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Protein

Engulfment and cell motility protein 1

Gene

ELMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.2 Publications

GO - Molecular functioni

  • SH3 domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Phagocytosis

Enzyme and pathway databases

ReactomeiR-HSA-164944 Nef and signal transduction
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SIGNORiQ92556

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 1
Alternative name(s):
Protein ced-12 homolog
Gene namesi
Name:ELMO1
Synonyms:KIAA0281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000155849.15
HGNCiHGNC:16286 ELMO1
MIMi606420 gene
neXtProtiNX_Q92556

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9844
OpenTargetsiENSG00000155849
PharmGKBiPA27754

Polymorphism and mutation databases

BioMutaiELMO1
DMDMi30923321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537121 – 727Engulfment and cell motility protein 1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphotyrosine; by HCK1 Publication1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei216Phosphotyrosine; by HCK1 Publication1
Modified residuei344PhosphoserineBy similarity1
Modified residuei395Phosphotyrosine; by HCK1 Publication1
Modified residuei511Phosphotyrosine; by HCK1 Publication1
Modified residuei720Phosphotyrosine; by HCK1 Publication1

Post-translational modificationi

Phosphorylated by HCK.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92556
MaxQBiQ92556
PaxDbiQ92556
PeptideAtlasiQ92556
PRIDEiQ92556
ProteomicsDBi75312
75313 [Q92556-2]
75314 [Q92556-3]

PTM databases

iPTMnetiQ92556
PhosphoSitePlusiQ92556

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in the spleen and placenta.

Gene expression databases

BgeeiENSG00000155849 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExiHS_ELMO1
ExpressionAtlasiQ92556 baseline and differential
GenevisibleiQ92556 HS

Interactioni

Subunit structurei

Interacts with ADGRB1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Interacts with ADGRB3 (PubMed:24567399).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115180, 23 interactors
CORUMiQ92556
DIPiDIP-31095N
IntActiQ92556, 11 interactors
MINTiQ92556
STRINGi9606.ENSP00000312185

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92556
SMRiQ92556
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92556

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 492ELMOPROSITE-ProRule annotationAdd BLAST174
Domaini555 – 676PHAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi707 – 714SH3-binding8

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
HOVERGENiHBG051463
InParanoidiQ92556
KOiK12366
OMAiINVCRPA
OrthoDBiEOG091G03JJ
PhylomeDBiQ92556
TreeFamiTF312966

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030715 ELMO1
IPR006816 ELMO_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12771:SF23 PTHR12771:SF23, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
PF04727 ELMO_CED12, 1 hit
PF16457 PH_12, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92556-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA
60 70 80 90 100
LQHADSSNFY ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK
110 120 130 140 150
LEALKDLASL SRDVTFAQEF INLDGISLLT QMVESGTERY QKLQKIMKPC
160 170 180 190 200
FGDMLSFTLT AFVELMDHGI VSWDTFSVAF IKKIASFVNK SAIDISILQR
210 220 230 240 250
SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ TYTIAVINAL
260 270 280 290 300
FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL
310 320 330 340 350
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS
360 370 380 390 400
MYTRDYKKLG FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL
410 420 430 440 450
ENSSREDKHE CPFGRSSIEL TKMLCEILKV GELPSETCND FHPMFFTHDR
460 470 480 490 500
SFEEFFCICI QLLNKTWKEM RATSEDFNKV MQVVKEQVMR ALTTKPSSLD
510 520 530 540 550
QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI QPEILELIKQ
560 570 580 590 600
QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP
610 620 630 640 650
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC
660 670 680 690 700
QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD
710 720
LENIQIPDAP PPIPKEPSNY DFVYDCN
Length:727
Mass (Da):83,829
Last modified:May 16, 2003 - v2
Checksum:i053DCA73D2B0A4C6
GO
Isoform 2 (identifier: Q92556-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: Missing.

Show »
Length:247
Mass (Da):28,742
Checksum:iD02BCEC8D8A4383F
GO
Isoform 3 (identifier: Q92556-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-362: VLTFNLLEDR...TRDYKKLGFI → MSEHQKEQTL...GGETNAYCQM

Show »
Length:429
Mass (Da):49,915
Checksum:i36C411CBBE5CA12B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JIW2C9JIW2_HUMAN
Engulfment and cell motility protei...
ELMO1
149Annotation score:
H7C0S6H7C0S6_HUMAN
Engulfment and cell motility protei...
ELMO1
182Annotation score:
C9IZR8C9IZR8_HUMAN
Engulfment and cell motility protei...
ELMO1
167Annotation score:
C9JB20C9JB20_HUMAN
Engulfment and cell motility protei...
ELMO1
81Annotation score:
H7C3P3H7C3P3_HUMAN
Engulfment and cell motility protei...
ELMO1
193Annotation score:
H7C0N5H7C0N5_HUMAN
Engulfment and cell motility protei...
ELMO1
124Annotation score:
C9J5X3C9J5X3_HUMAN
Engulfment and cell motility protei...
ELMO1
59Annotation score:

Sequence cautioni

The sequence BAA13397 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti716E → A in CAB66721 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065824362I → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0074801 – 480Missing in isoform 2. 2 PublicationsAdd BLAST480
Alternative sequenceiVSP_0385501 – 298Missing in isoform 3. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_038551299 – 362VLTFN…KLGFI → MSEHQKEQTLDTPSLRTVTL TVRVHGFILEVSKTKNPPIP DTFWPPRWDHRPSPGGETNA YCQM in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398885 mRNA Translation: AAL14466.1
D87457 mRNA Translation: BAA13397.2 Different initiation.
AL136787 mRNA Translation: CAB66721.1
AK126565 mRNA Translation: BAC86597.1
CH236951 Genomic DNA Translation: EAL23979.1
CH471073 Genomic DNA Translation: EAW94076.1
BC003051 mRNA Translation: AAH03051.1
BC064635 mRNA Translation: AAH64635.1
BC077074 mRNA Translation: AAH77074.1
BC114341 mRNA Translation: AAI14342.1
CCDSiCCDS5449.1 [Q92556-1]
CCDS5450.1 [Q92556-2]
RefSeqiNP_001034548.1, NM_001039459.2 [Q92556-2]
NP_001193409.1, NM_001206480.2 [Q92556-1]
NP_001193411.1, NM_001206482.1 [Q92556-1]
NP_055615.8, NM_014800.10 [Q92556-1]
NP_569709.1, NM_130442.3 [Q92556-2]
XP_005249976.1, XM_005249919.2 [Q92556-1]
XP_006715868.1, XM_006715805.1 [Q92556-1]
XP_011513956.1, XM_011515654.1 [Q92556-1]
XP_016868327.1, XM_017012838.1
XP_016868328.1, XM_017012839.1 [Q92556-1]
UniGeneiHs.434989
Hs.656638

Genome annotation databases

EnsembliENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]
GeneIDi9844
KEGGihsa:9844
UCSCiuc003tfi.3 human [Q92556-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398885 mRNA Translation: AAL14466.1
D87457 mRNA Translation: BAA13397.2 Different initiation.
AL136787 mRNA Translation: CAB66721.1
AK126565 mRNA Translation: BAC86597.1
CH236951 Genomic DNA Translation: EAL23979.1
CH471073 Genomic DNA Translation: EAW94076.1
BC003051 mRNA Translation: AAH03051.1
BC064635 mRNA Translation: AAH64635.1
BC077074 mRNA Translation: AAH77074.1
BC114341 mRNA Translation: AAI14342.1
CCDSiCCDS5449.1 [Q92556-1]
CCDS5450.1 [Q92556-2]
RefSeqiNP_001034548.1, NM_001039459.2 [Q92556-2]
NP_001193409.1, NM_001206480.2 [Q92556-1]
NP_001193411.1, NM_001206482.1 [Q92556-1]
NP_055615.8, NM_014800.10 [Q92556-1]
NP_569709.1, NM_130442.3 [Q92556-2]
XP_005249976.1, XM_005249919.2 [Q92556-1]
XP_006715868.1, XM_006715805.1 [Q92556-1]
XP_011513956.1, XM_011515654.1 [Q92556-1]
XP_016868327.1, XM_017012838.1
XP_016868328.1, XM_017012839.1 [Q92556-1]
UniGeneiHs.434989
Hs.656638

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A697-722[»]
2VSZX-ray2.30A/B532-675[»]
3A98X-ray2.10B/D532-727[»]
ProteinModelPortaliQ92556
SMRiQ92556
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115180, 23 interactors
CORUMiQ92556
DIPiDIP-31095N
IntActiQ92556, 11 interactors
MINTiQ92556
STRINGi9606.ENSP00000312185

PTM databases

iPTMnetiQ92556
PhosphoSitePlusiQ92556

Polymorphism and mutation databases

BioMutaiELMO1
DMDMi30923321

Proteomic databases

EPDiQ92556
MaxQBiQ92556
PaxDbiQ92556
PeptideAtlasiQ92556
PRIDEiQ92556
ProteomicsDBi75312
75313 [Q92556-2]
75314 [Q92556-3]

Protocols and materials databases

DNASUi9844
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]
GeneIDi9844
KEGGihsa:9844
UCSCiuc003tfi.3 human [Q92556-1]

Organism-specific databases

CTDi9844
DisGeNETi9844
EuPathDBiHostDB:ENSG00000155849.15
GeneCardsiELMO1
HGNCiHGNC:16286 ELMO1
MIMi606420 gene
neXtProtiNX_Q92556
OpenTargetsiENSG00000155849
PharmGKBiPA27754
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
HOVERGENiHBG051463
InParanoidiQ92556
KOiK12366
OMAiINVCRPA
OrthoDBiEOG091G03JJ
PhylomeDBiQ92556
TreeFamiTF312966

Enzyme and pathway databases

ReactomeiR-HSA-164944 Nef and signal transduction
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SIGNORiQ92556

Miscellaneous databases

ChiTaRSiELMO1 human
EvolutionaryTraceiQ92556
GeneWikiiELMO1
GenomeRNAii9844
PROiPR:Q92556
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155849 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExiHS_ELMO1
ExpressionAtlasiQ92556 baseline and differential
GenevisibleiQ92556 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030715 ELMO1
IPR006816 ELMO_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12771:SF23 PTHR12771:SF23, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
PF04727 ELMO_CED12, 1 hit
PF16457 PH_12, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELMO1_HUMAN
AccessioniPrimary (citable) accession number: Q92556
Secondary accession number(s): A4D1X6
, Q29R79, Q6ZTJ0, Q96PB0, Q9H0I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: November 7, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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