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Entry version 180 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

DNA topoisomerase 2-binding protein 1

Gene

TOPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92547

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92547

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 2-binding protein 1
Alternative name(s):
DNA topoisomerase II-beta-binding protein 1
Short name:
TopBP1
DNA topoisomerase II-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPBP1
Synonyms:KIAA0259
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17008 TOPBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607760 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92547

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11073

Open Targets

More...
OpenTargetsi
ENSG00000163781

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934073

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3175

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOPBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453012

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726311 – 1522DNA topoisomerase 2-binding protein 1Add BLAST1522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei298PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei779PhosphothreonineCombined sources1
Modified residuei848PhosphothreonineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei861PhosphothreonineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei886PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1064PhosphothreonineCombined sources1
Modified residuei1504PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues in response to X-ray irradiation.2 Publications
Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-3258
CPTAC-3290
CPTAC-3291
CPTAC-950

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92547

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92547

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92547

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92547

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92547

PeptideAtlas

More...
PeptideAtlasi
Q92547

PRoteomics IDEntifications database

More...
PRIDEi
Q92547

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75308

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92547

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92547

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, brain, placenta, lung and kidney.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163781 Expressed in 225 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92547 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92547 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022451
HPA036738
HPA036739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLE (PubMed:11395493).

Interacts with RAD9A (PubMed:11395493).

Interacts with UBR5 (PubMed:11714696).

Interacts with E2F1 (PubMed:12697828, PubMed:15075294).

Interacts with PML (PubMed:12773567).

Interacts with SMARCA2 (PubMed:15075294).

Interacts with SMARCA4 (PubMed:15075294).

Interacts with RHNO1 (PubMed:21659603). May interact with TOP2B (PubMed:9461304).

Interacts with TICRR (PubMed:20080954).

Interacts with HELB (PubMed:25933514).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116256, 68 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q92547

Database of interacting proteins

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DIPi
DIP-24263N

Protein interaction database and analysis system

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IntActi
Q92547, 31 interactors

Molecular INTeraction database

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MINTi
Q92547

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260810

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92547

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92547

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q92547

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 189BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini195 – 284BRCT 2PROSITE-ProRule annotationAdd BLAST90
Domaini354 – 444BRCT 3PROSITE-ProRule annotationAdd BLAST91
Domaini548 – 633BRCT 4PROSITE-ProRule annotationAdd BLAST86
Domaini641 – 738BRCT 5PROSITE-ProRule annotationAdd BLAST98
Domaini900 – 991BRCT 6PROSITE-ProRule annotationAdd BLAST92
Domaini1259 – 1351BRCT 7PROSITE-ProRule annotationAdd BLAST93
Domaini1389 – 1486BRCT 8PROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi852 – 858Nuclear localization signalSequence analysis7
Motifi1517 – 1520Nuclear localization signalSequence analysis4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1929 Eukaryota
ENOG410XPFH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154662

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92547

KEGG Orthology (KO)

More...
KOi
K10728

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRAFRSQ

Database of Orthologous Groups

More...
OrthoDBi
557169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92547

TreeFam database of animal gene trees

More...
TreeFami
TF326403

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR035960 Secretoglobin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48201 SSF48201, 1 hit
SSF52113 SSF52113, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92547-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRNDKEPFF VKFLKSSDNS KCFFKALESI KEFQSEEYLQ IITEEEALKI
60 70 80 90 100
KENDRSLYIC DPFSGVVFDH LKKLGCRIVG PQVVIFCMHH QRCVPRAEHP
110 120 130 140 150
VYNMVMSDVT ISCTSLEKEK REEVHKYVQM MGGRVYRDLN VSVTHLIAGE
160 170 180 190 200
VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ EKKITRYTDI NMEDFKCPIF
210 220 230 240 250
LGCIICVTGL CGLDRKEVQQ LTVKHGGQYM GQLKMNECTH LIVQEPKGQK
260 270 280 290 300
YECAKRWNVH CVTTQWFFDS IEKGFCQDES IYKTEPRPEA KTMPNSSTPT
310 320 330 340 350
SQINTIDSRT LSDVSNISNI NASCVSESIC NSLNSKLEPT LENLENLDVS
360 370 380 390 400
AFQAPEDLLD GCRIYLCGFS GRKLDKLRRL INSGGGVRFN QLNEDVTHVI
410 420 430 440 450
VGDYDDELKQ FWNKSAHRPH VVGAKWLLEC FSKGYMLSEE PYIHANYQPV
460 470 480 490 500
EIPVSHKPES KAALLKKKNS SFSKKDFAPS EKHEQADEDL LSQYENGSST
510 520 530 540 550
VVEAKTSEAR PFNDSTHAEP LNDSTHISLQ EENQSSVSHC VPDVSTITEE
560 570 580 590 600
GLFSQKSFLV LGFSNENESN IANIIKENAG KIMSLLSRTV ADYAVVPLLG
610 620 630 640 650
CEVEATVGEV VTNTWLVTCI DYQTLFDPKS NPLFTPVPVM TGMTPLEDCV
660 670 680 690 700
ISFSQCAGAE KESLTFLANL LGASVQEYFV RKSNAKKGMF ASTHLILKER
710 720 730 740 750
GGSKYEAAKK WNLPAVTIAW LLETARTGKR ADESHFLIEN STKEERSLET
760 770 780 790 800
EITNGINLNS DTAEHPGTRL QTHRKTVVTP LDMNRFQSKA FRAVVSQHAR
810 820 830 840 850
QVAASPAVGQ PLQKEPSLHL DTPSKFLSKD KLFKPSFDVK DALAALETPG
860 870 880 890 900
RPSQQKRKPS TPLSEVIVKN LQLALANSSR NAVALSASPQ LKEAQSEKEE
910 920 930 940 950
APKPLHKVVV CVSKKLSKKQ SELNGIAASL GADYRWSFDE TVTHFIYQGR
960 970 980 990 1000
PNDTNREYKS VKERGVHIVS EHWLLDCAQE CKHLPESLYP HTYNPKMSLD
1010 1020 1030 1040 1050
ISAVQDGRLC NSRLLSAVSS TKDDEPDPLI LEENDVDNMA TNNKESAPSN
1060 1070 1080 1090 1100
GSGKNDSKGV LTQTLEMREN FQKQLQEIMS ATSIVKPQGQ RTSLSRSGCN
1110 1120 1130 1140 1150
SASSTPDSTR SARSGRSRVL EALRQSRQTV PDVNTEPSQN EQIIWDDPTA
1160 1170 1180 1190 1200
REERARLASN LQWPSCPTQY SELQVDIQNL EDSPFQKPLH DSEIAKQAVC
1210 1220 1230 1240 1250
DPGNIRVTEA PKHPISEELE TPIKDSHLIP TPQAPSIAFP LANPPVAPHP
1260 1270 1280 1290 1300
REKIITIEET HEELKKQYIF QLSSLNPQER IDYCHLIEKL GGLVIEKQCF
1310 1320 1330 1340 1350
DPTCTHIVVG HPLRNEKYLA SVAAGKWVLH RSYLEACRTA GHFVQEEDYE
1360 1370 1380 1390 1400
WGSSSILDVL TGINVQQRRL ALAAMRWRKK IQQRQESGIV EGAFSGWKVI
1410 1420 1430 1440 1450
LHVDQSREAG FKRLLQSGGA KVLPGHSVPL FKEATHLFSD LNKLKPDDSG
1460 1470 1480 1490 1500
VNIAEAAAQN VYCLRTEYIA DYLMQESPPH VENYCLPEAI SFIQNNKELG
1510 1520
TGLSQKRKAP TEKNKIKRPR VH
Length:1,522
Mass (Da):170,679
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02C25880EDCD6AC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1F2I3L1F2_HUMAN
DNA topoisomerase 2-binding protein...
TOPBP1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD63A0A2R8YD63_HUMAN
DNA topoisomerase 2-binding protein...
TOPBP1
1,517Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13389 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA34202 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti457K → Q in BAA34202 (PubMed:9461304).Curated1
Sequence conflicti457K → Q in BAA13389 (PubMed:9039502).Curated1
Sequence conflicti911C → R in BAH13754 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059733817S → L. Corresponds to variant dbSNP:rs17301766Ensembl.1
Natural variantiVAR_057007955N → S. Corresponds to variant dbSNP:rs10935070Ensembl.1
Natural variantiVAR_0597341042N → S. Corresponds to variant dbSNP:rs10935070Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019397 mRNA Translation: BAA34202.1 Different initiation.
D87448 mRNA Translation: BAA13389.1 Different initiation.
AK302584 mRNA Translation: BAH13754.1
AC016255 Genomic DNA No translation available.
AC083905 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46919.1

NCBI Reference Sequences

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RefSeqi
NP_008958.2, NM_007027.3
XP_016861125.1, XM_017005636.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260810; ENSP00000260810; ENSG00000163781

Database of genes from NCBI RefSeq genomes

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GeneIDi
11073

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11073

UCSC genome browser

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UCSCi
uc003eps.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019397 mRNA Translation: BAA34202.1 Different initiation.
D87448 mRNA Translation: BAA13389.1 Different initiation.
AK302584 mRNA Translation: BAH13754.1
AC016255 Genomic DNA No translation available.
AC083905 Genomic DNA No translation available.
CCDSiCCDS46919.1
RefSeqiNP_008958.2, NM_007027.3
XP_016861125.1, XM_017005636.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF6NMR-A326-444[»]
2XNHX-ray2.80A1-287[»]
2XNKX-ray2.60A/B/C/D1-290[»]
3AL2X-ray2.00A1264-1493[»]
3AL3X-ray2.15A1264-1493[»]
3JVEX-ray1.34A893-996[»]
3OLCX-ray2.40X1-290[»]
3PD7X-ray1.26A/B893-994[»]
3UENX-ray1.90A549-746[»]
3UEOX-ray2.60A/B/C/D549-746[»]
6RMLX-ray2.81A/B1-290[»]
6RMMX-ray3.53A/B/C/D548-741[»]
SMRiQ92547
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116256, 68 interactors
CORUMiQ92547
DIPiDIP-24263N
IntActiQ92547, 31 interactors
MINTiQ92547
STRINGi9606.ENSP00000260810

Chemistry databases

BindingDBiQ92547
ChEMBLiCHEMBL3175

PTM databases

iPTMnetiQ92547
PhosphoSitePlusiQ92547

Polymorphism and mutation databases

BioMutaiTOPBP1
DMDMi296453012

Proteomic databases

CPTACiCPTAC-3258
CPTAC-3290
CPTAC-3291
CPTAC-950
EPDiQ92547
jPOSTiQ92547
MassIVEiQ92547
MaxQBiQ92547
PaxDbiQ92547
PeptideAtlasiQ92547
PRIDEiQ92547
ProteomicsDBi75308

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260810; ENSP00000260810; ENSG00000163781
GeneIDi11073
KEGGihsa:11073
UCSCiuc003eps.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11073
DisGeNETi11073

GeneCards: human genes, protein and diseases

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GeneCardsi
TOPBP1
HGNCiHGNC:17008 TOPBP1
HPAiCAB022451
HPA036738
HPA036739
MIMi607760 gene
neXtProtiNX_Q92547
OpenTargetsiENSG00000163781
PharmGKBiPA134934073

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1929 Eukaryota
ENOG410XPFH LUCA
GeneTreeiENSGT00940000157001
HOGENOMiHOG000154662
InParanoidiQ92547
KOiK10728
OMAiHRAFRSQ
OrthoDBi557169at2759
PhylomeDBiQ92547
TreeFamiTF326403

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SignaLinkiQ92547
SIGNORiQ92547

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TOPBP1 human
EvolutionaryTraceiQ92547

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TOPBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11073

Pharos

More...
Pharosi
Q92547

Protein Ontology

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PROi
PR:Q92547

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163781 Expressed in 225 organ(s), highest expression level in intestine
ExpressionAtlasiQ92547 baseline and differential
GenevisibleiQ92547 HS

Family and domain databases

Gene3Di3.40.50.10190, 9 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF00533 BRCT, 4 hits
PF12738 PTCB-BRCT, 2 hits
SMARTiView protein in SMART
SM00292 BRCT, 7 hits
SUPFAMiSSF48201 SSF48201, 1 hit
SSF52113 SSF52113, 6 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92547
Secondary accession number(s): B7Z7W8, Q7LGC1, Q9UEB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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