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UniProtKB - Q92563 (TICN2_HUMAN)

Entry version 187 (16 Oct 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Testican-2

Gene

SPOCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in diverse steps of neurogenesis. Binds calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Protein family/group databases

MEROPS protease database

More...MEROPSi		I31.954

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testican-2
Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPOCK2
Synonyms:KIAA0275, TICN2
ORF Names:UNQ269/PRO306
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13564 SPOCK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607988 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92563

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9806

Open Targets

More...OpenTargetsi		ENSG00000107742

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394560

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92563

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPOCK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		24212500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002670123 – 424Testican-2Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 101By similarity
Disulfide bondi95 ↔ 111By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 337By similarity
Disulfide bondi348 ↔ 355By similarity
Disulfide bondi357 ↔ 376By similarity
Glycosylationi383O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi388O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92563

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92563

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92563

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92563

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92563

PeptideAtlas

More...PeptideAtlasi		Q92563

PRoteomics IDEntifications database

More...PRIDEi		Q92563

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75319 [Q92563-1]
8867

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92563

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92563

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Also found in lung and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107742 Expressed in 210 organ(s), highest expression level in metanephric glomerulus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92563 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92563 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA044605

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115146, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q92563, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362201

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92563

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini310 – 376Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 416Glu-richAdd BLAST24

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3555 Eukaryota
ENOG410Y6A8 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000293295

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92563

KEGG Orthology (KO)

More...KOi		K08136

Identification of Orthologs from Complete Genome Data

More...OMAi		TRIHGNP

Database of Orthologous Groups

More...OrthoDBi		1235834at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92563

TreeFam database of animal gene trees

More...TreeFami		TF317779

Family and domain databases

Conserved Domains Database

More...CDDi		cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ 
        60         70         80         90        100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV 
       110        120        130        140        150
CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS 
       160        170        180        190        200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT 
       210        220        230        240        250
GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI 
       260        270        280        290        300
GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA 
       310        320        330        340        350
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ 
       360        370        380        390        400
SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET 
       410        420 
EEAGEEAEEE EGEAGEADDG GYIW
Length:424
Mass (Da):46,779
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7894E657FC2257F
GO
Isoform 2 (identifier: Q92563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
     78-424: Missing.

Note: No experimental confirmation available.
Show »
Length:77
Mass (Da):8,311
Checksum:i09ACECE0F615B8CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H283F5H283_HUMAN
Testican-2
SPOCK2
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13404 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357C → R in AAQ89280 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022020353G → S. Corresponds to variant dbSNP:rs2306322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04566864 – 77EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_04566978 – 424Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ001453 mRNA Translation: CAA04774.1
D87465 mRNA Translation: BAA13404.2 Different initiation.
AY358921 mRNA Translation: AAQ89280.1
AK307091 mRNA No translation available.
AC022392 Genomic DNA No translation available.
BC023558 mRNA Translation: AAH23558.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44431.1 [Q92563-2]
CCDS7313.1 [Q92563-1]

NCBI Reference Sequences

More...RefSeqi		NP_001127906.1, NM_001134434.1 [Q92563-2]
NP_001231879.1, NM_001244950.1 [Q92563-1]
NP_055582.1, NM_014767.2 [Q92563-1]
XP_016872474.1, XM_017016985.1 [Q92563-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317376; ENSP00000321108; ENSG00000107742 [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742 [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742 [Q92563-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9806

UCSC genome browser

More...UCSCi		uc001jso.3 human [Q92563-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001453 mRNA Translation: CAA04774.1
D87465 mRNA Translation: BAA13404.2 Different initiation.
AY358921 mRNA Translation: AAQ89280.1
AK307091 mRNA No translation available.
AC022392 Genomic DNA No translation available.
BC023558 mRNA Translation: AAH23558.1
CCDSiCCDS44431.1 [Q92563-2]
CCDS7313.1 [Q92563-1]
RefSeqiNP_001127906.1, NM_001134434.1 [Q92563-2]
NP_001231879.1, NM_001244950.1 [Q92563-1]
NP_055582.1, NM_014767.2 [Q92563-1]
XP_016872474.1, XM_017016985.1 [Q92563-2]

3D structure databases

SMRiQ92563
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115146, 2 interactors
IntActiQ92563, 3 interactors
STRINGi9606.ENSP00000362201

Protein family/group databases

MEROPSiI31.954

PTM databases

iPTMnetiQ92563
PhosphoSitePlusiQ92563

Polymorphism and mutation databases

BioMutaiSPOCK2
DMDMi24212500

Proteomic databases

EPDiQ92563
jPOSTiQ92563
MassIVEiQ92563
MaxQBiQ92563
PaxDbiQ92563
PeptideAtlasiQ92563
PRIDEiQ92563
ProteomicsDBi75319 [Q92563-1]
8867

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		9806

Genome annotation databases

EnsembliENST00000317376; ENSP00000321108; ENSG00000107742 [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742 [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742 [Q92563-2]
GeneIDi9806
KEGGihsa:9806
UCSCiuc001jso.3 human [Q92563-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9806
DisGeNETi9806

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPOCK2
HGNCiHGNC:13564 SPOCK2
HPAiHPA044605
MIMi607988 gene
neXtProtiNX_Q92563
OpenTargetsiENSG00000107742
PharmGKBiPA128394560

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00940000157107
HOGENOMiHOG000293295
InParanoidiQ92563
KOiK08136
OMAiTRIHGNP
OrthoDBi1235834at2759
PhylomeDBiQ92563
TreeFamiTF317779

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPOCK2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPOCK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9806
PharosiQ92563

Protein Ontology

More...PROi		PR:Q92563

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107742 Expressed in 210 organ(s), highest expression level in metanephric glomerulus
ExpressionAtlasiQ92563 baseline and differential
GenevisibleiQ92563 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTICN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92563
Secondary accession number(s): C9J767, Q6UW87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 1, 1997
Last modified: October 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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