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UniProtKB - Q92563 (TICN2_HUMAN)
Protein
Testican-2
Gene
SPOCK2
Organism
Homo sapiens (Human)
Status
Functioni
May participate in diverse steps of neurogenesis. Binds calcium.
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- extracellular matrix binding Source: Ensembl
- glycosaminoglycan binding Source: Ensembl
- metalloendopeptidase inhibitor activity Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- extracellular matrix organization Source: UniProtKB
- negative regulation of endopeptidase activity Source: ParkinsonsUK-UCL
- peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
- positive regulation of cell motility Source: ParkinsonsUK-UCL
- positive regulation of cell-substrate adhesion Source: Ensembl
- regulation of cell differentiation Source: UniProtKB
- synapse assembly Source: UniProtKB
Keywordsi
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q92563 |
SignaLinki | Q92563 |
Protein family/group databases
MEROPSi | I31.954 |
Names & Taxonomyi
Protein namesi | Recommended name: Testican-2Alternative name(s): SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 |
Gene namesi | Name:SPOCK2 Synonyms:KIAA0275, TICN2 ORF Names:UNQ269/PRO306 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13564, SPOCK2 |
MIMi | 607988, gene |
neXtProti | NX_Q92563 |
VEuPathDBi | HostDB:ENSG00000107742 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Other locations
- extracellular matrix Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 9806 |
OpenTargetsi | ENSG00000107742 |
PharmGKBi | PA128394560 |
Miscellaneous databases
Pharosi | Q92563, Tbio |
Genetic variation databases
BioMutai | SPOCK2 |
DMDMi | 24212500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000026701 | 23 – 424 | Testican-2Add BLAST | 402 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 72 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 90 ↔ 101 | By similarity | ||
Disulfide bondi | 95 ↔ 111 | By similarity | ||
Disulfide bondi | 136 ↔ 166 | By similarity | ||
Disulfide bondi | 139 ↔ 159 | By similarity | ||
Disulfide bondi | 148 ↔ 180 | By similarity | ||
Glycosylationi | 225 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 313 ↔ 337 | By similarity | ||
Disulfide bondi | 348 ↔ 355 | By similarity | ||
Disulfide bondi | 357 ↔ 376 | By similarity | ||
Glycosylationi | 383 | O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis | 1 | |
Glycosylationi | 388 | O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis | 1 |
Post-translational modificationi
Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, ProteoglycanProteomic databases
EPDi | Q92563 |
jPOSTi | Q92563 |
MassIVEi | Q92563 |
MaxQBi | Q92563 |
PaxDbi | Q92563 |
PeptideAtlasi | Q92563 |
PRIDEi | Q92563 |
ProteomicsDBi | 75319 [Q92563-1] 8867 |
PTM databases
GlyGeni | Q92563, 6 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q92563 |
PhosphoSitePlusi | Q92563 |
Expressioni
Tissue specificityi
Highly expressed in brain. Also found in lung and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000107742, Expressed in metanephric glomerulus and 224 other tissues |
ExpressionAtlasi | Q92563, baseline and differential |
Genevisiblei | Q92563, HS |
Organism-specific databases
HPAi | ENSG00000107742, Tissue enhanced (brain, lymphoid tissue) |
Interactioni
Binary interactionsi
Q92563
With | #Exp. | IntAct |
---|---|---|
ENKD1 [Q9H0I2] | 3 | EBI-311086,EBI-744099 |
Protein-protein interaction databases
BioGRIDi | 115146, 54 interactors |
IntActi | Q92563, 4 interactors |
STRINGi | 9606.ENSP00000362201 |
Miscellaneous databases
RNActi | Q92563, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q92563 |
SASBDBi | Q92563 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 182 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 310 – 376 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 387 – 424 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 390 – 417 | Acidic residuesSequence analysisAdd BLAST | 28 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3555, Eukaryota |
GeneTreei | ENSGT00940000157107 |
HOGENOMi | CLU_037217_1_0_1 |
InParanoidi | Q92563 |
OMAi | SACKLEQ |
OrthoDBi | 1235834at2759 |
PhylomeDBi | Q92563 |
TreeFami | TF317779 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR019577, SPARC/Testican_Ca-bd-dom IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF10591, SPARC_Ca_bdg, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q92563-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ
60 70 80 90 100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV
110 120 130 140 150
CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS
160 170 180 190 200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT
210 220 230 240 250
GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI
260 270 280 290 300
GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA
310 320 330 340 350
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ
360 370 380 390 400
SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET
410 420
EEAGEEAEEE EGEAGEADDG GYIW
Sequence cautioni
The sequence BAA13404 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 357 | C → R in AAQ89280 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022020 | 353 | G → S. Corresponds to variant dbSNP:rs2306322EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045668 | 64 – 77 | EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_045669 | 78 – 424 | Missing in isoform 2. 1 PublicationAdd BLAST | 347 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001453 mRNA Translation: CAA04774.1 D87465 mRNA Translation: BAA13404.2 Different initiation. AY358921 mRNA Translation: AAQ89280.1 AK307091 mRNA No translation available. AC022392 Genomic DNA No translation available. BC023558 mRNA Translation: AAH23558.1 |
CCDSi | CCDS44431.1 [Q92563-2] CCDS7313.1 [Q92563-1] |
RefSeqi | NP_001127906.1, NM_001134434.1 [Q92563-2] NP_001231879.1, NM_001244950.1 [Q92563-1] NP_055582.1, NM_014767.2 [Q92563-1] XP_016872474.1, XM_017016985.1 [Q92563-2] |
Genome annotation databases
Ensembli | ENST00000317376.8; ENSP00000321108.4; ENSG00000107742.14 ENST00000373109.7; ENSP00000362201.2; ENSG00000107742.14 ENST00000412663.5; ENSP00000397715.1; ENSG00000107742.14 [Q92563-2] |
GeneIDi | 9806 |
KEGGi | hsa:9806 |
MANE-Selecti | ENST00000373109.7; ENSP00000362201.2; NM_001244950.2; NP_001231879.1 |
UCSCi | uc001jso.3, human [Q92563-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001453 mRNA Translation: CAA04774.1 D87465 mRNA Translation: BAA13404.2 Different initiation. AY358921 mRNA Translation: AAQ89280.1 AK307091 mRNA No translation available. AC022392 Genomic DNA No translation available. BC023558 mRNA Translation: AAH23558.1 |
CCDSi | CCDS44431.1 [Q92563-2] CCDS7313.1 [Q92563-1] |
RefSeqi | NP_001127906.1, NM_001134434.1 [Q92563-2] NP_001231879.1, NM_001244950.1 [Q92563-1] NP_055582.1, NM_014767.2 [Q92563-1] XP_016872474.1, XM_017016985.1 [Q92563-2] |
3D structure databases
AlphaFoldDBi | Q92563 |
SASBDBi | Q92563 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115146, 54 interactors |
IntActi | Q92563, 4 interactors |
STRINGi | 9606.ENSP00000362201 |
Protein family/group databases
MEROPSi | I31.954 |
PTM databases
GlyGeni | Q92563, 6 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q92563 |
PhosphoSitePlusi | Q92563 |
Genetic variation databases
BioMutai | SPOCK2 |
DMDMi | 24212500 |
Proteomic databases
EPDi | Q92563 |
jPOSTi | Q92563 |
MassIVEi | Q92563 |
MaxQBi | Q92563 |
PaxDbi | Q92563 |
PeptideAtlasi | Q92563 |
PRIDEi | Q92563 |
ProteomicsDBi | 75319 [Q92563-1] 8867 |
Protocols and materials databases
Antibodypediai | 29217, 98 antibodies from 24 providers |
DNASUi | 9806 |
Genome annotation databases
Ensembli | ENST00000317376.8; ENSP00000321108.4; ENSG00000107742.14 ENST00000373109.7; ENSP00000362201.2; ENSG00000107742.14 ENST00000412663.5; ENSP00000397715.1; ENSG00000107742.14 [Q92563-2] |
GeneIDi | 9806 |
KEGGi | hsa:9806 |
MANE-Selecti | ENST00000373109.7; ENSP00000362201.2; NM_001244950.2; NP_001231879.1 |
UCSCi | uc001jso.3, human [Q92563-1] |
Organism-specific databases
CTDi | 9806 |
DisGeNETi | 9806 |
GeneCardsi | SPOCK2 |
HGNCi | HGNC:13564, SPOCK2 |
HPAi | ENSG00000107742, Tissue enhanced (brain, lymphoid tissue) |
MIMi | 607988, gene |
neXtProti | NX_Q92563 |
OpenTargetsi | ENSG00000107742 |
PharmGKBi | PA128394560 |
VEuPathDBi | HostDB:ENSG00000107742 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3555, Eukaryota |
GeneTreei | ENSGT00940000157107 |
HOGENOMi | CLU_037217_1_0_1 |
InParanoidi | Q92563 |
OMAi | SACKLEQ |
OrthoDBi | 1235834at2759 |
PhylomeDBi | Q92563 |
TreeFami | TF317779 |
Enzyme and pathway databases
PathwayCommonsi | Q92563 |
SignaLinki | Q92563 |
Miscellaneous databases
BioGRID-ORCSi | 9806, 13 hits in 1072 CRISPR screens |
ChiTaRSi | SPOCK2, human |
GeneWikii | SPOCK2 |
GenomeRNAii | 9806 |
Pharosi | Q92563, Tbio |
PROi | PR:Q92563 |
RNActi | Q92563, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107742, Expressed in metanephric glomerulus and 224 other tissues |
ExpressionAtlasi | Q92563, baseline and differential |
Genevisiblei | Q92563, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR019577, SPARC/Testican_Ca-bd-dom IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF10591, SPARC_Ca_bdg, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TICN2_HUMAN | |
Accessioni | Q92563Primary (citable) accession number: Q92563 Secondary accession number(s): C9J767, Q6UW87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot