UniProtKB - Q92556 (ELMO1_HUMAN)
Engulfment and cell motility protein 1
ELMO1
Functioni
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
2 PublicationsGO - Molecular functioni
- SH3 domain binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- actin filament organization Source: GO_Central
- apoptotic process Source: UniProtKB
- cell migration Source: InterPro
- cell motility Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- Rac protein signal transduction Source: UniProtKB
- regulation of catalytic activity Source: GOC
Keywordsi
Biological process | Apoptosis, Phagocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q92556 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q92556 |
SIGNORi | Q92556 |
Names & Taxonomyi
Protein namesi | Recommended name: Engulfment and cell motility protein 1Alternative name(s): Protein ced-12 homolog |
Gene namesi | Name:ELMO1 Synonyms:KIAA0281 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16286, ELMO1 |
MIMi | 606420, gene |
neXtProti | NX_Q92556 |
VEuPathDBi | HostDB:ENSG00000155849 |
Subcellular locationi
Plasma membrane
Cytoplasm and Cytosol
Note: Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- guanyl-nucleotide exchange factor complex Source: WormBase
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9844 |
OpenTargetsi | ENSG00000155849 |
PharmGKBi | PA27754 |
Miscellaneous databases
Pharosi | Q92556, Tbio |
Genetic variation databases
BioMutai | ELMO1 |
DMDMi | 30923321 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153712 | 1 – 727 | Engulfment and cell motility protein 1Add BLAST | 727 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | Phosphotyrosine; by HCK1 Publication | 1 | |
Modified residuei | 100 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 105 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 216 | Phosphotyrosine; by HCK1 Publication | 1 | |
Modified residuei | 344 | PhosphoserineBy similarity | 1 | |
Modified residuei | 395 | Phosphotyrosine; by HCK1 Publication | 1 | |
Modified residuei | 511 | Phosphotyrosine; by HCK1 Publication | 1 | |
Modified residuei | 720 | Phosphotyrosine; by HCK1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1759 |
EPDi | Q92556 |
jPOSTi | Q92556 |
MassIVEi | Q92556 |
MaxQBi | Q92556 |
PaxDbi | Q92556 |
PeptideAtlasi | Q92556 |
PRIDEi | Q92556 |
ProteomicsDBi | 75312 [Q92556-1] 75313 [Q92556-2] 75314 [Q92556-3] |
PTM databases
iPTMneti | Q92556 |
MetOSitei | Q92556 |
PhosphoSitePlusi | Q92556 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000155849, Expressed in corpus callosum and 215 other tissues |
ExpressionAtlasi | Q92556, baseline and differential |
Genevisiblei | Q92556, HS |
Organism-specific databases
HPAi | ENSG00000155849, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with ADGRB1 (By similarity).
Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site.
Part of a complex with DOCK1 and RAC1.
Part of a complex with DOCK1 and CRK isoform CRK-II.
Interacts with PLEKHG6.
Interacts with HCK (via SH3 domain).
Interacts with ADGRB3 (PubMed:24567399).
By similarity5 PublicationsBinary interactionsi
Q92556
With | #Exp. | IntAct |
---|---|---|
DOCK1 [Q14185] | 17 | EBI-346417,EBI-446740 |
HCK [P08631] | 4 | EBI-346417,EBI-346340 |
RHOG [P84095] | 3 | EBI-346417,EBI-446579 |
TRIM54 [Q9BYV2] | 3 | EBI-346417,EBI-2130429 |
ZNF398 [Q8TD17] | 5 | EBI-346417,EBI-8643207 |
Isoform 1 [Q92556-1]
With | #Exp. | IntAct |
---|---|---|
ADGRB1 [O14514] | 2 | EBI-15668002,EBI-1995178 |
Adgrb1 [Q3UHD1] from Mus musculus. | 9 | EBI-15668002,EBI-911280 |
GO - Molecular functioni
- SH3 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115180, 31 interactors |
CORUMi | Q92556 |
DIPi | DIP-31095N |
IntActi | Q92556, 21 interactors |
MINTi | Q92556 |
STRINGi | 9606.ENSP00000312185 |
Miscellaneous databases
RNActi | Q92556, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92556 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92556 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 319 – 492 | ELMOPROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 555 – 676 | PHAdd BLAST | 122 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 707 – 714 | SH3-binding | 8 |
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG2999, Eukaryota |
GeneTreei | ENSGT00940000155994 |
HOGENOMi | CLU_097960_0_0_1 |
InParanoidi | Q92556 |
OMAi | WESHARP |
PhylomeDBi | Q92556 |
TreeFami | TF312966 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR030715, ELMO1 IPR024574, ELMO_ARM IPR006816, ELMO_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR12771:SF23, PTHR12771:SF23, 1 hit |
Pfami | View protein in Pfam PF11841, DUF3361, 1 hit PF04727, ELMO_CED12, 1 hit PF16457, PH_12, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51335, ELMO, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA
60 70 80 90 100
LQHADSSNFY ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK
110 120 130 140 150
LEALKDLASL SRDVTFAQEF INLDGISLLT QMVESGTERY QKLQKIMKPC
160 170 180 190 200
FGDMLSFTLT AFVELMDHGI VSWDTFSVAF IKKIASFVNK SAIDISILQR
210 220 230 240 250
SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ TYTIAVINAL
260 270 280 290 300
FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL
310 320 330 340 350
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS
360 370 380 390 400
MYTRDYKKLG FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL
410 420 430 440 450
ENSSREDKHE CPFGRSSIEL TKMLCEILKV GELPSETCND FHPMFFTHDR
460 470 480 490 500
SFEEFFCICI QLLNKTWKEM RATSEDFNKV MQVVKEQVMR ALTTKPSSLD
510 520 530 540 550
QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI QPEILELIKQ
560 570 580 590 600
QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP
610 620 630 640 650
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC
660 670 680 690 700
QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD
710 720
LENIQIPDAP PPIPKEPSNY DFVYDCN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C3P3 | H7C3P3_HUMAN | Engulfment and cell motility protei... | ELMO1 | 193 | Annotation score: | ||
C9IZR8 | C9IZR8_HUMAN | Engulfment and cell motility protei... | ELMO1 | 167 | Annotation score: | ||
C9JIW2 | C9JIW2_HUMAN | Engulfment and cell motility protei... | ELMO1 | 149 | Annotation score: | ||
H7C0N5 | H7C0N5_HUMAN | Engulfment and cell motility protei... | ELMO1 | 124 | Annotation score: | ||
C9JB20 | C9JB20_HUMAN | Engulfment and cell motility protei... | ELMO1 | 81 | Annotation score: | ||
H7C0S6 | H7C0S6_HUMAN | Engulfment and cell motility protei... | ELMO1 | 182 | Annotation score: | ||
C9J5X3 | C9J5X3_HUMAN | Engulfment and cell motility protei... | ELMO1 | 59 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 716 | E → A in CAB66721 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065824 | 362 | I → S1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007480 | 1 – 480 | Missing in isoform 2. 2 PublicationsAdd BLAST | 480 | |
Alternative sequenceiVSP_038550 | 1 – 298 | Missing in isoform 3. 1 PublicationAdd BLAST | 298 | |
Alternative sequenceiVSP_038551 | 299 – 362 | VLTFN…KLGFI → MSEHQKEQTLDTPSLRTVTL TVRVHGFILEVSKTKNPPIP DTFWPPRWDHRPSPGGETNA YCQM in isoform 3. 1 PublicationAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF398885 mRNA Translation: AAL14466.1 D87457 mRNA Translation: BAA13397.2 Different initiation. AL136787 mRNA Translation: CAB66721.1 AK126565 mRNA Translation: BAC86597.1 CH236951 Genomic DNA Translation: EAL23979.1 CH471073 Genomic DNA Translation: EAW94076.1 BC003051 mRNA Translation: AAH03051.1 BC064635 mRNA Translation: AAH64635.1 BC077074 mRNA Translation: AAH77074.1 BC114341 mRNA Translation: AAI14342.1 |
CCDSi | CCDS5449.1 [Q92556-1] CCDS5450.1 [Q92556-2] |
RefSeqi | NP_001034548.1, NM_001039459.2 [Q92556-2] NP_001193409.1, NM_001206480.2 [Q92556-1] NP_001193411.1, NM_001206482.1 [Q92556-1] NP_055615.8, NM_014800.10 [Q92556-1] NP_569709.1, NM_130442.3 [Q92556-2] XP_005249976.1, XM_005249919.2 [Q92556-1] XP_006715868.1, XM_006715805.1 [Q92556-1] XP_011513956.1, XM_011515654.1 [Q92556-1] XP_016868327.1, XM_017012838.1 XP_016868328.1, XM_017012839.1 [Q92556-1] |
Genome annotation databases
Ensembli | ENST00000310758; ENSP00000312185; ENSG00000155849 ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2] ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2] ENST00000442504; ENSP00000406952; ENSG00000155849 ENST00000448602; ENSP00000394458; ENSG00000155849 |
GeneIDi | 9844 |
KEGGi | hsa:9844 |
MANE-Selecti | ENST00000310758.9; ENSP00000312185.4; NM_014800.11; NP_055615.8 |
UCSCi | uc003tfi.3, human [Q92556-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF398885 mRNA Translation: AAL14466.1 D87457 mRNA Translation: BAA13397.2 Different initiation. AL136787 mRNA Translation: CAB66721.1 AK126565 mRNA Translation: BAC86597.1 CH236951 Genomic DNA Translation: EAL23979.1 CH471073 Genomic DNA Translation: EAW94076.1 BC003051 mRNA Translation: AAH03051.1 BC064635 mRNA Translation: AAH64635.1 BC077074 mRNA Translation: AAH77074.1 BC114341 mRNA Translation: AAI14342.1 |
CCDSi | CCDS5449.1 [Q92556-1] CCDS5450.1 [Q92556-2] |
RefSeqi | NP_001034548.1, NM_001039459.2 [Q92556-2] NP_001193409.1, NM_001206480.2 [Q92556-1] NP_001193411.1, NM_001206482.1 [Q92556-1] NP_055615.8, NM_014800.10 [Q92556-1] NP_569709.1, NM_130442.3 [Q92556-2] XP_005249976.1, XM_005249919.2 [Q92556-1] XP_006715868.1, XM_006715805.1 [Q92556-1] XP_011513956.1, XM_011515654.1 [Q92556-1] XP_016868327.1, XM_017012838.1 XP_016868328.1, XM_017012839.1 [Q92556-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RQR | NMR | - | A | 697-722 | [»] | |
2VSZ | X-ray | 2.30 | A/B | 532-675 | [»] | |
3A98 | X-ray | 2.10 | B/D | 532-727 | [»] | |
6JPP | NMR | - | A | 1-113 | [»] | |
6TGB | electron microscopy | 5.50 | B | 1-727 | [»] | |
6TGC | electron microscopy | 4.10 | B/E | 1-727 | [»] | |
7DPA | electron microscopy | 3.80 | C/F | 1-727 | [»] | |
SMRi | Q92556 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115180, 31 interactors |
CORUMi | Q92556 |
DIPi | DIP-31095N |
IntActi | Q92556, 21 interactors |
MINTi | Q92556 |
STRINGi | 9606.ENSP00000312185 |
PTM databases
iPTMneti | Q92556 |
MetOSitei | Q92556 |
PhosphoSitePlusi | Q92556 |
Genetic variation databases
BioMutai | ELMO1 |
DMDMi | 30923321 |
Proteomic databases
CPTACi | CPTAC-1759 |
EPDi | Q92556 |
jPOSTi | Q92556 |
MassIVEi | Q92556 |
MaxQBi | Q92556 |
PaxDbi | Q92556 |
PeptideAtlasi | Q92556 |
PRIDEi | Q92556 |
ProteomicsDBi | 75312 [Q92556-1] 75313 [Q92556-2] 75314 [Q92556-3] |
Protocols and materials databases
Antibodypediai | 12940, 232 antibodies from 34 providers |
DNASUi | 9844 |
Genome annotation databases
Ensembli | ENST00000310758; ENSP00000312185; ENSG00000155849 ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2] ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2] ENST00000442504; ENSP00000406952; ENSG00000155849 ENST00000448602; ENSP00000394458; ENSG00000155849 |
GeneIDi | 9844 |
KEGGi | hsa:9844 |
MANE-Selecti | ENST00000310758.9; ENSP00000312185.4; NM_014800.11; NP_055615.8 |
UCSCi | uc003tfi.3, human [Q92556-1] |
Organism-specific databases
CTDi | 9844 |
DisGeNETi | 9844 |
GeneCardsi | ELMO1 |
HGNCi | HGNC:16286, ELMO1 |
HPAi | ENSG00000155849, Tissue enhanced (brain) |
MIMi | 606420, gene |
neXtProti | NX_Q92556 |
OpenTargetsi | ENSG00000155849 |
PharmGKBi | PA27754 |
VEuPathDBi | HostDB:ENSG00000155849 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2999, Eukaryota |
GeneTreei | ENSGT00940000155994 |
HOGENOMi | CLU_097960_0_0_1 |
InParanoidi | Q92556 |
OMAi | WESHARP |
PhylomeDBi | Q92556 |
TreeFami | TF312966 |
Enzyme and pathway databases
PathwayCommonsi | Q92556 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q92556 |
SIGNORi | Q92556 |
Miscellaneous databases
BioGRID-ORCSi | 9844, 7 hits in 1045 CRISPR screens |
ChiTaRSi | ELMO1, human |
EvolutionaryTracei | Q92556 |
GeneWikii | ELMO1 |
GenomeRNAii | 9844 |
Pharosi | Q92556, Tbio |
PROi | PR:Q92556 |
RNActi | Q92556, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155849, Expressed in corpus callosum and 215 other tissues |
ExpressionAtlasi | Q92556, baseline and differential |
Genevisiblei | Q92556, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR030715, ELMO1 IPR024574, ELMO_ARM IPR006816, ELMO_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR12771:SF23, PTHR12771:SF23, 1 hit |
Pfami | View protein in Pfam PF11841, DUF3361, 1 hit PF04727, ELMO_CED12, 1 hit PF16457, PH_12, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51335, ELMO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ELMO1_HUMAN | |
Accessioni | Q92556Primary (citable) accession number: Q92556 Secondary accession number(s): A4D1X6 Q9H0I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 16, 2003 | |
Last modified: | February 23, 2022 | |
This is version 200 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references