UniProtKB - Q92556 (ELMO1_HUMAN)

BLAST

>sp|Q92556|ELMO1_HUMAN Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFY
ITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEF
INLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAF
IKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQ
TYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVL
TFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLG
FINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIEL
TKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKV
MQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKI
QPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP
HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKH
EYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNY
DFVYDCN

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History
Entry version 180 (07 Nov 2018)
Sequence version 2 (16 May 2003)
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Protein

Engulfment and cell motility protein 1

Gene

ELMO1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.2 Publications

GO - Molecular functionⁱ

SH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12029088

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: UniProtKB
Inferred from genetic interactionⁱ
- 11595183
apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11595183
cell migration Source: InterPro
cell motility
Source: UniProtKB
Inferred from genetic interactionⁱ
- 11595183
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
phagocytosis, engulfment
Source: UniProtKB
Inferred from genetic interactionⁱ
- 11595183
Rac protein signal transduction
Source: UniProtKB
Inferred from genetic interactionⁱ
- 11595183
regulation of defense response to virus by virus Source: Reactome
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Phagocytosis

Biological process

Apoptosis, Phagocytosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-164944 Nef and signal transduction R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SIGNORⁱ	Q92556

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Engulfment and cell motility protein 1 Alternative name(s): Protein ced-12 homolog
Gene namesⁱ	Name:ELMO1 Synonyms:KIAA0281
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155849.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16286 ELMO1
MIMⁱ	606420 gene
neXtProtⁱ	NX_Q92556

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9844
Open Targets More...OpenTargetsⁱ	ENSG00000155849
PharmGKBⁱ	PA27754

Polymorphism and mutation databases

BioMutaⁱ	ELMO1
DMDMⁱ	30923321

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153712	1 – 727	Engulfment and cell motility protein 1Add BLAST		727

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	Phosphotyrosine; by HCK1 Publication	1
Modified residueⁱ	100	N6-acetyllysineCombined sources	1
Modified residueⁱ	105	N6-acetyllysineCombined sources	1
Modified residueⁱ	216	Phosphotyrosine; by HCK1 Publication	1
Modified residueⁱ	344	PhosphoserineBy similarity	1
Modified residueⁱ	395	Phosphotyrosine; by HCK1 Publication	1
Modified residueⁱ	511	Phosphotyrosine; by HCK1 Publication	1
Modified residueⁱ	720	Phosphotyrosine; by HCK1 Publication	1

Post-translational modificationⁱ

Phosphorylated by HCK.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q92556
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92556
PaxDbⁱ	Q92556
PeptideAtlas More...PeptideAtlasⁱ	Q92556
PRIDEⁱ	Q92556
ProteomicsDBⁱ	75312 75313 [Q92556-2] 75314 [Q92556-3]

PTM databases

iPTMnetⁱ	Q92556
PhosphoSitePlusⁱ	Q92556

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with a higher expression in the spleen and placenta.

Gene expression databases

Bgeeⁱ	ENSG00000155849 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ELMO1
ExpressionAtlasⁱ	Q92556 baseline and differential
Genevisibleⁱ	Q92556 HS

Interactionⁱ

Subunit structureⁱ

Interacts with ADGRB1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Interacts with ADGRB3 (PubMed:24567399).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ADGRB1	O14514	2	EBI-15668002,EBI-1995178
Adgrb1	Q3UHD1	9	EBI-15668002,EBI-911280	From Mus musculus.
DOCK1	Q14185	16	EBI-346417,EBI-446740
HCK	P08631	4	EBI-346417,EBI-346340
RHOG	P84095	3	EBI-346417,EBI-446579
TRIM54	Q9BYV2	3	EBI-346417,EBI-2130429
ZNF398	Q8TD17	3	EBI-346417,EBI-8643207

GO - Molecular functionⁱ

SH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12029088

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115180, 23 interactors
CORUMⁱ	Q92556
Database of interacting proteins More...DIPⁱ	DIP-31095N
IntActⁱ	Q92556, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q92556
STRINGⁱ	9606.ENSP00000312185

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	532 – 558	Combined sources	27
Beta strandⁱ	560 – 563	Combined sources	4
Beta strandⁱ	569 – 571	Combined sources	3
Beta strandⁱ	573 – 579	Combined sources	7
Beta strandⁱ	583 – 590	Combined sources	8
Beta strandⁱ	607 – 609	Combined sources	3
Helixⁱ	610 – 612	Combined sources	3
Beta strandⁱ	613 – 618	Combined sources	6
Helixⁱ	619 – 621	Combined sources	3
Helixⁱ	623 – 625	Combined sources	3
Helixⁱ	638 – 640	Combined sources	3
Beta strandⁱ	641 – 646	Combined sources	6
Turnⁱ	647 – 649	Combined sources	3
Beta strandⁱ	650 – 655	Combined sources	6
Helixⁱ	659 – 672	Combined sources	14
Helixⁱ	680 – 697	Combined sources	18
Helixⁱ	699 – 701	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92556
SMRⁱ	Q92556
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92556

EvolutionaryTraceⁱ

Q92556

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	319 – 492	ELMOPROSITE-ProRule annotationAdd BLAST		174
Domainⁱ	555 – 676	PHAdd BLAST		122

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	707 – 714	SH3-binding		8

Keywords - Domainⁱ

SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG2999 Eukaryota ENOG410XPKN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014155
HOGENOMⁱ	HOG000230985
HOVERGENⁱ	HBG051463
InParanoidⁱ	Q92556
KEGG Orthology (KO) More...KOⁱ	K12366
OMAⁱ	INVCRPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03JJ
PhylomeDBⁱ	Q92556
TreeFamⁱ	TF312966

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR024574 DUF3361 IPR030715 ELMO1 IPR006816 ELMO_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR12771:SF23 PTHR12771:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11841 DUF3361, 1 hit PF04727 ELMO_CED12, 1 hit PF16457 PH_12, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51335 ELMO, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92556-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA 
        60         70         80         90        100
LQHADSSNFY ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK 
       110        120        130        140        150
LEALKDLASL SRDVTFAQEF INLDGISLLT QMVESGTERY QKLQKIMKPC 
       160        170        180        190        200
FGDMLSFTLT AFVELMDHGI VSWDTFSVAF IKKIASFVNK SAIDISILQR 
       210        220        230        240        250
SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ TYTIAVINAL 
       260        270        280        290        300
FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL 
       310        320        330        340        350
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS 
       360        370        380        390        400
MYTRDYKKLG FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL 
       410        420        430        440        450
ENSSREDKHE CPFGRSSIEL TKMLCEILKV GELPSETCND FHPMFFTHDR 
       460        470        480        490        500
SFEEFFCICI QLLNKTWKEM RATSEDFNKV MQVVKEQVMR ALTTKPSSLD 
       510        520        530        540        550
QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI QPEILELIKQ 
       560        570        580        590        600
QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP 
       610        620        630        640        650
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC 
       660        670        680        690        700
QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD 
       710        720 
LENIQIPDAP PPIPKEPSNY DFVYDCN

Length:727

Mass (Da):83,829

Last modified:May 16, 2003 - v2

Checksum:ⁱ053DCA73D2B0A4C6

Isoform 2 (identifier: Q92556-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-480: Missing.

« Hide

        10         20         30         40         50
MQVVKEQVMR ALTTKPSSLD QFKSKLQNLS YTEILKIRQS ERMNQEDFQS 
        60         70         80         90        100
RPILELKEKI QPEILELIKQ QRLNRLVEGT CFRKLNARRR QDKFWYCRLS 
       110        120        130        140        150
PNHKVLHYGD LEESPQGEVP HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA 
       160        170        180        190        200
LKQNKEVLEL AFSILYDSNC QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD 
       210        220        230        240 
LTRNDLDTLL SMEIKLRLLD LENIQIPDAP PPIPKEPSNY DFVYDCN

Show »

Length:247

Mass (Da):28,742

Checksum:ⁱD02BCEC8D8A4383F

Isoform 3 (identifier: Q92556-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-298: Missing.
299-362: VLTFNLLEDR...TRDYKKLGFI → MSEHQKEQTL...GGETNAYCQM

« Hide

        10         20         30         40         50
MSEHQKEQTL DTPSLRTVTL TVRVHGFILE VSKTKNPPIP DTFWPPRWDH 
        60         70         80         90        100
RPSPGGETNA YCQMNHVNPA MDFTQTPPGM LALDNMLYFA KHHQDAYIRI 
       110        120        130        140        150
VLENSSREDK HECPFGRSSI ELTKMLCEIL KVGELPSETC NDFHPMFFTH 
       160        170        180        190        200
DRSFEEFFCI CIQLLNKTWK EMRATSEDFN KVMQVVKEQV MRALTTKPSS 
       210        220        230        240        250
LDQFKSKLQN LSYTEILKIR QSERMNQEDF QSRPILELKE KIQPEILELI 
       260        270        280        290        300
KQQRLNRLVE GTCFRKLNAR RRQDKFWYCR LSPNHKVLHY GDLEESPQGE 
       310        320        330        340        350
VPHDSLQDKL PVADIKAVVT GKDCPHMKEK GALKQNKEVL ELAFSILYDS 
       360        370        380        390        400
NCQLNFIAPD KHEYCIWTDG LNALLGKDMM SDLTRNDLDT LLSMEIKLRL 
       410        420 
LDLENIQIPD APPPIPKEPS NYDFVYDCN

Show »

Length:429

Mass (Da):49,915

Checksum:ⁱ36C411CBBE5CA12B

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JIW2	C9JIW2_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	149	Annotation score:
H7C0S6	H7C0S6_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	182	Annotation score:
C9IZR8	C9IZR8_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	167	Annotation score:
C9JB20	C9JB20_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	81	Annotation score:
H7C3P3	H7C3P3_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	193	Annotation score:
H7C0N5	H7C0N5_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	124	Annotation score:
C9J5X3	C9J5X3_HUMAN	Engulfment and cell motility protei... Engulfment and cell motility protein 1	ELMO1	59	Annotation score:

Sequence cautionⁱ

The sequence BAA13397 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	716	E → A in CAB66721 (PubMed:11230166).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065824	362	I → S1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_007480	1 – 480	Missing in isoform 2. 2 PublicationsAdd BLAST	480
Alternative sequenceⁱVSP_038550	1 – 298	Missing in isoform 3. 1 PublicationAdd BLAST	298
Alternative sequenceⁱVSP_038551	299 – 362	VLTFN…KLGFI → MSEHQKEQTLDTPSLRTVTL TVRVHGFILEVSKTKNPPIP DTFWPPRWDHRPSPGGETNA YCQM in isoform 3. 1 PublicationAdd BLAST	64

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF398885 mRNA Translation: AAL14466.1 D87457 mRNA Translation: BAA13397.2 Different initiation. AL136787 mRNA Translation: CAB66721.1 AK126565 mRNA Translation: BAC86597.1 CH236951 Genomic DNA Translation: EAL23979.1 CH471073 Genomic DNA Translation: EAW94076.1 BC003051 mRNA Translation: AAH03051.1 BC064635 mRNA Translation: AAH64635.1 BC077074 mRNA Translation: AAH77074.1 BC114341 mRNA Translation: AAI14342.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5449.1 [Q92556-1] CCDS5450.1 [Q92556-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034548.1, NM_001039459.2 [Q92556-2] NP_001193409.1, NM_001206480.2 [Q92556-1] NP_001193411.1, NM_001206482.1 [Q92556-1] NP_055615.8, NM_014800.10 [Q92556-1] NP_569709.1, NM_130442.3 [Q92556-2] XP_005249976.1, XM_005249919.2 [Q92556-1] XP_006715868.1, XM_006715805.1 [Q92556-1] XP_011513956.1, XM_011515654.1 [Q92556-1] XP_016868327.1, XM_017012838.1 XP_016868328.1, XM_017012839.1 [Q92556-1]
UniGeneⁱ	Hs.434989 Hs.656638

Genome annotation databases

Ensemblⁱ	ENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1] ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2] ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2] ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1] ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]
GeneIDⁱ	9844
KEGGⁱ	hsa:9844
UCSC genome browser More...UCSCⁱ	uc003tfi.3 human [Q92556-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92556	Engulfment and cell motility 1 (Ced-12 homolog, C. elegans)		HUMAN		727	UniRef100_Q92556
ELMO1 isoform 1		PANTR		727
Engulfment and cell motility 1		AOTNA		727
Engulfment and cell motility 1		CALJA		727
Engulfment and cell motility 1		SAIBB		727
+2
Q92556-2	Engulfment and cell motility 1		PANTR		769	UniRef100_A0A2I3S6R6
ELMO1 isoform 15		PONAB		247
Uncharacterized protein		CALJA		247
engulfment and cell motility protein 1-like isoform X2		TARSY		247
Uncharacterized protein		OTOGA		247
+10

Protein	Similar proteins		Species	Score	Length	Source
Q92556	Engulfment and cell motility protein 1		MOUSE		727	UniRef90_Q92556
Engulfment and cell motility 1 (Ced-12 homolog, C. elegans)		HUMAN		727
ELMO1 isoform 1		PANTR		727
Engulfment and cell motility 1		AOTNA		727
Engulfment and cell motility 1		CALJA		727
+338
Q92556-2	Engulfment and cell motility 1		PANTR		769	UniRef90_A0A2I3S6R6
ELMO1 isoform 15		PONAB		247
Uncharacterized protein		CALJA		247
engulfment and cell motility protein 1-like isoform X2		TARSY		247
Uncharacterized protein		OTOGA		247
+32
Q92556-3	Engulfment and cell motility protein 1		FUKDA		345	UniRef90_Q92556-3
UPI0005589849		black rockcod		349

Protein	Similar proteins		Species	Score	Length	Source
Q92556	Engulfment and cell motility protein 1		MOUSE		727	UniRef50_Q92556
Engulfment and cell motility protein 2		BOVIN		720
Engulfment and cell motility protein 2		HUMAN		720
Engulfment and cell motility protein 2		PONAB		720
ELMO1 isoform 1		PANTR		727
+966
Q92556-2	Engulfment and cell motility 1		PANTR		769	UniRef50_A0A2I3S6R6
ELMO1 isoform 15		PONAB		247
Uncharacterized protein		CALJA		247
engulfment and cell motility protein 1-like isoform X2		TARSY		247
Uncharacterized protein		OTOGA		247
+34
Q92556-3	Engulfment and cell motility protein 1		FUKDA		345	UniRef50_Q92556-3
Engulfment and cell motility protein 1 (Fragment)		Stegodyphus mimosarum		347
Uncharacterized protein (Fragment)		ONCMY		367
Im:7143453 protein (Fragment)		DANRE		360
Uncharacterized protein (Fragment)		Homalodisca liturata		360
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF398885 mRNA Translation: AAL14466.1 D87457 mRNA Translation: BAA13397.2 Different initiation. AL136787 mRNA Translation: CAB66721.1 AK126565 mRNA Translation: BAC86597.1 CH236951 Genomic DNA Translation: EAL23979.1 CH471073 Genomic DNA Translation: EAW94076.1 BC003051 mRNA Translation: AAH03051.1 BC064635 mRNA Translation: AAH64635.1 BC077074 mRNA Translation: AAH77074.1 BC114341 mRNA Translation: AAI14342.1
CCDSⁱ	CCDS5449.1 [Q92556-1] CCDS5450.1 [Q92556-2]
RefSeqⁱ	NP_001034548.1, NM_001039459.2 [Q92556-2] NP_001193409.1, NM_001206480.2 [Q92556-1] NP_001193411.1, NM_001206482.1 [Q92556-1] NP_055615.8, NM_014800.10 [Q92556-1] NP_569709.1, NM_130442.3 [Q92556-2] XP_005249976.1, XM_005249919.2 [Q92556-1] XP_006715868.1, XM_006715805.1 [Q92556-1] XP_011513956.1, XM_011515654.1 [Q92556-1] XP_016868327.1, XM_017012838.1 XP_016868328.1, XM_017012839.1 [Q92556-1]
UniGeneⁱ	Hs.434989 Hs.656638

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RQR	NMR	-	A	697-722	[»]
	2VSZ	X-ray	2.30	A/B	532-675	[»]
	3A98	X-ray	2.10	B/D	532-727	[»]
ProteinModelPortalⁱ	Q92556
SMRⁱ	Q92556
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115180, 23 interactors
CORUMⁱ	Q92556
DIPⁱ	DIP-31095N
IntActⁱ	Q92556, 11 interactors
MINTⁱ	Q92556
STRINGⁱ	9606.ENSP00000312185

PTM databases

iPTMnetⁱ	Q92556
PhosphoSitePlusⁱ	Q92556

Polymorphism and mutation databases

BioMutaⁱ	ELMO1
DMDMⁱ	30923321

Proteomic databases

EPDⁱ	Q92556
MaxQBⁱ	Q92556
PaxDbⁱ	Q92556
PeptideAtlasⁱ	Q92556
PRIDEⁱ	Q92556
ProteomicsDBⁱ	75312 75313 [Q92556-2] 75314 [Q92556-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9844
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310758; ENSP00000312185; ENSG00000155849 [Q92556-1] ENST00000396040; ENSP00000379355; ENSG00000155849 [Q92556-2] ENST00000396045; ENSP00000379360; ENSG00000155849 [Q92556-2] ENST00000442504; ENSP00000406952; ENSG00000155849 [Q92556-1] ENST00000448602; ENSP00000394458; ENSG00000155849 [Q92556-1]
GeneIDⁱ	9844
KEGGⁱ	hsa:9844
UCSCⁱ	uc003tfi.3 human [Q92556-1]

Organism-specific databases

CTDⁱ	9844
DisGeNETⁱ	9844
EuPathDBⁱ	HostDB:ENSG00000155849.15
GeneCardsⁱ	ELMO1
HGNCⁱ	HGNC:16286 ELMO1
MIMⁱ	606420 gene
neXtProtⁱ	NX_Q92556
OpenTargetsⁱ	ENSG00000155849
PharmGKBⁱ	PA27754
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2999 Eukaryota ENOG410XPKN LUCA
GeneTreeⁱ	ENSGT00390000014155
HOGENOMⁱ	HOG000230985
HOVERGENⁱ	HBG051463
InParanoidⁱ	Q92556
KOⁱ	K12366
OMAⁱ	INVCRPA
OrthoDBⁱ	EOG091G03JJ
PhylomeDBⁱ	Q92556
TreeFamⁱ	TF312966

Enzyme and pathway databases

Reactomeⁱ	R-HSA-164944 Nef and signal transduction R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SIGNORⁱ	Q92556

Miscellaneous databases

ChiTaRSⁱ	ELMO1 human
EvolutionaryTraceⁱ	Q92556
GeneWikiⁱ	ELMO1
GenomeRNAiⁱ	9844
Protein Ontology More...PROⁱ	PR:Q92556
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155849 Expressed in 206 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ELMO1
ExpressionAtlasⁱ	Q92556 baseline and differential
Genevisibleⁱ	Q92556 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR024574 DUF3361 IPR030715 ELMO1 IPR006816 ELMO_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR12771:SF23 PTHR12771:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF11841 DUF3361, 1 hit PF04727 ELMO_CED12, 1 hit PF16457 PH_12, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51335 ELMO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELMO1_HUMAN
Accessionⁱ	Q92556Primary (citable) accession number: Q92556 Secondary accession number(s): A4D1X6 , Q29R79, Q6ZTJ0, Q96PB0, Q9H0I1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 16, 2003
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q92556 (ELMO1_HUMAN)

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Engulfment and cell motility protein 1

ELMO1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

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Keywords - Cellular componenti

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

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Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ