631, Regulation of signaling by CBL
SignaLinkiQ92569
SIGNORiQ92569

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8503, 6 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIK3R3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PIK3R3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8503
PharosiQ92569, Tbio

Protein Ontology

More...
PROi
PR:Q92569
RNActiQ92569, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117461, Expressed in nasal cavity epithelium and 226 other tissues
ExpressionAtlasiQ92569, baseline and differential
GenevisibleiQ92569, HS

Family and domain databases

CDDicd09930, SH2_cSH2_p85_like, 1 hit
cd09942, SH2_nSH2_p85_like, 1 hit
Gene3Di3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR032498, PI3K_P85_iSH2
IPR035020, PI3kinase_P85_cSH2
IPR035022, PI3kinase_P85_nSH2
IPR000980, SH2
IPR036860, SH2_dom_sf
PfamiView protein in Pfam
PF16454, PI3K_P85_iSH2, 1 hit
PF00017, SH2, 2 hits
PRINTSiPR00401, SH2DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 2 hits
SUPFAMiSSF55550, SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001, SH2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP55G_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1
, D3DQ12, O60482, Q5T4P1, Q5T4P2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: October 7, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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