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UniProtKB - Q92556 (ELMO1_HUMAN)

Entry version 194 (07 Oct 2020)
Sequence version 2 (16 May 2003)
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Protein

Engulfment and cell motility protein 1

Gene

ELMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rac GTPase binding Source: GO_Central
  • SH3 domain binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Phagocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92556

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-164944, Nef and signal transduction
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9664422, FCGR3A-mediated phagocytosis

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92556

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Engulfment and cell motility protein 1
Alternative name(s):
Protein ced-12 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELMO1
Synonyms:KIAA0281
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000155849.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:16286, ELMO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606420, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92556

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9844

Open Targets

More...OpenTargetsi		ENSG00000155849

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27754

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92556, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELMO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		30923321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001537121 – 727Engulfment and cell motility protein 1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Phosphotyrosine; by HCK1 Publication1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei216Phosphotyrosine; by HCK1 Publication1
Modified residuei344PhosphoserineBy similarity1
Modified residuei395Phosphotyrosine; by HCK1 Publication1
Modified residuei511Phosphotyrosine; by HCK1 Publication1
Modified residuei720Phosphotyrosine; by HCK1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by HCK.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1759

Encyclopedia of Proteome Dynamics

More...EPDi		Q92556

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92556

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92556

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92556

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92556

PeptideAtlas

More...PeptideAtlasi		Q92556

PRoteomics IDEntifications database

More...PRIDEi		Q92556

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75312 [Q92556-1]
75313 [Q92556-2]
75314 [Q92556-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92556

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q92556

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92556

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with a higher expression in the spleen and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155849, Expressed in corpus callosum and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92556, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92556, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155849, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADGRB1 (By similarity).

Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site.

Part of a complex with DOCK1 and RAC1.

Part of a complex with DOCK1 and CRK isoform CRK-II.

Interacts with PLEKHG6.

Interacts with HCK (via SH3 domain).

Interacts with ADGRB3 (PubMed:24567399).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115180, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92556

Database of interacting proteins

More...DIPi		DIP-31095N

Protein interaction database and analysis system

More...IntActi		Q92556, 20 interactors

Molecular INTeraction database

More...MINTi		Q92556

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312185

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92556, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92556

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92556

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 492ELMOPROSITE-ProRule annotationAdd BLAST174
Domaini555 – 676PHAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi707 – 714SH3-binding8

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2999, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155994

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_097960_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92556

KEGG Orthology (KO)

More...KOi		K12366

Identification of Orthologs from Complete Genome Data

More...OMAi		WESHARP

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92556

TreeFam database of animal gene trees

More...TreeFami		TF312966

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024574, DUF3361
IPR030715, ELMO1
IPR006816, ELMO_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR12771:SF23, PTHR12771:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11841, DUF3361, 1 hit
PF04727, ELMO_CED12, 1 hit
PF16457, PH_12, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51335, ELMO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92556-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA 
        60         70         80         90        100
LQHADSSNFY ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK 
       110        120        130        140        150
LEALKDLASL SRDVTFAQEF INLDGISLLT QMVESGTERY QKLQKIMKPC 
       160        170        180        190        200
FGDMLSFTLT AFVELMDHGI VSWDTFSVAF IKKIASFVNK SAIDISILQR 
       210        220        230        240        250
SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ TYTIAVINAL 
       260        270        280        290        300
FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL 
       310        320        330        340        350
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS 
       360        370        380        390        400
MYTRDYKKLG FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL 
       410        420        430        440        450
ENSSREDKHE CPFGRSSIEL TKMLCEILKV GELPSETCND FHPMFFTHDR 
       460        470        480        490        500
SFEEFFCICI QLLNKTWKEM RATSEDFNKV MQVVKEQVMR ALTTKPSSLD 
       510        520        530        540        550
QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI QPEILELIKQ 
       560        570        580        590        600
QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP 
       610        620        630        640        650
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC 
       660        670        680        690        700
QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD 
       710        720 
LENIQIPDAP PPIPKEPSNY DFVYDCN
Length:727
Mass (Da):83,829
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i053DCA73D2B0A4C6
GO
Isoform 2 (identifier: Q92556-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: Missing.

Show »
Length:247
Mass (Da):28,742
Checksum:iD02BCEC8D8A4383F
GO
Isoform 3 (identifier: Q92556-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-362: VLTFNLLEDR...TRDYKKLGFI → MSEHQKEQTL...GGETNAYCQM

Show »
Length:429
Mass (Da):49,915
Checksum:i36C411CBBE5CA12B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3P3H7C3P3_HUMAN
Engulfment and cell motility protei...
ELMO1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIW2C9JIW2_HUMAN
Engulfment and cell motility protei...
ELMO1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZR8C9IZR8_HUMAN
Engulfment and cell motility protei...
ELMO1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0N5H7C0N5_HUMAN
Engulfment and cell motility protei...
ELMO1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0S6H7C0S6_HUMAN
Engulfment and cell motility protei...
ELMO1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JB20C9JB20_HUMAN
Engulfment and cell motility protei...
ELMO1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5X3C9J5X3_HUMAN
Engulfment and cell motility protei...
ELMO1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13397 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti716E → A in CAB66721 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065824362I → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074801 – 480Missing in isoform 2. 2 PublicationsAdd BLAST480
Alternative sequenceiVSP_0385501 – 298Missing in isoform 3. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_038551299 – 362VLTFN…KLGFI → MSEHQKEQTLDTPSLRTVTL TVRVHGFILEVSKTKNPPIP DTFWPPRWDHRPSPGGETNA YCQM in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF398885 mRNA Translation: AAL14466.1
D87457 mRNA Translation: BAA13397.2 Different initiation.
AL136787 mRNA Translation: CAB66721.1
AK126565 mRNA Translation: BAC86597.1
CH236951 Genomic DNA Translation: EAL23979.1
CH471073 Genomic DNA Translation: EAW94076.1
BC003051 mRNA Translation: AAH03051.1
BC064635 mRNA Translation: AAH64635.1
BC077074 mRNA Translation: AAH77074.1
BC114341 mRNA Translation: AAI14342.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5449.1 [Q92556-1]
CCDS5450.1 [Q92556-2]

NCBI Reference Sequences

More...RefSeqi		NP_001034548.1, NM_001039459.2 [Q92556-2]
NP_001193409.1, NM_001206480.2 [Q92556-1]
NP_001193411.1, NM_001206482.1 [Q92556-1]
NP_055615.8, NM_014800.10 [Q92556-1]
NP_569709.1, NM_130442.3 [Q92556-2]
XP_005249976.1, XM_005249919.2 [Q92556-1]
XP_006715868.1, XM_006715805.1 [Q92556-1]
XP_011513956.1, XM_011515654.1 [Q92556-1]
XP_016868327.1, XM_017012838.1
XP_016868328.1, XM_017012839.1 [Q92556-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9844

UCSC genome browser

More...UCSCi		uc003tfi.3, human [Q92556-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398885 mRNA Translation: AAL14466.1
D87457 mRNA Translation: BAA13397.2 Different initiation.
AL136787 mRNA Translation: CAB66721.1
AK126565 mRNA Translation: BAC86597.1
CH236951 Genomic DNA Translation: EAL23979.1
CH471073 Genomic DNA Translation: EAW94076.1
BC003051 mRNA Translation: AAH03051.1
BC064635 mRNA Translation: AAH64635.1
BC077074 mRNA Translation: AAH77074.1
BC114341 mRNA Translation: AAI14342.1
CCDSiCCDS5449.1 [Q92556-1]
CCDS5450.1 [Q92556-2]
RefSeqiNP_001034548.1, NM_001039459.2 [Q92556-2]
NP_001193409.1, NM_001206480.2 [Q92556-1]
NP_001193411.1, NM_001206482.1 [Q92556-1]
NP_055615.8, NM_014800.10 [Q92556-1]
NP_569709.1, NM_130442.3 [Q92556-2]
XP_005249976.1, XM_005249919.2 [Q92556-1]
XP_006715868.1, XM_006715805.1 [Q92556-1]
XP_011513956.1, XM_011515654.1 [Q92556-1]
XP_016868327.1, XM_017012838.1
XP_016868328.1, XM_017012839.1 [Q92556-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A697-722[»]
2VSZX-ray2.30A/B532-675[»]
3A98X-ray2.10B/D532-727[»]
6JPPNMR-A1-113[»]
SMRiQ92556
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115180, 26 interactors
CORUMiQ92556
DIPiDIP-31095N
IntActiQ92556, 20 interactors
MINTiQ92556
STRINGi9606.ENSP00000312185

PTM databases

iPTMnetiQ92556
MetOSiteiQ92556
PhosphoSitePlusiQ92556

Polymorphism and mutation databases

BioMutaiELMO1
DMDMi30923321

Proteomic databases

CPTACiCPTAC-1759
EPDiQ92556
jPOSTiQ92556
MassIVEiQ92556
MaxQBiQ92556
PaxDbiQ92556
PeptideAtlasiQ92556
PRIDEiQ92556
ProteomicsDBi75312 [Q92556-1]
75313 [Q92556-2]
75314 [Q92556-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12940, 220 antibodies

The DNASU plasmid repository

More...DNASUi		9844

Genome annotation databases

EnsembliENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]
GeneIDi9844
KEGGihsa:9844
UCSCiuc003tfi.3, human [Q92556-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9844
DisGeNETi9844
EuPathDBiHostDB:ENSG00000155849.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		ELMO1
HGNCiHGNC:16286, ELMO1
HPAiENSG00000155849, Tissue enhanced (brain)
MIMi606420, gene
neXtProtiNX_Q92556
OpenTargetsiENSG00000155849
PharmGKBiPA27754

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2999, Eukaryota
GeneTreeiENSGT00940000155994
HOGENOMiCLU_097960_0_0_1
InParanoidiQ92556
KOiK12366
OMAiWESHARP
PhylomeDBiQ92556
TreeFamiTF312966

Enzyme and pathway databases

PathwayCommonsiQ92556
ReactomeiR-HSA-164944, Nef and signal transduction
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-9664422, FCGR3A-mediated phagocytosis
SIGNORiQ92556

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9844, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ELMO1, human
EvolutionaryTraceiQ92556

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ELMO1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9844
PharosiQ92556, Tbio

Protein Ontology

More...PROi		PR:Q92556
RNActiQ92556, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155849, Expressed in corpus callosum and 215 other tissues
ExpressionAtlasiQ92556, baseline and differential
GenevisibleiQ92556, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024574, DUF3361
IPR030715, ELMO1
IPR006816, ELMO_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR12771:SF23, PTHR12771:SF23, 1 hit
PfamiView protein in Pfam
PF11841, DUF3361, 1 hit
PF04727, ELMO_CED12, 1 hit
PF16457, PH_12, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335, ELMO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELMO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92556
Secondary accession number(s): A4D1X6
, Q29R79, Q6ZTJ0, Q96PB0, Q9H0I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: October 7, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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