UniProtKB - Q92563 (TICN2_HUMAN)

BLAST

>sp|Q92563|TICN2_HUMAN Testican-2 OS=Homo sapiens OX=9606 GN=SPOCK2 PE=1 SV=1
MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
IKQPTVKLHGNKDSICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC
PCPTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDK
SLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTA
EWCFCFWREKPPCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQ
LGLELTGTRTHGSPDCDDIVGFSGDFGSGVGWEDEEEKETEEAGEEAEEEEGEAGEADDG
GYIW

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History
Entry version 178 (07 Nov 2018)
Sequence version 1 (01 Feb 1997)
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Protein

Testican-2

Gene

SPOCK2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May participate in diverse steps of neurogenesis. Binds calcium.

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10386950
collagen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extracellular matrix binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glycosaminoglycan binding Source: Ensembl
metalloendopeptidase inhibitor activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 12810672

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to leukemia inhibitory factor Source: Ensembl
extracellular matrix organization
Source: UniProtKB
Non-traceable author statementⁱ
- 10386950
negative regulation of endopeptidase activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 12810672
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
positive regulation of cell motility
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 12810672
positive regulation of cell-substrate adhesion Source: Ensembl
regulation of cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10386950
synapse assembly
Source: UniProtKB
Non-traceable author statementⁱ
- 10386950

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium

Ligand

Calcium

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.954

MEROPSⁱ

I31.954

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Testican-2 Alternative name(s): SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene namesⁱ	Name:SPOCK2 Synonyms:KIAA0275, TICN2 ORF Names:UNQ269/PRO306
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107742.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13564 SPOCK2
MIMⁱ	607988 gene
neXtProtⁱ	NX_Q92563

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9806
Open Targets More...OpenTargetsⁱ	ENSG00000107742
PharmGKBⁱ	PA128394560

Polymorphism and mutation databases

BioMutaⁱ	SPOCK2
DMDMⁱ	24212500

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST		22
ChainⁱPRO_0000026701	23 – 424	Testican-2Add BLAST		402

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	72	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	90 ↔ 101	By similarity
Disulfide bondⁱ	95 ↔ 111	By similarity
Disulfide bondⁱ	136 ↔ 166	By similarity
Disulfide bondⁱ	139 ↔ 159	By similarity
Disulfide bondⁱ	148 ↔ 180	By similarity
Glycosylationⁱ	225	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	313 ↔ 337	By similarity
Disulfide bondⁱ	348 ↔ 355	By similarity
Disulfide bondⁱ	357 ↔ 376	By similarity
Glycosylationⁱ	383	O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis	1
Glycosylationⁱ	388	O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis	1

Post-translational modificationⁱ

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92563
PaxDbⁱ	Q92563
PeptideAtlas More...PeptideAtlasⁱ	Q92563
PRIDEⁱ	Q92563
ProteomicsDBⁱ	75319

PTM databases

iPTMnetⁱ	Q92563
PhosphoSitePlusⁱ	Q92563

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain. Also found in lung and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107742 Expressed in 210 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_SPOCK2
ExpressionAtlasⁱ	Q92563 baseline and differential
Genevisibleⁱ	Q92563 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044605

HPAⁱ

HPA044605

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115146, 2 interactors
IntActⁱ	Q92563, 2 interactors
STRINGⁱ	9606.ENSP00000321108

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92563
SMRⁱ	Q92563
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	130 – 182	Kazal-likePROSITE-ProRule annotationAdd BLAST		53
Domainⁱ	310 – 376	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		67

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	393 – 416	Glu-richAdd BLAST		24

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3555 Eukaryota ENOG410Y6A8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046429
HOGENOMⁱ	HOG000293295
HOVERGENⁱ	HBG026595
InParanoidⁱ	Q92563
KEGG Orthology (KO) More...KOⁱ	K08136
OMAⁱ	HRIKQPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G086I
PhylomeDBⁱ	Q92563
TreeFamⁱ	TF317779

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR019577 SPARC/Testican_Ca-bd-dom IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07648 Kazal_2, 1 hit PF10591 SPARC_Ca_bdg, 1 hit PF00086 Thyroglobulin_1, 1 hit
SMARTⁱ	View protein in SMART SM00280 KAZAL, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q92563-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ 
        60         70         80         90        100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV 
       110        120        130        140        150
CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS 
       160        170        180        190        200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT 
       210        220        230        240        250
GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI 
       260        270        280        290        300
GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA 
       310        320        330        340        350
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ 
       360        370        380        390        400
SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET 
       410        420 
EEAGEEAEEE EGEAGEADDG GYIW

Length:424

Mass (Da):46,779

Last modified:February 1, 1997 - v1

Checksum:ⁱB7894E657FC2257F

Isoform 2 (identifier: Q92563-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
78-424: Missing.

« Hide

        10         20         30         40         50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ 
        60         70 
YSGKIKHWNR FRDVPSSDPP STTQATP

Note: No experimental confirmation available.

Show »

Length:77

Mass (Da):8,311

Checksum:ⁱ09ACECE0F615B8CC

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5H283	F5H283_HUMAN		Testican-2 Testican-2	SPOCK2	423	Annotation score:

Sequence cautionⁱ

The sequence BAA13404 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	357	C → R in AAQ89280 (PubMed:12975309).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022020	353	G → S. Corresponds to variant dbSNP:rs2306322Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045668	64 – 77	EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationAdd BLAST		14
Alternative sequenceⁱVSP_045669	78 – 424	Missing in isoform 2. 1 PublicationAdd BLAST		347

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ001453 mRNA Translation: CAA04774.1 D87465 mRNA Translation: BAA13404.2 Different initiation. AY358921 mRNA Translation: AAQ89280.1 AK307091 mRNA No translation available. AC022392 Genomic DNA No translation available. BC023558 mRNA Translation: AAH23558.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44431.1 [Q92563-2] CCDS7313.1 [Q92563-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001127906.1, NM_001134434.1 [Q92563-2] NP_001231879.1, NM_001244950.1 [Q92563-1] NP_055582.1, NM_014767.2 [Q92563-1] XP_016872474.1, XM_017016985.1 [Q92563-2]
UniGeneⁱ	Hs.523009

Genome annotation databases

Ensemblⁱ	ENST00000317376; ENSP00000321108; ENSG00000107742 [Q92563-1] ENST00000373109; ENSP00000362201; ENSG00000107742 [Q92563-1] ENST00000412663; ENSP00000397715; ENSG00000107742 [Q92563-2]
GeneIDⁱ	9806
KEGGⁱ	hsa:9806
UCSC genome browser More...UCSCⁱ	uc001jso.3 human [Q92563-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92563	Testican-2		MOUSE		423	UniRef90_Q92563
SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2		RAT		425
cDNA FLJ77237, highly similar to Homo sapiens sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 (SPOCK2), mRNA		HUMAN		424
Uncharacterized protein		CERAT		424
Uncharacterized protein		MANLE		424
+57
Q92563-2	SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2		PANTR		77	UniRef90_A0A2I3SBL5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2		SAIBB		78
Uncharacterized protein		CALJA		78
Uncharacterized protein		Cebus capucinus imitator		78
Uncharacterized protein		AOTNA		78
+12

Protein	Similar proteins		Species	Score	Length	Source
Q92563	Testican-2		MOUSE		423	UniRef50_Q92563
SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2		RAT		425
Testican-2 isoform 2		CALJA		424
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2		PONAB		424
cDNA FLJ77237, highly similar to Homo sapiens sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 (SPOCK2), mRNA		HUMAN		424
+60
Q92563-2	SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2		PANTR		77	UniRef50_A0A2I3SBL5
Uncharacterized protein		CALJA		78
Uncharacterized protein		Cebus capucinus imitator		78
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2		SAIBB		78
Uncharacterized protein		AOTNA		78
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ001453 mRNA Translation: CAA04774.1 D87465 mRNA Translation: BAA13404.2 Different initiation. AY358921 mRNA Translation: AAQ89280.1 AK307091 mRNA No translation available. AC022392 Genomic DNA No translation available. BC023558 mRNA Translation: AAH23558.1
CCDSⁱ	CCDS44431.1 [Q92563-2] CCDS7313.1 [Q92563-1]
RefSeqⁱ	NP_001127906.1, NM_001134434.1 [Q92563-2] NP_001231879.1, NM_001244950.1 [Q92563-1] NP_055582.1, NM_014767.2 [Q92563-1] XP_016872474.1, XM_017016985.1 [Q92563-2]
UniGeneⁱ	Hs.523009

3D structure databases

ProteinModelPortalⁱ	Q92563
SMRⁱ	Q92563
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115146, 2 interactors
IntActⁱ	Q92563, 2 interactors
STRINGⁱ	9606.ENSP00000321108

Protein family/group databases

MEROPSⁱ	I31.954

MEROPSⁱ

I31.954

PTM databases

iPTMnetⁱ	Q92563
PhosphoSitePlusⁱ	Q92563

Polymorphism and mutation databases

BioMutaⁱ	SPOCK2
DMDMⁱ	24212500

Proteomic databases

MaxQBⁱ	Q92563
PaxDbⁱ	Q92563
PeptideAtlasⁱ	Q92563
PRIDEⁱ	Q92563
ProteomicsDBⁱ	75319

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9806
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000317376; ENSP00000321108; ENSG00000107742 [Q92563-1] ENST00000373109; ENSP00000362201; ENSG00000107742 [Q92563-1] ENST00000412663; ENSP00000397715; ENSG00000107742 [Q92563-2]
GeneIDⁱ	9806
KEGGⁱ	hsa:9806
UCSCⁱ	uc001jso.3 human [Q92563-1]

Organism-specific databases

CTDⁱ	9806
DisGeNETⁱ	9806
EuPathDBⁱ	HostDB:ENSG00000107742.12
GeneCardsⁱ	SPOCK2
HGNCⁱ	HGNC:13564 SPOCK2
HPAⁱ	HPA044605
MIMⁱ	607988 gene
neXtProtⁱ	NX_Q92563
OpenTargetsⁱ	ENSG00000107742
PharmGKBⁱ	PA128394560
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3555 Eukaryota ENOG410Y6A8 LUCA
GeneTreeⁱ	ENSGT00510000046429
HOGENOMⁱ	HOG000293295
HOVERGENⁱ	HBG026595
InParanoidⁱ	Q92563
KOⁱ	K08136
OMAⁱ	HRIKQPA
OrthoDBⁱ	EOG091G086I
PhylomeDBⁱ	Q92563
TreeFamⁱ	TF317779

Miscellaneous databases

ChiTaRSⁱ	SPOCK2 human
GeneWikiⁱ	SPOCK2
GenomeRNAiⁱ	9806
Protein Ontology More...PROⁱ	PR:Q92563
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107742 Expressed in 210 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_SPOCK2
ExpressionAtlasⁱ	Q92563 baseline and differential
Genevisibleⁱ	Q92563 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR019577 SPARC/Testican_Ca-bd-dom IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfamⁱ	View protein in Pfam PF07648 Kazal_2, 1 hit PF10591 SPARC_Ca_bdg, 1 hit PF00086 Thyroglobulin_1, 1 hit
SMARTⁱ	View protein in SMART SM00280 KAZAL, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF100895 SSF100895, 1 hit SSF47473 SSF47473, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TICN2_HUMAN
Accessionⁱ	Q92563Primary (citable) accession number: Q92563 Secondary accession number(s): C9J767, Q6UW87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q92563 (TICN2_HUMAN)

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Testican-2

SPOCK2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ