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Entry version 147 (17 Jun 2020)
Sequence version 2 (26 Apr 2004)
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Protein

Protein FAM168A

Gene

FAM168A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM168A
Alternative name(s):
Tongue cancer chemotherapy resistance-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM168A
Synonyms:KIAA0280, TCRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000054965.10

Human Gene Nomenclature Database

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HGNCi
HGNC:28999 FAM168A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616316 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92567

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Associated with cisplatin (DDP)-resistance and radioresistance in the treatment of lung cancer as well as oral squamous cell carcinoma and poor clinical outcome in patients.4 Publications

Organism-specific databases

DisGeNET

More...
DisGeNETi
23201

Open Targets

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OpenTargetsi
ENSG00000054965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387077

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92567 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM168A

Domain mapping of disease mutations (DMDM)

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DMDMi
46576628

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507421 – 244Protein FAM168AAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei102Asymmetric dimethylarginineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92567

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92567

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92567

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92567

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92567

PeptideAtlas

More...
PeptideAtlasi
Q92567

PRoteomics IDEntifications database

More...
PRIDEi
Q92567

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75324 [Q92567-1]
75325 [Q92567-2]
75326 [Q92567-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92567

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92567

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000054965 Expressed in C1 segment of cervical spinal cord and 219 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92567 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000054965 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLB (PubMed:25260657).

Interacts with AKT1 and MT1X (PubMed:23251525). May interact with FAM168B (PubMed:22771904).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q92567
With#Exp.IntAct
C1orf94 [Q6P1W5]3EBI-7957930,EBI-946029
CALCOCO2 [Q13137]3EBI-7957930,EBI-739580
DAB1 [O75553]3EBI-7957930,EBI-7875264
DAZAP2 [Q15038]3EBI-7957930,EBI-724310
DTX2 [Q86UW9]6EBI-7957930,EBI-740376
KLHL42 [Q9P2K6]3EBI-7957930,EBI-739890
NAF1 [Q96HR8]3EBI-7957930,EBI-2515597
OTUB2 [Q96DC9]5EBI-7957930,EBI-746259
OTULIN [Q96BN8]3EBI-7957930,EBI-750730
PRR20C [P86479]3EBI-7957930,EBI-10172814
R3HDM2 - isoform 2 [Q9Y2K5-2]3EBI-7957930,EBI-10326419
RBPMS [Q93062]5EBI-7957930,EBI-740322
SF1 [Q15637]4EBI-7957930,EBI-744603
SMAP2 [Q8WU79]3EBI-7957930,EBI-2822515
SNRPC [Q5TAL4]3EBI-7957930,EBI-10246938
SS18L1 [O75177]4EBI-7957930,EBI-744674
TAX1BP1 [Q86VP1]3EBI-7957930,EBI-529518
TNIP1 [Q15025]3EBI-7957930,EBI-357849
UBASH3B [Q8TF42]4EBI-7957930,EBI-1380492
UBE2V1 [Q13404]4EBI-7957930,EBI-1050671
VPS37C [A5D8V6]3EBI-7957930,EBI-2559305
Isoform 2 [Q92567-2]
With#Exp.IntAct
ALKBH4 [Q9NXW9]3EBI-11978259,EBI-8637516
ATXN1 [P54253]3EBI-11978259,EBI-930964
ATXN1L [P0C7T5]3EBI-11978259,EBI-8624731
BOLL - isoform 4 [Q8N9W6-4]3EBI-11978259,EBI-11983447
C10orf55 [Q5SWW7]3EBI-11978259,EBI-12809220
CAMK2A [Q9UQM7]3EBI-11978259,EBI-1383687
DAZAP2 [Q15038]5EBI-11978259,EBI-724310
DCUN1D1 [Q96GG9]5EBI-11978259,EBI-740086
DTX2 [Q86UW9]3EBI-11978259,EBI-740376
EPN2 - isoform 2 [O95208-2]3EBI-11978259,EBI-12135243
EPN3 [I6L9I8]3EBI-11978259,EBI-12866582
FAM168B - isoform 2 [A1KXE4-2]3EBI-11978259,EBI-12193763
HGS [A0A0S2Z4Q4]3EBI-11978259,EBI-16429135
HGS [O14964]8EBI-11978259,EBI-740220
HIP1 [O00291]3EBI-11978259,EBI-473886
HR [O43593]3EBI-11978259,EBI-2880706
KRTAP19-1 [Q8IUB9]3EBI-11978259,EBI-12811111
KRTAP19-5 [Q3LI72]3EBI-11978259,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-11978259,EBI-10241353
KRTAP3-1 [Q9BYR8]3EBI-11978259,EBI-9996449
KRTAP3-3 [Q9BYR6]3EBI-11978259,EBI-3957694
KRTAP6-2 [Q3LI66]5EBI-11978259,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-11978259,EBI-18394498
KRTAP8-1 [Q8IUC2]3EBI-11978259,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-11978259,EBI-9088686
MEIS2 - isoform 4 [O14770-4]3EBI-11978259,EBI-8025850
NAF1 [Q96HR8]3EBI-11978259,EBI-2515597
NFYC - isoform 1 [Q13952-2]3EBI-11978259,EBI-11956831
OTUB2 [Q96DC9]3EBI-11978259,EBI-746259
OTULIN [Q96BN8]3EBI-11978259,EBI-750730
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-11978259,EBI-11022007
PEF1 [Q9UBV8]3EBI-11978259,EBI-724639
PITX1 [P78337]3EBI-11978259,EBI-748265
PLEKHB2 [Q96CS7]3EBI-11978259,EBI-373552
PROP1 [O75360]3EBI-11978259,EBI-9027467
PRR20D [P86480]3EBI-11978259,EBI-12754095
PSORS1C1 - isoform 2 [Q9UIG5-2]3EBI-11978259,EBI-14831475
RBFOX1 - isoform 5 [Q9NWB1-5]4EBI-11978259,EBI-12123390
RBPMS - isoform C [Q93062-3]3EBI-11978259,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-11978259,EBI-11987469
RHOXF2 [Q9BQY4]6EBI-11978259,EBI-372094
RNF216 [Q9NWF9]3EBI-11978259,EBI-723313
RPS27A [P62979]3EBI-11978259,EBI-357375
SECISBP2 [Q96T21]3EBI-11978259,EBI-954116
TAX1BP1 [Q86VP1]3EBI-11978259,EBI-529518
TFAP2D [Q7Z6R9]3EBI-11978259,EBI-11952651
TFG [Q92734]3EBI-11978259,EBI-357061
TIAL1 - isoform 2 [Q01085-2]5EBI-11978259,EBI-11064654
TNK1 - isoform 2 [Q13470-2]3EBI-11978259,EBI-11018037
TOLLIP [Q9H0E2]3EBI-11978259,EBI-74615
UBA52 [P62987]3EBI-11978259,EBI-357304
UBAC1 [Q9BSL1]3EBI-11978259,EBI-749370
UBC [P0CG48]3EBI-11978259,EBI-3390054
UBQLN2 [Q9UHD9]3EBI-11978259,EBI-947187
UBXN6 [Q9BZV1]3EBI-11978259,EBI-1993899
UBXN7 [O94888]3EBI-11978259,EBI-1993627
YOD1 [Q5VVQ6]5EBI-11978259,EBI-2510804
YTHDF1 [Q9BYJ9]3EBI-11978259,EBI-1051237

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116810, 91 interactors

Protein interaction database and analysis system

More...
IntActi
Q92567, 79 interactors

Molecular INTeraction database

More...
MINTi
Q92567

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000064778

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92567 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92567

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM168 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHUV Eukaryota
ENOG410XR79 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_065824_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92567

Identification of Orthologs from Complete Genome Data

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OMAi
MAMSAGC

Database of Orthologous Groups

More...
OrthoDBi
1348118at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92567

TreeFam database of animal gene trees

More...
TreeFami
TF331128

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029247 FAM168A/MANI

The PANTHER Classification System

More...
PANTHERi
PTHR31844 PTHR31844, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14944 TCRP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q92567-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP
60 70 80 90 100
EFQFLHSAYA TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA
110 120 130 140 150
FRYTAGTPYK VPPTQSNTAP PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG
160 170 180 190 200
AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI YPAPVAAPRT NGVAMGMVAG
210 220 230 240
TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV PPHW
Length:244
Mass (Da):26,184
Last modified:April 26, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60E3E9621665D30C
GO
Isoform 2 (identifier: Q92567-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.

Show »
Length:235
Mass (Da):25,061
Checksum:i8236A41DEBEAC93D
GO
Isoform 3 (identifier: Q92567-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.
     102-208: RYTAGTPYKV...AGTTMAMSAG → S

Show »
Length:129
Mass (Da):13,785
Checksum:i6D2B99442C0475A1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13408 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01009551 – 59Missing in isoform 2 and isoform 3. 3 Publications9
Alternative sequenceiVSP_034630102 – 208RYTAG…AMSAG → S in isoform 3. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF363480 mRNA Translation: ABM69287.1
EF197985 mRNA Translation: ABM69272.1
D87470 mRNA Translation: BAA13408.1 Different initiation.
AK292054 mRNA Translation: BAF84743.1
BC052341 mRNA Translation: AAH52341.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41689.1 [Q92567-2]
CCDS66165.1 [Q92567-3]
CCDS73346.1 [Q92567-1]

NCBI Reference Sequences

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RefSeqi
NP_001272979.1, NM_001286050.1 [Q92567-1]
NP_001272980.1, NM_001286051.1 [Q92567-3]
NP_055974.1, NM_015159.2 [Q92567-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000064778; ENSP00000064778; ENSG00000054965 [Q92567-1]
ENST00000356467; ENSP00000348852; ENSG00000054965 [Q92567-2]
ENST00000450446; ENSP00000390501; ENSG00000054965 [Q92567-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23201

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23201

UCSC genome browser

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UCSCi
uc001oty.3 human [Q92567-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF363480 mRNA Translation: ABM69287.1
EF197985 mRNA Translation: ABM69272.1
D87470 mRNA Translation: BAA13408.1 Different initiation.
AK292054 mRNA Translation: BAF84743.1
BC052341 mRNA Translation: AAH52341.1
CCDSiCCDS41689.1 [Q92567-2]
CCDS66165.1 [Q92567-3]
CCDS73346.1 [Q92567-1]
RefSeqiNP_001272979.1, NM_001286050.1 [Q92567-1]
NP_001272980.1, NM_001286051.1 [Q92567-3]
NP_055974.1, NM_015159.2 [Q92567-2]

3D structure databases

SMRiQ92567
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116810, 91 interactors
IntActiQ92567, 79 interactors
MINTiQ92567
STRINGi9606.ENSP00000064778

PTM databases

iPTMnetiQ92567
PhosphoSitePlusiQ92567

Polymorphism and mutation databases

BioMutaiFAM168A
DMDMi46576628

Proteomic databases

EPDiQ92567
jPOSTiQ92567
MassIVEiQ92567
MaxQBiQ92567
PaxDbiQ92567
PeptideAtlasiQ92567
PRIDEiQ92567
ProteomicsDBi75324 [Q92567-1]
75325 [Q92567-2]
75326 [Q92567-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
50128 39 antibodies

The DNASU plasmid repository

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DNASUi
23201

Genome annotation databases

EnsembliENST00000064778; ENSP00000064778; ENSG00000054965 [Q92567-1]
ENST00000356467; ENSP00000348852; ENSG00000054965 [Q92567-2]
ENST00000450446; ENSP00000390501; ENSG00000054965 [Q92567-3]
GeneIDi23201
KEGGihsa:23201
UCSCiuc001oty.3 human [Q92567-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23201
DisGeNETi23201
EuPathDBiHostDB:ENSG00000054965.10

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM168A
HGNCiHGNC:28999 FAM168A
HPAiENSG00000054965 Tissue enhanced (brain)
MIMi616316 gene
neXtProtiNX_Q92567
OpenTargetsiENSG00000054965
PharmGKBiPA162387077

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUV Eukaryota
ENOG410XR79 LUCA
GeneTreeiENSGT00390000005140
HOGENOMiCLU_065824_1_0_1
InParanoidiQ92567
OMAiMAMSAGC
OrthoDBi1348118at2759
PhylomeDBiQ92567
TreeFamiTF331128

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23201 71 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM168A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23201
PharosiQ92567 Tbio

Protein Ontology

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PROi
PR:Q92567
RNActiQ92567 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000054965 Expressed in C1 segment of cervical spinal cord and 219 other tissues
GenevisibleiQ92567 HS

Family and domain databases

InterProiView protein in InterPro
IPR029247 FAM168A/MANI
PANTHERiPTHR31844 PTHR31844, 1 hit
PfamiView protein in Pfam
PF14944 TCRP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF168A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92567
Secondary accession number(s): A2ICY2, A2ID81, Q86UG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: June 17, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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